Toxicologic Pathology
... patients, are likely to share some common biochemical effects, most probably not related to their primary mechanism of action. By comparing, in preclinical studies, the “off-target” biochemical effects of a number of compounds that are known to cause clinical DILI, it should be possible to discover ...
... patients, are likely to share some common biochemical effects, most probably not related to their primary mechanism of action. By comparing, in preclinical studies, the “off-target” biochemical effects of a number of compounds that are known to cause clinical DILI, it should be possible to discover ...
Summary of Product Characteristics
... Breaks and aberrations were not observed on chromosome analysis of marrow cells from patients treated with vinblastine sulfate although chromosomal changes have been noted in some hamster lung cell in vitro tests. The use of small amounts of vinblastine sulfate daily for long periods is not advisabl ...
... Breaks and aberrations were not observed on chromosome analysis of marrow cells from patients treated with vinblastine sulfate although chromosomal changes have been noted in some hamster lung cell in vitro tests. The use of small amounts of vinblastine sulfate daily for long periods is not advisabl ...
Central Nervous System Activity Studies of Baptisia tinctoria (L.) R
... stress, which lead to social isolation and poor quality of life [1]. More than 650 million people suffer from these mental disorders. Around 6-7% of India’s population suffers from a mental disorder either due to stress, depression, anxiety or any other cause [2]. Psychotherapeutics are noneffective ...
... stress, which lead to social isolation and poor quality of life [1]. More than 650 million people suffer from these mental disorders. Around 6-7% of India’s population suffers from a mental disorder either due to stress, depression, anxiety or any other cause [2]. Psychotherapeutics are noneffective ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) ISSN: 2278-3008.
... The study showed that the extract at 12.5 and 25 mg/kg b w did not protect the animals against PTZ-induced seizure. However, the extract at dose level of 50 mg/kg b w offered 20% protection and significantly prolonged the onset of seizure in mice when compared to the control group. Anticonvulsant ac ...
... The study showed that the extract at 12.5 and 25 mg/kg b w did not protect the animals against PTZ-induced seizure. However, the extract at dose level of 50 mg/kg b w offered 20% protection and significantly prolonged the onset of seizure in mice when compared to the control group. Anticonvulsant ac ...
Cefazolin Injection, USP in GALAXY Container (PL 2040
... Prolonged use of cefazolin may result in the overgrowth of nonsusceptible organisms. Careful clinical observation of the patient is essential. When cefazolin is administered to patients with low urinary output because of impaired renal function, lower daily dosage is required (see DOSAGE AND ADMINIS ...
... Prolonged use of cefazolin may result in the overgrowth of nonsusceptible organisms. Careful clinical observation of the patient is essential. When cefazolin is administered to patients with low urinary output because of impaired renal function, lower daily dosage is required (see DOSAGE AND ADMINIS ...
Articaine: Efficacy and Paresthesia in Dental Local Anesthesia
... 1982.1 It was reported to have superb diffusion capabilities, adequate duration (with the inclusion of a vasoconstrictor) and a very effective performance. A thiophene ring replaced the aniline ring on the lipophilic section of the molecule and, for the first time in local anesthetics, a sulfur atom ...
... 1982.1 It was reported to have superb diffusion capabilities, adequate duration (with the inclusion of a vasoconstrictor) and a very effective performance. A thiophene ring replaced the aniline ring on the lipophilic section of the molecule and, for the first time in local anesthetics, a sulfur atom ...
Effects of the putative dopamine D receptor antagonist PNU 99194A
... The dopamine D 3 receptor antagonist 5,6-dimethoxy-2Ždi-n-propylamino.indan hydrochloride ŽPNU 99194A; formerly U 99194A. was a generous gift of Pharmacia and Upjohn ŽKalamazoo, MI, USA.. PNU 99194A maleate that was used for motor activity assessment was obtained from Research Biochemicals Internati ...
... The dopamine D 3 receptor antagonist 5,6-dimethoxy-2Ždi-n-propylamino.indan hydrochloride ŽPNU 99194A; formerly U 99194A. was a generous gift of Pharmacia and Upjohn ŽKalamazoo, MI, USA.. PNU 99194A maleate that was used for motor activity assessment was obtained from Research Biochemicals Internati ...
Meta-analysis of Oral Triptan Therapy for Migraine: Number Needed
... Nonetheless, nearly all triptan trials use comparable protocols. We therefore assumed, for the sake of analysis, that all placebocontrolled studies not involving direct comparison of triptans were fundamentally comparable.22 We used the clinical endpoint of pain free at 2 hours as the indicator of e ...
... Nonetheless, nearly all triptan trials use comparable protocols. We therefore assumed, for the sake of analysis, that all placebocontrolled studies not involving direct comparison of triptans were fundamentally comparable.22 We used the clinical endpoint of pain free at 2 hours as the indicator of e ...
Terbutaline Sulfate Injection, USP
... administered orally at doses up to 50 mg/kg (apBeta-adrenergic receptor blocking agents not only proximately 810 times the maximum recommended block the pulmonary effect of beta-agonists, such daily sc dose for adults on a mg/m2 basis). A reproas Terbutaline Sulfate Injection, USP, but may productio ...
... administered orally at doses up to 50 mg/kg (apBeta-adrenergic receptor blocking agents not only proximately 810 times the maximum recommended block the pulmonary effect of beta-agonists, such daily sc dose for adults on a mg/m2 basis). A reproas Terbutaline Sulfate Injection, USP, but may productio ...
Valsartan to losartan conversion
... desired brand to find out the drug price. Losartan official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Learn about clinical pharmacology for the drug Cozaar (Losartan Potassium). Valsartan (trade name Diovan) is an a ...
... desired brand to find out the drug price. Losartan official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Learn about clinical pharmacology for the drug Cozaar (Losartan Potassium). Valsartan (trade name Diovan) is an a ...
Prescribing Information
... and was dose-related in the U.S. studies. Withdrawal from these clinical studies of FLOMAX capsules because of abnormal ejaculation was also dose-dependent, with 8 of 492 patients (1.6%) in the 0.8 mg group and no patients in the 0.4 mg or placebo groups discontinuing treatment due to abnormal ejacu ...
... and was dose-related in the U.S. studies. Withdrawal from these clinical studies of FLOMAX capsules because of abnormal ejaculation was also dose-dependent, with 8 of 492 patients (1.6%) in the 0.8 mg group and no patients in the 0.4 mg or placebo groups discontinuing treatment due to abnormal ejacu ...
61570-10 Lipitor (Master)
... The impact on clinical outcomes of the differences in lipid-altering effects between treatments shown in Table 2 is not known. Table 2 does not contain data comparing the effects of atorvastatin 10 mg and higher doses of lovastatin, pravastatin, and simvastatin. The drugs compared in the studies sum ...
... The impact on clinical outcomes of the differences in lipid-altering effects between treatments shown in Table 2 is not known. Table 2 does not contain data comparing the effects of atorvastatin 10 mg and higher doses of lovastatin, pravastatin, and simvastatin. The drugs compared in the studies sum ...
Ketamine Parenteral and Oral Dose Recommendations
... If converting patients from Ketamine infusion to oral, administer first oral dose 4 to 8 hrs after infusion stopped • May titrate every 48-72 hrs • Typical starting dose in ketamine naïve patient: 10mg-30mg PO Q8h o Maximum Reported Oral Dose: 800mg/day ...
... If converting patients from Ketamine infusion to oral, administer first oral dose 4 to 8 hrs after infusion stopped • May titrate every 48-72 hrs • Typical starting dose in ketamine naïve patient: 10mg-30mg PO Q8h o Maximum Reported Oral Dose: 800mg/day ...
Lesson 4: Calculations used to determine patient
... guidelines, usually a dosing range and from that calculating what amount of drug the patient should receive for each dose, and how much total drug you will thus need to fill the patient’s prescription. Let’s look at each step. 1. Locate dosing guidelines. You decide that you need to calculate a pati ...
... guidelines, usually a dosing range and from that calculating what amount of drug the patient should receive for each dose, and how much total drug you will thus need to fill the patient’s prescription. Let’s look at each step. 1. Locate dosing guidelines. You decide that you need to calculate a pati ...
Overview of drug-interactions between coumarin
... there are several reports of warfarin and interactions with noscapine. Sixteen cases have been reported of a drug interaction between noscapine and warfarin which lead to an INR increase in 15 cases and bleeding in one case. One patient developed an INR higher than 8 [12]. In 2006 SWEDIS received a ...
... there are several reports of warfarin and interactions with noscapine. Sixteen cases have been reported of a drug interaction between noscapine and warfarin which lead to an INR increase in 15 cases and bleeding in one case. One patient developed an INR higher than 8 [12]. In 2006 SWEDIS received a ...
Actemra CC
... Initial approval/extended approval: Initial approval is for 4 months (4 doses) of therapy with 4 mg/kg initially and then every 4 weeks (weeks 0, 4, 8, and 12). Patients are evaluated for response after the fourth dose. Approve for an additional 12 months of therapy if the patient has responded (les ...
... Initial approval/extended approval: Initial approval is for 4 months (4 doses) of therapy with 4 mg/kg initially and then every 4 weeks (weeks 0, 4, 8, and 12). Patients are evaluated for response after the fourth dose. Approve for an additional 12 months of therapy if the patient has responded (les ...
AVELOX PRODUCT INFORMATION
... Possible interethnic differences were examined in Caucasian, Japanese, Black and other ethnic groups. No clinically relevant interethnic differences in pharmacokinetics could be detected. Renal impairment The pharmacokinetics of moxifloxacin are not significantly changed by renal impairment (includi ...
... Possible interethnic differences were examined in Caucasian, Japanese, Black and other ethnic groups. No clinically relevant interethnic differences in pharmacokinetics could be detected. Renal impairment The pharmacokinetics of moxifloxacin are not significantly changed by renal impairment (includi ...
Tricyclic Antidepressants
... Only available in a limited number of centres • Results in rapid fluid shifts causing significant haemodynamic effects (hypoxia and hypotension) – may not be tolerated in patients with severe poisoning ...
... Only available in a limited number of centres • Results in rapid fluid shifts causing significant haemodynamic effects (hypoxia and hypotension) – may not be tolerated in patients with severe poisoning ...
1 PRODUCT INFORMATION FLIXOTIDE NEBULES NAME OF THE
... doses of fluticasone propionate up to 57 µg/kg/day by inhalation or in an 18 month study in mice receiving oral doses of fluticasone propionate up to 1 mg/kg/day. There was no evidence of a mutagenic potential in a standard battery of mutagenicity assays. A fertility study in rats showed decreased m ...
... doses of fluticasone propionate up to 57 µg/kg/day by inhalation or in an 18 month study in mice receiving oral doses of fluticasone propionate up to 1 mg/kg/day. There was no evidence of a mutagenic potential in a standard battery of mutagenicity assays. A fertility study in rats showed decreased m ...
THERMOSENSITIVE MICROGELS OF POLY
... water, and connected in the areas of polymer where the hydrophilic functional groups exist. Increased temperature in the course of synthesis affects the isolation of the polymer phase with low water content from the external aqueous phase. This phenomenon manifests itself in turbidity or opalescence ...
... water, and connected in the areas of polymer where the hydrophilic functional groups exist. Increased temperature in the course of synthesis affects the isolation of the polymer phase with low water content from the external aqueous phase. This phenomenon manifests itself in turbidity or opalescence ...
us equine
... • First and only licensed antibiotic that offers a full 10-day course of therapy in just 2 treatments. • One single sustained dose provides therapeutic care for 96 hours. • The sustained-release nature of the product means less systemic exposure to the antibiotic with comparable efficacy. • 100% ef ...
... • First and only licensed antibiotic that offers a full 10-day course of therapy in just 2 treatments. • One single sustained dose provides therapeutic care for 96 hours. • The sustained-release nature of the product means less systemic exposure to the antibiotic with comparable efficacy. • 100% ef ...
auranofin - Oxford Academic
... The two basic ligands of auranofin, namely triethylphosphine oxide and 2,3,4,6-tetra-o-acetyl-1-thiob--glucopyranosato were without biological activity and gold sodium thiomalate, gold thioglucose and thiomalic acid did not affect rat paw oedema significantly. Auranofin was shown to suppress adjuva ...
... The two basic ligands of auranofin, namely triethylphosphine oxide and 2,3,4,6-tetra-o-acetyl-1-thiob--glucopyranosato were without biological activity and gold sodium thiomalate, gold thioglucose and thiomalic acid did not affect rat paw oedema significantly. Auranofin was shown to suppress adjuva ...
Tepoxalin - American Academy of Veterinary Pharmacology and
... Note: As with other nonsteroidal anti-inflammatory drugs (NSAIDs), adverse effects, sometimes severe, may occur in individual animals with administration of tepoxalin.{R-2} Gastrointestinal side effects are the most common;{R-2} however, safety studies have shown evidence that tepoxalin can be toler ...
... Note: As with other nonsteroidal anti-inflammatory drugs (NSAIDs), adverse effects, sometimes severe, may occur in individual animals with administration of tepoxalin.{R-2} Gastrointestinal side effects are the most common;{R-2} however, safety studies have shown evidence that tepoxalin can be toler ...
1. NAME OF THE MEDICINAL PRODUCT Dompicare 20 mg, film
... erythromycin, ketoconazole, itraconazole and nefazodone (see section 4.4 Special warnings and special precautions for use). Systemic exposure of domperidone can be reduced by inducers of CYP3A4 such as rifampicin, carbamazepine, efavirenz and St. John’s wort. In vitro and animal in vivo studies sugg ...
... erythromycin, ketoconazole, itraconazole and nefazodone (see section 4.4 Special warnings and special precautions for use). Systemic exposure of domperidone can be reduced by inducers of CYP3A4 such as rifampicin, carbamazepine, efavirenz and St. John’s wort. In vitro and animal in vivo studies sugg ...
COMPARATIVE HEPATOPROTECTIVE ACTIVITY OF LIV-52 AND SILYMARINE AGAINST
... Bicalutamide is a nonsteroidal antiandrogenic drug used in treatment of prostate cancer. Bicalutamide is extensively metabolized by liver and reported to have hepatotoxicity. The present study was conducted to compare the hepatoprotective activity of two formulations, Liv-52 and Silymarine against B ...
... Bicalutamide is a nonsteroidal antiandrogenic drug used in treatment of prostate cancer. Bicalutamide is extensively metabolized by liver and reported to have hepatotoxicity. The present study was conducted to compare the hepatoprotective activity of two formulations, Liv-52 and Silymarine against B ...