intravenous buprenorphine in humans
... about one half of control values. Walsh et al.28 reported a small decrease in respiratory rate that appeared to plateau as the sublingual dose of buprenorphine was increased to 32 mg. However, after subcutaneous administration of doses up to 8 mg, decreases in respiratory rate were not reported.° Ou ...
... about one half of control values. Walsh et al.28 reported a small decrease in respiratory rate that appeared to plateau as the sublingual dose of buprenorphine was increased to 32 mg. However, after subcutaneous administration of doses up to 8 mg, decreases in respiratory rate were not reported.° Ou ...
presentation source
... • Because Viagra is a vasodilator (although mainly locally), it needs to be used cautiously because it lowers blood pressure. • Viagra should not be given to patients who are taking nitrates, because nitrates are also a strong vasodilator. The use of both could cause major heart problems. • Also, th ...
... • Because Viagra is a vasodilator (although mainly locally), it needs to be used cautiously because it lowers blood pressure. • Viagra should not be given to patients who are taking nitrates, because nitrates are also a strong vasodilator. The use of both could cause major heart problems. • Also, th ...
Chloral hydrate has general CNS depressant effects believed to be
... 30 to 60 minutes, which lasts about 4 to 8 hours. When used as a premedicant in children and infants, sedation usually occurs within 15 minutes and sleep by 40 minutes, with most fully awake within 2 hours. Chloral hydrate is rapidly and extensively metabolized in the liver and erythrocytes by alcoh ...
... 30 to 60 minutes, which lasts about 4 to 8 hours. When used as a premedicant in children and infants, sedation usually occurs within 15 minutes and sleep by 40 minutes, with most fully awake within 2 hours. Chloral hydrate is rapidly and extensively metabolized in the liver and erythrocytes by alcoh ...
morphine sulfate
... the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. Morphine is a potent medicinal agent of great utility but also with considerable potential for harmful effect, including psychological and physical tolerance and ...
... the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. Morphine is a potent medicinal agent of great utility but also with considerable potential for harmful effect, including psychological and physical tolerance and ...
Sprycel for Chronic Myeloid Leukemia and Philadelphia
... surrogate end point for at least one of these outcomes. In 1992, the Code of Federal Regulations was modified to add a section on Accelerated Approval (Subpart H). This addition allows accelerated approval of drugs for serious or lifethreatening diseases if the drug seems to provide a benefit over a ...
... surrogate end point for at least one of these outcomes. In 1992, the Code of Federal Regulations was modified to add a section on Accelerated Approval (Subpart H). This addition allows accelerated approval of drugs for serious or lifethreatening diseases if the drug seems to provide a benefit over a ...
Lotrel - Novartis
... Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The adverse reaction information fro ...
... Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The adverse reaction information fro ...
20-Drug-Therapy-Diuretic-Therapy
... whereas other thiazides are given elsewhere. The pharmacologic characteristics of metolazone are similar to those of other thiazides. Some formulations of the drug are absorbed poorly and slowly, and it has a long elimination half-life (about two days).7 Thus, metolazone accumulates over a period of ...
... whereas other thiazides are given elsewhere. The pharmacologic characteristics of metolazone are similar to those of other thiazides. Some formulations of the drug are absorbed poorly and slowly, and it has a long elimination half-life (about two days).7 Thus, metolazone accumulates over a period of ...
Endothelium-Dependent Modulation of
... such as noradrenaline at room temperatures of between 22 and 26°C [22, 341. The lack of basal tone contrasts with human forearm resistance vessels, which have also been used to investigate local vascular responses. Intrinsic vascular tone is a disadvantage when investigating inhibition by dilator ag ...
... such as noradrenaline at room temperatures of between 22 and 26°C [22, 341. The lack of basal tone contrasts with human forearm resistance vessels, which have also been used to investigate local vascular responses. Intrinsic vascular tone is a disadvantage when investigating inhibition by dilator ag ...
Antimicrobial tissue concentrations. Infect Dis Clin N Am 17
... subinhibitory, although effective concentrations are attained in plasma. In the authors’ group, microdialysis studies of several antibiotics (eg, piperacillin [45], ceftriaxone [46], piperacillin-tazobactam combinations [47], cefaclor [21,48], cefpodoxime, and cefixime [49]) in animals and humans have ...
... subinhibitory, although effective concentrations are attained in plasma. In the authors’ group, microdialysis studies of several antibiotics (eg, piperacillin [45], ceftriaxone [46], piperacillin-tazobactam combinations [47], cefaclor [21,48], cefpodoxime, and cefixime [49]) in animals and humans have ...
ASMQ brochure
... ASMQ FDC is well tolerated. The 2010 WHO malaria guidelines acknowledge that “side effects, where this [ASMQ] ACT has been deployed, were seldom debilitating and it has been well tolerated”. No serious adverse events were reported during the study in Brazil that included over 23,000 patients, includ ...
... ASMQ FDC is well tolerated. The 2010 WHO malaria guidelines acknowledge that “side effects, where this [ASMQ] ACT has been deployed, were seldom debilitating and it has been well tolerated”. No serious adverse events were reported during the study in Brazil that included over 23,000 patients, includ ...
OXYTROL®
... doctor should monitor you for these effects after starting OXYTROL. See “What should I avoid while using OXYTROL.” • Swelling (angioedema). The active ingredient in OXYTROL, oxybutynin can cause swelling around the eyes, lips, genitals, hands or feet. Some people who have taken oxybutynin medicines ...
... doctor should monitor you for these effects after starting OXYTROL. See “What should I avoid while using OXYTROL.” • Swelling (angioedema). The active ingredient in OXYTROL, oxybutynin can cause swelling around the eyes, lips, genitals, hands or feet. Some people who have taken oxybutynin medicines ...
Information for patients and healthcare providers
... Bumetanide is a loop diuretic with a rapid onset and short duration of action. Pharmacological and clinical studies have shown that 1 mg bumetanide has a diuretic potency equivalent to approximately 40 mg furosemide. The major site of bumetanide action is the ascending limb of the loop of Henle. The ...
... Bumetanide is a loop diuretic with a rapid onset and short duration of action. Pharmacological and clinical studies have shown that 1 mg bumetanide has a diuretic potency equivalent to approximately 40 mg furosemide. The major site of bumetanide action is the ascending limb of the loop of Henle. The ...
1 Phenol Synonym: carbolic acid CAS: 108-95
... reaction with uridine diphosphate (UDP)-glucuronic acid, in the presence of UDPglucuronate transferase [6]. Small amounts of phenol are oxidized to catechol and quinol, which are mainly conjugated [1]. Excretion: Phenol is rapidly secreted through the kidney, primarily conjugated with glucosiduronid ...
... reaction with uridine diphosphate (UDP)-glucuronic acid, in the presence of UDPglucuronate transferase [6]. Small amounts of phenol are oxidized to catechol and quinol, which are mainly conjugated [1]. Excretion: Phenol is rapidly secreted through the kidney, primarily conjugated with glucosiduronid ...
HIGHLIGHTS OF PRESCRIBING INFORMATION
... 6 ADVERSE REACTIONS The most common adverse reactions (>0.5% of subjects) reported in clinical trials were dizziness and hypersensitivity. 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials o ...
... 6 ADVERSE REACTIONS The most common adverse reactions (>0.5% of subjects) reported in clinical trials were dizziness and hypersensitivity. 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials o ...
VAGINAL BLEEDING AFTER USE OF SINGLE DOSE ORAL
... Misoprostol is a synthetic prostaglandin-E1 analogue. It can be used in both gastroenterological and gynecological conditions. In gastroenterologic use, misoprostol therapy indicated in patients who have duodenal or gastric ulcer due to use nonsteroidal anti-inflammatory drugs (NSAIDs). It acts upon ...
... Misoprostol is a synthetic prostaglandin-E1 analogue. It can be used in both gastroenterological and gynecological conditions. In gastroenterologic use, misoprostol therapy indicated in patients who have duodenal or gastric ulcer due to use nonsteroidal anti-inflammatory drugs (NSAIDs). It acts upon ...
PDF
... DNA was extracted using DNA extraction kit (QIAamp DNA Mini Kit; Qiagen, USA) and Real-Time PCR was performed using a standard protocol recommended by the manufacturer (iQ SYBR Green Supermix, Bio-Rad, Japan). One µL of template DNA was added to 19 µL of reaction mixture containing 0.5 µL of each pr ...
... DNA was extracted using DNA extraction kit (QIAamp DNA Mini Kit; Qiagen, USA) and Real-Time PCR was performed using a standard protocol recommended by the manufacturer (iQ SYBR Green Supermix, Bio-Rad, Japan). One µL of template DNA was added to 19 µL of reaction mixture containing 0.5 µL of each pr ...
Flumazenil, naloxone and the coma cocktail
... administered to patients who had previously seized (0/7) or had also reportedly overdosed on a proconvulsant drug (8/336). None of the 83 patients younger than 12 years of age reportedly seized [18]. These datasets, however, are limited by incomplete clinical information and ascertainment of outcome ...
... administered to patients who had previously seized (0/7) or had also reportedly overdosed on a proconvulsant drug (8/336). None of the 83 patients younger than 12 years of age reportedly seized [18]. These datasets, however, are limited by incomplete clinical information and ascertainment of outcome ...
Scandinavian clinical practice guideline on fluid and drug therapy in
... risk estimates were taken from the control arms of randomized trials in the systematic reviews – in the absence of available high-quality observational data. Recommendations were based on the predefined PICO questions. When moving from evidence to recommendations, four factors were considered and in ...
... risk estimates were taken from the control arms of randomized trials in the systematic reviews – in the absence of available high-quality observational data. Recommendations were based on the predefined PICO questions. When moving from evidence to recommendations, four factors were considered and in ...
F Part 7.2: Management of Cardiac Arrest
... Administration of resuscitation drugs into the trachea, however, results in lower blood concentrations than the same dose given intravascularly. Furthermore, recent animal studies24 –27 suggest that the lower epinephrine concentrations achieved when the drug is delivered by the endotracheal route ma ...
... Administration of resuscitation drugs into the trachea, however, results in lower blood concentrations than the same dose given intravascularly. Furthermore, recent animal studies24 –27 suggest that the lower epinephrine concentrations achieved when the drug is delivered by the endotracheal route ma ...
FEMME Protocol - University of Birmingham
... questions about appropriate treatment for which there is insufficient reliable evidence. The prevalence of sub-fertile women with fibroids, whether the fibroids are implicated or not, will rise. If untreated this may lead to an adverse effect on fertility and pregnancy outcomes as well as menstrual ...
... questions about appropriate treatment for which there is insufficient reliable evidence. The prevalence of sub-fertile women with fibroids, whether the fibroids are implicated or not, will rise. If untreated this may lead to an adverse effect on fertility and pregnancy outcomes as well as menstrual ...
Page 1 of 39 KEPPRA (levetiracetam) Rx only 250 mg, 500 mg, 750
... seizures. Levetiracetam did not inhibit single seizures induced by maximal stimulation with electrical current or different chemoconvulsants and showed only minimal activity in submaximal stimulation and in threshold tests. Protection was observed, however, against secondarily generalized activity f ...
... seizures. Levetiracetam did not inhibit single seizures induced by maximal stimulation with electrical current or different chemoconvulsants and showed only minimal activity in submaximal stimulation and in threshold tests. Protection was observed, however, against secondarily generalized activity f ...
Hydrocodone Bitartrate and Acetaminophen Tablets USP 5 mg/325
... Hypersensitivity/anaphylaxis – There have been post-marketing reports of hypersensitivity and anaphylaxis associated with use of acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent repor ...
... Hypersensitivity/anaphylaxis – There have been post-marketing reports of hypersensitivity and anaphylaxis associated with use of acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent repor ...