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Amino Acids
Amino Acids

... The intracellular pH is also near 7, so about half the imidazole groups will be protonated. In other words, the imidazole groups can easily abstract a proton or give one up, as is required for catalysis, and remain unchanged at the end of the reaction. It is more likely that the pK of these groups i ...
Molecular Mechanisms of Long Noncoding RNAs
Molecular Mechanisms of Long Noncoding RNAs

No Evidence of Neandertal mtDNA Contribution to Early Modern
No Evidence of Neandertal mtDNA Contribution to Early Modern

... compatible with results suggesting that the extent of Neandertal mtDNA diversity was similar to that of current humans and lower than that of the great apes (Krings et al. 2000; Schmitz et al. 2002). It is noteworthy that this result is not an artifact created by discarding ‘‘modern-like’’ mtDNA seq ...
From gene to protein in higher plant mitochondria
From gene to protein in higher plant mitochondria

... have yielded in vitro as well as in vivo data demonstrating that three such single-subunit enzymes are coded by the nuclear genome, one of each being targeted to plastids and mitochondria and the third being imported into both organelles [28–30]. In the monocots maize and wheat similar mitochondrial ...
Mechanisms of fast and stringent search in homologous pairing of
Mechanisms of fast and stringent search in homologous pairing of

... PH, and shear force, suggesting that it may serve as the ‘default’ mode of chromosome pairing in vivo [2]. Various models have been proposed to explain the homology-dependent attraction between dsDNA molecules [9–11], many of which attribute this interaction to hydrophobic forces or electrostatics. ...
C-Collate3 740..903
C-Collate3 740..903

... Structures: Visualization.) A giant-loop, random walk model was proposed for interphase chromosome structure based on statistical analysis of the average distance between two chromosome sites, observed in nuclei by FISH, as a function of genomic distance. In this model, 30 nm chromatin ®bers are arr ...
types of gel - WordPress.com
types of gel - WordPress.com

... TYPES OF GEL 1. Agarose Agarose gels are made from the natural polysaccharide polymers extracted from seaweed. Agarose gels are easily cast and handled compared to other matrices, because the gel setting is a physical rather than chemical change. Samples are also easily recovered. After the experime ...
transition metal complexes of amino acid and peptide derivatives
transition metal complexes of amino acid and peptide derivatives

... The main goal of this work was to reveal the interaction between some transition metal ions and amino acid and peptides derivatives. The studied ligands contain carboxylate and/or imidazole groups in their side chains, which are the main binding sites of metalloenzymes. For the bis(imidazol-2-yl) de ...
Discovering the Distribution of Palindromic Sequences in the
Discovering the Distribution of Palindromic Sequences in the

... The appropriate .fasta files from GenBank were downloaded: Homo sapiens Chromosome 18, GRCh37.p5 Primary Assembly (region: 48,556,583 to 48,611,412) and Homo sapiens SMAD family member 4 (SMAD4)12 ( accession number NM_005359). The large deletion mutations on the SMAD4 database were converted into a ...
Bio CET 2015 Key Answers
Bio CET 2015 Key Answers

... 2) Marino ewes with Bikaneri Rams 3) Superior Bull with Superior Cow 4) Bikaneri ewes with Marino Rams Ans. (4) The nitrogen base found only in DNA is also called 1) Uracil 2) 5-methyl uracil 3) Guanine 4) NH4Cl Ans. (2) The hormone which acts on Sertoli cells and stiniulates the process of spermiog ...
HLRCC Science
HLRCC Science

... and DNA replication, mistakes can be made. Mistakes can also occur when DNA is damaged by radiation, sunlight and chemicals. Often the cells can repair damaged DNA, but as we get older our repair mechanisms don't work as well and mutations can accumulate. There are many different types of mutations ...
Non-Type 1 Cystinuria Marker DNA Test for Mastiff
Non-Type 1 Cystinuria Marker DNA Test for Mastiff

... non-­‐sex  chromosomes  are  referred  to  as  autosomes.    So,  when  looking  at  an  individual’s  DNA,   there  are  two  copies  of  each  autosome,  and  therefore  two  copies  of  each  gene  or  DNA  marker   (except  in   ...
Lecture 2
Lecture 2

... adjacent strand through hydrogen bonds. Amino acids in anti-parallel strands on the other hand interact with only one amino acid on an adjacent strand. Protein secondary structures – Turns & Loops: Almost all proteins exhibit a compact, globular structure which is possible only if there are turns or ...
Coenzyme A and Acyl Carrier Protein
Coenzyme A and Acyl Carrier Protein

... different chain-length groups, i.e. short-chain (2-3 carbons), medium-chain (4-12 carbons), long-chain (12-22 carbons), so-called ‘bubble-gum’ (14-24 carbons) and very-long-chain (18-26 or more carbons) fatty acid substrates. The enzymes are distinguished by two highly conserved sequence elements, i ...
Chem 499 Final Exam Name
Chem 499 Final Exam Name

... c. What percent of a drug is left after 6 half lives? Show your work. (3 pts) 14. a. Match the log P values with the compounds below and explain your reasoning. What is the KP value for each compound? (log P values = -3.1, 1.0 and 3.6) (5 pts) H H ...
An accessible database for mouse and human whole transcriptome
An accessible database for mouse and human whole transcriptome

Export To Word
Export To Word

... together. The amino acids and their interactions create the specific shapes of proteins. In this activity you will be translating strands of DNA to mRNA, and then into small sequences of amino acids. The amino acids will then be bonded together based on their properties. The proteins will be analyze ...
Predicting_tRNA_and_tmRNA_genes_12-2-16
Predicting_tRNA_and_tmRNA_genes_12-2-16

... GeneMark or Glimmer that has high coding potential. In general, violation of either of the two latter of the three preceding conditions is sufficient for exclusion of a potential tRNA from an annotation (we have found a single high scoring tRNA that is not part of the rest of the large cluster, howe ...
Predicting tRNA and tmRNA genes Aragorn - SEA
Predicting tRNA and tmRNA genes Aragorn - SEA

... GeneMark or Glimmer that has high coding potential. In general, violation of either of the two latter of the three preceding conditions is sufficient for exclusion of a potential tRNA from an annotation (we have found a single high scoring tRNA that is not part of the rest of the large cluster, howe ...
Toward D-peptide biosynthesis: Elongation Factor P
Toward D-peptide biosynthesis: Elongation Factor P

... two consecutive D-amino acids, and hence enables the translation of D-peptides. Life is an anti-entropic phenomenon with two mutually-reinforcing characters: homochirality and stereospecific catalysis. The exclusive presence of L-amino acids in proteins of the living world is a prominent example of ...
Free Amino Acids Glycine and Glutamic Acid Inhibit Angiogenesis
Free Amino Acids Glycine and Glutamic Acid Inhibit Angiogenesis

... Previous studies from our lab have shown that amino acids act as antiglycating agents and can be beneficial in diabetes mellitus. Accumulation of advanced glycation end products (AGE) in uncontrolled diabetes mellitus can induce microvascular complications such as diabetic retinopathy that results i ...
Peptides and proteins Chapter 36:
Peptides and proteins Chapter 36:

Zygorrhynchus moelleri
Zygorrhynchus moelleri

... The ability of intact unstarved cells to oxidize tricarboxylic acid cycle intermediates, acetate and glucose was examined. At high pH values (6.8) only glucose and acetate stimulated the rate of oxygen uptake (Table 1). When the p H value was lowered to about 3.4 all the intermediates tested were ox ...
MIT Department of Biology 7.28, Spring 2005
MIT Department of Biology 7.28, Spring 2005

... The HYPHAE and BLUE genes are found on the same chromosome. If the two genes were on separate chromosomes, you would expect to observe independent assortment of the alleles of the HYPHAE and BLUE genes. This means that 50% of the time you would observe tetrads of the parental class (2 hairy, white ...
SGD sample annotations
SGD sample annotations

... - Use of the with/from column (column 8): At SGD, for the evidence codes IGI and IPI, the most frequent source of identifiers in the ‘with’ column for SGD is SGD itself, as experiments to which the IGI and IPI codes are applied generally deal with genetic or physical interactions within yeast. In bo ...
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Nucleic acid analogue



Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pucker-shaped pentose sugar, either ribose or deoxyribose, and one of four nucleobases.An analogue may have any of these altered. Typically the analogue nucleobases confer, among other things, different base pairing and base stacking properties. Examples include universal bases, which can pair with all four canonical bases, and phosphate-sugar backbone analogues such as PNA, which affect the properties of the chain (PNA can even form a triple helix).Nucleic acid analogues are also called Xeno Nucleic Acid and represent one of the main pillars of xenobiology, the design of new-to-nature forms of life based on alternative biochemistries.Artificial nucleic acids include peptide nucleic acid (PNA), Morpholino and locked nucleic acid (LNA), as well as glycol nucleic acid (GNA) and threose nucleic acid (TNA). Each of these is distinguished from naturally occurring DNA or RNA by changes to the backbone of the molecule.In May 2014, researchers announced that they had successfully introduced two new artificial nucleotides into bacterial DNA, and by including individual artificial nucleotides in the culture media, were able to passage the bacteria 24 times; they did not create mRNA or proteins able to use the artificial nucleotides. The artificial nucleotides featured 2 fused aromatic rings.
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