REVIEW Chiral Toxicology: It`s the Same Thing...Only Different
... Drug Development FDA initial guidance on chiral drugs was set forth in 1992, as the differential actions and toxicities of enantiomers became more evident, and as the technology for chiral drug development and detection advanced (U.S. Food and Drug Administration, 1992). Identified chiral-specific i ...
... Drug Development FDA initial guidance on chiral drugs was set forth in 1992, as the differential actions and toxicities of enantiomers became more evident, and as the technology for chiral drug development and detection advanced (U.S. Food and Drug Administration, 1992). Identified chiral-specific i ...
Strattera (atomoxetine)
... Strattera (atomoxetine) is the first in a new class of nonstimulant medications to be approved for the treatment of attention-deficit/hyperactivity disorder (ADHD). Its mode of action is unlike that of the stimulants, methylphenidate and amphetamines. Strattera therefore appears to have little or no ...
... Strattera (atomoxetine) is the first in a new class of nonstimulant medications to be approved for the treatment of attention-deficit/hyperactivity disorder (ADHD). Its mode of action is unlike that of the stimulants, methylphenidate and amphetamines. Strattera therefore appears to have little or no ...
Prescribing Information as of XXXX ALLEGRA (fexofenadine hydrochloride)
... Three clinical safety studies in 845 children aged 6 months to 5 years with allergic rhinitis comparing 15 mg BID (n=85) and 30 mg BID (n=330) of an experimental formulation of fexofenadine to placebo (n=430) have been conducted. In general, fexofenadine hydrochloride was well tolerated in these stu ...
... Three clinical safety studies in 845 children aged 6 months to 5 years with allergic rhinitis comparing 15 mg BID (n=85) and 30 mg BID (n=330) of an experimental formulation of fexofenadine to placebo (n=430) have been conducted. In general, fexofenadine hydrochloride was well tolerated in these stu ...
Research Article DEVELOPMENT AND CHARACTERIZATION OF COMPRESSED ODT FORMULATION OF INSOLUBLE LOW BITTER DRUG
... rapidly, usually within a matter of seconds, when placed under the tongue. ODT delayed release is a solid dosage form containing medicinal substances which disintegrates rapidly, usually within matter of seconds, when place upon the tongue, but which releases a drug (or drugs ...
... rapidly, usually within a matter of seconds, when placed under the tongue. ODT delayed release is a solid dosage form containing medicinal substances which disintegrates rapidly, usually within matter of seconds, when place upon the tongue, but which releases a drug (or drugs ...
Chapters 1 - Canadian Liver Foundation
... Antiviral Therapy for HCV Genotype 1: CASL Recommendations Triple therapy including peginterferon (PEG-IFN), ribavirin (RBV), and a protease inhibitor (telaprevir or boceprevir) is the new standard of care in treatment-naïve and previous treatment failures. Boceprevir (800 mg every 8 hours with ...
... Antiviral Therapy for HCV Genotype 1: CASL Recommendations Triple therapy including peginterferon (PEG-IFN), ribavirin (RBV), and a protease inhibitor (telaprevir or boceprevir) is the new standard of care in treatment-naïve and previous treatment failures. Boceprevir (800 mg every 8 hours with ...
Antibody–drug conjugates nonclinical support: from early to late
... Depending on the linker lability and ADC stability, the processing of serum may cause deconjugation and release of cytotoxic small molecule drug that may interfere in quantitation of small molecule analyte of some ADCs. The plasma matrix is thus preferred for LC–MS-based quantitation of the antibody ...
... Depending on the linker lability and ADC stability, the processing of serum may cause deconjugation and release of cytotoxic small molecule drug that may interfere in quantitation of small molecule analyte of some ADCs. The plasma matrix is thus preferred for LC–MS-based quantitation of the antibody ...
Prodrugs: A challenge for the drug development
... The basic aim of prodrug design is to mask undesirable drug properties, such as low solubility in water or lipid membranes, low target selectivity, chemical instability, undesirable taste, irritation or pain after local administration, presystemic metabolism and toxicity [54, 70, 74]. In general, th ...
... The basic aim of prodrug design is to mask undesirable drug properties, such as low solubility in water or lipid membranes, low target selectivity, chemical instability, undesirable taste, irritation or pain after local administration, presystemic metabolism and toxicity [54, 70, 74]. In general, th ...
QT variability during initial exposure to sotalol: experience based on
... sotalol, dofetilide, ibutilide, disopyramide, or procainamide. Of these, 672 were patients initiating sotalol and 7 of these (1%) developed TdP after sotalol administration. Among the patients who developed TdP, the number of sotalol doses administered before TdP onset were one dose for one TdP pati ...
... sotalol, dofetilide, ibutilide, disopyramide, or procainamide. Of these, 672 were patients initiating sotalol and 7 of these (1%) developed TdP after sotalol administration. Among the patients who developed TdP, the number of sotalol doses administered before TdP onset were one dose for one TdP pati ...
Identification of Epidermal Growth Factor
... least three ligands, EGF, transforming growth factor-a (TGF-a), and amphiregulin (7,8). An autocrine growth pathway has been proposed for TGF-a in normal and malignant human breast epithelium (9). ErbB2 (also called HER2 and neu) is a 185-kd transmembrane tyrosine kinase with considerable homology t ...
... least three ligands, EGF, transforming growth factor-a (TGF-a), and amphiregulin (7,8). An autocrine growth pathway has been proposed for TGF-a in normal and malignant human breast epithelium (9). ErbB2 (also called HER2 and neu) is a 185-kd transmembrane tyrosine kinase with considerable homology t ...
Medical Therapy of Glaucoma
... 30 fold more selective for alpha 2 receptors than apraclonidine Decreases aqueous production (and possibly increasing uveoscleral outflow- not a big ...
... 30 fold more selective for alpha 2 receptors than apraclonidine Decreases aqueous production (and possibly increasing uveoscleral outflow- not a big ...
In Vitro Cytotoxicity, Protein Binding, Red Blood Cell Partitioning
... clinical trials (1-5). The drug has neither marked renal nor myeloid toxicity; its dose-limiting toxicity is peripheral neuropathy (1). In preliminary clinical studies, it has shown antitumor activity against colorectal carcinoma, melanoma, and glioma, as well as against the tumors traditionally tre ...
... clinical trials (1-5). The drug has neither marked renal nor myeloid toxicity; its dose-limiting toxicity is peripheral neuropathy (1). In preliminary clinical studies, it has shown antitumor activity against colorectal carcinoma, melanoma, and glioma, as well as against the tumors traditionally tre ...
hyperthermia - Calgary Emergency Medicine
... Overall good animal data supporting a detrimental effect on serotonergic system Human studies more limited and hampered by methodological weaknessess No clear evidence, but “highly suggestive” ...
... Overall good animal data supporting a detrimental effect on serotonergic system Human studies more limited and hampered by methodological weaknessess No clear evidence, but “highly suggestive” ...
mechanisms of la toxicity
... Intralipid was initially recommended as a last resort after failure of response to standard resuscitation, but the trend has now moved to early use of the drug in order to prevent progression to cardiac arrest; and case reports have even associated the use of lipid with reversal of altered mentation ...
... Intralipid was initially recommended as a last resort after failure of response to standard resuscitation, but the trend has now moved to early use of the drug in order to prevent progression to cardiac arrest; and case reports have even associated the use of lipid with reversal of altered mentation ...
OPTIMIZATION AND EVALUATION OF CIPROFLOXACIN SWELLABLE FLOATING MATRIX
... to incomplete absorption of drugs having absorption window especially in the upper part of the small intestine.3 Drugs having a short half-life are eliminated quickly from the blood circulation. Various oral controlled delivery systems have been designed which can overcome these problems and release ...
... to incomplete absorption of drugs having absorption window especially in the upper part of the small intestine.3 Drugs having a short half-life are eliminated quickly from the blood circulation. Various oral controlled delivery systems have been designed which can overcome these problems and release ...
Aspects to consider when using a syringe driver in the community
... syringe plunger carefully and slowly. The line takes 1ml of liquid, leaving 16mls of fluid in the syringe. Priming the line is necessary when changing the site of the cannula but is not necessary when re-loading the syringe each day. When renewing or setting up, always measure the length of liquid i ...
... syringe plunger carefully and slowly. The line takes 1ml of liquid, leaving 16mls of fluid in the syringe. Priming the line is necessary when changing the site of the cannula but is not necessary when re-loading the syringe each day. When renewing or setting up, always measure the length of liquid i ...
HYPOTHESES 59
... raised concerns for public health (Callaway and Grob 1998), and extensive clinical data on its somatic, psychological, and neurophysiological effects are indicated. Ayahuasca, also known as Daime or Hoasca in Brazil, Yajé in Colombia, or Natem in Ecuador, is generally obtained by infusing the shredd ...
... raised concerns for public health (Callaway and Grob 1998), and extensive clinical data on its somatic, psychological, and neurophysiological effects are indicated. Ayahuasca, also known as Daime or Hoasca in Brazil, Yajé in Colombia, or Natem in Ecuador, is generally obtained by infusing the shredd ...
A comparative bioequivalence study of two prolonged
... allows for convenient once daily administration. A major advantage of extended release metoprolol formulations lies in the higher cardio-selectivity of lower rather than higher metoprolol plasma concentrations. In addition, the lower peak plasma concentrations tend to reduce adverse effects and, the ...
... allows for convenient once daily administration. A major advantage of extended release metoprolol formulations lies in the higher cardio-selectivity of lower rather than higher metoprolol plasma concentrations. In addition, the lower peak plasma concentrations tend to reduce adverse effects and, the ...
CHLOROMYCETIN CAPSULES
... organisms susceptible to its antimicrobial effects when less potentially hazardous therapeutic agents are ineffective or contraindicated. However, chloramphenicol may be chosen to initiate antibiotic therapy on the clinical impression that one of the conditions below is believed to be present. In vi ...
... organisms susceptible to its antimicrobial effects when less potentially hazardous therapeutic agents are ineffective or contraindicated. However, chloramphenicol may be chosen to initiate antibiotic therapy on the clinical impression that one of the conditions below is believed to be present. In vi ...
HEALTHCARE SECTOR SECONDARY RESEARCH SAMPLE REPORT
... human B-lymphocyte and macrophage activation Platelet activating factor agonist ...
... human B-lymphocyte and macrophage activation Platelet activating factor agonist ...
Adverse drug reactions in patients with gastroenterological diseases
... important intervention in the care of the elderly.1, 2 Nonetheless, because age and morbidity lead to signi®cant changes in organ functions, pharmacokinetics and pharmacodynamics pharmacotherapy may endanger the health of an older patient by causing an adverse drug reaction.3, 4 Additional factors r ...
... important intervention in the care of the elderly.1, 2 Nonetheless, because age and morbidity lead to signi®cant changes in organ functions, pharmacokinetics and pharmacodynamics pharmacotherapy may endanger the health of an older patient by causing an adverse drug reaction.3, 4 Additional factors r ...
literature review
... intracellular targets. The knowledge of the intracellular distribution can also help to understand the side effects and pharmacokinetics of a drug, as well as the lack of response in e.g. some multidrug resistant cancer cells. Intracellular concentrations are also important to know when predicting t ...
... intracellular targets. The knowledge of the intracellular distribution can also help to understand the side effects and pharmacokinetics of a drug, as well as the lack of response in e.g. some multidrug resistant cancer cells. Intracellular concentrations are also important to know when predicting t ...
SEMINAR ON BUCCAL DRUG DELIVERY SYSTUM
... designed to promote drug absorption through oral mucosa(buccal) This may enable more rapid absorption of drug that have a long Tmax. In case where the patient is vomiting frequently. Or in migraine gastric transit may be so severely compromised. In such circumtance this delivery may be advantage ...
... designed to promote drug absorption through oral mucosa(buccal) This may enable more rapid absorption of drug that have a long Tmax. In case where the patient is vomiting frequently. Or in migraine gastric transit may be so severely compromised. In such circumtance this delivery may be advantage ...
intestinal metabolism: the role of enzyme localization in phenol
... low and high doses were 7.29 ⴞ 1.39 (n ⴝ 4) and 3.55 ⴞ 1.16 ml/min (n ⴝ 3), respectively, indicating saturation at the higher dose. Moreover, there was a decrease in the area under the curve ratio (metabolite/phenol) at the high luminal dose. Luminal administration, in general, produced greater gluc ...
... low and high doses were 7.29 ⴞ 1.39 (n ⴝ 4) and 3.55 ⴞ 1.16 ml/min (n ⴝ 3), respectively, indicating saturation at the higher dose. Moreover, there was a decrease in the area under the curve ratio (metabolite/phenol) at the high luminal dose. Luminal administration, in general, produced greater gluc ...
EFFECT OF POLOXAMER 188 ON IN VITRO DISSOLUTION
... associated with slow drug absorption leading eventually to inadequate and variable bioavailability1, 2. Based upon their solubility and permeability characteristics, the Biopharmaceutical Classification System (BCS) categorizes drugs in two major classes, class II and IV3. The BCS class II drugs are ...
... associated with slow drug absorption leading eventually to inadequate and variable bioavailability1, 2. Based upon their solubility and permeability characteristics, the Biopharmaceutical Classification System (BCS) categorizes drugs in two major classes, class II and IV3. The BCS class II drugs are ...