Biological effects of Extracellular fibrinogen binding protein (Efb) in
... identify and characterise bacterial factors that contribute to infection. S. aureus produces a diverse array of virulence factors, among these Extracellular fibrinogen binding protein, Efb. Efb is one of several fibrinogen-binding proteins produced by S. aureus. Efb is produced in vivo during infect ...
... identify and characterise bacterial factors that contribute to infection. S. aureus produces a diverse array of virulence factors, among these Extracellular fibrinogen binding protein, Efb. Efb is one of several fibrinogen-binding proteins produced by S. aureus. Efb is produced in vivo during infect ...
Chromatin Association of Gcn4 Is Limited by Post
... ABSTRACT The Saccharomyces cerevisiae transcription factor Gcn4 is expressed during amino acid starvation and its abundance is controlled by ubiquitin-mediated proteolysis. Cdk8, a kinase component of the RNA polymerase II Mediator complex, phosphorylates Gcn4 which triggers its ubiquitination/prot ...
... ABSTRACT The Saccharomyces cerevisiae transcription factor Gcn4 is expressed during amino acid starvation and its abundance is controlled by ubiquitin-mediated proteolysis. Cdk8, a kinase component of the RNA polymerase II Mediator complex, phosphorylates Gcn4 which triggers its ubiquitination/prot ...
Mitochondrial trafficking and anchoring in neurons
... bi-directional transport: dynein motors drive retrograde movement, whereas kinesin motors mediate anterograde transport. Of the 45 kinesin motor genes identified, the kinesin-1 family (KIF5) is the key motor driving mitochondrial transport in neurons (Hurd and Saxton, 1996; Tanaka et al., 1998; Górs ...
... bi-directional transport: dynein motors drive retrograde movement, whereas kinesin motors mediate anterograde transport. Of the 45 kinesin motor genes identified, the kinesin-1 family (KIF5) is the key motor driving mitochondrial transport in neurons (Hurd and Saxton, 1996; Tanaka et al., 1998; Górs ...
tau strains and their propagation in experimental disease models
... [16], and agyrophilic grain disease brain tissue [17, 18], while Pick’s disease inclusions are predominantly composed of 3R isoforms [19]. Prions are infectious agents composed of alternatively folded protein with the ability to transmit disease through recruitment and conversion of normally folded ...
... [16], and agyrophilic grain disease brain tissue [17, 18], while Pick’s disease inclusions are predominantly composed of 3R isoforms [19]. Prions are infectious agents composed of alternatively folded protein with the ability to transmit disease through recruitment and conversion of normally folded ...
History of the Glycosaminoglycan Symposia in the Scientific Context
... Most commonly, tissue is digested using alkaline pH and/or proteolytic enzymes. – Alternately, autolysis or a salt extraction can be performed. ...
... Most commonly, tissue is digested using alkaline pH and/or proteolytic enzymes. – Alternately, autolysis or a salt extraction can be performed. ...
Phylogenetic Classification of Protozoa Based on the
... linker polypeptide, even within the Apicomplexans, varies significantly in length; the entire linker in C. hominis is 58 amino acids, the linker in Toxoplasma gondii is 72 amino acids, and the linker in P. falciparum is 89 amino acids. The linker in ChDHFR-TS plays an important role in the structure ...
... linker polypeptide, even within the Apicomplexans, varies significantly in length; the entire linker in C. hominis is 58 amino acids, the linker in Toxoplasma gondii is 72 amino acids, and the linker in P. falciparum is 89 amino acids. The linker in ChDHFR-TS plays an important role in the structure ...
Reduced Vglut2/Slc17a6 gene expression levels
... Alerts: Sign up at eneuro.org/alerts to receive customized email alerts when the fully formatted version of this article is published. Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. This is an open-access article distributed und ...
... Alerts: Sign up at eneuro.org/alerts to receive customized email alerts when the fully formatted version of this article is published. Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. This is an open-access article distributed und ...
Bioconjug. Chem. 2013, DOI: 10.1021/bc400032x
... In our previous publications,34−36 we used a copolymer of mPEG and MBC/PCC for delivery of hydrophobic drugs which get solubilized in the core of the micelles. However, the current work focuses on delivery of hydrophilic drug, gemcitabine, which itself is a challenging molecule for encapsulation in ...
... In our previous publications,34−36 we used a copolymer of mPEG and MBC/PCC for delivery of hydrophobic drugs which get solubilized in the core of the micelles. However, the current work focuses on delivery of hydrophilic drug, gemcitabine, which itself is a challenging molecule for encapsulation in ...
Phylogenetic Classification of Protozoa Based on the Structure of
... linker polypeptide, even within the Apicomplexans, varies significantly in length; the entire linker in C. hominis is 58 amino acids, the linker in Toxoplasma gondii is 72 amino acids, and the linker in P. falciparum is 89 amino acids. The linker in ChDHFR-TS plays an important role in the structure ...
... linker polypeptide, even within the Apicomplexans, varies significantly in length; the entire linker in C. hominis is 58 amino acids, the linker in Toxoplasma gondii is 72 amino acids, and the linker in P. falciparum is 89 amino acids. The linker in ChDHFR-TS plays an important role in the structure ...
Lipoprotein Lipase in the Arterial Wall
... The role of apolipoproteins in the interaction between LPL and triglyceride-rich lipoproteins during hydrolysis of triglycerides has been studied extensively. Efficient hydrolysis of triglyceride-rich lipoproteins depends on 1 of the several apolipoproteins present on the surface of these particles, ...
... The role of apolipoproteins in the interaction between LPL and triglyceride-rich lipoproteins during hydrolysis of triglycerides has been studied extensively. Efficient hydrolysis of triglyceride-rich lipoproteins depends on 1 of the several apolipoproteins present on the surface of these particles, ...
Two different but converging messenger pathways to intracellular
... play a role, but it would also seem reasonable to consider the possibility that other Ca2+-releasing messengers may be of functional importance. Both cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) release Ca2+ from sea-urchin egg microsomes (Galione, 1993; Genazz ...
... play a role, but it would also seem reasonable to consider the possibility that other Ca2+-releasing messengers may be of functional importance. Both cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) release Ca2+ from sea-urchin egg microsomes (Galione, 1993; Genazz ...
Murine Regulatory T Cells Contain Hyperproliferative and Death
... than Tcon, particularly when the stimulation was weak (Fig. 1D). Differential sensitivity to activation-induced death between proliferating Treg and Tcon The differences of Treg proliferation between total Treg and live Treg prompted us to examine survival and death of Treg during in vitro culture. ...
... than Tcon, particularly when the stimulation was weak (Fig. 1D). Differential sensitivity to activation-induced death between proliferating Treg and Tcon The differences of Treg proliferation between total Treg and live Treg prompted us to examine survival and death of Treg during in vitro culture. ...
Cationic albumin-conjugated pegylated nanoparticles as novel drug
... Recently, immunoliposomes, in which the brain specific targetors were covalently conjugated to polyethyleneglycol (PEG) modified liposomes (pegylated liposomes) as drug carrier via the tips of its functional PEG strands, proved to be successful in brain drug delivery. Its advantages over the drug–ta ...
... Recently, immunoliposomes, in which the brain specific targetors were covalently conjugated to polyethyleneglycol (PEG) modified liposomes (pegylated liposomes) as drug carrier via the tips of its functional PEG strands, proved to be successful in brain drug delivery. Its advantages over the drug–ta ...
Muscle length and myonuclear position are
... The size, shape and organization of tissues and individual cells directly impact their physiology. A pressing question in cell and developmental biology is how different morphogenetic processes that are necessary for the functional development of a common tissue are coordinated. Skeletal muscle prov ...
... The size, shape and organization of tissues and individual cells directly impact their physiology. A pressing question in cell and developmental biology is how different morphogenetic processes that are necessary for the functional development of a common tissue are coordinated. Skeletal muscle prov ...
OglIb~3 Integrin Dissociation Induced by EDTA Results in
... causes tension in others, resulting in their collapsed appearance. On the other hand, when human platelets are incubated for 30 min at 37"C with 5 mM EDTA and then resuspended in a calcium containing medium, they lose their ability to bind fibrinogen and to aggregate in response to ADP stimulation ( ...
... causes tension in others, resulting in their collapsed appearance. On the other hand, when human platelets are incubated for 30 min at 37"C with 5 mM EDTA and then resuspended in a calcium containing medium, they lose their ability to bind fibrinogen and to aggregate in response to ADP stimulation ( ...
Microbiology
... The Edw. ictaluri host factors that modulate phage–host interactions have not been described previously. This study identified eleven unique Edw. ictaluri host factors essential for phage infection by screening a transposon mutagenized library of two Edw. ictaluri strains for phageresistant mutants. ...
... The Edw. ictaluri host factors that modulate phage–host interactions have not been described previously. This study identified eleven unique Edw. ictaluri host factors essential for phage infection by screening a transposon mutagenized library of two Edw. ictaluri strains for phageresistant mutants. ...
Nitrate regulation of metabolism and growth Mark Stitt
... and internal nitrate concentration can be varied independently of the rate of nitrate assimilation and the resulting changes in the levels of downstream metabolites and growth rate [6••,7••,11,12,13•,14,15••]. Complementary approaches to identify nitrate-regulated processes include investigating the ...
... and internal nitrate concentration can be varied independently of the rate of nitrate assimilation and the resulting changes in the levels of downstream metabolites and growth rate [6••,7••,11,12,13•,14,15••]. Complementary approaches to identify nitrate-regulated processes include investigating the ...
Augmenting Glutathione in Chronic Fatigue Syndrome (ME/CFS) by
... form cystine, and cysteine is more useable by the liver for making glutathione, particularly in a person who is depleted in glutathione. The “undenatured” and “nondenatured” whey protein products can be problematical for those with allergies to whey proteins, and the goat-milk based version Goatein ...
... form cystine, and cysteine is more useable by the liver for making glutathione, particularly in a person who is depleted in glutathione. The “undenatured” and “nondenatured” whey protein products can be problematical for those with allergies to whey proteins, and the goat-milk based version Goatein ...
Serine Residues 286, 288, and 293 within the CIITA: A
... to undergo nuclear import (19 –21, 26). The purpose of this dual subcellular localization remains to be determined. Treatment of cells with leptomycin B, an inhibitor of nuclear export, causes accumulation of CIITA in the nucleus. Export of CIITA is probably mediated by one or more nuclear export si ...
... to undergo nuclear import (19 –21, 26). The purpose of this dual subcellular localization remains to be determined. Treatment of cells with leptomycin B, an inhibitor of nuclear export, causes accumulation of CIITA in the nucleus. Export of CIITA is probably mediated by one or more nuclear export si ...
Axonal of Kinesin in the Chain Isoforms
... major axonal transport rate components, less has been known about underlying molecular mechanisms. Discovery of the mechanochemical ATPase kinesin (Brady, 1985b; Vale et al., 1985) provided a candidate motor molecule for movement of membrane bounded organelles in FC, but questions remained about mot ...
... major axonal transport rate components, less has been known about underlying molecular mechanisms. Discovery of the mechanochemical ATPase kinesin (Brady, 1985b; Vale et al., 1985) provided a candidate motor molecule for movement of membrane bounded organelles in FC, but questions remained about mot ...
The Presynaptic Microtubule Cytoskeleton in Physiological and
... preparations derived from mammal Calyx of Held synapses by electron tomography, where MTs form a mitochondrionassociated adherens complex (MAC) that determines the precise anchoring of these organelles in the presynaptic terminal (Perkins et al., 2010). By immunocytochemistry, prominent MT bundles t ...
... preparations derived from mammal Calyx of Held synapses by electron tomography, where MTs form a mitochondrionassociated adherens complex (MAC) that determines the precise anchoring of these organelles in the presynaptic terminal (Perkins et al., 2010). By immunocytochemistry, prominent MT bundles t ...
A basic serine protease from Paecilomyces lilacinus
... The purified enzyme was incubated for 40min at 4OC with individual inhibitors and subsequently protease activity was determined. Protease activity was expressed as a percentage of the activity found in the absence of inhibitor. The final concentration of inhibitor was 1 mM. Vitellin (1 mg) was incub ...
... The purified enzyme was incubated for 40min at 4OC with individual inhibitors and subsequently protease activity was determined. Protease activity was expressed as a percentage of the activity found in the absence of inhibitor. The final concentration of inhibitor was 1 mM. Vitellin (1 mg) was incub ...
2004__MORRIS_et_al_Transpor... - Institute of Experimental Botany
... Auxin Efflux Carriers Are Multi-Component Systems It is probable that auxin efflux carriers are multi-component systems consisting of at least two, but possibly more individual protein components, each with a different function (61). The synthetic auxin transport inhibitor NPA strongly inhibits auxi ...
... Auxin Efflux Carriers Are Multi-Component Systems It is probable that auxin efflux carriers are multi-component systems consisting of at least two, but possibly more individual protein components, each with a different function (61). The synthetic auxin transport inhibitor NPA strongly inhibits auxi ...
DORNRÖSCHEN is a direct target of the auxin response factor
... Przemeck et al., 1996). ARFs bind to TGTCTC auxin response elements (AuxRE) in promoters of auxin-responsive genes (Ulmasov et al., 1997a) and function in combination with Aux/IAA (auxin/indole acetic acid) inhibitors, which dimerize with ARF activators in an auxin-regulated manner and hence modulat ...
... Przemeck et al., 1996). ARFs bind to TGTCTC auxin response elements (AuxRE) in promoters of auxin-responsive genes (Ulmasov et al., 1997a) and function in combination with Aux/IAA (auxin/indole acetic acid) inhibitors, which dimerize with ARF activators in an auxin-regulated manner and hence modulat ...