Age-related qualitative shift in emotional behaviour: Paradoxical
... This OAA effect seems to be progressive, starting around the second minute of trial 1 and may even increase with further retesting [22,35]. Prior maze experience is also known to reduce or even abolish the anxiolytic effects of drugs that bind to the GABA-A receptor complex such as benzodiazepines, ...
... This OAA effect seems to be progressive, starting around the second minute of trial 1 and may even increase with further retesting [22,35]. Prior maze experience is also known to reduce or even abolish the anxiolytic effects of drugs that bind to the GABA-A receptor complex such as benzodiazepines, ...
TARCEVA Product Monograph
... Patients with Brain Metastases: Pivotal trial BR.21 excluded patients with CNS metastases that were symptomatic, and those with asymptomatic metastases but not on a stable dose of corticosteroids for at least 4 weeks prior to randomization. Therefore, the safety of TARCEVA in this patient population ...
... Patients with Brain Metastases: Pivotal trial BR.21 excluded patients with CNS metastases that were symptomatic, and those with asymptomatic metastases but not on a stable dose of corticosteroids for at least 4 weeks prior to randomization. Therefore, the safety of TARCEVA in this patient population ...
Product Monograph January 4, 2017
... Assurance that health-care education activities on pain management with ULTRAM® include balanced, evidence-based and current information. Commitment to take reasonable actions to inform health-care professionals that there is Health Canadaapproved patient information on benefits and risks, and to en ...
... Assurance that health-care education activities on pain management with ULTRAM® include balanced, evidence-based and current information. Commitment to take reasonable actions to inform health-care professionals that there is Health Canadaapproved patient information on benefits and risks, and to en ...
Review of Vasodilators in Acute Decompensated Heart Failure
... intubation, and/or myocardial infarction (MI) in Figure 4.18 ...
... intubation, and/or myocardial infarction (MI) in Figure 4.18 ...
Opioid Receptor Imaging with Positron Emission Tomography and
... moderate to high doses of methadone, significant numbers of mu receptors remain unoccupied and thus available for action by the endogenous opioid ligands in critical brain regions. These unoccupied receptors are also available for action by exogenous opioid ligands commonly used for the relief of pa ...
... moderate to high doses of methadone, significant numbers of mu receptors remain unoccupied and thus available for action by the endogenous opioid ligands in critical brain regions. These unoccupied receptors are also available for action by exogenous opioid ligands commonly used for the relief of pa ...
Paracetamol-induced hypotension on the intensive care unit
... Paracetamol use has previously been reported to be associated with hypotension on the ICU, consistent with the observations in our patient. 3-10 Whereas in our case the drug was administrated orally, the great majority of the studies concern intravenous paracetamol administration. Estimating an inci ...
... Paracetamol use has previously been reported to be associated with hypotension on the ICU, consistent with the observations in our patient. 3-10 Whereas in our case the drug was administrated orally, the great majority of the studies concern intravenous paracetamol administration. Estimating an inci ...
Pharmacokinetic/Pharmacodynamic Parameters: Rationale
... the lungs of neutropenic mice are shown in figure 4. In this study, pairs of mice were treated with multiple dosage regimens that varied both in the dose and the dosing interval. The number of cfus remaining in the lung after 24 hours of therapy, the peak/MIC and 24-hour AUC/MIC ratios, and the perc ...
... the lungs of neutropenic mice are shown in figure 4. In this study, pairs of mice were treated with multiple dosage regimens that varied both in the dose and the dosing interval. The number of cfus remaining in the lung after 24 hours of therapy, the peak/MIC and 24-hour AUC/MIC ratios, and the perc ...
Development of a facile antibody–drug conjugate
... the latter being unstable during circulation.6 While heterogeneous ADCs have unpredictable safety and PK proles and show batch-to-batch variability, the instability of maleimide chemistry results in off-target toxicity.4 These shortcomings with current linker technologies have hindered the concept o ...
... the latter being unstable during circulation.6 While heterogeneous ADCs have unpredictable safety and PK proles and show batch-to-batch variability, the instability of maleimide chemistry results in off-target toxicity.4 These shortcomings with current linker technologies have hindered the concept o ...
LYRICA® Hard Capsule 75mg, 150mg, 300mg
... LYRICA treatment may cause peripheral edema. In short-term trials of patients without clinically significant heart or peripheral vascular disease, there was no apparent association between peripheral edema and cardiovascular complications such as hypertension or congestive heart failure. Peripheral ...
... LYRICA treatment may cause peripheral edema. In short-term trials of patients without clinically significant heart or peripheral vascular disease, there was no apparent association between peripheral edema and cardiovascular complications such as hypertension or congestive heart failure. Peripheral ...
The Use of Mucoadhesive Polymers to Enhance the Hypotensive
... laucoma is a group of eye diseases characterized by atrophy of the optic nerve and loss of retinal ganglion cells, which leads to a loss of visual acuity and visual field. This disease is the second leading cause of blindness in the world, and it is expected that the number of people who have it wil ...
... laucoma is a group of eye diseases characterized by atrophy of the optic nerve and loss of retinal ganglion cells, which leads to a loss of visual acuity and visual field. This disease is the second leading cause of blindness in the world, and it is expected that the number of people who have it wil ...
Epclusa - Gilead
... In the Phase 3 trial of subjects with decompensated cirrhosis (ASTRAL-4), lipase was assessed when amylase values were greater than or equal to 1.5xULN. Isolated, asymptomatic lipase elevations of greater than 3xULN were observed in 2% of subjects treated with EPCLUSA with ribavirin for 12 weeks. Cr ...
... In the Phase 3 trial of subjects with decompensated cirrhosis (ASTRAL-4), lipase was assessed when amylase values were greater than or equal to 1.5xULN. Isolated, asymptomatic lipase elevations of greater than 3xULN were observed in 2% of subjects treated with EPCLUSA with ribavirin for 12 weeks. Cr ...
Effects of ()-HA-966, CGS-19755, Phencyclidine, and Dizocilpine on
... Pigeons typically reached criterion-level performance of the repeated acquisition procedure after 6 to 8 months of training. Values of baseline percent errors and response rates were very similar across animals. In baseline sessions, most errors were made as the first few reinforcers were earned (i. ...
... Pigeons typically reached criterion-level performance of the repeated acquisition procedure after 6 to 8 months of training. Values of baseline percent errors and response rates were very similar across animals. In baseline sessions, most errors were made as the first few reinforcers were earned (i. ...
CYANOKIT® Administration Guide
... intravenous infusion over 15 minutes. One 5 g vial is a complete starting dose. (2.1) • Depending upon the severity of the poisoning and the clinical response, a second dose of 5 g may be administered by intravenous infusion for a total dose of 10 g. (2.1) • The rate of infusion for the second 5 g d ...
... intravenous infusion over 15 minutes. One 5 g vial is a complete starting dose. (2.1) • Depending upon the severity of the poisoning and the clinical response, a second dose of 5 g may be administered by intravenous infusion for a total dose of 10 g. (2.1) • The rate of infusion for the second 5 g d ...
Is there an interaction between erythromycin and statins?
... [6]. This has been shown in a short trial where pravastatin 40mg or lovastatin was given to 12 healthy subjects once daily for 14 days followed by a further week with erythromycin 500mg three times daily. The pharmacokinetics of pravastatin did not change [13, 17]. However, in another interaction st ...
... [6]. This has been shown in a short trial where pravastatin 40mg or lovastatin was given to 12 healthy subjects once daily for 14 days followed by a further week with erythromycin 500mg three times daily. The pharmacokinetics of pravastatin did not change [13, 17]. However, in another interaction st ...
analgesic and anti-inflammatory activity of different fractions of
... (normal reactions) and which did not show large variation when tested on 4 separated occasions on Eddy’s hot plate were selected. Group I received 2% gum acacia (10 ml/kg b.w.p.o) as control and Group II received standard drug, pentazocine (10 mg/kg, i.p). Remaining Groups were administered with dif ...
... (normal reactions) and which did not show large variation when tested on 4 separated occasions on Eddy’s hot plate were selected. Group I received 2% gum acacia (10 ml/kg b.w.p.o) as control and Group II received standard drug, pentazocine (10 mg/kg, i.p). Remaining Groups were administered with dif ...
Inhibition of platelet aggregability by losartan in essential hypertension
... because it occurs at doses 1,000-fold higher than those required for binding to vascular AT1 receptors 8, 9, 13. Although the argument has been posed that chronic therapy with losartan (80 to 120 mg oral dose) may expose platelets to circulating drug concentrations amounting to 1 µmol/L 8, 13 this s ...
... because it occurs at doses 1,000-fold higher than those required for binding to vascular AT1 receptors 8, 9, 13. Although the argument has been posed that chronic therapy with losartan (80 to 120 mg oral dose) may expose platelets to circulating drug concentrations amounting to 1 µmol/L 8, 13 this s ...
AusPAR: Zonisamide
... zonisamide exposure in epileptic patients during steady-state dosing. Evaluator’s overall conclusions on pharmacokinetics The ratios of the geometric means indicated that the Black and Asian race groups had 4% lower and 20% higher peak serum zonisamide exposure (that is, Cmax), respectively, compare ...
... zonisamide exposure in epileptic patients during steady-state dosing. Evaluator’s overall conclusions on pharmacokinetics The ratios of the geometric means indicated that the Black and Asian race groups had 4% lower and 20% higher peak serum zonisamide exposure (that is, Cmax), respectively, compare ...
MIRAPEX ER Prescribing Information
... MIRAPEX ER tablets may be tapered off at a rate of 0.75 mg per day until the daily dose has been reduced to 0.75 mg. Thereafter, the dose may be reduced by 0.375 mg per day [see Warnings and Precautions (5.9)]. Dosing in Patients with Renal Impairment In patients with moderate renal impairment (crea ...
... MIRAPEX ER tablets may be tapered off at a rate of 0.75 mg per day until the daily dose has been reduced to 0.75 mg. Thereafter, the dose may be reduced by 0.375 mg per day [see Warnings and Precautions (5.9)]. Dosing in Patients with Renal Impairment In patients with moderate renal impairment (crea ...
ASPIRIN
... been fitting for >5 minutes (and is still fitting), or if fits recur in rapid succession without time for full recovery in between. There is no value in giving this drug “preventatively” if the fit has ceased. In any clearly sick or ill child, there must be no delay at the scene while administering the ...
... been fitting for >5 minutes (and is still fitting), or if fits recur in rapid succession without time for full recovery in between. There is no value in giving this drug “preventatively” if the fit has ceased. In any clearly sick or ill child, there must be no delay at the scene while administering the ...
In vivo and in vitro studies on drug metabolism and
... the possible involvement of CYP1A2 in selegiline metabolism. A human liver microsomal enzyme-assay system was used in the in vitro experiments to examine the potential drug-drug interactions. The CYP isoforms involved in lidocaine metabolism were characterized by a combination of enzyme kinetic, che ...
... the possible involvement of CYP1A2 in selegiline metabolism. A human liver microsomal enzyme-assay system was used in the in vitro experiments to examine the potential drug-drug interactions. The CYP isoforms involved in lidocaine metabolism were characterized by a combination of enzyme kinetic, che ...
Use of Antithrombotics in Non-Valvular Atrial Fibrillation
... DOACs, and the American Heart Association has not made a stance on selection of one DOAC over another. It is accepted that any of the DOACs could be considered as first line therapy.3 Selection of oral anticoagulation, therefore, should be based on patient-specific factors such as renal function, ag ...
... DOACs, and the American Heart Association has not made a stance on selection of one DOAC over another. It is accepted that any of the DOACs could be considered as first line therapy.3 Selection of oral anticoagulation, therefore, should be based on patient-specific factors such as renal function, ag ...
to obtain your Full Skin Care Routine with Refissa
... that exceeded the dermal maximally tolerated dose (MTD) of tretinoin and because they were within the background natural occurrence rate for these tumors in this strain of mice. There was no evidence of carcinogenic potential when tretinoin was administered topically at a dose 5 times the average re ...
... that exceeded the dermal maximally tolerated dose (MTD) of tretinoin and because they were within the background natural occurrence rate for these tumors in this strain of mice. There was no evidence of carcinogenic potential when tretinoin was administered topically at a dose 5 times the average re ...
Good Clinical Practice Guidelines (India)
... The history of Good Clinical Practice (GCP) statute traces back to one of the oldest enduring traditions in the history of medicine: The Hippocratic Oath. As the guiding ethical code it is primarily known for its edict to do no harm to the patient. However, the complexities of modern medicine resear ...
... The history of Good Clinical Practice (GCP) statute traces back to one of the oldest enduring traditions in the history of medicine: The Hippocratic Oath. As the guiding ethical code it is primarily known for its edict to do no harm to the patient. However, the complexities of modern medicine resear ...
Inhaled Corticosteroids - University of Michigan
... Observational cohort study compared ICS users to non-users, all of whom had a diagnosis of asthma or COPD (103,289 ICS users vs. 98,257 non-users) Nested case-control analysis compared patients with diagnosis of cataracts to control patients without a diagnosis of cataracts from the base cohort ...
... Observational cohort study compared ICS users to non-users, all of whom had a diagnosis of asthma or COPD (103,289 ICS users vs. 98,257 non-users) Nested case-control analysis compared patients with diagnosis of cataracts to control patients without a diagnosis of cataracts from the base cohort ...
Timing and Characteristics of Cumulative Evidence Available on
... between 2000 and 2013. Our search of ClinicalTrials.gov identified 7,757 studies, which included 1,258,315 participants. Only one-third of identified studies were randomized controlled trials. Of 1,631 randomized trials with advanced recruitment status, 906 were conducted in therapeutic areas for wh ...
... between 2000 and 2013. Our search of ClinicalTrials.gov identified 7,757 studies, which included 1,258,315 participants. Only one-third of identified studies were randomized controlled trials. Of 1,631 randomized trials with advanced recruitment status, 906 were conducted in therapeutic areas for wh ...