• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
CDKN2 (p16/MTS1) Gene Deletion or CDK4
CDKN2 (p16/MTS1) Gene Deletion or CDK4

... CDKN2, MTS2, and surrounding loci in a series of 70 human glioma tissue samples. The findings support a role for the CDKN2 gene as a tumor suppressor gene in glioblastomas and anaplastic astrocytomas; furthermore we have found that CDK4 gene amplification is a com mon abnormality in tumors not showi ...
Scientists have found that memories might be passed down through
Scientists have found that memories might be passed down through

... The researchers now hope to carry out further work to understand how the information comes to be stored on the DNA in the first place. They also want to explore whether similar effects can be seen in the genes of humans. Professor Marcus Pembrey, a paediatric geneticist at University College London, ...
Cancer Prone Disease Section Waardenburg syndrome (WS) Atlas of Genetics and Cytogenetics
Cancer Prone Disease Section Waardenburg syndrome (WS) Atlas of Genetics and Cytogenetics

... syndrome. Hum Mol Genet. 2000 Aug 12;9(13):1907-17 Tachibana M. MITF: a stream flowing for pigment cells. ...
gene therapy: ethical and social issues
gene therapy: ethical and social issues

... and naked DNA (no protein envelope) that can be placed directly into cells by microinjection. Three types of gene manipulation are possible. Gene addition, in which the genetic material is added to the target cells with no attempt to incorporate it into chromosomes, is the only method used in human ...
Gene Regulation
Gene Regulation

2/8
2/8

... •“Poisonous interactions” – products interact to form a toxic product (usually allele-specific) •“Sequestration interactions” – product of one mutation sequesters the other to a suboptimal concentration in the cell (usually one allelespecific) •Combined haplo-insufficiency (allele non-specific) ...
Chapter 1 Genes Are DNA
Chapter 1 Genes Are DNA

genetic screening - University of Calgary
genetic screening - University of Calgary

Understanding Lynch Syndrome - Hereditary Nonpolyposis
Understanding Lynch Syndrome - Hereditary Nonpolyposis

... It is possible that index genetic testing may not identify a specific mutation. In such cases, it is still possible that a gene mutation is being passed down in the family, but it cannot currently be detected. This may be due to the limits of technology, or it may mean that the mutation is in anothe ...
NIOSH 2013 Pesticide Handler Personal Protective Technology Stakeholders Meeting
NIOSH 2013 Pesticide Handler Personal Protective Technology Stakeholders Meeting

Identification of a cystic fibrosis mutation W19X in Tunisia
Identification of a cystic fibrosis mutation W19X in Tunisia

... 2 (figure 1). Patterns of wild-type genotype and CF mutant genotypes could not be distinguished. However, only by additional heteroduplex-based assay of mixing the proband sample and the standard wild-type control, similar profile to those observed in heterozygous parents were noted. These results cl ...
Mutation screening of phenylketonuria in the Far East of
Mutation screening of phenylketonuria in the Far East of

... In this study, a total of 60 variant alleles from 30 PKU patients was analyzed, using genomic DNAs from dried blood spots on PKU cards. Haplotype analysis of the PAH gene was done by RFLP and VNTR analysis. Various mutations in the PAH gene were determined by restriction enzyme digestion assay, ARMS ...
HSV-1 - Iranian Biomedical Journal
HSV-1 - Iranian Biomedical Journal

... Background: Recent research on several DNA fragments covering open reading frames (ORF) 1-37 shows a new genetic marker in ORF 6 which is specific for differentiating wild-type varicella-zoster virus (VZV) strains from Oka varicella vaccine strain. On the other hand, herpes simplex virus (HSV) genom ...


... pylori infections remain asymptomatic, with only 15% of those infected developing any significant pathology. Gastric cancer occurs in only 0.5 - 2% of all H. pylori infections.11 Although the mechanisms by which H. pylori causes disease have been studied intensively, it remains to be shown why a maj ...
Chain of Survival and EMSC - PathophysiologyMTSUWeatherspoon
Chain of Survival and EMSC - PathophysiologyMTSUWeatherspoon

... multiple of 23 chromosomes ◦ A cell containing three copies of one chromosome is trisomic (trisomy) ◦ Monosomy is the presence of only one copy of any chromosome ◦ Monosomy is often fatal, but infants can survive with trisomy of certain chromosomes  “It is better to have extra than less” ...
Fact Sheet 14 | EPIGENETICS This fact sheet describes epigenetics
Fact Sheet 14 | EPIGENETICS This fact sheet describes epigenetics

... used by the cells to make protein products because both the maternal and paternal genes are usually active or ‘expressed’ in the cells. The expression, however, or activity of a small number of the many genes in the cells is dependent on whether the gene copy was passed down from the father or the m ...
New Title - Gravette School District
New Title - Gravette School District

... grown on another food source, such as glucose, it would have no need for these proteins. Remarkably, the bacterium almost seems to “know” when the products of these genes are needed. The lac genes are turned off by repressors and turned on by the presence of lactose. This process tells us a great de ...
P Cross
P Cross

... • Some obvious human traits are almost impossible to associate with a single gene. • These traits, such as the shape of your eyes or ears, polygenic meaning they are controlled by many genes. • Many of your personal traits are only partially governed by genetics. • epigenetics is the study of herita ...
PowerPoint - Isaac Newton Institute
PowerPoint - Isaac Newton Institute

Integrating Gene Expression Analysis into Genome-Wide
Integrating Gene Expression Analysis into Genome-Wide

... This graph illustrates observations from eQTL analysis that have been reported in the current literature. The diagonal band indicates cis-eQTL. These eQTL are detected when the locus that affects mRNA abundance overlaps the location of the affected gene. The horizontal band represents a trans-band o ...
p53 AND CANCER - Journal of Chemical and Pharmaceutical
p53 AND CANCER - Journal of Chemical and Pharmaceutical

... Trp53 is a master transcription factor which regulates the expression of a plethora of genes involved in the crucial biological processes, many of which encipher proteins that control the cell cycle or induce apoptosis. Because of its critical impact on cell predestination, cellular p53 activity mus ...
Differentially Expressed Genes in Blood from Young Pigs between
Differentially Expressed Genes in Blood from Young Pigs between

... samples were prepared and globin transcripts were depleted by an RNase H-mediated method before RNA sequencing. One hundred base pair paired-end sequencing was run on the Illumina HiSeq 2000 platform. Reads were mapped to the pig reference genome (Sscrofa10.2.76) using aligner STAR after quality tri ...
Karyotyping, FISH and CGH array
Karyotyping, FISH and CGH array

... the lymphocytes into mitotically active cells. The timing of harvesting of the cells is engineered such that a maximum number of cells are in metaphase. The cells are then fixed, and spread onto a slide. The chromosomes are stained using a number of stains, usually Giemsa (G-banding and Rbanding), w ...
rabbit - Ensembl Mobile Site
rabbit - Ensembl Mobile Site

... domains/signatures of interest and labelled where appropriate. Stable identifiers were assigned to each gene, transcript, exon and translation. (When annotating a species for the first time, these identifiers are autogenerated. In all subsequent annotations for a species, the stable identifiers are ...
chapter 8 and 9
chapter 8 and 9

... Genotype - the sequence of nucleotides in the DNA of an organism Wild type - characteristics similar to the organism as it occurs in nature. Prototroph - requires the same nutrients as the wild type. Auxotroph - a strain that has lost the ability to synthesize a specific compound; as a consequence, ...
< 1 ... 159 160 161 162 163 164 165 166 167 ... 504 >

Oncogenomics



Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report