Drug formulary - Johns Hopkins University
... sure that you are totally familiar with the agent(s) that you intend to use. While many will provide anesthesia (unconsciousness) and analgesia (absence of pain) they may also have profound effects on the biologic parameters that you intend to study. Drug dosages are usually based on body weight-be ...
... sure that you are totally familiar with the agent(s) that you intend to use. While many will provide anesthesia (unconsciousness) and analgesia (absence of pain) they may also have profound effects on the biologic parameters that you intend to study. Drug dosages are usually based on body weight-be ...
Investigating the Suitability of Isomalt and Liquid Glucose as Sugar
... problem of dysphagia which is commonly associated with pediatric, geriatric, patients suffering from nausea (in cancer patients) and other patients having a problem in swallowing tablets. Hard candy lozenges prepared from Isomalt alone and in combination with corn syrup (liquid glucose) exhibits goo ...
... problem of dysphagia which is commonly associated with pediatric, geriatric, patients suffering from nausea (in cancer patients) and other patients having a problem in swallowing tablets. Hard candy lozenges prepared from Isomalt alone and in combination with corn syrup (liquid glucose) exhibits goo ...
In vivo pharmacokinetics and in vitro pharmacodynamics of
... concentrations of nepafenac were significantly higher than the concentrations of any of the other 3 individual analytes (P!.05) and decreased steadily after Tmax was reached at the first time point of 30 minutes. Ketorolac concentrations peaked at 60 minutes and slowly decreased throughout the remai ...
... concentrations of nepafenac were significantly higher than the concentrations of any of the other 3 individual analytes (P!.05) and decreased steadily after Tmax was reached at the first time point of 30 minutes. Ketorolac concentrations peaked at 60 minutes and slowly decreased throughout the remai ...
Differentiating neuropathic pain, opioid
... in the course of two months the dose of controlled-release morphine sulphate was increased to 460 mg bd. Besides this, he was taking 30 mg of oral morphine 4–6 times daily, usually with some pain relief which persisted for 3–4 hours. Altogether, the morphine sulphate dose averaged 1100 mg daily. He ...
... in the course of two months the dose of controlled-release morphine sulphate was increased to 460 mg bd. Besides this, he was taking 30 mg of oral morphine 4–6 times daily, usually with some pain relief which persisted for 3–4 hours. Altogether, the morphine sulphate dose averaged 1100 mg daily. He ...
Levonorgestrel - Therapeutic Goods Administration
... The company has justified not supplying biopharmaceutic data for the proposed product largely on the basis that it is mainly locally acting with a low (< 121 ng/mL) concentration of levonorgestrel in serum. A level A in vitro-in-vivo correlation was developed using in vitro levonorgestrel release da ...
... The company has justified not supplying biopharmaceutic data for the proposed product largely on the basis that it is mainly locally acting with a low (< 121 ng/mL) concentration of levonorgestrel in serum. A level A in vitro-in-vivo correlation was developed using in vitro levonorgestrel release da ...
Vandetanib - Therapeutic Goods Administration
... Clinical trial formulations A number of different formulations have been used during clinical development. Phase I tablet formulations The first vandetanib tablets used were size matched 1, 5 and 25 mg tablets. The higher strength tablets had slow disintegration times. To allow use of higher doses, ...
... Clinical trial formulations A number of different formulations have been used during clinical development. Phase I tablet formulations The first vandetanib tablets used were size matched 1, 5 and 25 mg tablets. The higher strength tablets had slow disintegration times. To allow use of higher doses, ...
PDF Version - Cardiological Society of India
... Novel oral anticoagulants should not be given to patients with severe renal impairment (CrCl < 15–30 mL/min) and those on dialysis. Dabigatran is renally cleared and may not be the choice in patients with renal impairment patients. However if it is used, then it should be used in reduced dosage as 1 ...
... Novel oral anticoagulants should not be given to patients with severe renal impairment (CrCl < 15–30 mL/min) and those on dialysis. Dabigatran is renally cleared and may not be the choice in patients with renal impairment patients. However if it is used, then it should be used in reduced dosage as 1 ...
prescribing information
... approximately 19 hours (13% to 15% CV). The mean Cmax for sumatriptan when given as TREXIMET is similar to that of sumatriptan when given as IMITREX® (sumatriptan succinate) Tablets 100 mg alone. The median sumatriptan Tmax is only slightly different (1 hour for TREXIMET and 1.5 hours for IMITREX). ...
... approximately 19 hours (13% to 15% CV). The mean Cmax for sumatriptan when given as TREXIMET is similar to that of sumatriptan when given as IMITREX® (sumatriptan succinate) Tablets 100 mg alone. The median sumatriptan Tmax is only slightly different (1 hour for TREXIMET and 1.5 hours for IMITREX). ...
highlights of prescribing information
... Picato® gel or ingenol mebutate. The effects of ingenol mebutate on fertility have not been evaluated. Ingenol mebutate was negative in the Ames test, in vitro mouse lymphoma assay, and in vivo rat micronucleus test, but positive in the Syrian hamster embryo (SHE) cell transformation assay. 14 CLINI ...
... Picato® gel or ingenol mebutate. The effects of ingenol mebutate on fertility have not been evaluated. Ingenol mebutate was negative in the Ames test, in vitro mouse lymphoma assay, and in vivo rat micronucleus test, but positive in the Syrian hamster embryo (SHE) cell transformation assay. 14 CLINI ...
The Effects of Morphine, Nicotine and Epibatidine on Lymphocyte
... Felten, 1995). Recent studies have demonstrated that selective drugs of abuse modulate both immune cell activities and the hypothalamic-pituitary-adrenal (HPA) axis. In particular, this and other laboratories have demonstrated that opioid drugs such as morphine suppress the immune system via activat ...
... Felten, 1995). Recent studies have demonstrated that selective drugs of abuse modulate both immune cell activities and the hypothalamic-pituitary-adrenal (HPA) axis. In particular, this and other laboratories have demonstrated that opioid drugs such as morphine suppress the immune system via activat ...
patient information p atient in fo rm atio nphys ic ia n info
... The concomitant use of OXYTROL with other anticholinergic drugs, or with other agents that produce dry mouth, constipation, somnolence, and/or other anticholinergic-like effects may increase the frequency and/or severity of such effects. Anticholinergic agents may potentially alter the absorption of ...
... The concomitant use of OXYTROL with other anticholinergic drugs, or with other agents that produce dry mouth, constipation, somnolence, and/or other anticholinergic-like effects may increase the frequency and/or severity of such effects. Anticholinergic agents may potentially alter the absorption of ...
REDUCING OF ERROR IN THE MEDICATION PROCESS OF A PRIVATE... NORTHEAST OF THAILAND Original Article
... considered to make hospital guidelines. The hospital guidelines were already constructed such as high alert drug manual, LASA drug list, and injectable drug manual. In addition, the hospital drug list including generic name, trade name, and drug strength was categorized and inform to doctors in docu ...
... considered to make hospital guidelines. The hospital guidelines were already constructed such as high alert drug manual, LASA drug list, and injectable drug manual. In addition, the hospital drug list including generic name, trade name, and drug strength was categorized and inform to doctors in docu ...
ESTIMATION OF THE ANTI-ULCER PROPERTIES OF KETOTIFEN IN ASPIRIN AND... STRESS INDUCED ALBINO RATS
... Material and methods: Antiulcer activity of ketotifen was studied using aspirin and swimming induced ulcer model in albino rats. The antiulcer activity of ketotifen1 mg & 2 mg/kg orally was compared with the standard drug ranitidine 10 mg/kg orally. The ulcer index was calculated and other parameter ...
... Material and methods: Antiulcer activity of ketotifen was studied using aspirin and swimming induced ulcer model in albino rats. The antiulcer activity of ketotifen1 mg & 2 mg/kg orally was compared with the standard drug ranitidine 10 mg/kg orally. The ulcer index was calculated and other parameter ...
Quantitative Structure-Activity Relationship Modeling to Predict Drug-Drug Interactions
... Acetaminophen, also known as paracetamol, is commonly used for its analgesic (pain reliever) and antipyretic (fever reducer) effect and is metabolized by the liver. Acetaminophen is also associated with hepatotoxicity and is known to lead to cell death in vitro [7]. Several compounds are known to in ...
... Acetaminophen, also known as paracetamol, is commonly used for its analgesic (pain reliever) and antipyretic (fever reducer) effect and is metabolized by the liver. Acetaminophen is also associated with hepatotoxicity and is known to lead to cell death in vitro [7]. Several compounds are known to in ...
Reflection paper on the data requirements for - EMA
... reduced and if appropriate, it may be decided on a case-by-case basis which studies could be waived. In the comprehensive evaluation of the new liposomal product the body of evidence obtained in quality, non-clinical and clinical studies must be considered as a whole. If e.g. any relevant difference ...
... reduced and if appropriate, it may be decided on a case-by-case basis which studies could be waived. In the comprehensive evaluation of the new liposomal product the body of evidence obtained in quality, non-clinical and clinical studies must be considered as a whole. If e.g. any relevant difference ...
Fluoxetin Mylan dispersible tablet ENG SmPC
... The risk of withdrawal symptoms may be dependent on several factors, including the duration and dose of therapy and the rate of dose reduction. Dizziness, sensory disturbances (including paraesthesia), sleep disturbances (including insomnia and intense dreams), asthenia, agitation or anxiety, nausea ...
... The risk of withdrawal symptoms may be dependent on several factors, including the duration and dose of therapy and the rate of dose reduction. Dizziness, sensory disturbances (including paraesthesia), sleep disturbances (including insomnia and intense dreams), asthenia, agitation or anxiety, nausea ...
Pravin R - Pivot Pharmaceuticals
... Experienced in drug development of antivirals, anti-inflammatory, cancer, hemoglobinopathies, immunosuppression and CNS agents Successfully led to the discovery and IND filing of many novel, first-in-class drugs across various enzyme and ion channel targets Broad experience in global regulatory drug ...
... Experienced in drug development of antivirals, anti-inflammatory, cancer, hemoglobinopathies, immunosuppression and CNS agents Successfully led to the discovery and IND filing of many novel, first-in-class drugs across various enzyme and ion channel targets Broad experience in global regulatory drug ...
Collagenase clostridium histolyticum
... This AusPAR describes the submission by Actelion Pharmaceuticals Australia Pty Ltd to register a new biological entity, collagenase clostridium histolyticum, for the treatment of Dupuytren’s contracture in adult patients with palpable cord. Dupuytren’s contracture is a relatively common disorder in ...
... This AusPAR describes the submission by Actelion Pharmaceuticals Australia Pty Ltd to register a new biological entity, collagenase clostridium histolyticum, for the treatment of Dupuytren’s contracture in adult patients with palpable cord. Dupuytren’s contracture is a relatively common disorder in ...
SPIRIT 2013 explanation and elaboration: guidance for
... rely on protocols to appraise the conduct and reporting of clinical trials. To meet the needs of these diverse stakeholders, protocols should adequately address key trial elements. However, protocols often lack information on important concepts relating to study design and dissemination plans.2-12 G ...
... rely on protocols to appraise the conduct and reporting of clinical trials. To meet the needs of these diverse stakeholders, protocols should adequately address key trial elements. However, protocols often lack information on important concepts relating to study design and dissemination plans.2-12 G ...
Lipofen (fenofibrate capsules USP) 50 mg and 150 mg
... however, a difference in the rate of cholelithiasis and cholecystitis requiring surgery between the two groups (3.0% vs. 1.8%). In a study conducted by the World Health Organization (WHO), 5000 subjects without known coronary artery disease were treated with placebo or clofibrate for 5 years and fol ...
... however, a difference in the rate of cholelithiasis and cholecystitis requiring surgery between the two groups (3.0% vs. 1.8%). In a study conducted by the World Health Organization (WHO), 5000 subjects without known coronary artery disease were treated with placebo or clofibrate for 5 years and fol ...
this PDF file - International Journal of Advances in Medicine
... Tuohy needle was introduced until the ligamentum flavum was pierced. The stylette was withdrawn and a 5ml glass syringe with smoothly moving piston was attached tightly to the hub of the Tuohy needle. The needle was slowly moved until there was loss of resistance. This indicated the epidural space. ...
... Tuohy needle was introduced until the ligamentum flavum was pierced. The stylette was withdrawn and a 5ml glass syringe with smoothly moving piston was attached tightly to the hub of the Tuohy needle. The needle was slowly moved until there was loss of resistance. This indicated the epidural space. ...
Challenges of drug-resistant malaria Shweta Sinha , Bikash Medhi , and Rakesh Sehgal
... Of the various antimalarial drugs available, the aminoquinoline chloroquine was the agent of choice for many decades because of its safety, efficacy and affordability. However, parasite resistance to this drug was initially observed in Thailand in 1957 and then on the border of Colombia and Venezuel ...
... Of the various antimalarial drugs available, the aminoquinoline chloroquine was the agent of choice for many decades because of its safety, efficacy and affordability. However, parasite resistance to this drug was initially observed in Thailand in 1957 and then on the border of Colombia and Venezuel ...
Chapter-1 Introduction
... The World Health Organization (WHO) has recently recommended bio waivers for Class III and some Class II drugs and American Association of Pharmaceutical Scientists (AAPS-FDA) scientific conferences have recommended bio waivers for Class III compounds as well. ...
... The World Health Organization (WHO) has recently recommended bio waivers for Class III and some Class II drugs and American Association of Pharmaceutical Scientists (AAPS-FDA) scientific conferences have recommended bio waivers for Class III compounds as well. ...
elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide
... permeable into cells and due to increased plasma stability and intracellular activation through hydrolysis by cathepsin A, tenofovir alafenamide is more efficient than tenofovir disoproxil fumarate in loading tenofovir into peripheral blood mononuclear cells (PBMCs), including lymphocytes and macrop ...
... permeable into cells and due to increased plasma stability and intracellular activation through hydrolysis by cathepsin A, tenofovir alafenamide is more efficient than tenofovir disoproxil fumarate in loading tenofovir into peripheral blood mononuclear cells (PBMCs), including lymphocytes and macrop ...
this PDF file
... minutes was recorded, amounting to a prolongation of the barbiturate sleeping time of 53.67 minutes (29.8%). Increasing the dose of the extract to 4mg/kg resulted in mean sleeping time of 283.67±2.9 minutes which a further prolongation of the sleeping time of 103.67 minutes (57.59%). The potentiatio ...
... minutes was recorded, amounting to a prolongation of the barbiturate sleeping time of 53.67 minutes (29.8%). Increasing the dose of the extract to 4mg/kg resulted in mean sleeping time of 283.67±2.9 minutes which a further prolongation of the sleeping time of 103.67 minutes (57.59%). The potentiatio ...