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Central Dogma Activity Worksheet
Central Dogma Activity Worksheet

... Every cell in your body has the same "blueprint" or the same DNA. Like the blueprints of a house tell the builders how to construct a house, the DNA "blueprint" tells the cell how to build the organism. Yet, how can a heart be so different from a brain if all the cells contain the same instructions? ...
Variation in Inherited Characteristics
Variation in Inherited Characteristics

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Genetic Engineering
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Protein synthesis test review key
Protein synthesis test review key

... 12. What happens to the mRNA sequence if the DNA sequence changes? What happens to the sequence of amino acids of the DNA sequence changes? What happens to the final protein if the DNA sequence changes? If the DNA sequence changes, then the mRNA sequence will change. The amino acids may or may not c ...
Topics that we have covered
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...  Can cause Genetic disorders.  Typically found in centromeres and telomeres so it is thought to be used for structure.  Interspersed Repetitive DNA—Copies of similar sequences but not repetitive. ...
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Mutations - Biology R: 4(A,C)

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Session 4 - OpenWetWare
Session 4 - OpenWetWare

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HGP - eduBuzz.org
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... Uses physical properties of DNA (size and charge) to separate molecules Gel electrophoresis involves running an electric current through an agarose gel. DNA is loaded into wells at the negative end. DNA is repelled, and moves through the agarose gel at different speeds depending on the size of a fra ...
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... The three molecules that comprise DNA are called a nucleotide and because nucleotides repeat themselves throughout the DNA molecule, DNA is called a polymer. (Polymers are molecules that consist of repeating units) III. The DNA molecule is two strands of the repeating deoxyribose, phosphate and base ...
Lecture Notes - Course Notes
Lecture Notes - Course Notes

... as post-transcriptional processing, involving cleavages of some sequences and additions of others. The fully processed, mature mRNA, is then transported to the cytoplasm, where translation takes place. It is the 3’ to 5’ strand of the DNA that is usually transcribed, but the 5’ to 3’ sequence of the ...
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Inheritance and the Structure of DNA

... • nucleotides are added from the 5’ end; creating a complementary strand of 3’->5’sporadically • since polymerase moves in a 5’->3’ it will move around to find location on the original strand that it can match up with to create segments on the new complementary DNA • this leaves gaps (called Okazaki ...
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Answers to Mastering Concepts Questions
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... 1. In a point mutations, one DNA base is substituted for another. Point mutations include missense mutations (which change a triplet base so it specifies a different amino acid) and nonsense mutations (which change an amino acid-encoding codon into a stop codon). Mutations that involve insertion or ...
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Gene mutation and sickle cell
Gene mutation and sickle cell

... How does sickle cell anaemia occur? • Single base substitution in the RNA sequence that codes for the beta chain of haemoglobin. • This results in a different amino acid being produced – valine instead of glutamate. • This type of mutation in the DNA sequence is called a point mutation. ...
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Deoxyribozyme



Deoxyribozymes, also called DNA enzymes, DNAzymes, or catalytic DNA, are DNA oligonucleotides that are capable of catalyzing specific chemical reactions, similar to the action of other biological enzymes, such as proteins or ribozymes (enzymes composed of RNA).However, in contrast to the abundance of protein enzymes in biological systems and the discovery of biological ribozymes in the 1980s,there are no known naturally occurring deoxyribozymes.Deoxyribozymes should not be confused with DNA aptamers which are oligonucleotides that selectively bind a target ligand, but do not catalyze a subsequent chemical reaction.With the exception of ribozymes, nucleic acid molecules within cells primarily serve as storage of genetic information due to its ability to form complementary base pairs, which allows for high-fidelity copying and transfer of genetic information. In contrast, nucleic acid molecules are more limited in their catalytic ability, in comparison to protein enzymes, to just three types of interactions: hydrogen bonding, pi stacking, and metal-ion coordination. This is due to the limited number of functional groups of the nucleic acid monomers: while proteins are built from up to twenty different amino acids with various functional groups, nucleic acids are built from just four chemically similar nucleobases. In addition, DNA lacks the 2'-hydroxyl group found in RNA which limits the catalytic competency of deoxyribozymes even in comparison to ribozymes.In addition to the inherent inferiority of DNA catalytic activity, the apparent lack of naturally occurring deoxyribozymes may also be due to the primarily double-stranded conformation of DNA in biological systems which would limit its physical flexibility and ability to form tertiary structures, and so would drastically limit the ability of double-stranded DNA to act as a catalyst; though there are a few known instances of biological single-stranded DNA such as multicopy single-stranded DNA (msDNA), certain viral genomes, and the replication fork formed during DNA replication. Further structural differences between DNA and RNA may also play a role in the lack of biological deoxyribozymes, such as the additional methyl group of the DNA base thymidine compared to the RNA base uracil or the tendency of DNA to adopt the B-form helix while RNA tends to adopt the A-form helix. However, it has also been shown that DNA can form structures that RNA cannot, which suggests that, though there are differences in structures that each can form, neither is inherently more or less catalytic due to their possible structural motifs.
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