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Mutations
Mutations

... Example: Sickle cell anemia ...
single cells
single cells

... FISH is a cytogenetic technique that uses fluorescent probes that bind to only those parts of the chromosome with a high degree of sequence complementarity. It was developed by biomedical researchers in the early 1980s and is used for detecting RNA (mRNA, long non-coding RNA and miRNA) or DNA sequen ...
Discuss how living things need to adapt to changing
Discuss how living things need to adapt to changing

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Environmental Health: sanitation, water, pesticide and - Wk 1-2
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... 2. Indirect acting carcinogens/procarcinogens: require metabolic conversion in vivo to produce ultimate carcinogens capable of transforming cells. Molecular targets of chemical carcinogens  Malignant transformation results usually from mutations that affect oncogenes, tumour suppressor genes and ge ...
Teacher Notes - Ursinus College Student, Faculty and Staff Web
Teacher Notes - Ursinus College Student, Faculty and Staff Web

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Genetics SHOW
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Teacher`s Guide for “Heredity” CT State Standards National Science
Teacher`s Guide for “Heredity” CT State Standards National Science

... 2. Pedigree
–
a
diagram
which
is
used
to
map
out
genetic
relationships
 within
a
family
line
 3. Chromosomes
–
an
organized
structure
of
DNA
that
contains
genes
 4. DNA
–
deoxyribonucleic
acid
–
found
in
nucleus
of
cells
which
 contains
hereditary
material

 5. Base
pairs
–
DNA
consists
of
4
base
pa ...
Cynthia Smith - people.csail.mit.edu
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DNA - Ms Futch
DNA - Ms Futch

... (4) Staining the sorted DNA makes them visible to the naked eye. Although we cannot see a single strand of DNA, we can see larger groups of stained DNA strands. These groups show up as bands in the gel. Describe how fast different size fragments move. Short strands move through the gel quicker than ...
DNA - NIU Department of Biological Sciences
DNA - NIU Department of Biological Sciences

... 2. Insertions or deletions of large pieces of DNA. 3. Combining parts of 2 different genes together. Mutations are very common: every cell contains multiple mutations. Also, everyone is genetically different from every other person due to the accumulation of mutations. Genetic load: on average, each ...
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Deoxyribozyme



Deoxyribozymes, also called DNA enzymes, DNAzymes, or catalytic DNA, are DNA oligonucleotides that are capable of catalyzing specific chemical reactions, similar to the action of other biological enzymes, such as proteins or ribozymes (enzymes composed of RNA).However, in contrast to the abundance of protein enzymes in biological systems and the discovery of biological ribozymes in the 1980s,there are no known naturally occurring deoxyribozymes.Deoxyribozymes should not be confused with DNA aptamers which are oligonucleotides that selectively bind a target ligand, but do not catalyze a subsequent chemical reaction.With the exception of ribozymes, nucleic acid molecules within cells primarily serve as storage of genetic information due to its ability to form complementary base pairs, which allows for high-fidelity copying and transfer of genetic information. In contrast, nucleic acid molecules are more limited in their catalytic ability, in comparison to protein enzymes, to just three types of interactions: hydrogen bonding, pi stacking, and metal-ion coordination. This is due to the limited number of functional groups of the nucleic acid monomers: while proteins are built from up to twenty different amino acids with various functional groups, nucleic acids are built from just four chemically similar nucleobases. In addition, DNA lacks the 2'-hydroxyl group found in RNA which limits the catalytic competency of deoxyribozymes even in comparison to ribozymes.In addition to the inherent inferiority of DNA catalytic activity, the apparent lack of naturally occurring deoxyribozymes may also be due to the primarily double-stranded conformation of DNA in biological systems which would limit its physical flexibility and ability to form tertiary structures, and so would drastically limit the ability of double-stranded DNA to act as a catalyst; though there are a few known instances of biological single-stranded DNA such as multicopy single-stranded DNA (msDNA), certain viral genomes, and the replication fork formed during DNA replication. Further structural differences between DNA and RNA may also play a role in the lack of biological deoxyribozymes, such as the additional methyl group of the DNA base thymidine compared to the RNA base uracil or the tendency of DNA to adopt the B-form helix while RNA tends to adopt the A-form helix. However, it has also been shown that DNA can form structures that RNA cannot, which suggests that, though there are differences in structures that each can form, neither is inherently more or less catalytic due to their possible structural motifs.
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