Xenopus tropicalis Ken-ichi T. S and Hisato I
... information on CYP1 genes in amphibians is relatively scarce. In the present study, we attempt to characterize CYP1 genes in Xenopus tropicalis, the only amphibian species whose genome has been sequenced. A novel CYP1 gene, CYP1D was identified in the X. tropicalis genome sequence, besides the genes ...
... information on CYP1 genes in amphibians is relatively scarce. In the present study, we attempt to characterize CYP1 genes in Xenopus tropicalis, the only amphibian species whose genome has been sequenced. A novel CYP1 gene, CYP1D was identified in the X. tropicalis genome sequence, besides the genes ...
Disproportionate Roles for the X Chromosome and
... genetics. By measuring intraspecific polymorphism and interspecific divergence across genomes, evolutionary properties of those mutations targeted by natural selection can be discovered. Under this framework as well, generalities are widely sought and difficult to identify. A useful way to make progres ...
... genetics. By measuring intraspecific polymorphism and interspecific divergence across genomes, evolutionary properties of those mutations targeted by natural selection can be discovered. Under this framework as well, generalities are widely sought and difficult to identify. A useful way to make progres ...
File
... Answer: Genes 1 and 2 are linked, since they yield less than 25% wild-type. Twenty-five percent wild-type is expected for independent assortment, the other recombinant—the double mutant—being among the albino progeny. The 25 wild types in the 1 × 2 cross are presumably accompanied by the albino, rec ...
... Answer: Genes 1 and 2 are linked, since they yield less than 25% wild-type. Twenty-five percent wild-type is expected for independent assortment, the other recombinant—the double mutant—being among the albino progeny. The 25 wild types in the 1 × 2 cross are presumably accompanied by the albino, rec ...
Y genetic variation and phenotypic diversity in health and disease
... mouse model was made possible due to two genetic mutations. First, a genetic mutation in the retrovirally infected EK.CCE embryonic stem cell line (from 129/SvEv mice) [18,19] deleted the region containing the testesdetermining gene Sry on ChrY, resulting in the development of XY female mice [20]. S ...
... mouse model was made possible due to two genetic mutations. First, a genetic mutation in the retrovirally infected EK.CCE embryonic stem cell line (from 129/SvEv mice) [18,19] deleted the region containing the testesdetermining gene Sry on ChrY, resulting in the development of XY female mice [20]. S ...
Genetics advances and learning disability
... involved have been directly due to the study of disorders associated with learning disability, adding important new concepts such as dynamic mutations, imprinting and uniparental disomy to human genetics in general (the meaning of these terms will be explained below). The fact that there are more me ...
... involved have been directly due to the study of disorders associated with learning disability, adding important new concepts such as dynamic mutations, imprinting and uniparental disomy to human genetics in general (the meaning of these terms will be explained below). The fact that there are more me ...
Genetics Notes
... reshaped the study of genetics. His first idea was that genes come in different forms. This causes organisms of the same species to still have some differences. ...
... reshaped the study of genetics. His first idea was that genes come in different forms. This causes organisms of the same species to still have some differences. ...
Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease.
... Initially, LD mapping methods depend on allelic associations between single markers (typically microsatellites) and disease, which are compared between affected subjects and suitable controls from the same population. Recessive diseases are straightforward for such analyses, because both chromosomes ...
... Initially, LD mapping methods depend on allelic associations between single markers (typically microsatellites) and disease, which are compared between affected subjects and suitable controls from the same population. Recessive diseases are straightforward for such analyses, because both chromosomes ...
Molecular genetics in Streptococcus thermophilus
... and cheese. Only recently has progress been made in the genetics of this organism. Several gene transfer techniques such as conjugation (Gasson and Davies, 1980; Romero et al, 1987), transformation (Mercenier et al, 1988; Somkuti and Steinberg, 1988) and transfection (Mercenier et al, 1989) have bee ...
... and cheese. Only recently has progress been made in the genetics of this organism. Several gene transfer techniques such as conjugation (Gasson and Davies, 1980; Romero et al, 1987), transformation (Mercenier et al, 1988; Somkuti and Steinberg, 1988) and transfection (Mercenier et al, 1989) have bee ...
IJEB 55(1) 15-20
... have suggested these free DNA ends can move within a wide range, up to 2 μm26,29,30. But according to more recent studies the end of a broken mammalian chromosome is shown to have very limited mobility which can move no more than 0.2 μm31. Thus, based on these studies the proximity is considered to ...
... have suggested these free DNA ends can move within a wide range, up to 2 μm26,29,30. But according to more recent studies the end of a broken mammalian chromosome is shown to have very limited mobility which can move no more than 0.2 μm31. Thus, based on these studies the proximity is considered to ...
Spr01Final Exam Answer Key
... What is the most likely type of mutation would you expect to get that would produce a lac constitutive phenotype? (2pts) Any mutation that inactivates the lacI gene 15.) What what is the most likely type of mutation would you expect to get that would produce an ara constitutive phenotype? (2pts) A s ...
... What is the most likely type of mutation would you expect to get that would produce a lac constitutive phenotype? (2pts) Any mutation that inactivates the lacI gene 15.) What what is the most likely type of mutation would you expect to get that would produce an ara constitutive phenotype? (2pts) A s ...
Genetic Linkage Mapping of Zebrafish Genes and
... rodent cells. As such, markers that tend to be present in the same hybrid cell lines are closer together than those that are coretained infrequently. One limitation of this approach is that RH maps tend to have more uncertainty in the order of closely spaced markers than genetic maps, but an importa ...
... rodent cells. As such, markers that tend to be present in the same hybrid cell lines are closer together than those that are coretained infrequently. One limitation of this approach is that RH maps tend to have more uncertainty in the order of closely spaced markers than genetic maps, but an importa ...
Article Mitochondrial DNA turnover occurs during preimplantation
... mtDNA and also because of the unusual nature of replication during the earliest stages of development (Cummins, 2002). MtDNA accumulates to high concentrations in the mature oocyte, being expanded from 101 copies per primordial germ cell to 105 copies in each mature oocyte. It was believed that no f ...
... mtDNA and also because of the unusual nature of replication during the earliest stages of development (Cummins, 2002). MtDNA accumulates to high concentrations in the mature oocyte, being expanded from 101 copies per primordial germ cell to 105 copies in each mature oocyte. It was believed that no f ...
Q&A: Evolutionary capacitance Open Access Joanna Masel
... The phenotypes of mutants such as gene knockouts are more variable than the phenotypes of the wild type [26], but this does not necessarily reflect mutational robustness. It does demonstrate the high robustness provided by the gene to the microenvironmental perturbations inherent in normal developme ...
... The phenotypes of mutants such as gene knockouts are more variable than the phenotypes of the wild type [26], but this does not necessarily reflect mutational robustness. It does demonstrate the high robustness provided by the gene to the microenvironmental perturbations inherent in normal developme ...
osteogenesis imperfecta
... I collagen gene mutation has been detected in types VVII OI (Table 2). In the case of type VII OI, the existence of extended affected families has enabled the chromosome location of the gene defect to be mapped to chromosome 3p22-24.1 (Labuda et al., 2002). This locus is on a different chromosome fr ...
... I collagen gene mutation has been detected in types VVII OI (Table 2). In the case of type VII OI, the existence of extended affected families has enabled the chromosome location of the gene defect to be mapped to chromosome 3p22-24.1 (Labuda et al., 2002). This locus is on a different chromosome fr ...
BRCA2 Is Required for Homology-Directed Repair of Chromosomal
... Figure 2. HDR of an Induced DSB in CAPAN-1 Cells Is Defective (A) The recombination repair substrate DR-GFP is composed of two differentially mutated GFP genes, SceGFP and iGFP. When I-SceI endonuclease is expressed in cells containing the DR-GFP substrate in their genome, a DSB will be introduced a ...
... Figure 2. HDR of an Induced DSB in CAPAN-1 Cells Is Defective (A) The recombination repair substrate DR-GFP is composed of two differentially mutated GFP genes, SceGFP and iGFP. When I-SceI endonuclease is expressed in cells containing the DR-GFP substrate in their genome, a DSB will be introduced a ...
Chronic Myeloid Leukemia
... Apperley, J. (2015). Chronic myeloid leukaemia. The Lancet. 385:9976, 1447–1459 CML Society of Canada. (2010, March 18). CML Animation. Retrieved from https://www.youtube.com/watch?v=3tu3CWKbb4M Corey, S., Cortes, J. (2010). Chronic Myeloid Leukemia: Pathophysiology and Therapeutics. Deniniger, M., ...
... Apperley, J. (2015). Chronic myeloid leukaemia. The Lancet. 385:9976, 1447–1459 CML Society of Canada. (2010, March 18). CML Animation. Retrieved from https://www.youtube.com/watch?v=3tu3CWKbb4M Corey, S., Cortes, J. (2010). Chronic Myeloid Leukemia: Pathophysiology and Therapeutics. Deniniger, M., ...
STM
... Upstream regulators control the expression of Knotted1-like homeobox (KNOX) genes. KNOX proteins function as heterodimers with BELL protein co-factors to activate or repress target genes, thus producing a cellular read-out. The mechanistic basis for KNOX gene regulation is either direct, mediated th ...
... Upstream regulators control the expression of Knotted1-like homeobox (KNOX) genes. KNOX proteins function as heterodimers with BELL protein co-factors to activate or repress target genes, thus producing a cellular read-out. The mechanistic basis for KNOX gene regulation is either direct, mediated th ...
Mutations in S-Cone Pigment Genes and the Absence of Colour
... autosomal S-cone genes. If the two copies of the gene differ in nucleotide sequence this would be apparent in the autoradiograms as bands in two lanes at one nucleotide position in the sequence ladder. Alternatively, if the two autosomal copies of the gene are the same, then a band appears in only o ...
... autosomal S-cone genes. If the two copies of the gene differ in nucleotide sequence this would be apparent in the autoradiograms as bands in two lanes at one nucleotide position in the sequence ladder. Alternatively, if the two autosomal copies of the gene are the same, then a band appears in only o ...
UNIFR Rusconi 2002
... Basic understanding of 'genes and genomes': what is a gene, how many genes, molecular biology dogma genetic diseases, environmental factors, Essential concepts on 'molecular medicine' applications and problems, ageing as the major disease Genomics and other 'omics' essential technologies Application ...
... Basic understanding of 'genes and genomes': what is a gene, how many genes, molecular biology dogma genetic diseases, environmental factors, Essential concepts on 'molecular medicine' applications and problems, ageing as the major disease Genomics and other 'omics' essential technologies Application ...
Conservation, relocation and duplication in genome evolution
... 16 757 worm genes (, 86% of the entire genome [1]). In genes that are sensitive to RNA interference (RNAi), the presence of double-stranded RNA results in destruction of the endogenous transcripts and often results in mutant phenotypes. In these experiments, the mutant phenotypes were grouped into t ...
... 16 757 worm genes (, 86% of the entire genome [1]). In genes that are sensitive to RNA interference (RNAi), the presence of double-stranded RNA results in destruction of the endogenous transcripts and often results in mutant phenotypes. In these experiments, the mutant phenotypes were grouped into t ...
NuGEN Introduces Target Enrichment Technology for
... curated by the Wellcome Trust Sanger Institute's Catalog of Somatic Mutations in Cancer (COSMIC). The proprietary NuGEN technology uses a unique single primer strategy that requires only one partner exon to be targeted, thereby enabling not only detection of known fusion events but also discovery of ...
... curated by the Wellcome Trust Sanger Institute's Catalog of Somatic Mutations in Cancer (COSMIC). The proprietary NuGEN technology uses a unique single primer strategy that requires only one partner exon to be targeted, thereby enabling not only detection of known fusion events but also discovery of ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.