Gene Co-expression Networks: Functional Organization of
... What is gene set enrichment analysis? How can we find experiments biologically similar to ours? GEO database universe Cmap perturbagene database and how it’s useful to us The wonderful story of ciclopirox ...
... What is gene set enrichment analysis? How can we find experiments biologically similar to ours? GEO database universe Cmap perturbagene database and how it’s useful to us The wonderful story of ciclopirox ...
LETTERS TO THE EDITOR
... Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia Treatment of childhood acute lymphoblastic leukemia (ALL) combines different classes of chemotherapeutic agents, such as Vinca alkaloids, anthracyclines and glucocorticoids (GCs). Although such therapy nowadays cures the ...
... Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia Treatment of childhood acute lymphoblastic leukemia (ALL) combines different classes of chemotherapeutic agents, such as Vinca alkaloids, anthracyclines and glucocorticoids (GCs). Although such therapy nowadays cures the ...
Genome duplication, divergent resolution and
... divergent resolution. The hypothesis that natural selection will favour speciation over hybridization in populations fixed for different copies of a duplicated locus. Red bars represent a locus duplicated (along with all other loci) during a tetraploidy event. In this hypothetical example, diploidiz ...
... divergent resolution. The hypothesis that natural selection will favour speciation over hybridization in populations fixed for different copies of a duplicated locus. Red bars represent a locus duplicated (along with all other loci) during a tetraploidy event. In this hypothetical example, diploidiz ...
![P[acman]: A BAC Transgenic Platform for Targeted Insertion of](http://s1.studyres.com/store/data/015771109_1-230af42a78d308ddb0e06d89019d2ef2-300x300.png)
P[acman]: A BAC Transgenic Platform for Targeted Insertion of
... copy number, facilitating plasmid maintenance and recombineering, but is induced to high copy number for plasmid isolation. Recombineering allows gap repair and mutagenesis in bacteria. Gap repair efficiently retrieves DNA fragments up to 133 kilobases long from P1 or BAC clones. fC31mediated transg ...
... copy number, facilitating plasmid maintenance and recombineering, but is induced to high copy number for plasmid isolation. Recombineering allows gap repair and mutagenesis in bacteria. Gap repair efficiently retrieves DNA fragments up to 133 kilobases long from P1 or BAC clones. fC31mediated transg ...
Heartwood extractives – from phenotype to candidate genes
... pinosylvin concentration. The coding region of one PST-1 allele contains a 10 bp deletion, causing a frameshift and an early stop codon. This deletion resembles a deletion observed in P. densiflora PDSTS3 gene, coding for a homologous stilbene synthase (Kodan et al. 2002). ...
... pinosylvin concentration. The coding region of one PST-1 allele contains a 10 bp deletion, causing a frameshift and an early stop codon. This deletion resembles a deletion observed in P. densiflora PDSTS3 gene, coding for a homologous stilbene synthase (Kodan et al. 2002). ...
Milestone1
... Proteins are linear chains of amino acid residues that fold into complex 3D structures that carry out cellular functions. Proteins that have similar linear sequences of amino acid residues often fold into similar 3D shapes and have similar functions. In lecture, we discussed the term “homology” in t ...
... Proteins are linear chains of amino acid residues that fold into complex 3D structures that carry out cellular functions. Proteins that have similar linear sequences of amino acid residues often fold into similar 3D shapes and have similar functions. In lecture, we discussed the term “homology” in t ...
GenoWatch: a disease gene mining browser for association study
... National Science Council, Taiwan, under Grant no. ...
... National Science Council, Taiwan, under Grant no. ...
Deletion of GLI3 supports the homology of the human Greig
... third translocation breakpoint was shown to be located approximately 10 kbp downstream of the expressed sequence. Thus, mutations of GLI3 resulting in a reduced gene dosage are probably responsible for the deVelopment of GCPS. To characterize the GLI3 gene in Xt mutant mice, we isolated different GL ...
... third translocation breakpoint was shown to be located approximately 10 kbp downstream of the expressed sequence. Thus, mutations of GLI3 resulting in a reduced gene dosage are probably responsible for the deVelopment of GCPS. To characterize the GLI3 gene in Xt mutant mice, we isolated different GL ...
Dynamics of insertion sequence elements during experimental
... load of IS-mediated deleterious mutations, with the difference being whether horizontal transfer of the elements, or selection of beneficial mutations generated by the elements, is the main force responsible for maintaining them in genomes. The field of evolutionary biology has long been interested ...
... load of IS-mediated deleterious mutations, with the difference being whether horizontal transfer of the elements, or selection of beneficial mutations generated by the elements, is the main force responsible for maintaining them in genomes. The field of evolutionary biology has long been interested ...
EXPERIMENTAL DESIGN is - Universitat de Barcelona
... and Analysis of the Variance In experimental design the different sources of variability influencing the observed response may be identified. These sources can be related with the response using a linear model Analysis of the variance can be used to separately estimate and test the relative impo ...
... and Analysis of the Variance In experimental design the different sources of variability influencing the observed response may be identified. These sources can be related with the response using a linear model Analysis of the variance can be used to separately estimate and test the relative impo ...
control. Luciferase reporters were stable for at least several weeks in
... the nature of toxicity, and they can be run in a high-throughput format. On the other hand, the concept of using positive response as a measure of toxicity could make it more difficult to avoid false-negative results. The exposure of a biosensor too close to the lethal concentration of a toxic compo ...
... the nature of toxicity, and they can be run in a high-throughput format. On the other hand, the concept of using positive response as a measure of toxicity could make it more difficult to avoid false-negative results. The exposure of a biosensor too close to the lethal concentration of a toxic compo ...
Ovarian surface epithelium: family history and early events in
... inclusion cysts, invaginations and ovarian stromal hyperplasia in prophylactically removed ovaries from high-risk individuals [13]. Although only 9 of the 20 women studied by Salazar et al. (1996) have documented germline BRCA1 mutations, the study provides us with valuable information on phenotypic ...
... inclusion cysts, invaginations and ovarian stromal hyperplasia in prophylactically removed ovaries from high-risk individuals [13]. Although only 9 of the 20 women studied by Salazar et al. (1996) have documented germline BRCA1 mutations, the study provides us with valuable information on phenotypic ...
Molecular parasitology in the 21st Century
... and biochemical characteristics not found in other cells. The completion of the genome projects of most human protist parasites and the development of novel molecular tools for their study guarantee a rapid progress in understanding how they invade, modify and survive within their hosts. The ultimat ...
... and biochemical characteristics not found in other cells. The completion of the genome projects of most human protist parasites and the development of novel molecular tools for their study guarantee a rapid progress in understanding how they invade, modify and survive within their hosts. The ultimat ...
Making Sense of Complicated Microarray Data
... Even though none of the genes is differentially expressed, about 1% of the genes (i.e., 100 genes) will be erroneously concluded to be differentially expressed, because we have decided to “live with” a p-value of 0.01 If only one gene were being studied, a 1% margin of error might not be a big d ...
... Even though none of the genes is differentially expressed, about 1% of the genes (i.e., 100 genes) will be erroneously concluded to be differentially expressed, because we have decided to “live with” a p-value of 0.01 If only one gene were being studied, a 1% margin of error might not be a big d ...
Host-induced epidemic spread of the cholera bacterium
... Testing of the human shed V.cholerae occurred in order to test if the hyperinfectious phenotype was maintatined. • V.cholerae samples that were freshly shed were diluted in pond water that was free from contaminants of V.cholerae • Incubation at room temperature for 5 hrs, then diluted samples were ...
... Testing of the human shed V.cholerae occurred in order to test if the hyperinfectious phenotype was maintatined. • V.cholerae samples that were freshly shed were diluted in pond water that was free from contaminants of V.cholerae • Incubation at room temperature for 5 hrs, then diluted samples were ...
Molecular Cloning and Characterization of an
... melanoma. Because of its stage-specific expression, this antigen has been considered as one of the interesting MAAs. ME491 antigen is also strongly expressed in adenocarcinomas of the colon and prostate, and to a lesser degree in some other human tumors (8, 9). It is detected even on undifferentiate ...
... melanoma. Because of its stage-specific expression, this antigen has been considered as one of the interesting MAAs. ME491 antigen is also strongly expressed in adenocarcinomas of the colon and prostate, and to a lesser degree in some other human tumors (8, 9). It is detected even on undifferentiate ...
Identification of eight novel coagulation factor XIII subunit A mutations
... wild-type residues at the positions of the human FXIIIA mutations. (Refer to Figure 1 for orientation of mutated residue positions with respect to the entire FXIIIA monomer.) (A) Tyr167 shown with hydrogen bonds (thin blue lines) to nearby β-staves (dark green ribbons, arrowheads point in the N-term ...
... wild-type residues at the positions of the human FXIIIA mutations. (Refer to Figure 1 for orientation of mutated residue positions with respect to the entire FXIIIA monomer.) (A) Tyr167 shown with hydrogen bonds (thin blue lines) to nearby β-staves (dark green ribbons, arrowheads point in the N-term ...
Sequence Alignment - Faculty of Science at Bilkent University
... affect anthocyanin pathway elements jump in/out of transcription factor genes (C or R) sectoring phenotype - somatic mutations whole kernel effected - germ line mutation ...
... affect anthocyanin pathway elements jump in/out of transcription factor genes (C or R) sectoring phenotype - somatic mutations whole kernel effected - germ line mutation ...
Interpretation of Arabidopsis Thaliana and T
... zinc transporters, homeostasis, and lignin biosynthesis • Each gene has its own function which ultimately helps the plant in deficient and sufficient ...
... zinc transporters, homeostasis, and lignin biosynthesis • Each gene has its own function which ultimately helps the plant in deficient and sufficient ...
Complete genome sequence of an M1 strain of Streptococcus
... metabolism and the facultative anaerobic environment in which this organism resides. Additionally, only a few amino acids are synthesized, in accord with the fastidious growth requirements of the organism. This synthetic deficiency is offset by scavenging resources from the environment; S. pyogenes ...
... metabolism and the facultative anaerobic environment in which this organism resides. Additionally, only a few amino acids are synthesized, in accord with the fastidious growth requirements of the organism. This synthetic deficiency is offset by scavenging resources from the environment; S. pyogenes ...
CDKN2 (p16/MTS1) Gene Deletion or CDK4
... CDKN2, MTS2, and surrounding loci in a series of 70 human glioma tissue samples. The findings support a role for the CDKN2 gene as a tumor suppressor gene in glioblastomas and anaplastic astrocytomas; furthermore we have found that CDK4 gene amplification is a com mon abnormality in tumors not showi ...
... CDKN2, MTS2, and surrounding loci in a series of 70 human glioma tissue samples. The findings support a role for the CDKN2 gene as a tumor suppressor gene in glioblastomas and anaplastic astrocytomas; furthermore we have found that CDK4 gene amplification is a com mon abnormality in tumors not showi ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.