Managing Calcium Channel Blocker
... Calcium channel blockers (CCBs) are potent agents and may be useful additions to the regimen of patients with resistant hypertension, as they were in the two cases presented here. The most common class-specific side effect responsible for intolerance and patient nonadherence to therapy is peripheral ...
... Calcium channel blockers (CCBs) are potent agents and may be useful additions to the regimen of patients with resistant hypertension, as they were in the two cases presented here. The most common class-specific side effect responsible for intolerance and patient nonadherence to therapy is peripheral ...
Augments Anti-CD40 SGN-40–Induced Cytotoxicity in Human
... monoclonal antibody, mediates cytotoxicity against human multiple myeloma (MM) cells via suppression of interleukin (IL)-6–induced proliferative and antiapoptotic effects as well as antibody-dependent cell-mediated cytotoxicity (ADCC). Here, we studied the clinical significance of an immunomodulator ...
... monoclonal antibody, mediates cytotoxicity against human multiple myeloma (MM) cells via suppression of interleukin (IL)-6–induced proliferative and antiapoptotic effects as well as antibody-dependent cell-mediated cytotoxicity (ADCC). Here, we studied the clinical significance of an immunomodulator ...
Low Molecular Weight Heparins
... offer advantages over traditional unfractionated heparin, including a more predictable pharmacokinetic profile and ease of use. There are several LMWHs available for clinical use in Canada: dalteparin, enoxaparin, nadroparin and tinzaparin. In addition, fondaparinux, an indirect factor-Xa inhibitor, ...
... offer advantages over traditional unfractionated heparin, including a more predictable pharmacokinetic profile and ease of use. There are several LMWHs available for clinical use in Canada: dalteparin, enoxaparin, nadroparin and tinzaparin. In addition, fondaparinux, an indirect factor-Xa inhibitor, ...
: " ¯ CONCERTA™ International Non
... patients requiring long-term therapy should be carefully monitored. Patients who are not growing or gaining weight as expected should have their treatment interrupted. CONCERTA must be swallowed whole with the aid of liquids. Tablets should not be chewed, divided, or crushed. The medication is conta ...
... patients requiring long-term therapy should be carefully monitored. Patients who are not growing or gaining weight as expected should have their treatment interrupted. CONCERTA must be swallowed whole with the aid of liquids. Tablets should not be chewed, divided, or crushed. The medication is conta ...
Product Monograph - Ask Novartis Pharma
... pharmacological bone changes (nonproliferative hyperostosis) typically observed following long term bisphosphonate administration to young animals with growing skeletons gave clear evidence of systemic exposure to zoledronic acid in both species at all doses. Six mutagenicity studies were conducted ...
... pharmacological bone changes (nonproliferative hyperostosis) typically observed following long term bisphosphonate administration to young animals with growing skeletons gave clear evidence of systemic exposure to zoledronic acid in both species at all doses. Six mutagenicity studies were conducted ...
Antifilarial Lead Molecules Isolated from Trachyspermum ammi
... the adult worms and so new drugs are urgently required. In this regard, natural products have made and continue to make important contributions to this therapeutic area. This study demonstrates that the crude and purified extracts of T. ammi are effective in killing the adult bovine filarial worms i ...
... the adult worms and so new drugs are urgently required. In this regard, natural products have made and continue to make important contributions to this therapeutic area. This study demonstrates that the crude and purified extracts of T. ammi are effective in killing the adult bovine filarial worms i ...
Drug Treatments for Metastasis of the Lewis Lung Carcinoma: Lack
... After this initial use of trypsin, the cells were passed using a solution of collagenase (24 units/cm2) and DNase (7 units/cm2). The collagenase compound had any effect on the growth of the primary tumor. To estimate tumor weight the amputated legs were first dried in a vacuum and DNase were dissolv ...
... After this initial use of trypsin, the cells were passed using a solution of collagenase (24 units/cm2) and DNase (7 units/cm2). The collagenase compound had any effect on the growth of the primary tumor. To estimate tumor weight the amputated legs were first dried in a vacuum and DNase were dissolv ...
and delayed-type allergic reactions to amide local anesthetics
... symptoms occurred within 1 hour after administration and, as opposed to delayed-type allergic reactions, clinical features were not limited to cutaneous signs. Indeed, systemic signs, including neurological, respiratory, and cardiovascular symptoms were reported. Urticaria, angiooedema, bronchospasm ...
... symptoms occurred within 1 hour after administration and, as opposed to delayed-type allergic reactions, clinical features were not limited to cutaneous signs. Indeed, systemic signs, including neurological, respiratory, and cardiovascular symptoms were reported. Urticaria, angiooedema, bronchospasm ...
Calorimetry
... macromolecular target, the interaction of an excipient with a drug, the degradation of a protein therapeutic upon storage, or the slow transformation of a drug from a metastable to a stable polymorphic form all give rise to minute changes in heat, the analysis of which provides fundamental insights ...
... macromolecular target, the interaction of an excipient with a drug, the degradation of a protein therapeutic upon storage, or the slow transformation of a drug from a metastable to a stable polymorphic form all give rise to minute changes in heat, the analysis of which provides fundamental insights ...
International Journal for Pharmaceutical Research Scholars (IJPRS)
... taste of the active ingredient. This masked active ingredient is then swallowed by the patient's saliva along with the soluble and insoluble excipients3,4. Some drugs are absorbed from the oral cavity, pharynx and esophagus as the saliva passes down into the stomach. Thus the bioavailability of drug ...
... taste of the active ingredient. This masked active ingredient is then swallowed by the patient's saliva along with the soluble and insoluble excipients3,4. Some drugs are absorbed from the oral cavity, pharynx and esophagus as the saliva passes down into the stomach. Thus the bioavailability of drug ...
Dabigatran versus Warfarin in Patients with Atrial Fibrillation
... Downloaded from www.nejm.org at VANDERBILT UNIVERSITY on November 15, 2010. For personal use only. No other uses without permission. Copyright © 2009 Massachusetts Medical Society. All rights reserved. ...
... Downloaded from www.nejm.org at VANDERBILT UNIVERSITY on November 15, 2010. For personal use only. No other uses without permission. Copyright © 2009 Massachusetts Medical Society. All rights reserved. ...
ANALGESIC AND ANTHELMINTIC ACTIVITY OF VARIOUS EXTRACTS OF ANDROGRAPHIS Research Article
... were divided into groups of 6 each. Diclofenac sodium (50 mg/kg, p.o.) was used as standard. The tail-flick latency was assessed by the analgesiometer (Techno, India). The magnitude of the current which was passing through the naked nichrome wire was kept constant at 6 ampere. The tail skin was kept ...
... were divided into groups of 6 each. Diclofenac sodium (50 mg/kg, p.o.) was used as standard. The tail-flick latency was assessed by the analgesiometer (Techno, India). The magnitude of the current which was passing through the naked nichrome wire was kept constant at 6 ampere. The tail skin was kept ...
PDF - World Journal of Pharmaceutical Sciences
... in wire mesh cages to avoid coprophagy under controlled environmental conditions. Food was withdrawn for 36h (40) but water was allowed ad libitum. The absence of ulcers in some of the treated groups has revealed that the pre-fasting conditions alone doesn't induce ulcer. As described in the studies ...
... in wire mesh cages to avoid coprophagy under controlled environmental conditions. Food was withdrawn for 36h (40) but water was allowed ad libitum. The absence of ulcers in some of the treated groups has revealed that the pre-fasting conditions alone doesn't induce ulcer. As described in the studies ...
long lasting β2 agonists
... airway inflammation may be masked leading to delayed presentation of an exacerbation.10 ...
... airway inflammation may be masked leading to delayed presentation of an exacerbation.10 ...
Diphenhydramine Hydrochloride Injection, USPRx only
... MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines. Carcinogenes is , Mutagenes is , Impairment of Fertility Long-term studies in animals to determine mutagenic and carcinogenic potential have not been performed. Pregnancy Teratogenic Effects—Pregnancy Catego ...
... MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines. Carcinogenes is , Mutagenes is , Impairment of Fertility Long-term studies in animals to determine mutagenic and carcinogenic potential have not been performed. Pregnancy Teratogenic Effects—Pregnancy Catego ...
Thromboxane Receptors Antagonists and/or Synthase Inhibitors
... Western countries. Several clinical conditions are characterized by increased incidence of cardiovascular events and enhanced thromboxane (TX)-dependent platelet activation. Enhanced TX generation may be explained by mechanisms relatively insensitive to aspirin. More potent drugs possibly overcoming ...
... Western countries. Several clinical conditions are characterized by increased incidence of cardiovascular events and enhanced thromboxane (TX)-dependent platelet activation. Enhanced TX generation may be explained by mechanisms relatively insensitive to aspirin. More potent drugs possibly overcoming ...
Cardiovascular Pharmacology
... the positive inotropic effect of a reduction of extracellular K+ can also be explained by this mechanism, as this inhibits the activity of the pump in addition, this increase in [Ca++] results in an increase in the iSI during phase 2, thus more Ca++ is available during each AP, triggering the releas ...
... the positive inotropic effect of a reduction of extracellular K+ can also be explained by this mechanism, as this inhibits the activity of the pump in addition, this increase in [Ca++] results in an increase in the iSI during phase 2, thus more Ca++ is available during each AP, triggering the releas ...
Diagnosis and Management of Delirium in Ventilated ICU Patients
... Fentanyl if patient is in pain ...
... Fentanyl if patient is in pain ...
Prescribing Information including Medication Guide
... spasticity/dystonia, muscle mass, body weight, and response to any previous botulinum toxin injections. The frequency of XEOMIN repeat treatments should be determined by clinical response, but should generally be no more frequent than every 12 weeks [see Clinical Studies (14.2)]. 2.4 Blepharospasm T ...
... spasticity/dystonia, muscle mass, body weight, and response to any previous botulinum toxin injections. The frequency of XEOMIN repeat treatments should be determined by clinical response, but should generally be no more frequent than every 12 weeks [see Clinical Studies (14.2)]. 2.4 Blepharospasm T ...
m5zn_776561dda50e649
... ● Medicinal chemistry is a chemistry-based discipline, also involving aspects of biological, medical and pharmaceutical sciences. It is concerned with the invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation ...
... ● Medicinal chemistry is a chemistry-based discipline, also involving aspects of biological, medical and pharmaceutical sciences. It is concerned with the invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation ...
Ocular Delivery of peptides and proteins
... • Can be delivered by the ocular route and has been reported to increase blood glucose ...
... • Can be delivered by the ocular route and has been reported to increase blood glucose ...
Magnesium Sulfate
... entirely broken down in the body, with 90 percent of the compound being released through the urine within 24 hours.12 Consequently, it does not act as a cure for preeclampsia, but rather as a treatment for eclampsia during individual births. It is currently being studied for use as a prophylactic. I ...
... entirely broken down in the body, with 90 percent of the compound being released through the urine within 24 hours.12 Consequently, it does not act as a cure for preeclampsia, but rather as a treatment for eclampsia during individual births. It is currently being studied for use as a prophylactic. I ...
HIV-RELATED EXCESS BELLY FAT
... increases due to normal metabolic and hormonal changes. Modifying this physiologic change of pregnancy with EGRIFTA® offers no known benefit and could result in fetal harm. Tesamorelin acetate administration to rats during organogenesis and lactation resulted in hydrocephalus in offspring at a dose ...
... increases due to normal metabolic and hormonal changes. Modifying this physiologic change of pregnancy with EGRIFTA® offers no known benefit and could result in fetal harm. Tesamorelin acetate administration to rats during organogenesis and lactation resulted in hydrocephalus in offspring at a dose ...
November 2014 PBAC Meeting
... The PBAC noted that injectable MS drugs were also being considered as part of the first tranche of the Post Market Review of PBS Authorities (item 9.2 refers). The PBAC advised that any recommendation to amend these listings to Streamlined Authorities as part of its consideration of that Review woul ...
... The PBAC noted that injectable MS drugs were also being considered as part of the first tranche of the Post Market Review of PBS Authorities (item 9.2 refers). The PBAC advised that any recommendation to amend these listings to Streamlined Authorities as part of its consideration of that Review woul ...
Options of drugs for intermittent presumptive treatment for malaria in
... In Tanzania, Schellenberg and colleagues showed that IPTi with sulfadoxine/ pyrimethamine (SP) at 2, 3, and 9 months of age given with daily iron supplementation from 2-6 months of age, reduced the incidence of severe anaemia (PCV <25%) by 50% and episodes of malaria by 59% without significant rebo ...
... In Tanzania, Schellenberg and colleagues showed that IPTi with sulfadoxine/ pyrimethamine (SP) at 2, 3, and 9 months of age given with daily iron supplementation from 2-6 months of age, reduced the incidence of severe anaemia (PCV <25%) by 50% and episodes of malaria by 59% without significant rebo ...