INTRODUCTION (586 words)
... Pmax value was derived using the threshold procedure. Figure 1A shows the dose-response curve for a group of animals (n=8; test group used to demonstrate threshold procedure and analyses) that self-administered cocaine through a descending series of 11 unit-injection doses on an FR1 reinforcement sc ...
... Pmax value was derived using the threshold procedure. Figure 1A shows the dose-response curve for a group of animals (n=8; test group used to demonstrate threshold procedure and analyses) that self-administered cocaine through a descending series of 11 unit-injection doses on an FR1 reinforcement sc ...
First Oral Dose in Humans
... than the exploratory formulation approach. In practice, the formulation strategy is always decided by the project team on the basis of collected scientific and business information. The exploratory formu- Figure 1: Exploratory formulation approach versus commercial formulation lation approach is pro ...
... than the exploratory formulation approach. In practice, the formulation strategy is always decided by the project team on the basis of collected scientific and business information. The exploratory formu- Figure 1: Exploratory formulation approach versus commercial formulation lation approach is pro ...
EFFECTS OF MUCOADHESIVE POLYMERS COMBINATION ON THE PROPERTIES OF LISINPRIL
... required detaching the tablet. The bioadhesive property of the prepared tablets of the formulations (F1, F2, and F3) with combined polymers, HPMC K100M and Chitosan showed the bioadhesive strengths of 2.64, 3.12, and 3.43 N respectively. The formulations (F4, F5, and F6) with HPMC K100M and CMC show ...
... required detaching the tablet. The bioadhesive property of the prepared tablets of the formulations (F1, F2, and F3) with combined polymers, HPMC K100M and Chitosan showed the bioadhesive strengths of 2.64, 3.12, and 3.43 N respectively. The formulations (F4, F5, and F6) with HPMC K100M and CMC show ...
CONCERTA Extended-Release Tablets PRODUCT INFORMATION
... state (Day 4) clearance and half-life parameters were similar, indicating that there was no time dependency in the pharmacokinetics of methylphenidate. The ratio of metabolite (PPAA) to parent drug (MPH) was constant across doses from 54 to 144 mg/day, both after single dose and upon multiple dosing ...
... state (Day 4) clearance and half-life parameters were similar, indicating that there was no time dependency in the pharmacokinetics of methylphenidate. The ratio of metabolite (PPAA) to parent drug (MPH) was constant across doses from 54 to 144 mg/day, both after single dose and upon multiple dosing ...
Position paper Discordant conclusions from HIV clinical trials — an
... starts. ‘ITT exposed’ analysis includes only patients who received at least one dose of study medication. In the 2NN trial, there was a significant difference in efficacy between twice daily NVP and EFV in naive patients when only patients who received at least one dose of study drug were included ( ...
... starts. ‘ITT exposed’ analysis includes only patients who received at least one dose of study medication. In the 2NN trial, there was a significant difference in efficacy between twice daily NVP and EFV in naive patients when only patients who received at least one dose of study drug were included ( ...
- The University of Liverpool Repository
... for their relevance. All study types available in English, excluding those that were single patient case reports, were included for the purposes of this review. Using these methods, treatment regimens of established SLE therapeutics/drugs will be covered as well as emerging biological therapies in ...
... for their relevance. All study types available in English, excluding those that were single patient case reports, were included for the purposes of this review. Using these methods, treatment regimens of established SLE therapeutics/drugs will be covered as well as emerging biological therapies in ...
01/27/2012 - The Medical University of South Carolina
... that affects cognitive or emotional functions to the extent that capacity for judgment and reasoning is significantly diminished (Institutional Review Board Guidebook, 1993). Others, including persons under the influence of or dependent on drugs or alcohol, those suffering from degenerative diseases ...
... that affects cognitive or emotional functions to the extent that capacity for judgment and reasoning is significantly diminished (Institutional Review Board Guidebook, 1993). Others, including persons under the influence of or dependent on drugs or alcohol, those suffering from degenerative diseases ...
Chronic heart failure - Pharmaceutical Journal
... mechanisms, suggested that Mesren 400mg tablets be prescribed instead of the market leader Asacol MR for all new patients and those who require a change to their drug regimen. I believe, however, that this proposed approach might only result in short-term savings. Once current strategies in manageme ...
... mechanisms, suggested that Mesren 400mg tablets be prescribed instead of the market leader Asacol MR for all new patients and those who require a change to their drug regimen. I believe, however, that this proposed approach might only result in short-term savings. Once current strategies in manageme ...
ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITY OF ALKALOID FRACTION OF TRICHOPUS ZEYLANICUS GAERTN.
... Male Swiss albino mice weighing 25-75 gm were selected for the study of anxiolytic and antidepressant activity. Adult Albino rats (Wistar strain) of either sex weighing between 120-200 gm were used for study. The animals were obtained from the Department of Pharmacology, J.K.K Nataraja College of ph ...
... Male Swiss albino mice weighing 25-75 gm were selected for the study of anxiolytic and antidepressant activity. Adult Albino rats (Wistar strain) of either sex weighing between 120-200 gm were used for study. The animals were obtained from the Department of Pharmacology, J.K.K Nataraja College of ph ...
Drugs acting on RAAS by Dr Vignesh S
... ARBs - well tolerated in patients who are intolerant of ACEIused in symptomatic and asymptomatic pts of HFrEF <40% who are ACE-intolerant for reasons other than hyperkalemia or renal insufficiency As with ACEI, ARBs should also be initiated in low doses, uptitrated every 3-5 days, and BP,RFT,Potassi ...
... ARBs - well tolerated in patients who are intolerant of ACEIused in symptomatic and asymptomatic pts of HFrEF <40% who are ACE-intolerant for reasons other than hyperkalemia or renal insufficiency As with ACEI, ARBs should also be initiated in low doses, uptitrated every 3-5 days, and BP,RFT,Potassi ...
DEVELOPMENT AND INVITRO EVALUATION OF SALBUTAMOL SULPHATE MUCOADHESIVE BUCCAL PATCHES
... 1997) by repeatedly folding one patch at the same place till it broke or folded upto 300 times manually, which was considered satisfactory to reveal good patch properties. This test was done on five patches. Uniformity of weight of the patches11 Patches sizes of 1x1 cm2 were ...
... 1997) by repeatedly folding one patch at the same place till it broke or folded upto 300 times manually, which was considered satisfactory to reveal good patch properties. This test was done on five patches. Uniformity of weight of the patches11 Patches sizes of 1x1 cm2 were ...
INTRODUCTION Ziprasidone is second
... chemical transformation of drugs to desired products occurs by enzymes which are contributed either from microorganisms (bacteria and fungus) or animals (5,6). Biotransformation studies of drugs and the toxicity of metabolites are important in drug development (7). Transformation of drug by the appl ...
... chemical transformation of drugs to desired products occurs by enzymes which are contributed either from microorganisms (bacteria and fungus) or animals (5,6). Biotransformation studies of drugs and the toxicity of metabolites are important in drug development (7). Transformation of drug by the appl ...
Thymidylate Synthase Inhibitors
... RFC; polyglutamation of this potent TS inhibitor leads to its higher cellular retention without augmenting its TS inhibitory activity. Currently in clinical trials, AG337 (p.o. and i.v. forms) and AG331 (both by Agouron, La Jolla, CA) are lipophilic potent TS inhibitors with action independent of th ...
... RFC; polyglutamation of this potent TS inhibitor leads to its higher cellular retention without augmenting its TS inhibitory activity. Currently in clinical trials, AG337 (p.o. and i.v. forms) and AG331 (both by Agouron, La Jolla, CA) are lipophilic potent TS inhibitors with action independent of th ...
Welchol - dsi.com
... placebo) in trials of patients with primary hyperlipidemia [See Adverse Reactions (6.1) and Clinical Studies (14.1)]. In clinical trials in patients with type 2 diabetes, greater increases in TG levels occurred when WELCHOL was used as monotherapy (median increase 9.7% compared to placebo) and when ...
... placebo) in trials of patients with primary hyperlipidemia [See Adverse Reactions (6.1) and Clinical Studies (14.1)]. In clinical trials in patients with type 2 diabetes, greater increases in TG levels occurred when WELCHOL was used as monotherapy (median increase 9.7% compared to placebo) and when ...
Science of Homoeopathy
... grams) of any substance contains N= 6.022x1023 molecules. Therefore all homoeopotencies equal to or higher than the 12th on the centesimal scale or 24th on the decimal scale, representing a 1024 fold dilution, do not contain any trace molecule of the original drug in the patient dose. But the Law of ...
... grams) of any substance contains N= 6.022x1023 molecules. Therefore all homoeopotencies equal to or higher than the 12th on the centesimal scale or 24th on the decimal scale, representing a 1024 fold dilution, do not contain any trace molecule of the original drug in the patient dose. But the Law of ...
Sustained release drug delivery system
... The advantages of administering a single dose of a drug that is released over an extended period of time, instead of numerous doses, have been obvious to the Pharmaceutical industry for some time. The desire to maintain a near-constant or uniform blood level of a drug often translates into better pa ...
... The advantages of administering a single dose of a drug that is released over an extended period of time, instead of numerous doses, have been obvious to the Pharmaceutical industry for some time. The desire to maintain a near-constant or uniform blood level of a drug often translates into better pa ...
SPIRIVA® 18 microgram, inhalation powder, hard capsule
... significantly longer dissociation half-life than ipratropium. As an N-quaternary anticholinergic, tiotropium bromide is topically (broncho-) selective when administered by inhalation, demonstrating an acceptable therapeutic range before systemic anticholinergic effects may occur. Pharmacodynamic eff ...
... significantly longer dissociation half-life than ipratropium. As an N-quaternary anticholinergic, tiotropium bromide is topically (broncho-) selective when administered by inhalation, demonstrating an acceptable therapeutic range before systemic anticholinergic effects may occur. Pharmacodynamic eff ...
Orally disintegrating tablets - Journal of Applied Pharmaceutical
... mouth (Fig. 1). The lining of the oral cavity is referred to as the oral mucosa, and includes the buccal, sublingual, gingival, palatal and labial mucosa. The buccal, sublingual and the mucosal tissues at the ventral surface of the tongue account for about 60% of the oral mucosal surface area. The t ...
... mouth (Fig. 1). The lining of the oral cavity is referred to as the oral mucosa, and includes the buccal, sublingual, gingival, palatal and labial mucosa. The buccal, sublingual and the mucosal tissues at the ventral surface of the tongue account for about 60% of the oral mucosal surface area. The t ...
Draft Minutes of the Formulary Sub Group (FSG
... tacrolimus used under wet wraps can cause problems. EC agreed to investigate ongoing supply problems with Diprobase. ...
... tacrolimus used under wet wraps can cause problems. EC agreed to investigate ongoing supply problems with Diprobase. ...
fosamprenavir - DavisPlus
... CYP3A4; it also inhibits and induces this enzyme system. The action of any other medication that is also handled by or affects this system may be altered by concurrent use.qblood levels and risk of toxicity from flecainide, propafenone, rifampin, ergot derivatives (dihydroergotamine, ergotamine, erg ...
... CYP3A4; it also inhibits and induces this enzyme system. The action of any other medication that is also handled by or affects this system may be altered by concurrent use.qblood levels and risk of toxicity from flecainide, propafenone, rifampin, ergot derivatives (dihydroergotamine, ergotamine, erg ...
Fentanyl and Ativan In-Service
... degree of protein binding means that Ativan’s volume of distribution is mainly in the vascular compartment, versus Valium which gets absorbed by body fat. The higher volume in the vascular compartment makes Ativan unsuitable for oral or rectal administration as compared to Valium. ...
... degree of protein binding means that Ativan’s volume of distribution is mainly in the vascular compartment, versus Valium which gets absorbed by body fat. The higher volume in the vascular compartment makes Ativan unsuitable for oral or rectal administration as compared to Valium. ...
Drug List
... For a full list of medications approved for use by EMS professionals, please refer to the North Carolina Medical Board document entitled: Approved Medications for Credentialed EMS Personnel. Individual EMS Systems may or may not utilize these or other approved drugs. Individual EMS Systems are stron ...
... For a full list of medications approved for use by EMS professionals, please refer to the North Carolina Medical Board document entitled: Approved Medications for Credentialed EMS Personnel. Individual EMS Systems may or may not utilize these or other approved drugs. Individual EMS Systems are stron ...
Codeine Intoxication in the Neonate
... Novahistine DH is an antitussive, decongestant, and antihistamine preparation. In each 5-mL formulation, there are 30 mg of pseudoephedrine hydrochloride, 10 mg of codeine phosphate, 2 mg of chlorpheniramine maleate, and 5% alcohol. With 2 doses of Novahistine DH, this infant received 4 mg of codein ...
... Novahistine DH is an antitussive, decongestant, and antihistamine preparation. In each 5-mL formulation, there are 30 mg of pseudoephedrine hydrochloride, 10 mg of codeine phosphate, 2 mg of chlorpheniramine maleate, and 5% alcohol. With 2 doses of Novahistine DH, this infant received 4 mg of codein ...
4.0 4.1 Introduction ................................................................................................................................ 63
... establishing dosing regimes because most pharmaceuticals are developed for multiple use. Acute effects are more important for oncologic drugs because the margins of safety may be smaller. Single-dose studies may also be useful for developing imaging agents where it is important to understand tissue ...
... establishing dosing regimes because most pharmaceuticals are developed for multiple use. Acute effects are more important for oncologic drugs because the margins of safety may be smaller. Single-dose studies may also be useful for developing imaging agents where it is important to understand tissue ...
BioInvent Financial Statement
... BioInvent will work with researchers led by Dr. Thorsten Hagemann, senior research fellow at Cancer Research UK, to identify new target proteins for drug development. BioInvent’s F.I.R.S.T™ technology will be used in this collaboration, while Dr. Hagemann and his group, which is financed by Cancer R ...
... BioInvent will work with researchers led by Dr. Thorsten Hagemann, senior research fellow at Cancer Research UK, to identify new target proteins for drug development. BioInvent’s F.I.R.S.T™ technology will be used in this collaboration, while Dr. Hagemann and his group, which is financed by Cancer R ...