ACE Inhibitors and Angiotensin II
... There are many comparable parameters which influence the rational choice of drugs from the same class.13 These include efficacy, potency, route of administration, frequency of dosing, drug interactions, safety, side effects and cost. Drugs in the same class are not often compared with each other and ...
... There are many comparable parameters which influence the rational choice of drugs from the same class.13 These include efficacy, potency, route of administration, frequency of dosing, drug interactions, safety, side effects and cost. Drugs in the same class are not often compared with each other and ...
METHIMAZOLE - American Academy of Veterinary Pharmacology
... Note: Gastrointestinal signs have been reported in as many as 23% of closely-monitored cats administered recommended dosages (5 mg a day).{R-2} One large retrospective reported an incidence of 11% and resolution of signs in many cats without ending treatment; however, some persistently vomited while ...
... Note: Gastrointestinal signs have been reported in as many as 23% of closely-monitored cats administered recommended dosages (5 mg a day).{R-2} One large retrospective reported an incidence of 11% and resolution of signs in many cats without ending treatment; however, some persistently vomited while ...
![[4] The Liposomal Formulation of Doxorubicin](http://s1.studyres.com/store/data/007838511_1-0212b85a03e63c40bef0b4484e091e4e-300x300.png)
[4] The Liposomal Formulation of Doxorubicin
... Pieter R. Cullis, Thomas D. Madden, and Marcel B. Bally Abstract ...
... Pieter R. Cullis, Thomas D. Madden, and Marcel B. Bally Abstract ...
1. Clinical Pharmacology
... • Opioid antagonists (naloxone and naltrexone): Buprenorphine has affinity for µ opioid receptors similar to the opioid antagonists. In the event of overdose of buprenorphine, very high doses of naloxone may be required to partially reverse its effects. Cases have been reported in which naloxone in ...
... • Opioid antagonists (naloxone and naltrexone): Buprenorphine has affinity for µ opioid receptors similar to the opioid antagonists. In the event of overdose of buprenorphine, very high doses of naloxone may be required to partially reverse its effects. Cases have been reported in which naloxone in ...
Médecins sans Frontières application - WHO archives
... In 1996, a WHO Expert Committee concluded that Azithromycin 20mg/kg was as effective as 67 weeks of topical tetracycline eye ointment, and that it was well tolerated with good patient compliance. The only problem was its high cost, and the committee urged the manufacturer to “consider all possible m ...
... In 1996, a WHO Expert Committee concluded that Azithromycin 20mg/kg was as effective as 67 weeks of topical tetracycline eye ointment, and that it was well tolerated with good patient compliance. The only problem was its high cost, and the committee urged the manufacturer to “consider all possible m ...
ACMD Advisory Council on the Misuse of Drugs ACMD consideration of tramadol
... 3.3. Tramadol undergoes liver metabolism and is excreted via the kidney. The elimination half-life is 6 hours for tramadol and 7.5 hours for its active metabolite. The analgesic effect begins within about an hour of oral dosing, peaks at 2-3 hours and lasts for about 6 hours. The maximum recommended ...
... 3.3. Tramadol undergoes liver metabolism and is excreted via the kidney. The elimination half-life is 6 hours for tramadol and 7.5 hours for its active metabolite. The analgesic effect begins within about an hour of oral dosing, peaks at 2-3 hours and lasts for about 6 hours. The maximum recommended ...
AusPAR: Buprenorphine - Therapeutic Goods Administration
... marketed in a Member State other than that in which they were first authorised. Any national marketing authorisation granted by an EU Member State's national authority can be used to support an application for its mutual recognition by other Member States. ...
... marketed in a Member State other than that in which they were first authorised. Any national marketing authorisation granted by an EU Member State's national authority can be used to support an application for its mutual recognition by other Member States. ...
... These are generic applications for Cetirizine Dihydrochloride 10 mg Film-Coated Tablets, submitted under Article 10(1) of Directive 2001/83/EC, as amended. The applications refer to the UK reference (innovator) product, Zirtek 10mg, originally licensed to UCB S.A (PL 05221/0001) on 16 August 1988. T ...
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... mineral and organic acids and most alkalies. Phenolphthalein-titrated solutions are colorless at pH< 8.5 and pink to deep-red at pH> 9. Phenolphthalein is not suitable, however, for titrating ammonia or alkaloids; carbonate solutions should be boiled before titration because of a high sensitivity to ...
... mineral and organic acids and most alkalies. Phenolphthalein-titrated solutions are colorless at pH< 8.5 and pink to deep-red at pH> 9. Phenolphthalein is not suitable, however, for titrating ammonia or alkaloids; carbonate solutions should be boiled before titration because of a high sensitivity to ...
Wolfe - Intranasal naloxone in safe injection setting
... the case is consistent with heroin overdose An intramuscular dose of naloxone (Narcan) is administered and the patient is successfully resuscitated. Unfortunately, the medic suffers a contaminated needle stick after providing the intramuscular injection. The patient admits to being infected w ...
... the case is consistent with heroin overdose An intramuscular dose of naloxone (Narcan) is administered and the patient is successfully resuscitated. Unfortunately, the medic suffers a contaminated needle stick after providing the intramuscular injection. The patient admits to being infected w ...
sulfasalazine - IARC Monographs on the Evaluation of Carcinogenic
... Crohn disease, as well as psoriatic and rheumatoid arthritis, including juvenile rheumatoid arthritis (IMS Health, 2012a; eMC, 2013; Table 1.2). The use of sulfasalazine for the treatment of urticaria has also been reported (McGirt et al., 2006). Sulfasalazine is recommended as a third-line medicati ...
... Crohn disease, as well as psoriatic and rheumatoid arthritis, including juvenile rheumatoid arthritis (IMS Health, 2012a; eMC, 2013; Table 1.2). The use of sulfasalazine for the treatment of urticaria has also been reported (McGirt et al., 2006). Sulfasalazine is recommended as a third-line medicati ...
Sumatriptan Succinate Injection - Pack Insert
... The incidence of adverse reactions in controlled clinical trials was not affected by gender or age of the subjects. There were insufficient data to assess the impact of race on the incidence of adverse reactions. Cluster Headache: In the controlled clinical trials assessing the efficacy of sumatript ...
... The incidence of adverse reactions in controlled clinical trials was not affected by gender or age of the subjects. There were insufficient data to assess the impact of race on the incidence of adverse reactions. Cluster Headache: In the controlled clinical trials assessing the efficacy of sumatript ...
Taclonex - LEO Pharma
... (1.4%), skin depigmentation (1.4%), ecchymosis (1.0%), erythema (1.0%) and hand dermatitis (1.0%). One case of serious flare-up of psoriasis was reported. 6.2 Post-marketing Experience ...
... (1.4%), skin depigmentation (1.4%), ecchymosis (1.0%), erythema (1.0%) and hand dermatitis (1.0%). One case of serious flare-up of psoriasis was reported. 6.2 Post-marketing Experience ...
Reynolds-Psych-Panels-11-20-12
... CYP2D6 Poor Metabolizer (PM): This patient’s genotype is consistent with a lack of CYP2D6 enzymatic activity. PMs are at increased risk of drug-induced side effects due to diminished drug elimination of active drugs or lack of therapeutic effect resulting from failure to generate the active form of ...
... CYP2D6 Poor Metabolizer (PM): This patient’s genotype is consistent with a lack of CYP2D6 enzymatic activity. PMs are at increased risk of drug-induced side effects due to diminished drug elimination of active drugs or lack of therapeutic effect resulting from failure to generate the active form of ...
Product Monograph
... As with levodopa, SINEMET® may cause involuntary movements and mental disturbances. These reactions are thought to be due to increased brain dopamine following administration of levodopa. Because carbidopa permits more levodopa to reach the brain and thus, more dopamine to be formed, dyskinesias may ...
... As with levodopa, SINEMET® may cause involuntary movements and mental disturbances. These reactions are thought to be due to increased brain dopamine following administration of levodopa. Because carbidopa permits more levodopa to reach the brain and thus, more dopamine to be formed, dyskinesias may ...
warning: addiction, abuse, and misuse
... hours. Use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression. Conversion from Other Opioids to KADIAN Discontinue all other around-the-clock opioid drugs when KADIAN therapy is initiated. There are no established conversion ratios from other opio ...
... hours. Use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression. Conversion from Other Opioids to KADIAN Discontinue all other around-the-clock opioid drugs when KADIAN therapy is initiated. There are no established conversion ratios from other opio ...
LC-Tandem MS Detection of Covalent Binding of Acetaminophen to
... formation of reactive metabolites is considered to be a major trigger in the cascade of events leading to these adverse events (Williams et al., 2002). Drugs can be bioactivated both by phase I and by phase II enzymes to reactive electrophilic intermediates, which subsequently react with nucleophili ...
... formation of reactive metabolites is considered to be a major trigger in the cascade of events leading to these adverse events (Williams et al., 2002). Drugs can be bioactivated both by phase I and by phase II enzymes to reactive electrophilic intermediates, which subsequently react with nucleophili ...
Biowaiver extension potential to BCS Class III high solubility
... currently under scrutiny. In vivo bioequivalence data of different formulations of Class III drugs would support such an extension. The objective of this work was to demonstrate the bioequivalence of two marketed IR tablet products of a Class III drug, metformin hydrochloride, that are rapidly disso ...
... currently under scrutiny. In vivo bioequivalence data of different formulations of Class III drugs would support such an extension. The objective of this work was to demonstrate the bioequivalence of two marketed IR tablet products of a Class III drug, metformin hydrochloride, that are rapidly disso ...
SPC Ciprofloxacin 200mg/100mL solution for infusion
... Other severe infections in accordance with official guidance, or after careful benefit-risk evaluation when other treatments cannot be used, or after failure to conventional therapy and when the microbiological documentation can justify a ciprofloxacin use. The use of ciprofloxacin for specific seve ...
... Other severe infections in accordance with official guidance, or after careful benefit-risk evaluation when other treatments cannot be used, or after failure to conventional therapy and when the microbiological documentation can justify a ciprofloxacin use. The use of ciprofloxacin for specific seve ...
Warnings and Precautions
... Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death [see Warnings and Precautions (5.1)]. Quetiapine Fumarate Tablets are not approved for the treatment of patients with dementia-related psychosis [see Warnings and Precautions (5.1)]. S ...
... Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death [see Warnings and Precautions (5.1)]. Quetiapine Fumarate Tablets are not approved for the treatment of patients with dementia-related psychosis [see Warnings and Precautions (5.1)]. S ...
Clinical and pharmacological evaluation of buprenorphine and
... effects and was considered liable to abuse by these subjects. The buprenorphine and naloxone combination was very aversive and not substantially different from naloxone alone. Following the combination dose, opiate agonist effects did eventually emerge but they were always delayed and attenuated whe ...
... effects and was considered liable to abuse by these subjects. The buprenorphine and naloxone combination was very aversive and not substantially different from naloxone alone. Following the combination dose, opiate agonist effects did eventually emerge but they were always delayed and attenuated whe ...
Australian public assessment for Febuxostat (FBX)
... The extent of these FBX pharmacokinetic changes in exposure was consistent with those observed in two previous food effect studies (see below). In the first study, a single dose 40 mg fed versus fasted study (TMX-##-002), in which an average 46% decrease in Cmax and a 19% decrease in AUC∞ were obser ...
... The extent of these FBX pharmacokinetic changes in exposure was consistent with those observed in two previous food effect studies (see below). In the first study, a single dose 40 mg fed versus fasted study (TMX-##-002), in which an average 46% decrease in Cmax and a 19% decrease in AUC∞ were obser ...
Chloral Hydrate Mixture 1g/10mL
... and non-conjugated hyperbilirubinaemia, decrease albumin binding of bilirubin, and contribute to metabolic acidosis. Chloral Hydrate Mixture is not recommended in infants and children when repetitive dosing would be necessary. Use in the Elderly: The dose of chloral hydrate may need to be reduced in ...
... and non-conjugated hyperbilirubinaemia, decrease albumin binding of bilirubin, and contribute to metabolic acidosis. Chloral Hydrate Mixture is not recommended in infants and children when repetitive dosing would be necessary. Use in the Elderly: The dose of chloral hydrate may need to be reduced in ...
Alaris® PK Syringe Pump
... the Cp50 or Cp95 (the concentrations required to elicit a specified clinical effect in 50 or 95% of patients respectively). For an example see Ausems et al.5 During the 1990’s it was increasingly appreciated that after a change in plasma concentration there is a temporal delay in equilibration betwe ...
... the Cp50 or Cp95 (the concentrations required to elicit a specified clinical effect in 50 or 95% of patients respectively). For an example see Ausems et al.5 During the 1990’s it was increasingly appreciated that after a change in plasma concentration there is a temporal delay in equilibration betwe ...
Effects of Acute and Repeated Administration of Oxycodone and
... maintain maximal rates before testing began. After stable responding was maintained, rats began frequency-rate training. During frequency-rate training, rats were presented with and allowed to respond for a series of 10 descending stimulation frequencies at 0.05 log unit increments (158 to 56 Hz; i. ...
... maintain maximal rates before testing began. After stable responding was maintained, rats began frequency-rate training. During frequency-rate training, rats were presented with and allowed to respond for a series of 10 descending stimulation frequencies at 0.05 log unit increments (158 to 56 Hz; i. ...