NIH Public Access
... New England Journal of Medicine in June 1948 3, was greeted with great enthusiasm when this agent was shown to produce, for the first time, remissions in children with acute lymphoblastic leukemia. While these remissions were short-lived, the activity of this agent established that this disease was ...
... New England Journal of Medicine in June 1948 3, was greeted with great enthusiasm when this agent was shown to produce, for the first time, remissions in children with acute lymphoblastic leukemia. While these remissions were short-lived, the activity of this agent established that this disease was ...
notes - UK Research - University of Kentucky
... proper use of anesthetics and analgesics in research animals is an ethical and scientific imperative.” “In general, unless the contrary is known or established, it should be assumed that procedures that cause pain in humans also cause pain in animals.” If a painful procedure must be conducted withou ...
... proper use of anesthetics and analgesics in research animals is an ethical and scientific imperative.” “In general, unless the contrary is known or established, it should be assumed that procedures that cause pain in humans also cause pain in animals.” If a painful procedure must be conducted withou ...
Warfarin – INR – Antibiotic Interactions
... increase INR and the effects of warfarin ***S-warfarin is 2-5 times more active than the R-enantiomer Related Information: A challenging aspect of warfarin management has always been keeping patients’ INR within the therapeutic window. Once on a stable dose of warfarin, numerous factors can affect I ...
... increase INR and the effects of warfarin ***S-warfarin is 2-5 times more active than the R-enantiomer Related Information: A challenging aspect of warfarin management has always been keeping patients’ INR within the therapeutic window. Once on a stable dose of warfarin, numerous factors can affect I ...
Nitroglycerin Transdermal System NITRO-DUR 0.2 (Rated release in vivo
... high) doses of nitroglycerin, tolerance clearly occurs. There is moreover, physical dependence since chest pain, acute myocardial infarction, and even sudden death have occurred during temporary withdrawal of nitroglycerin from these workers. In clinical trials of angina patients, there are reports ...
... high) doses of nitroglycerin, tolerance clearly occurs. There is moreover, physical dependence since chest pain, acute myocardial infarction, and even sudden death have occurred during temporary withdrawal of nitroglycerin from these workers. In clinical trials of angina patients, there are reports ...
data sheet
... dose every 2 weeks is recommended. When enzyme inducing medicines are withdrawn, topiramate levels will increase. A decrease in TOPAMAX dosage may be required if clinically indicated. Adults: Titration for monotherapy should begin at 25 mg as a single (nightly) dose for one week or longer. The dosag ...
... dose every 2 weeks is recommended. When enzyme inducing medicines are withdrawn, topiramate levels will increase. A decrease in TOPAMAX dosage may be required if clinically indicated. Adults: Titration for monotherapy should begin at 25 mg as a single (nightly) dose for one week or longer. The dosag ...
Toxicology NY State Poison Centers Letter The
... dL, 105 mg/dL, and 133.8 mg/dL, respectively. Approximately 20 hours post-ingestion, the patient arrived at a tertiary care center, had a seizure, developed cardiopulmonary arrest, and died before hemodialysis could be initiated. The antemortem salicylate concentration was 503 mg/dL. What are salicy ...
... dL, 105 mg/dL, and 133.8 mg/dL, respectively. Approximately 20 hours post-ingestion, the patient arrived at a tertiary care center, had a seizure, developed cardiopulmonary arrest, and died before hemodialysis could be initiated. The antemortem salicylate concentration was 503 mg/dL. What are salicy ...
Committee on Drugs 1997;99;918 DOI: 10.1542/peds.99.6.918
... circulation of these drugs is noted in adults, which affects drug response, especially with repeated dosing.3 The relative immaturity of hepatic enzyme systems that metabolize drugs in young children may enhance the risk of adverse effects of such medications, especially in infants younger than 6 mo ...
... circulation of these drugs is noted in adults, which affects drug response, especially with repeated dosing.3 The relative immaturity of hepatic enzyme systems that metabolize drugs in young children may enhance the risk of adverse effects of such medications, especially in infants younger than 6 mo ...
the agents influencing functions of the effectory organs and systems
... A *Activation of alpha-1-adrenoreceptors B Activation of serotonin receptors C Activation of beta-adrenoreceptors D Activation of dopamine receptors E Block of M-cholinoreceptors 1. The patient suffering from arterial hypertension with hyperkinetic type of circulation and the high contents of rennin ...
... A *Activation of alpha-1-adrenoreceptors B Activation of serotonin receptors C Activation of beta-adrenoreceptors D Activation of dopamine receptors E Block of M-cholinoreceptors 1. The patient suffering from arterial hypertension with hyperkinetic type of circulation and the high contents of rennin ...
NEXIUM ® I.V. - PI
... • Adults: Dose is either 20 mg or 40 mg NEXIUM given once daily by intravenous injection (no less than 3 minutes) or intravenous infusion (10 minutes to 30 minutes). • Pediatric: Give the following doses once daily as an intravenous infusion over 10 minutes to 30 minutes. (2.1): • 1 year to 17 ...
... • Adults: Dose is either 20 mg or 40 mg NEXIUM given once daily by intravenous injection (no less than 3 minutes) or intravenous infusion (10 minutes to 30 minutes). • Pediatric: Give the following doses once daily as an intravenous infusion over 10 minutes to 30 minutes. (2.1): • 1 year to 17 ...
Hypersensitivity reactions to non beta
... was present in contaminated food, or added to cell culture media and administered during in vitro fertilization, or during immunotherapy with phytohemagglutinin-lymphokineactivated killer cells, or absorbed through skin lesions of a subject affected by hand allergic contact dermatitis. In most of th ...
... was present in contaminated food, or added to cell culture media and administered during in vitro fertilization, or during immunotherapy with phytohemagglutinin-lymphokineactivated killer cells, or absorbed through skin lesions of a subject affected by hand allergic contact dermatitis. In most of th ...
DRUG INTERACTIONS WITH INTEGRASE INHIBITORS
... tenofovir, proton-pump inhibitors and other interacting drugs were not allowed. Compared to historical data of RAL 400 mg single dose, RAL Cmax ↑ 2.81-fold, AUC ↑ 18%, Ctrough ↓ 85%. 4/15 subjects had RAL Ctrough <33 nM. Atazanavir concentrations were not ...
... tenofovir, proton-pump inhibitors and other interacting drugs were not allowed. Compared to historical data of RAL 400 mg single dose, RAL Cmax ↑ 2.81-fold, AUC ↑ 18%, Ctrough ↓ 85%. 4/15 subjects had RAL Ctrough <33 nM. Atazanavir concentrations were not ...
NOROXIN TABLETS (NORFLOXACIN)
... norfloxacin. Convulsions, increased intracranial pressure (including pseudotumor cerebri), and toxic psychoses have been reported in patients receiving drugs in this class. Quinolones may also cause central nervous system (CNS) stimulation which may lead to tremors, restlessness, lightheadedness, co ...
... norfloxacin. Convulsions, increased intracranial pressure (including pseudotumor cerebri), and toxic psychoses have been reported in patients receiving drugs in this class. Quinolones may also cause central nervous system (CNS) stimulation which may lead to tremors, restlessness, lightheadedness, co ...
Symposium Highlights
... The presence of four drugs was tested—cyclophosphamide, ifosfamide, fluorouracil, and methotrexate. High-performance liquid chromatography was used to detect fluorouracil and methotrexate, and gas chromatography was used for cyclophosphamide and ifosfamide. The following types of samples were taken: ...
... The presence of four drugs was tested—cyclophosphamide, ifosfamide, fluorouracil, and methotrexate. High-performance liquid chromatography was used to detect fluorouracil and methotrexate, and gas chromatography was used for cyclophosphamide and ifosfamide. The following types of samples were taken: ...
Rethinking and Restructuring the FDA Drug Approval Process in
... Long-term Arthritis Safety Study (CLASS), sponsored by Pfizer. The paper also analyzed two smaller studies, including Study 090, which Merck sponsored but never published. Although the VIGOR study was designed to measure the GI toxicity of Vioxx for patients with rheumatoid arthritis, it actually de ...
... Long-term Arthritis Safety Study (CLASS), sponsored by Pfizer. The paper also analyzed two smaller studies, including Study 090, which Merck sponsored but never published. Although the VIGOR study was designed to measure the GI toxicity of Vioxx for patients with rheumatoid arthritis, it actually de ...
Drug Testing - Mayo Medical Laboratories
... *These are approximate detection times for the drug or metabolites in urine. The actual detection time depends on dose, frequency of use, and individual metabolism. Note: These tests do not differentiate between dextro (+) amphetamines (eg, dexamphetamine) and racemic mixtures of dextro (+) and levo ...
... *These are approximate detection times for the drug or metabolites in urine. The actual detection time depends on dose, frequency of use, and individual metabolism. Note: These tests do not differentiate between dextro (+) amphetamines (eg, dexamphetamine) and racemic mixtures of dextro (+) and levo ...
US Product Labeling @std Template for PLR
... documented HLA-B*5701 allele assessment. Discontinue ZIAGEN immediately if a hypersensitivity reaction is suspected, regardless of HLA-B*5701 status and even when other diagnoses are possible [see Contraindications (4), Warnings and Precautions (5.1)]. Following a hypersensitivity reaction to ZIAGEN ...
... documented HLA-B*5701 allele assessment. Discontinue ZIAGEN immediately if a hypersensitivity reaction is suspected, regardless of HLA-B*5701 status and even when other diagnoses are possible [see Contraindications (4), Warnings and Precautions (5.1)]. Following a hypersensitivity reaction to ZIAGEN ...
Veterinary Technician`s Guide to Practical Math for Manor College
... maintain blood pressure, and to also treat a multitude of other medical ailments. All CRI’s require an indwelling intravenous catheter and a method of delivery. Some CRI’s require sampling lines because certain drugs can be irritating to the blood vessels. CRI’s allow for better precision in medicat ...
... maintain blood pressure, and to also treat a multitude of other medical ailments. All CRI’s require an indwelling intravenous catheter and a method of delivery. Some CRI’s require sampling lines because certain drugs can be irritating to the blood vessels. CRI’s allow for better precision in medicat ...
You can use morphine
... Morphine; essential pain relief medical use of narcotic drugs (opioids) is indispensable for the relief of pain and suffering morphine should be available at all times in adequate amounts and appropriate dosage forms for the relief of severe pain low national consumption of opioids is a matter ...
... Morphine; essential pain relief medical use of narcotic drugs (opioids) is indispensable for the relief of pain and suffering morphine should be available at all times in adequate amounts and appropriate dosage forms for the relief of severe pain low national consumption of opioids is a matter ...
View - Auro Pharma Inc
... may be administered. Twenty to 30 g of the activated charcoal may be given every four to six hours during the first 24 to 48 hours after ingestion. An ECG should be taken and close monitoring of cardiac function must be instituted if there is any evidence of dysrhythmia. Maintenance of an open airwa ...
... may be administered. Twenty to 30 g of the activated charcoal may be given every four to six hours during the first 24 to 48 hours after ingestion. An ECG should be taken and close monitoring of cardiac function must be instituted if there is any evidence of dysrhythmia. Maintenance of an open airwa ...
Rapanofal Package Insert
... Administration should commence promptly and be completed within 6 hours after the vials are opened. Any unused product should be discarded within 6 hours. Administer by intravenous injection only. The emulsion should not be mixed with other therapeutic agents or injected into containers of infusion ...
... Administration should commence promptly and be completed within 6 hours after the vials are opened. Any unused product should be discarded within 6 hours. Administer by intravenous injection only. The emulsion should not be mixed with other therapeutic agents or injected into containers of infusion ...
OLMESARTAN MEDOXOMIL/HYDROCHLOROTHIAZIDE 20/12
... Effects on ability to drive and use machines The effect of Olmesartan Medoxomil/Hydrochlorothiazide (Olmetec Plus) on the ability to drive and use machines has not been specifically studied. However, it should be borne in mind that dizziness or fatigue may occasionally occur in patients taking antih ...
... Effects on ability to drive and use machines The effect of Olmesartan Medoxomil/Hydrochlorothiazide (Olmetec Plus) on the ability to drive and use machines has not been specifically studied. However, it should be borne in mind that dizziness or fatigue may occasionally occur in patients taking antih ...
Full Prescribing Information
... Use of BELBUCA as the Initial Opioid Analgesic (opioid naïve patients) or in Patients who are not Opioid Tolerant (opioid- non-tolerant patients) Initiate treatment in opioid-naïve and opioid-non-tolerant patients with a 75 mcg film once daily or, if tolerated, every 12 hours (see Table 1) for at le ...
... Use of BELBUCA as the Initial Opioid Analgesic (opioid naïve patients) or in Patients who are not Opioid Tolerant (opioid- non-tolerant patients) Initiate treatment in opioid-naïve and opioid-non-tolerant patients with a 75 mcg film once daily or, if tolerated, every 12 hours (see Table 1) for at le ...
Descovy - Gilead
... tubular injury with severe hypophosphatemia), has been reported with the use of tenofovir prodrugs in both animal toxicology studies and human trials. In clinical trials of FTC+TAF with cobicistat (COBI) plus elvitegravir (EVG), there have been no cases of Fanconi syndrome or Proximal Renal Tubulopa ...
... tubular injury with severe hypophosphatemia), has been reported with the use of tenofovir prodrugs in both animal toxicology studies and human trials. In clinical trials of FTC+TAF with cobicistat (COBI) plus elvitegravir (EVG), there have been no cases of Fanconi syndrome or Proximal Renal Tubulopa ...
PATTON BOGGS, L.L. P. 1660
... so there is no sudden rush of ephedrine into the body. The differences between pure ephedrine and Ma huang also show up in formal animal safety studies; Minamatsu et al. (1991) compared pure ephedrine with an extract of Ma huang, and concluded that the extract was less lethal. They also noted that w ...
... so there is no sudden rush of ephedrine into the body. The differences between pure ephedrine and Ma huang also show up in formal animal safety studies; Minamatsu et al. (1991) compared pure ephedrine with an extract of Ma huang, and concluded that the extract was less lethal. They also noted that w ...
intravenous buprenorphine in humans
... about one half of control values. Walsh et al.28 reported a small decrease in respiratory rate that appeared to plateau as the sublingual dose of buprenorphine was increased to 32 mg. However, after subcutaneous administration of doses up to 8 mg, decreases in respiratory rate were not reported.° Ou ...
... about one half of control values. Walsh et al.28 reported a small decrease in respiratory rate that appeared to plateau as the sublingual dose of buprenorphine was increased to 32 mg. However, after subcutaneous administration of doses up to 8 mg, decreases in respiratory rate were not reported.° Ou ...