B Brro on nc
... Dept of Internal Medicine University Hospital CH-4031 Basel Switzerland Keywords: Adenosine-5'-monophosphate asthma bronchoprotection histamine salmeterol Received: February 11 1994 Accepted after revision July 8 1994 Supported by Swiss National Science Foundation, Grant No. 32-30154.90 and Glaxo, S ...
... Dept of Internal Medicine University Hospital CH-4031 Basel Switzerland Keywords: Adenosine-5'-monophosphate asthma bronchoprotection histamine salmeterol Received: February 11 1994 Accepted after revision July 8 1994 Supported by Swiss National Science Foundation, Grant No. 32-30154.90 and Glaxo, S ...
Primaquine-Induced Hemolytic Anemia: Formation and Hemotoxicity
... glucose-6-phosphate dehydrogenase (G6PD) activity (Dern et al., 1955; Degowin et al., 1966). Deficiency in erythrocytic G6PD has been shown to confer resistance to infection by the malarial parasite, which presumably accounts for the high incidence of G6PD deficiency in areas endemic for malaria (Be ...
... glucose-6-phosphate dehydrogenase (G6PD) activity (Dern et al., 1955; Degowin et al., 1966). Deficiency in erythrocytic G6PD has been shown to confer resistance to infection by the malarial parasite, which presumably accounts for the high incidence of G6PD deficiency in areas endemic for malaria (Be ...
Preservative-Free Ophthalmic Products - Scope e
... diseases, such as glaucoma, dry eye syndrome, infections, uveitic diseases, and ocular hypertension. To treat eye-related disorders, patients are often prescribed to use different medications under treatment regimens of varying length. In most of the ophthalmic medicaments, preservatives are added, ...
... diseases, such as glaucoma, dry eye syndrome, infections, uveitic diseases, and ocular hypertension. To treat eye-related disorders, patients are often prescribed to use different medications under treatment regimens of varying length. In most of the ophthalmic medicaments, preservatives are added, ...
Assessment report
... progress on docetaxel, cabazitaxel is approved as second-line chemotherapy with a 2.4 month survival advantage over mitoxantrone plus prednisone (de Bono, 2010). Abiraterone acetate, an oral inhibitor of androgen biosynthesis, has recently been approved, in combination with prednisone, for patients ...
... progress on docetaxel, cabazitaxel is approved as second-line chemotherapy with a 2.4 month survival advantage over mitoxantrone plus prednisone (de Bono, 2010). Abiraterone acetate, an oral inhibitor of androgen biosynthesis, has recently been approved, in combination with prednisone, for patients ...
Codeine and breastfeeding: Is it safe and what are the alternatives?
... cyanosis, and infant death (4, 10-12). A one-week-old infant was evaluated for conjunctivitis and in the process found to have bradycardia. The mother had ingested a single 30mg dose of codeine six days earlier. The infant’s heart rate normalized over 24 hours and remained stable over the next few m ...
... cyanosis, and infant death (4, 10-12). A one-week-old infant was evaluated for conjunctivitis and in the process found to have bradycardia. The mother had ingested a single 30mg dose of codeine six days earlier. The infant’s heart rate normalized over 24 hours and remained stable over the next few m ...
Several hospitals are participating in a study to test the efficacy of a
... and manufacturing information about the drug, data from animal testing, and designs for clinical testing. The NDA (choice B), which contains the results of the clinical studies, must be submitted following human testing in order to gain approval for general marketing of a drug for prescription use. ...
... and manufacturing information about the drug, data from animal testing, and designs for clinical testing. The NDA (choice B), which contains the results of the clinical studies, must be submitted following human testing in order to gain approval for general marketing of a drug for prescription use. ...
avodart soft gelatin capsules
... ----------------------- WARNINGS AND PRECAUTIONS ----------------------• AVODART reduces serum prostate-specific antigen (PSA) concentration by approximately 50%. However, any confirmed increase in PSA while on AVODART may signal the presence of prostate cancer and should be evaluated, even if those ...
... ----------------------- WARNINGS AND PRECAUTIONS ----------------------• AVODART reduces serum prostate-specific antigen (PSA) concentration by approximately 50%. However, any confirmed increase in PSA while on AVODART may signal the presence of prostate cancer and should be evaluated, even if those ...
The Transfer of Drugs and Therapeutics Into Human Breast Milk: An
... older than 6 months.2 In the near future, pharmacogenetics may also provide important guidance for individualized decisions. ...
... older than 6 months.2 In the near future, pharmacogenetics may also provide important guidance for individualized decisions. ...
For patients with severe COPD associated with chronic bronchitis
... Intermezzo (Transcept Pharmaceuticals) should only be used when a person has at least 4 hours of bedtime remaining. It should not be taken if alcohol has been consumed or with any other sleep aid. The recommended and maximum dose of Intermezzo is 1.75 mg for women and 3.5 mg for men, taken once per ...
... Intermezzo (Transcept Pharmaceuticals) should only be used when a person has at least 4 hours of bedtime remaining. It should not be taken if alcohol has been consumed or with any other sleep aid. The recommended and maximum dose of Intermezzo is 1.75 mg for women and 3.5 mg for men, taken once per ...
Guideline on Inhalational medicinal products
... impurities, process validation, stability testing, specifications) as well as safety and efficacy aspects, are described in other guidance documents, including ICH guidelines. Detailed guidance on pharmaceutical development study designs (e.g., priming studies) and the analytical procedures used pri ...
... impurities, process validation, stability testing, specifications) as well as safety and efficacy aspects, are described in other guidance documents, including ICH guidelines. Detailed guidance on pharmaceutical development study designs (e.g., priming studies) and the analytical procedures used pri ...
PRODUCT INFORMATION
... Citalopram has not been systematically evaluated in patients with a recent history of myocardial infarction or unstable heart disease. Patients with these diagnoses were generally excluded from clinical studies during the product’s premarketing testing. Clinical worsening and suicide risk associate ...
... Citalopram has not been systematically evaluated in patients with a recent history of myocardial infarction or unstable heart disease. Patients with these diagnoses were generally excluded from clinical studies during the product’s premarketing testing. Clinical worsening and suicide risk associate ...
Pharmacokinetics, toxicity, and cytochrome P450
... and P. berghei-infected mice [8]. The labeled complex distributed to all organs of both healthy and infected mice but with high intensity in liver, followed by lung, stomach, large intestine, and kidney. Accumulation in spleen was markedly noticeable in the infected mice. Plumbagin-labeled complex w ...
... and P. berghei-infected mice [8]. The labeled complex distributed to all organs of both healthy and infected mice but with high intensity in liver, followed by lung, stomach, large intestine, and kidney. Accumulation in spleen was markedly noticeable in the infected mice. Plumbagin-labeled complex w ...
Cytisine, the world`s oldest smoking cessation aid
... one to two tablets daily by days 21-25. Optimal doses and duration of treatment, however, are as yet undetermined because no human pharmacokinetic data have been published. ...
... one to two tablets daily by days 21-25. Optimal doses and duration of treatment, however, are as yet undetermined because no human pharmacokinetic data have been published. ...
Lethal Injection for Execution: Chemical Asphyxiation?
... Task Force, which concluded ‘‘it is not possible to administer so much of it that a lethal effect is guaranteed’’ [23], even in their population of profoundly ill patients. The most compelling evidence that even 5 g of thiopental alone may not be lethal, however, is that some California inmates cont ...
... Task Force, which concluded ‘‘it is not possible to administer so much of it that a lethal effect is guaranteed’’ [23], even in their population of profoundly ill patients. The most compelling evidence that even 5 g of thiopental alone may not be lethal, however, is that some California inmates cont ...
Dyslipemia are not associated with m-TOR, raptor or - HAL
... The statistical analyses were performed using R software version 2.10.1 (R foundation for statistical computing, http://www.r-project.org). Deviations from the Hardy-Weinberg equilibrium were assessed using the Hardy-Weinberg exact test with the package “SNPassoc”. Linear mixed effect models were fi ...
... The statistical analyses were performed using R software version 2.10.1 (R foundation for statistical computing, http://www.r-project.org). Deviations from the Hardy-Weinberg equilibrium were assessed using the Hardy-Weinberg exact test with the package “SNPassoc”. Linear mixed effect models were fi ...
Pro
... developing asthma. In this study, it was noted that the risk of asthma increases as total serum IgE concentration increases. A study investigated the association of self-reported asthma and serum IgE levels in a general population. These data are from a stratified cluster sample of 2657 patients fro ...
... developing asthma. In this study, it was noted that the risk of asthma increases as total serum IgE concentration increases. A study investigated the association of self-reported asthma and serum IgE levels in a general population. These data are from a stratified cluster sample of 2657 patients fro ...
Update and trends on pharmacokinetic studies in patients
... and simulation techniques may be useful to guide dosing recommendations in the target population with comorbid renal impairment. Common modeling and simulation methods can be broadly classified as top-down or bottom-up methods. Top-down methods rely on modeling of some available data, whereas bottom ...
... and simulation techniques may be useful to guide dosing recommendations in the target population with comorbid renal impairment. Common modeling and simulation methods can be broadly classified as top-down or bottom-up methods. Top-down methods rely on modeling of some available data, whereas bottom ...
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF
... The management of asthma should normally follow a stepwise programme, and the patient’s response should be monitored clinically and by lung function tests. Increasing use of shortacting inhaled bronchodilators, in particular ß2-agonists to control symptoms, indicates deterioration of asthma control. ...
... The management of asthma should normally follow a stepwise programme, and the patient’s response should be monitored clinically and by lung function tests. Increasing use of shortacting inhaled bronchodilators, in particular ß2-agonists to control symptoms, indicates deterioration of asthma control. ...
Guideline on the investigation of drug interactions - EMA
... intake needs to be investigated. The drug-drug interaction potential is usually investigated through in vitro studies followed by in vivo studies. The results of interaction studies are used to predict a number of other interactions based on the mechanisms involved. Treatment recommendations are dev ...
... intake needs to be investigated. The drug-drug interaction potential is usually investigated through in vitro studies followed by in vivo studies. The results of interaction studies are used to predict a number of other interactions based on the mechanisms involved. Treatment recommendations are dev ...
A Comparison of Once-Daily Extended-Release
... Results. The analyses of variance revealed large, statistically significant main effects for the within-subject factor of treatment for all 3 outcome measures (deportment, attention, and permanent product). The interactions of treatment ⴛ session were also highly significant for all 3 outcome measur ...
... Results. The analyses of variance revealed large, statistically significant main effects for the within-subject factor of treatment for all 3 outcome measures (deportment, attention, and permanent product). The interactions of treatment ⴛ session were also highly significant for all 3 outcome measur ...
Renerve G
... could increase the occurrence of accidental injury (fall). There have also been postmarketing reports of confusion, loss of consciousness and mental impairment. Therefore, patients should be advised to exercise caution until they are familiar with the potential effects of the medication. Concomitan ...
... could increase the occurrence of accidental injury (fall). There have also been postmarketing reports of confusion, loss of consciousness and mental impairment. Therefore, patients should be advised to exercise caution until they are familiar with the potential effects of the medication. Concomitan ...
AusPAR: Ruxolitinib - Therapeutic Goods Administration
... Anticancer Medicinal Products in Man1. Appendix 4, due for adoption in July 2013, has specific information on myelodysplastic syndromes2. Regulatory status This is an application for a new chemical entity. The sponsor was granted orphan designation for the indication on 23 April 2012. Similar applic ...
... Anticancer Medicinal Products in Man1. Appendix 4, due for adoption in July 2013, has specific information on myelodysplastic syndromes2. Regulatory status This is an application for a new chemical entity. The sponsor was granted orphan designation for the indication on 23 April 2012. Similar applic ...
Colistimethate Sodium 1 Million I.U. Powder for Solution for Injection
... Colistimethate Sodium is indicated in the treatment of the following infections where sensitivity testing suggests that they are caused by susceptible bacteria: ...
... Colistimethate Sodium is indicated in the treatment of the following infections where sensitivity testing suggests that they are caused by susceptible bacteria: ...
The Řie-Tozer Model of Drug D
... concentrations in tissues and biological fluids following drug administration and the magnitude and duration of pharmacological activities. Drug distribution is a complex process which may follow different pathways and patterns that are dependent on the drug's physicochemical properties and the phys ...
... concentrations in tissues and biological fluids following drug administration and the magnitude and duration of pharmacological activities. Drug distribution is a complex process which may follow different pathways and patterns that are dependent on the drug's physicochemical properties and the phys ...
Vinorelbine - BC Cancer Agency
... Mutagenicity: Not mutagenic in Ames test, but mutagenic in mammalian mutation tests. Fertility: No information found. ...
... Mutagenicity: Not mutagenic in Ames test, but mutagenic in mammalian mutation tests. Fertility: No information found. ...