References
... agar plates within 14–21 days of incubation at 37°C [7]. We found the MICs for 18 MDR-TB-strains in the range of 0.125–0.5 μg·mL−1 and 130 non-MDR-TB strains between 0.125–0.5 μg·mL−1 (n=4 with MIC=0.125 μg·mL−1, n=121 with MIC=0.25 μg·mL−1 and n=5 with MIC=0.5 μg·mL−1) (table 1). These results show ...
... agar plates within 14–21 days of incubation at 37°C [7]. We found the MICs for 18 MDR-TB-strains in the range of 0.125–0.5 μg·mL−1 and 130 non-MDR-TB strains between 0.125–0.5 μg·mL−1 (n=4 with MIC=0.125 μg·mL−1, n=121 with MIC=0.25 μg·mL−1 and n=5 with MIC=0.5 μg·mL−1) (table 1). These results show ...
- journal of evolution of medical and dental sciences
... Dexmedetomidine has been shown to attenuate the sympathoadrenal stimulation during intubation effectively.15,16 We observed that Dexmedetomidine effectively attenuates the vasopressor response of laryngoscopy, and intubation and the sympathoadrenal response occurring with pneumoperitoneum. Dexmedeto ...
... Dexmedetomidine has been shown to attenuate the sympathoadrenal stimulation during intubation effectively.15,16 We observed that Dexmedetomidine effectively attenuates the vasopressor response of laryngoscopy, and intubation and the sympathoadrenal response occurring with pneumoperitoneum. Dexmedeto ...
Requested DocAlert: Should Beta-Blockers Be Withheld
... found no significant differences in exercise capacity, quality of life, or the combined endpoint of all cause mortality and all cause hospitalisation. Carvedilol reduced all cause mortality over 58 months by 17% more than short acting metoprolol (34% v 40%) in one placebo controlled study, but it ha ...
... found no significant differences in exercise capacity, quality of life, or the combined endpoint of all cause mortality and all cause hospitalisation. Carvedilol reduced all cause mortality over 58 months by 17% more than short acting metoprolol (34% v 40%) in one placebo controlled study, but it ha ...
bioavailability enhancdement of poorly soluble drugs by smedds
... soft gelatin capsules, which have some disadvantages especially in the manufacturing process. An alternative method is the incorporation of liquid self emulsifying ingredients into a powder in order to create a solid dosage form (tablets, capsules). A pellet ...
... soft gelatin capsules, which have some disadvantages especially in the manufacturing process. An alternative method is the incorporation of liquid self emulsifying ingredients into a powder in order to create a solid dosage form (tablets, capsules). A pellet ...
Product Information: Dolutegravir (as sodium)
... vitro data. The apparent volume of distribution (following oral administration of suspension formulation, Vd/F) is estimated at 12.5 L. Binding of dolutegravir to plasma proteins was independent of concentration. Total blood and plasma drug-related radioactivity concentration ratios averaged between ...
... vitro data. The apparent volume of distribution (following oral administration of suspension formulation, Vd/F) is estimated at 12.5 L. Binding of dolutegravir to plasma proteins was independent of concentration. Total blood and plasma drug-related radioactivity concentration ratios averaged between ...
METHODS OF STUDYING BIOAVAILABILITY AND BIOEQUIVALENCE INTRODUCTION:
... 4. Avoids the ethical requirements of administering drugs to the healthy subjects. In multiple dose study, they prefer patients rather than healthy humans. ...
... 4. Avoids the ethical requirements of administering drugs to the healthy subjects. In multiple dose study, they prefer patients rather than healthy humans. ...
Oral Immunotherapy Agents - Blue Cross and Blue Shield of Kansas
... Treatment of grass pollen-induced allergic rhinitis with or without conjunctivitis confirmed by positive skin test or in vitro testing for pollenspecific IgE antibodies for any of the five grass species contained in this product. Oralair is approved for use in persons 10 through 65 years of age. ...
... Treatment of grass pollen-induced allergic rhinitis with or without conjunctivitis confirmed by positive skin test or in vitro testing for pollenspecific IgE antibodies for any of the five grass species contained in this product. Oralair is approved for use in persons 10 through 65 years of age. ...
Full Text - Cellular and Molecular Pharmacology
... [moclobemide] and SSRI [fluoxetine]) groups. Tedizolid phosphate, at exposures up to 30 times the human equivalent therapeutic exposure, did not cause an increased serotonergic response in mice, whereas linezolid, at approximately the human equivalent therapeutic exposure, caused an approximately 4.5 ...
... [moclobemide] and SSRI [fluoxetine]) groups. Tedizolid phosphate, at exposures up to 30 times the human equivalent therapeutic exposure, did not cause an increased serotonergic response in mice, whereas linezolid, at approximately the human equivalent therapeutic exposure, caused an approximately 4.5 ...
... A lead SN-38 HDC for which detailed evaluations has been done showed that the payload is released in tumor for a prolonged period of time (0.22uM and 0.38uM at 24h and72h respectively in tumor against 30nM at 24h and no drug quantified at 72h for irinotecan, at their maximum tolerated doses (MTDs). ...
Understanding Clinical Trial Design
... The purpose of this tutorial is to provide a strategy that research advocates can use to constructively contribute to planning clinical trials. It should also assist them to critically assess already designed trials they may be asked to critique (e.g., in grant proposals), as well as to evaluate com ...
... The purpose of this tutorial is to provide a strategy that research advocates can use to constructively contribute to planning clinical trials. It should also assist them to critically assess already designed trials they may be asked to critique (e.g., in grant proposals), as well as to evaluate com ...
Lamisil cutaneous spray, solution ENG SmPC
... oral doses of about 100 mg/kg a day. At high oral doses, the liver and possibly also the kidneys were identified as potential target organs. In a two-year oral carcinogenicity study in mice, no neoplastic or other abnormal findings attributable to treatment were made up to doses of 130 (males) and 1 ...
... oral doses of about 100 mg/kg a day. At high oral doses, the liver and possibly also the kidneys were identified as potential target organs. In a two-year oral carcinogenicity study in mice, no neoplastic or other abnormal findings attributable to treatment were made up to doses of 130 (males) and 1 ...
DICETEL PM
... There are no adequate data from the use of pinaverium bromide in pregnant women. Animal studies are insufficient with respect to effects on pregnancy, embryonal/ fetal development, parturition and/ or postnatal development. The potential risk for humans is unknown. The safety of DICETEL during pregn ...
... There are no adequate data from the use of pinaverium bromide in pregnant women. Animal studies are insufficient with respect to effects on pregnancy, embryonal/ fetal development, parturition and/ or postnatal development. The potential risk for humans is unknown. The safety of DICETEL during pregn ...
Number 6 - Laboratory Animal Boards Study Group
... after birth, 50% of the male and 80% of the female pet/pet pups were lost or found dead. Surviving pet/pet rats showed marked retardation of postnatal growth, and their body weights were 41% (female rats) and 32% (male rats) of those of normal rats at the adult stage. The pet/pet rats exhibited prop ...
... after birth, 50% of the male and 80% of the female pet/pet pups were lost or found dead. Surviving pet/pet rats showed marked retardation of postnatal growth, and their body weights were 41% (female rats) and 32% (male rats) of those of normal rats at the adult stage. The pet/pet rats exhibited prop ...
Clavis Pharma and Clovis Oncology Sign $380 Million Partnership
... expression of the hENT1 transporter that allows gemcitabine to enter tumour cells. In vitro data demonstrate that CP4126 overcomes this resistance mechanism. We now have the opportunity to show that a cytotoxic, which remains the backbone of cancer therapy, can become an effective, targeted therapy ...
... expression of the hENT1 transporter that allows gemcitabine to enter tumour cells. In vitro data demonstrate that CP4126 overcomes this resistance mechanism. We now have the opportunity to show that a cytotoxic, which remains the backbone of cancer therapy, can become an effective, targeted therapy ...
Natural Supplements 101 Introduction to Herbal Medicines HERB
... (100mg) or placebo Placed in rotating chair (4-17rpm) Vertical component to motion as well Recorded symptoms every 15s. up to six minutes Results: mean times P-90s., D-216s., G-335s. none of P or D gps able to stay in chair 6 minutes half subjects on ginger stayed full time(p<0.001) ...
... (100mg) or placebo Placed in rotating chair (4-17rpm) Vertical component to motion as well Recorded symptoms every 15s. up to six minutes Results: mean times P-90s., D-216s., G-335s. none of P or D gps able to stay in chair 6 minutes half subjects on ginger stayed full time(p<0.001) ...
PNH Research Summary - Aplastic Anemia and MDS
... people with PNH don’t have two important complement proteins, CD59 and CD55. Without these proteins, the complement system destroys red blood cells prematurely. ALXN1210 is a biological agent that quickly and completely inhibits complement protein attacks on blood cells. This drug prevents premature ...
... people with PNH don’t have two important complement proteins, CD59 and CD55. Without these proteins, the complement system destroys red blood cells prematurely. ALXN1210 is a biological agent that quickly and completely inhibits complement protein attacks on blood cells. This drug prevents premature ...
Pulmicort Respules
... receptor affinity studies, the 22R form was two times as active as the 22S epimer. In vitro studies indicated that the two forms of budesonide do not interconvert. The precise mechanism of corticosteroid actions on inflammation in asthma is not well known. Inflammation is an important component in t ...
... receptor affinity studies, the 22R form was two times as active as the 22S epimer. In vitro studies indicated that the two forms of budesonide do not interconvert. The precise mechanism of corticosteroid actions on inflammation in asthma is not well known. Inflammation is an important component in t ...
arsenic trioxide - Cancer Care Ontario
... funding information. The information set out in the drug monographs, regimen monographs, appendices and symptom management information (for health professionals) contained in the Drug Formulary (the "Formulary") is intended for healthcare providers and is to be used for informational purposes only. ...
... funding information. The information set out in the drug monographs, regimen monographs, appendices and symptom management information (for health professionals) contained in the Drug Formulary (the "Formulary") is intended for healthcare providers and is to be used for informational purposes only. ...
Hepatoprotective potential of Cordia subcordata Lam. against
... after 7days. Reduction in the levels of SGOT and SGPT towards the normal value is an indication of regeneration process. Reduction of ALP levels with concurrent depletion of raised bilirubin level suggests the stability of the biliary function during injury with CCl4. Bilirubin is the conventional i ...
... after 7days. Reduction in the levels of SGOT and SGPT towards the normal value is an indication of regeneration process. Reduction of ALP levels with concurrent depletion of raised bilirubin level suggests the stability of the biliary function during injury with CCl4. Bilirubin is the conventional i ...
Understanding VELCADE® (bortezomib)
... myeloma. The first of these oral presentations concerned the data from a trial that compared the efficacy of an approved HIV treatment, Viracept® (nelfinavir), in combination with Velcade + dexamethasone, versus Velcade + dexamethasone alone. All patients in the trial were refractory to previous tre ...
... myeloma. The first of these oral presentations concerned the data from a trial that compared the efficacy of an approved HIV treatment, Viracept® (nelfinavir), in combination with Velcade + dexamethasone, versus Velcade + dexamethasone alone. All patients in the trial were refractory to previous tre ...
Read - DIA
... Results: In study U24, 12 patients were to be enrolled in the study. Although 54 patients were refered by the offsite specialist to the clinical unit, 7 patients were finally enrolled and completed the study. Additionally, 23 of the 54 patients refered attended the screening visit, signed the consen ...
... Results: In study U24, 12 patients were to be enrolled in the study. Although 54 patients were refered by the offsite specialist to the clinical unit, 7 patients were finally enrolled and completed the study. Additionally, 23 of the 54 patients refered attended the screening visit, signed the consen ...
erlotinib - Cancer Care Ontario
... ** Improvement in DFS was noted but no statistically significant difference in overall survival or quality of life was seen. Mutation status must be confirmed prior to starting erlotinib; in the pivotal trial only patients with exon 19 deletions and exon 21 L858R point mutation were included- limite ...
... ** Improvement in DFS was noted but no statistically significant difference in overall survival or quality of life was seen. Mutation status must be confirmed prior to starting erlotinib; in the pivotal trial only patients with exon 19 deletions and exon 21 L858R point mutation were included- limite ...
Opioids Part 2 - The University of Sydney
... • Two active metabolites are responsible for most of the effect of LAAM – nor-LAAM (half-life >30 hours) – dinor-LAAM (half-life >100 hours) ...
... • Two active metabolites are responsible for most of the effect of LAAM – nor-LAAM (half-life >30 hours) – dinor-LAAM (half-life >100 hours) ...
2004 Guide to Psychiatric Drug Interactions
... three or more psychiatric medications being seen at the Biological Psychiatry Branch of the National Institute of Mental Health from the early 1970s to the mid 1990s (Figure 2).25 For all of the above reasons, patients on psychiatric medications are at risk for DDIs and these DDIs are likely to invo ...
... three or more psychiatric medications being seen at the Biological Psychiatry Branch of the National Institute of Mental Health from the early 1970s to the mid 1990s (Figure 2).25 For all of the above reasons, patients on psychiatric medications are at risk for DDIs and these DDIs are likely to invo ...