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Slide 1
Slide 1

... Types of Mutation 1. Induced – caused by mutagen; increased frequency of mutation b. Chemicals (1) nucleotide base analogues  mispairing (e.g. 5-bromouracil and thymine) (2) polycyclic flat molecules (e.g. EtBr)  intercalates DNA  inc. spacing of successive base pairs ...
Genetics Review
Genetics Review

... What are the sides of a DNA molecule made up of? During which phase does the copying of DNA occur? What are the middle “rungs” of the DNA ladder made up of? What are the 4 bases that are found in DNA? Adenine pairs with Guanine pairs with Cytosine pairs with Thymine pairs with What is another name f ...
Describe the central dogma of molecular biology.
Describe the central dogma of molecular biology.

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Teacher Kit Transcription
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...  Blank polypeptide chain upon which the student codes the amino acid sequence. If correct this code will correspond to the teacher key in Appendix B. The three letter abbreviations for the amino acids can be found in Appendix C and should be copied for student use. ...
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... is the process by which DNA fragments are drawn through an agarose gel from a negative to a positive charge due to the negative charge of the phosphate group on the single strand DNA.  The technique used to transfer DNA patterns for reading is called Southern ...
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Nucleic acid analogue



Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pucker-shaped pentose sugar, either ribose or deoxyribose, and one of four nucleobases.An analogue may have any of these altered. Typically the analogue nucleobases confer, among other things, different base pairing and base stacking properties. Examples include universal bases, which can pair with all four canonical bases, and phosphate-sugar backbone analogues such as PNA, which affect the properties of the chain (PNA can even form a triple helix).Nucleic acid analogues are also called Xeno Nucleic Acid and represent one of the main pillars of xenobiology, the design of new-to-nature forms of life based on alternative biochemistries.Artificial nucleic acids include peptide nucleic acid (PNA), Morpholino and locked nucleic acid (LNA), as well as glycol nucleic acid (GNA) and threose nucleic acid (TNA). Each of these is distinguished from naturally occurring DNA or RNA by changes to the backbone of the molecule.In May 2014, researchers announced that they had successfully introduced two new artificial nucleotides into bacterial DNA, and by including individual artificial nucleotides in the culture media, were able to passage the bacteria 24 times; they did not create mRNA or proteins able to use the artificial nucleotides. The artificial nucleotides featured 2 fused aromatic rings.
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