Supramolecularly engineered phospholipids
... carriers, gene delivery, contrast agents, as well as the surface modication of biomaterials.9–13 So far, several liposome-based drug delivery systems have been approved by the Food and Drug Administration (FDA) and numerous liposome-encapsulated agents have been used in clinical trials.14–17 Howeve ...
... carriers, gene delivery, contrast agents, as well as the surface modication of biomaterials.9–13 So far, several liposome-based drug delivery systems have been approved by the Food and Drug Administration (FDA) and numerous liposome-encapsulated agents have been used in clinical trials.14–17 Howeve ...
Acetaminophen
... medicinal use of acetaminophen. However, in light of the widespread use of this drug, it seems to be a very rare side-effect, and will probably represent a negligible risk at the low exposure doses from cosmetics. ii) Acetaminophen is commonly used and the recommended daily drug dose has the potenti ...
... medicinal use of acetaminophen. However, in light of the widespread use of this drug, it seems to be a very rare side-effect, and will probably represent a negligible risk at the low exposure doses from cosmetics. ii) Acetaminophen is commonly used and the recommended daily drug dose has the potenti ...
Appendix 10: Administering drugs via feeding tubes
... In addition to the general guidance (Box A10.B), the following should be considered when giving drugs via feeding tubes: • sterility with jejunal tube, use sterile water because the acid barrier in the stomach is bypassed; 1 some centres use an aseptic technique to reduce the risk of infective diar ...
... In addition to the general guidance (Box A10.B), the following should be considered when giving drugs via feeding tubes: • sterility with jejunal tube, use sterile water because the acid barrier in the stomach is bypassed; 1 some centres use an aseptic technique to reduce the risk of infective diar ...
Disassembling bacterial extracellular matrix with
... Infections caused by biofilm-forming bacteria are a major threat to hospitalized patients and the main cause of chronic obstructive pulmonary disease and cystic fibrosis. There is an urgent necessity for novel therapeutic approaches, since current antibiotic delivery fails to eliminate biofilm-prote ...
... Infections caused by biofilm-forming bacteria are a major threat to hospitalized patients and the main cause of chronic obstructive pulmonary disease and cystic fibrosis. There is an urgent necessity for novel therapeutic approaches, since current antibiotic delivery fails to eliminate biofilm-prote ...
Zolpidem Physical Dependence Assessed Across Increasing Doses
... Zolpidem did not increase the intake of palatable food in satiated rats (Yerbury and Cooper, 1989), standard food (i.e., rat chow) in food-restricted rats (Sanger and Zivkovic, 1988) or the consumption of hypertonic saline solutions in rehydrating rats (Cooper and Desa, 1988). However, zolpidem did ...
... Zolpidem did not increase the intake of palatable food in satiated rats (Yerbury and Cooper, 1989), standard food (i.e., rat chow) in food-restricted rats (Sanger and Zivkovic, 1988) or the consumption of hypertonic saline solutions in rehydrating rats (Cooper and Desa, 1988). However, zolpidem did ...
Transungual Drug Delivery: An Overview
... Enhancing nail penetration Physical, chemical and mechanical methods have been used to decrease the nail barrier. Within each of these broad categories, many techniques exist to enhance penetration. Mechanical modes of penetration enhancement are typically straightforward, and have the most in vivo ...
... Enhancing nail penetration Physical, chemical and mechanical methods have been used to decrease the nail barrier. Within each of these broad categories, many techniques exist to enhance penetration. Mechanical modes of penetration enhancement are typically straightforward, and have the most in vivo ...
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... The nomination of thimerosal is based on its wide use as a preservative in vaccines and other biological products, the large number of exposures, and the lack of toxicity data. Thimerosal (sodium ethylmercurithiosalicylate; also called thiomersal and merthiolate) was developed by Eli Lilly in the 19 ...
... The nomination of thimerosal is based on its wide use as a preservative in vaccines and other biological products, the large number of exposures, and the lack of toxicity data. Thimerosal (sodium ethylmercurithiosalicylate; also called thiomersal and merthiolate) was developed by Eli Lilly in the 19 ...
P-Glycoprotein functional activity in peripheral blood lymphocytes. Role of immunosuppressants,
... basolateral membranes, and mediate active transport in absorptive and secretory directions. ...
... basolateral membranes, and mediate active transport in absorptive and secretory directions. ...
Pharmacologic Category
... Pregnancy has produced dysmorphogenic effects in animals. Should only be used in severe cases of epilepsy and when resistant to other modes of therapy. Special Precautions: Concurrent administration of barbiturates, MAO inhibitors, analgesic agents that affect platelet function; monitor platelet and ...
... Pregnancy has produced dysmorphogenic effects in animals. Should only be used in severe cases of epilepsy and when resistant to other modes of therapy. Special Precautions: Concurrent administration of barbiturates, MAO inhibitors, analgesic agents that affect platelet function; monitor platelet and ...
Inhaled and intranasal fluticasone propionate and haematoma
... vulnerability of blood vessels because of a decreased collagen turnover due to an inhibition of fibrocyte function [4]. A relation between use of ICS and occurrence of easy bruising has clearly been demonstrated, just like a relationship between bruising and adrenal suppression [9]. Although a direc ...
... vulnerability of blood vessels because of a decreased collagen turnover due to an inhibition of fibrocyte function [4]. A relation between use of ICS and occurrence of easy bruising has clearly been demonstrated, just like a relationship between bruising and adrenal suppression [9]. Although a direc ...
Hard gelatin capsules today – and tomorrow
... specifically designed for preclinical research (PC caps™). PC caps™ are capsules for preclinical and animal trials. They could be described as size 9 capsules. The dimensions of the closed capsule are 7.18 mm in length and 2.06 mm in diameter, with a volume of 0.2 ml. They are especially suitable fo ...
... specifically designed for preclinical research (PC caps™). PC caps™ are capsules for preclinical and animal trials. They could be described as size 9 capsules. The dimensions of the closed capsule are 7.18 mm in length and 2.06 mm in diameter, with a volume of 0.2 ml. They are especially suitable fo ...
A Prospective Experimental Study on the Protective Effect of
... Ototoxicity is a general term used for damage of the cochlear and/or vestibular organs; it results from exposure to several therapeutic agents and chemical substances [1]. Tinnitus is usually the first symptom of ototoxicity. Other symptoms include imbalance, hearing loss, and vertigo [2]. Aminoglyc ...
... Ototoxicity is a general term used for damage of the cochlear and/or vestibular organs; it results from exposure to several therapeutic agents and chemical substances [1]. Tinnitus is usually the first symptom of ototoxicity. Other symptoms include imbalance, hearing loss, and vertigo [2]. Aminoglyc ...
Gastrointestinal bleeding with the new oral anticoagulants â
... (50%) is higher than that of dabigatran; however, even with these agents a significant amount of active drug is recovered in the faeces. Therefore, with all three NOACs, active anticoagulant is present within the lumen of the GI tract after oral ingestion, and in theory could (in combination with sy ...
... (50%) is higher than that of dabigatran; however, even with these agents a significant amount of active drug is recovered in the faeces. Therefore, with all three NOACs, active anticoagulant is present within the lumen of the GI tract after oral ingestion, and in theory could (in combination with sy ...
Coleus forskohlii Monograph - Alternative Medicine Review
... (aerosolized) 10-mg dose of dry forskolin powder, an asthma medication (0.4 mg fenoterol), or placebo. Both fenoterol and forskolin administration resulted in significant, equivalent bronchodilation, but patients taking fenoterol experienced marked finger tremor response and a decrease in plasma pot ...
... (aerosolized) 10-mg dose of dry forskolin powder, an asthma medication (0.4 mg fenoterol), or placebo. Both fenoterol and forskolin administration resulted in significant, equivalent bronchodilation, but patients taking fenoterol experienced marked finger tremor response and a decrease in plasma pot ...
TECTONA GRANDIS Research Article NEHA KHERA
... bearing mice were treated with different concentrations of lapachol (50, 100 mg/kg body weight) at various days alone and with radiation (CO60 gamma radiation 3, 6 Gy). In another group of ascetic bearing animals, the animals were irradiated with 3, 6 Gy of gamma radiation in combination with 50, 10 ...
... bearing mice were treated with different concentrations of lapachol (50, 100 mg/kg body weight) at various days alone and with radiation (CO60 gamma radiation 3, 6 Gy). In another group of ascetic bearing animals, the animals were irradiated with 3, 6 Gy of gamma radiation in combination with 50, 10 ...
Biliary Excretion of Antimicrobial Drugs
... single specimens for assay. Collections of T tube bile have been used for the majority of studies. There are, however, certain serious objections to the use of T tube drainage for bile collection. Hepatic function may be impaired by general anesthesia and the measurement of any antimicrobial drug wh ...
... single specimens for assay. Collections of T tube bile have been used for the majority of studies. There are, however, certain serious objections to the use of T tube drainage for bile collection. Hepatic function may be impaired by general anesthesia and the measurement of any antimicrobial drug wh ...
Antiemesis - proLekare.cz
... and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy: a randomized dose ranging pivotal study. Ann Oncol 2014;25:1340-1346. jNavari RM, Gray SE, Kerr AC. Olanzapine versus aprepitant for the prevention of chemotherapyinduced nausea and ...
... and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy: a randomized dose ranging pivotal study. Ann Oncol 2014;25:1340-1346. jNavari RM, Gray SE, Kerr AC. Olanzapine versus aprepitant for the prevention of chemotherapyinduced nausea and ...
Salicylate poisoning: An evidence-based consensus guideline for
... to salicylate, which is primarily responsible for the toxicity observed. Since salicylates are used for many everyday maladies such as fever, inflammation, and pain and for cardiovascular prophylaxis, they are found in most homes (Table 1). Dermal products are used for local relief of pain and soren ...
... to salicylate, which is primarily responsible for the toxicity observed. Since salicylates are used for many everyday maladies such as fever, inflammation, and pain and for cardiovascular prophylaxis, they are found in most homes (Table 1). Dermal products are used for local relief of pain and soren ...
Committee on Drugs 2001;108;1020 DOI: 10.1542/peds.108.4.1020
... and prolonged release products. Rumack and Matthew11 in their landmark 1975 study did not indicate a minimum dose for toxicity, but emphasized prolongation of the half-life of acetaminophen from liver toxicity. Reports of liver toxicity in pediatric patients have suggested a minimal, single acetamin ...
... and prolonged release products. Rumack and Matthew11 in their landmark 1975 study did not indicate a minimum dose for toxicity, but emphasized prolongation of the half-life of acetaminophen from liver toxicity. Reports of liver toxicity in pediatric patients have suggested a minimal, single acetamin ...
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[Product Monograph Template - Standard]
... Serious hypersensitivity reactions including apnea and bronchoconstriction have been reported in patients receiving polymyxin B sulphate by inhalation administration. Anaphylactoid reactions have been reported with parenteral administration of polymyxin B sulphate. Patients with a known allergy to b ...
... Serious hypersensitivity reactions including apnea and bronchoconstriction have been reported in patients receiving polymyxin B sulphate by inhalation administration. Anaphylactoid reactions have been reported with parenteral administration of polymyxin B sulphate. Patients with a known allergy to b ...
Report on the Deliberation Results August 25, 2009 Evaluation and
... The efficacy of the product has been shown in phase III clinical studies (P054, P055, ONO-5435-08 to -10) etc. No major safety problems have been identified in phase III clinical studies etc. Cardiovascular events and tumor development etc. during long-term use and the safety in patients with modera ...
... The efficacy of the product has been shown in phase III clinical studies (P054, P055, ONO-5435-08 to -10) etc. No major safety problems have been identified in phase III clinical studies etc. Cardiovascular events and tumor development etc. during long-term use and the safety in patients with modera ...
Evaluation of the use of static and dynamic models to predict drug
... human are not well-defined. A fixed variability of 40% of predicted mean AUC ratio is recommended. ...
... human are not well-defined. A fixed variability of 40% of predicted mean AUC ratio is recommended. ...
5.02 atazanavir + cobicistat
... - The assumed rates of market uptake for the proposed therapy were not justified. - Atazanavir/cobicistat FDC could substitute in clinical practice therapies other than atazanavir plus ritonavir. The submission explored the substitution of darunavir plus ritonavir, lopinavir/ritonavir FDC, and ataza ...
... - The assumed rates of market uptake for the proposed therapy were not justified. - Atazanavir/cobicistat FDC could substitute in clinical practice therapies other than atazanavir plus ritonavir. The submission explored the substitution of darunavir plus ritonavir, lopinavir/ritonavir FDC, and ataza ...
Full-Text PDF
... aspirin is a central mechanism for the prevention of vascular events and tumorigenesis. In this review we will discuss the clinical results related to the impact of aspirin on the risk of cancer. Then, we will explain in detail the pharmacology of aspirin at low and high doses in order to give a mec ...
... aspirin is a central mechanism for the prevention of vascular events and tumorigenesis. In this review we will discuss the clinical results related to the impact of aspirin on the risk of cancer. Then, we will explain in detail the pharmacology of aspirin at low and high doses in order to give a mec ...
IY12A Epirubicin inj pi jan12_1.ai
... • Bilirubin > 3 mg/dL or AST > 4 times upper limit of normal 1/4 of recommended starting dose Renal Impairment While no speci c dose recommendation can be made based on the limited available data in patients with renal impairment, consider lower doses in patients with severe renal impairment (serum ...
... • Bilirubin > 3 mg/dL or AST > 4 times upper limit of normal 1/4 of recommended starting dose Renal Impairment While no speci c dose recommendation can be made based on the limited available data in patients with renal impairment, consider lower doses in patients with severe renal impairment (serum ...