An overview of interactions between grapefruit juice and drugs ReView Abstract
... reduce the formation of artherosclerotic plaques.3,4 It may also inhibit cancer cell proliferation.5,6 As many as 15 years ago, investigators found that grapefruit juice can markedly augment oral drug bioavailability. This was an unexpected observation from an interaction study between the dihydropy ...
... reduce the formation of artherosclerotic plaques.3,4 It may also inhibit cancer cell proliferation.5,6 As many as 15 years ago, investigators found that grapefruit juice can markedly augment oral drug bioavailability. This was an unexpected observation from an interaction study between the dihydropy ...
Patient Information Instructions for Use
... Kineret has been associated with an increased incidence of serious infections (2%) vs. Placebo (< 1%) in clinical trials in RA. Administration of Kineret in RA should be discontinued if a patient develops a serious infection. In Kineret treated NOMID patients the risk of a NOMID flare when discont ...
... Kineret has been associated with an increased incidence of serious infections (2%) vs. Placebo (< 1%) in clinical trials in RA. Administration of Kineret in RA should be discontinued if a patient develops a serious infection. In Kineret treated NOMID patients the risk of a NOMID flare when discont ...
data sheet
... nervous system effects of methadone. Use in the Elderly: Methadone has a long plasma half life which may lead to accumulation, particularly if renal function is impaired (see Renal Impairment). In common with other opioids, methadone may cause confusion in this age group, therefore careful monitorin ...
... nervous system effects of methadone. Use in the Elderly: Methadone has a long plasma half life which may lead to accumulation, particularly if renal function is impaired (see Renal Impairment). In common with other opioids, methadone may cause confusion in this age group, therefore careful monitorin ...
New CMS Guidance to Surveyors: Pharmacy Services and
... medication distribution systems in which the quantity stored is minimal and a missing dose can be readily detected ...
... medication distribution systems in which the quantity stored is minimal and a missing dose can be readily detected ...
Overcoming of Vincristine Resistance in P388
... We have examined the effects of a series of membraneinteracting agents on the cytotoxicity of Vinca alkaloids against cultured cells. We have been exploring the possibility that the membrane-modifying agent might affect the function(s) of mi crotubules or alter the transport function of the drugs th ...
... We have examined the effects of a series of membraneinteracting agents on the cytotoxicity of Vinca alkaloids against cultured cells. We have been exploring the possibility that the membrane-modifying agent might affect the function(s) of mi crotubules or alter the transport function of the drugs th ...
Prescribing Information for SEROQUEL XR - PI
... 2.3 Dose Modifications in Elderly Patients Consideration should be given to a slower rate of dose titration and a lower target dose in the elderly and in patients who are debilitated or who have a predisposition to hypotensive reactions [see Use in Specific Populations (8.5, 8.7) and Clinical Pharma ...
... 2.3 Dose Modifications in Elderly Patients Consideration should be given to a slower rate of dose titration and a lower target dose in the elderly and in patients who are debilitated or who have a predisposition to hypotensive reactions [see Use in Specific Populations (8.5, 8.7) and Clinical Pharma ...
Lamictal - GSK Source
... protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidation [see Drug Interactions (7), Clinical Pharmacology (12.3)], the maintenance dose of LAMICTAL will in most cases need to be increased by as much as 2-fold over the recommended target maintenance do ...
... protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidation [see Drug Interactions (7), Clinical Pharmacology (12.3)], the maintenance dose of LAMICTAL will in most cases need to be increased by as much as 2-fold over the recommended target maintenance do ...
![The use of Iboga[ine] in Equatorial African Ritual Context and the](http://s1.studyres.com/store/data/007829040_1-51506740cfd9ae6cd9d625fff23e3367-300x300.png)
The use of Iboga[ine] in Equatorial African Ritual Context and the
... the former. The dose administered gradually over many hours to a Bwiti initiate in full initiation, as observed by us in the 1950s, was estimated to be as high at 35 mg/kg (for a chart of calculated dosage, see Table I) more than a third larger than the 20 mg/kg capsule self-help addiction interrupt ...
... the former. The dose administered gradually over many hours to a Bwiti initiate in full initiation, as observed by us in the 1950s, was estimated to be as high at 35 mg/kg (for a chart of calculated dosage, see Table I) more than a third larger than the 20 mg/kg capsule self-help addiction interrupt ...
Effects of Nonsteroidal Antiinflammatory Drugs on Platelet Function
... by strong agonists (e.g., collagen, thrombin), depending on the concentration of stimulus applied. Longterm administration of very low-dose aspirin (20 mg/ d) is sufficient to inhibit both ex vivo and in vivo thromboxane formation by more than 95%, an effect that blocks platelet aggregation by a var ...
... by strong agonists (e.g., collagen, thrombin), depending on the concentration of stimulus applied. Longterm administration of very low-dose aspirin (20 mg/ d) is sufficient to inhibit both ex vivo and in vivo thromboxane formation by more than 95%, an effect that blocks platelet aggregation by a var ...
Pharmacokinetics and pharmacodynamics of oral oxycodone in
... characteristics of oxycodone. An earlier study by Kalso et al5 suggested the presence of pharmacologically active metabolites in circulation after the oral administration of oxycodone. Displacement of tritium-labeled dihydromorphine binding to rat brain homogenates by plasma extracts from subjects a ...
... characteristics of oxycodone. An earlier study by Kalso et al5 suggested the presence of pharmacologically active metabolites in circulation after the oral administration of oxycodone. Displacement of tritium-labeled dihydromorphine binding to rat brain homogenates by plasma extracts from subjects a ...
labetalol hydrochloride injection usp
... There may be increased difficulty in treating an allergic-type reaction in patients on betablockers. In these patients, the reaction may be more severe due to pharmacological effects of beta-blockers and problems with fluid changes. Epinephrine should be administered with caution since it may not ha ...
... There may be increased difficulty in treating an allergic-type reaction in patients on betablockers. In these patients, the reaction may be more severe due to pharmacological effects of beta-blockers and problems with fluid changes. Epinephrine should be administered with caution since it may not ha ...
A multiparameter test of clot formation and fibrinolysis for in
... of the studies evaluating the ASA effect on fibrinolysis, however, are ambiguous. The impact of ASA activity is thought to be dependent on the initial plasma fibrinolytic activity, the dose, and the time of its administration [6]. Despite the fact that all the mechanisms by which ASA affects hemosta ...
... of the studies evaluating the ASA effect on fibrinolysis, however, are ambiguous. The impact of ASA activity is thought to be dependent on the initial plasma fibrinolytic activity, the dose, and the time of its administration [6]. Despite the fact that all the mechanisms by which ASA affects hemosta ...
PRODUCT MONOGRAPH CORDARONE® (Amiodarone
... CORDARONE is intended for use only in patients with the indicated life-threatening arrhythmias because its use is accompanied by substantial toxicity. CORDARONE has several potentially fatal toxicities, the most important of which is pulmonary toxicity (hypersensitivity pneumonitis or interstitial/a ...
... CORDARONE is intended for use only in patients with the indicated life-threatening arrhythmias because its use is accompanied by substantial toxicity. CORDARONE has several potentially fatal toxicities, the most important of which is pulmonary toxicity (hypersensitivity pneumonitis or interstitial/a ...
Guidelines for the training in and the
... At physiological pH midazolam becomes highly lipophilic permitting rapid transfer across the blood-brain barrier – an advantage over other benzodiazepines. The anticonvulsant action is thought to be due to enhancement of GABA (gamma aminobutyric acid), the main inhibitory neurotransmitter in the bra ...
... At physiological pH midazolam becomes highly lipophilic permitting rapid transfer across the blood-brain barrier – an advantage over other benzodiazepines. The anticonvulsant action is thought to be due to enhancement of GABA (gamma aminobutyric acid), the main inhibitory neurotransmitter in the bra ...
Metabolism, Excretion, and Pharmacokinetics of S-Allyl-L
... Institutional Animal Care and Use Committee. Male Sprague-Dawley rats (230– 280 g, Charles Liver Japan, Yokohama, Japan) and male beagle dogs (10–14 kg, Kitayama Labes, Nagano, Japan) were fasted overnight before the studies. All compounds of NAc-SAC, NAc-SACS, SAC, and SACS were dissolved in distil ...
... Institutional Animal Care and Use Committee. Male Sprague-Dawley rats (230– 280 g, Charles Liver Japan, Yokohama, Japan) and male beagle dogs (10–14 kg, Kitayama Labes, Nagano, Japan) were fasted overnight before the studies. All compounds of NAc-SAC, NAc-SACS, SAC, and SACS were dissolved in distil ...
Dronabinol and Marijuana in HIV
... not current smokers, dronabinol (2.5 mg 3 times daily) and marijuana (3.95% THC 3 times daily) administered for 3 weeks were well tolerated and resulted in more weight gain than placebo administration,22 while having no negative impact on antiretroviral pharmacokinetics or immune function.21–24 Amon ...
... not current smokers, dronabinol (2.5 mg 3 times daily) and marijuana (3.95% THC 3 times daily) administered for 3 weeks were well tolerated and resulted in more weight gain than placebo administration,22 while having no negative impact on antiretroviral pharmacokinetics or immune function.21–24 Amon ...
Nitrofurantoin - IARC Monographs on the Evaluation of
... animaIs. Controls had ovarian abscesses (18/50) and suppurative inflammation of the uterus (11/50). There was no significant increase in the incidence of any individual type of tumour; however, when tubular adenomas and benign mixed tumours of the ovary are combined, the incidence is significant: 0/ ...
... animaIs. Controls had ovarian abscesses (18/50) and suppurative inflammation of the uterus (11/50). There was no significant increase in the incidence of any individual type of tumour; however, when tubular adenomas and benign mixed tumours of the ovary are combined, the incidence is significant: 0/ ...
User guide - Medicines for Malaria Venture
... malaria: a randomised trial ; The Lancet, Volume 366, Issue 9487, Pages 717-725, 27 August 2005. 6 Dondorp A. et al. Artesunate versus quinine for Treatment of severe falciparum malaria in African Children (AQUAMAT): an open-label, randomised trial ; The Lancet, Volume 376, Issue 9753, Pages 1647- ...
... malaria: a randomised trial ; The Lancet, Volume 366, Issue 9487, Pages 717-725, 27 August 2005. 6 Dondorp A. et al. Artesunate versus quinine for Treatment of severe falciparum malaria in African Children (AQUAMAT): an open-label, randomised trial ; The Lancet, Volume 376, Issue 9753, Pages 1647- ...
CARISOPRODOL Tablets, USP Rx Only
... Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect rates observed in practice. The data described below are based on 138 ...
... Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect rates observed in practice. The data described below are based on 138 ...
Tumescent Technique Chronicles Local Anesthesia, Liposuction
... At this point in time, some surgeons, who insisted upon doing liposuction by general anesthesia using a technique that often required blood transfusions, were stating publicly that only they were sufficiently trained to do liposuction safely. Meanwhile a number of dermatologists, including Drs. Will ...
... At this point in time, some surgeons, who insisted upon doing liposuction by general anesthesia using a technique that often required blood transfusions, were stating publicly that only they were sufficiently trained to do liposuction safely. Meanwhile a number of dermatologists, including Drs. Will ...
MAGNESIUM SULFATE IN 5% DEXTROSE
... are retrospective epidemiological studies and case reports documenting fetal abnormalities such as hypocalcemia, skeletal demineralizations, osteopenia and other skeletal abnormalities with continuous maternal administration of magnesium sulfate for more than 5-7 days.1-12 Magnesium Sulfate in 5% De ...
... are retrospective epidemiological studies and case reports documenting fetal abnormalities such as hypocalcemia, skeletal demineralizations, osteopenia and other skeletal abnormalities with continuous maternal administration of magnesium sulfate for more than 5-7 days.1-12 Magnesium Sulfate in 5% De ...
Clinical guidelines: buprenorphine treatment of heroin dependence
... sedative drugs, such as alcohol or benzodiazepines, is still unclear, with several deaths having been reported. Naloxone is of limited use in resuscitating individuals who have overdosed on high doses of buprenorphine (See section 5.2 on Management of Overdose). Precaution should be exercised when b ...
... sedative drugs, such as alcohol or benzodiazepines, is still unclear, with several deaths having been reported. Naloxone is of limited use in resuscitating individuals who have overdosed on high doses of buprenorphine (See section 5.2 on Management of Overdose). Precaution should be exercised when b ...
PropoFlo - zoetisUS.com
... doses were similar in sighthounds compared to other animals, however, recoveries were delayed. 9. Cardiac arrhythmias: In one study, propofol increased myocardial sensitivity to the development of epinephrine-induced ventricular arrhythmias in a manner similar to other anesthetics6. In the clinical ...
... doses were similar in sighthounds compared to other animals, however, recoveries were delayed. 9. Cardiac arrhythmias: In one study, propofol increased myocardial sensitivity to the development of epinephrine-induced ventricular arrhythmias in a manner similar to other anesthetics6. In the clinical ...
Submission Guidelines for the CADTH Common Drug Review
... of a marketed product, but does not include the following variations of existing products being funded by drug plans (line extensions) containing the same active substance(s): • New dosage form with the same route of administration (e.g., if a drug in tablet form becomes available in capsule form, a ...
... of a marketed product, but does not include the following variations of existing products being funded by drug plans (line extensions) containing the same active substance(s): • New dosage form with the same route of administration (e.g., if a drug in tablet form becomes available in capsule form, a ...