5 Calcium Antagonists (Calcium Channel Blockers)
... In pooled trials of more than 5000 patients, it was necessary to withdraw nifedipine capsules in only approximately 5% (4). The side effects of nifedipine and verapamil are given in Table 5-3. Further clinical trials from 1984 to 1999 indicate that about 20% of patients complain of side effects from ...
... In pooled trials of more than 5000 patients, it was necessary to withdraw nifedipine capsules in only approximately 5% (4). The side effects of nifedipine and verapamil are given in Table 5-3. Further clinical trials from 1984 to 1999 indicate that about 20% of patients complain of side effects from ...
1. NAME OF THE MEDICINAL PRODUCT Dompicare 20 mg, film
... erythromycin, ketoconazole, itraconazole and nefazodone (see section 4.4 Special warnings and special precautions for use). Systemic exposure of domperidone can be reduced by inducers of CYP3A4 such as rifampicin, carbamazepine, efavirenz and St. John’s wort. In vitro and animal in vivo studies sugg ...
... erythromycin, ketoconazole, itraconazole and nefazodone (see section 4.4 Special warnings and special precautions for use). Systemic exposure of domperidone can be reduced by inducers of CYP3A4 such as rifampicin, carbamazepine, efavirenz and St. John’s wort. In vitro and animal in vivo studies sugg ...
COMPARATIVE HEPATOPROTECTIVE ACTIVITY OF LIV-52 AND SILYMARINE AGAINST
... Bicalutamide is a nonsteroidal antiandrogenic drug used in treatment of prostate cancer. Bicalutamide is extensively metabolized by liver and reported to have hepatotoxicity. The present study was conducted to compare the hepatoprotective activity of two formulations, Liv-52 and Silymarine against B ...
... Bicalutamide is a nonsteroidal antiandrogenic drug used in treatment of prostate cancer. Bicalutamide is extensively metabolized by liver and reported to have hepatotoxicity. The present study was conducted to compare the hepatoprotective activity of two formulations, Liv-52 and Silymarine against B ...
Central Nervous System Depressant, Analgesic and Antidiarrheal
... activity was evaluated by open field and hole cross tests; analgesic activity by acetic acid-induced writhing test and formalin-induced licking test; and anti-diarrheal activity was assessed in castor oil and magnesium-induced diarrhea rat model. The extracts were given orally in a rat model at dose ...
... activity was evaluated by open field and hole cross tests; analgesic activity by acetic acid-induced writhing test and formalin-induced licking test; and anti-diarrheal activity was assessed in castor oil and magnesium-induced diarrhea rat model. The extracts were given orally in a rat model at dose ...
The paradox of drug taking: The role of the aversive... ⁎ Anthony L. Riley
... learning is the analysis of inbred rat strains. Such strains are derived from full-sibling matings for at least 20 consecutive generations, as opposed to selectively bred strains in which the constituent members are unrelated [33]. Two of the most popular strains in such investigations are the C57BL ...
... learning is the analysis of inbred rat strains. Such strains are derived from full-sibling matings for at least 20 consecutive generations, as opposed to selectively bred strains in which the constituent members are unrelated [33]. Two of the most popular strains in such investigations are the C57BL ...
Gastro-Bismol
... The active drug substance Bismuth Subsalicylate is the subject of a PhEur monograph. This source of active has been used in a licensed product (PL: 00364/0025) in the UK since 18/07/1979. Critical manufacturing process parameters have been validated and form part of the in-process controls. This is ...
... The active drug substance Bismuth Subsalicylate is the subject of a PhEur monograph. This source of active has been used in a licensed product (PL: 00364/0025) in the UK since 18/07/1979. Critical manufacturing process parameters have been validated and form part of the in-process controls. This is ...
Kwartaalbericht
... and release to keratinocytes. It is controlled by multiple mediators (growth factors, cytokines) acting on melanocytes, keratinocytes and fibroblasts. The suggested aetiopathogenesis behind drug-induced vitiligo is: (1) activation of cytotoxic T cells directed against melanocyte antigens, (2) damage ...
... and release to keratinocytes. It is controlled by multiple mediators (growth factors, cytokines) acting on melanocytes, keratinocytes and fibroblasts. The suggested aetiopathogenesis behind drug-induced vitiligo is: (1) activation of cytotoxic T cells directed against melanocyte antigens, (2) damage ...
Signaled drug delivery and transport across the blood
... dierucoylphosphatidylcholine (DEPC) liposomes is reported in [35], where liposomes loaded with fluorescent molecules were subjected to focused ultrasound at different frequencies and intensities, for varying amounts of time. Release rates were estimated as the ultrasound parameters were varied. In S ...
... dierucoylphosphatidylcholine (DEPC) liposomes is reported in [35], where liposomes loaded with fluorescent molecules were subjected to focused ultrasound at different frequencies and intensities, for varying amounts of time. Release rates were estimated as the ultrasound parameters were varied. In S ...
Formulation and Evaluation of Itopride Hydrochloride Floating
... represents the fraction of drug released in time t, KP is the rate constant and n is the release exponent, indicative of the drug release mechanism. The Korsmeyer-Peppas model was employed in the in vitro drug release behaviour analysis of these formulations to distinguish between competing release ...
... represents the fraction of drug released in time t, KP is the rate constant and n is the release exponent, indicative of the drug release mechanism. The Korsmeyer-Peppas model was employed in the in vitro drug release behaviour analysis of these formulations to distinguish between competing release ...
Pepto – Bismol (Gastro-Bismol) (Bismuth Salicylate) PL 00129/0141
... The active drug substance Bismuth Subsalicylate is the subject of a PhEur monograph. This source of active has been used in a licensed product (PL: 00364/0025) in the UK since 18/07/1979. Critical manufacturing process parameters have been validated and form part of the in-process controls. This is ...
... The active drug substance Bismuth Subsalicylate is the subject of a PhEur monograph. This source of active has been used in a licensed product (PL: 00364/0025) in the UK since 18/07/1979. Critical manufacturing process parameters have been validated and form part of the in-process controls. This is ...
Enhancement of psychostimulant effect and development of
... The present study evaluated in mice the possible modification of psychostimulant methamphetamine (MET) effects by co-administration of piracetam (PIR) and the development of behavioural sensitisation to the psychostimulant in the case of combined treatment. On the Day 1 mice were randomly allocated ...
... The present study evaluated in mice the possible modification of psychostimulant methamphetamine (MET) effects by co-administration of piracetam (PIR) and the development of behavioural sensitisation to the psychostimulant in the case of combined treatment. On the Day 1 mice were randomly allocated ...
(Dosing, switching, and other practical information).
... Aripiprazole should be used with caution in patients who have a history of seizure disorder or have conditions associated with seizures. ...
... Aripiprazole should be used with caution in patients who have a history of seizure disorder or have conditions associated with seizures. ...
ROSUVASTATIN CORE SAFETY PROFILE
... Transporter protein inhibitors: Rosuvastatin is a substrate for certain transporter proteins including the hepatic uptake transporter OATP1B1 and efflux transporter BCRP. Concomitant administration of rosuvastatin with medicinal products that are inhibitors of these transporter proteins may result i ...
... Transporter protein inhibitors: Rosuvastatin is a substrate for certain transporter proteins including the hepatic uptake transporter OATP1B1 and efflux transporter BCRP. Concomitant administration of rosuvastatin with medicinal products that are inhibitors of these transporter proteins may result i ...
8 Aldosterone blockers: spironolactone and eplerenone
... III−IV, assuming that they are already being maintained on an ACE inhibitor and diuretic. Blood samples should be taken at weeks one, four, eight and 12 and every three months after that for the first year. Afterwards they should be monitored at least every six months. This is because of the signif ...
... III−IV, assuming that they are already being maintained on an ACE inhibitor and diuretic. Blood samples should be taken at weeks one, four, eight and 12 and every three months after that for the first year. Afterwards they should be monitored at least every six months. This is because of the signif ...
lopresor pi
... The effects of beta-blockers on thyroid hormone metabolism may result in elevations of serum free thyroxine (T4) levels. In the absence of any signs or symptoms of hyperthyroidism, additional investigation is necessary before a diagnosis of thyrotoxicosis can be made. Other metabolic effects: Beta-a ...
... The effects of beta-blockers on thyroid hormone metabolism may result in elevations of serum free thyroxine (T4) levels. In the absence of any signs or symptoms of hyperthyroidism, additional investigation is necessary before a diagnosis of thyrotoxicosis can be made. Other metabolic effects: Beta-a ...
Study Guide for NLN RN Pharmacology Exam
... Treat poison and overdose following oral ingestion. It binds to poison and prevent its absorption by the GI tract and it eliminate in the feces. Charcoal must be administered within 60 minutes of ingestion. Ipecac-induce emesis of stomach pups is also used. Charcoal may be given once or twice depend ...
... Treat poison and overdose following oral ingestion. It binds to poison and prevent its absorption by the GI tract and it eliminate in the feces. Charcoal must be administered within 60 minutes of ingestion. Ipecac-induce emesis of stomach pups is also used. Charcoal may be given once or twice depend ...
SHARED CARE GUIDELINES ON MELATONIN FOR SLEEP DISORDERS/DIFFICULTIES IN CHILDREN (NELFT)
... 15. Melatonin is generally well tolerated, but long term side effects have not been evaluated. The most commonly reported side-effects are headaches, dizziness, nausea, and drowsiness. Increased seizure activity has been reported in patients with epilepsy but there is also anecdotal evidence that se ...
... 15. Melatonin is generally well tolerated, but long term side effects have not been evaluated. The most commonly reported side-effects are headaches, dizziness, nausea, and drowsiness. Increased seizure activity has been reported in patients with epilepsy but there is also anecdotal evidence that se ...
Formulation Design and Characterization of Kollidon SR Based
... The purpose of the present study was to formulate sustained release Trimetazidine Dihydrochloride matrix tablets by using Kollidon SR as rate controlling polymer. Each of the formulated tablet contains 35 mg of Trimetazidine Dihydrochloride. The tablets were prepared by direct compression method. Th ...
... The purpose of the present study was to formulate sustained release Trimetazidine Dihydrochloride matrix tablets by using Kollidon SR as rate controlling polymer. Each of the formulated tablet contains 35 mg of Trimetazidine Dihydrochloride. The tablets were prepared by direct compression method. Th ...
Effect of Monthly Injectable Contraceptive (Mesigyna) on the Uterus
... on the uterus through binding to specific hormone binding proteins known as progesterone receptors (PRs). PRs are nuclear proteins found in epithelial, stromal and smooth muscle cells of the uterus. These receptors have high affinity to progesterone and can be detected by immunohistochemical assays ...
... on the uterus through binding to specific hormone binding proteins known as progesterone receptors (PRs). PRs are nuclear proteins found in epithelial, stromal and smooth muscle cells of the uterus. These receptors have high affinity to progesterone and can be detected by immunohistochemical assays ...
Therapeutic Interchanges
... separately) or to ipratropium/albuterol (DuoNeb®) nebulization solution. Ventilated patients may be switched to ipratropium/albuterol (DuoNeb®) nebulization solution. Atrovent® metered dose inhalers (MDIs) are not available for inpatient use at UPHSM. Non-ventilated patients may be switched to tiotr ...
... separately) or to ipratropium/albuterol (DuoNeb®) nebulization solution. Ventilated patients may be switched to ipratropium/albuterol (DuoNeb®) nebulization solution. Atrovent® metered dose inhalers (MDIs) are not available for inpatient use at UPHSM. Non-ventilated patients may be switched to tiotr ...
Drug allergy - Journal of Allergy and Clinical Immunology
... evaluating expression of CD63 or CD203C on basophils after stimulation with an allergen. There are very limited data using this method to evaluate patients with possible drug allergies to b-lactam antibiotics, NSAIDs, and muscle relaxants,9 and further confirmatory studies, especially with commercia ...
... evaluating expression of CD63 or CD203C on basophils after stimulation with an allergen. There are very limited data using this method to evaluate patients with possible drug allergies to b-lactam antibiotics, NSAIDs, and muscle relaxants,9 and further confirmatory studies, especially with commercia ...
Preparation, characterization, and in vivo evaluation of - e
... allergy, infection, and congestion, the use of this route for systemic administration of a drug is limited due to local untoward effects including irritation or injury to nasal mucosa from drugs or their excipients.10 However, the nasal route is one of the focused delivery options for the treatment ...
... allergy, infection, and congestion, the use of this route for systemic administration of a drug is limited due to local untoward effects including irritation or injury to nasal mucosa from drugs or their excipients.10 However, the nasal route is one of the focused delivery options for the treatment ...
FLAVERIA TRINERVIA HEPATOTOXICITY USING RATS Research Article
... Fig. 2: (A) Liver sections of normal control rats showing: Intact tissue architecture with normal hepatocytes and a well-preserved cytoplasm; well brought out central vein; prominent nucleus and nucleolus. (B) Liver section of the ethanol treated rats showing: infiltration of the lymphocytes, centri ...
... Fig. 2: (A) Liver sections of normal control rats showing: Intact tissue architecture with normal hepatocytes and a well-preserved cytoplasm; well brought out central vein; prominent nucleus and nucleolus. (B) Liver section of the ethanol treated rats showing: infiltration of the lymphocytes, centri ...
A randomised phase IIb trial of BEvACizumab added to
... anticoagulants for at least two weeks at the time of randomisation th Blood pressure below 95 centile for age and sex. Use of antihypertensive medication is permitted Males or females of reproductive potential may not participate unless they agree to use an adequate method of birth control, i.e. wit ...
... anticoagulants for at least two weeks at the time of randomisation th Blood pressure below 95 centile for age and sex. Use of antihypertensive medication is permitted Males or females of reproductive potential may not participate unless they agree to use an adequate method of birth control, i.e. wit ...
Keppra
... showed that patients randomized to one of the AEDs had approximately twice the risk (adjusted Relative Risk 1.8, 95% CI:1.2, 2.7) of suicidal thinking or behavior compared to patients randomized to placebo. In these trials, which had a median treatment duration of 12 weeks, the estimated incidence r ...
... showed that patients randomized to one of the AEDs had approximately twice the risk (adjusted Relative Risk 1.8, 95% CI:1.2, 2.7) of suicidal thinking or behavior compared to patients randomized to placebo. In these trials, which had a median treatment duration of 12 weeks, the estimated incidence r ...