Equality and Equity in Curriculum
... Cause and effect: Mechanism and explanation. Events have causes, sometimes simple, sometimes multifaceted. A major activity of science is investigating and explaining causal relationships and the mechanisms by which they are mediated. Such mechanisms can then be tested across given contexts and used ...
... Cause and effect: Mechanism and explanation. Events have causes, sometimes simple, sometimes multifaceted. A major activity of science is investigating and explaining causal relationships and the mechanisms by which they are mediated. Such mechanisms can then be tested across given contexts and used ...
Journal of Advanced Computing (2012) 1
... novelty of KNGP is that it can incorporate biological knowledge both as node weights (e.g., knowledge specific to single genes) and as link weights (e.g., knowledge related to pairs of genes) in the network. An example of a node weight is the number of Gene Ontology (GO) terms associated with a gene ...
... novelty of KNGP is that it can incorporate biological knowledge both as node weights (e.g., knowledge specific to single genes) and as link weights (e.g., knowledge related to pairs of genes) in the network. An example of a node weight is the number of Gene Ontology (GO) terms associated with a gene ...
Screening of a Specific Point Mutation in Tumor Suppressor p53
... samples, there might be mutations at other sites of p53 gene, because expression of mutated p53 gene was detected in the nuelei of hepatocellular carcinoma samples by using monoelonal antibodies which are specific for muta nt-type p53 proteins. Also the change of DNA content was found in the hepatoc ...
... samples, there might be mutations at other sites of p53 gene, because expression of mutated p53 gene was detected in the nuelei of hepatocellular carcinoma samples by using monoelonal antibodies which are specific for muta nt-type p53 proteins. Also the change of DNA content was found in the hepatoc ...
Statistical analysis of DNA microarray data
... • Genes that are not usually found in the samples (both control and test sample). E.g., yeast gene in human tissue samples. Note: Affy GeneChip protocol includes the spiking of control oligonucleotides into each sample. They are NOT for normalization. Instead, they are for other purposes such as gri ...
... • Genes that are not usually found in the samples (both control and test sample). E.g., yeast gene in human tissue samples. Note: Affy GeneChip protocol includes the spiking of control oligonucleotides into each sample. They are NOT for normalization. Instead, they are for other purposes such as gri ...
Normalization of gene expression measurements in tumor tissues
... For interpretation of quantitative gene expression measurements in clinical tumor samples, a normalizer is necessary to correct expression data for differences in cellular input, RNA quality, and RT efficiency between samples. In many studies, a single housekeeping gene is used for normalization. Ho ...
... For interpretation of quantitative gene expression measurements in clinical tumor samples, a normalizer is necessary to correct expression data for differences in cellular input, RNA quality, and RT efficiency between samples. In many studies, a single housekeeping gene is used for normalization. Ho ...
Horizontal Transfer of DNA From GM Crops to Bacteria and to
... results (Coughlan 2000). To date, they have not been able to isolate gut bacteria that have incorporated or expressed the bla gene after chickens had been fed GM maize for 5 d. They have also added pUC18 to silage effluent, saliva, and rumen fluid taken from sheep, but found no uptake by bacteria in ...
... results (Coughlan 2000). To date, they have not been able to isolate gut bacteria that have incorporated or expressed the bla gene after chickens had been fed GM maize for 5 d. They have also added pUC18 to silage effluent, saliva, and rumen fluid taken from sheep, but found no uptake by bacteria in ...
The history of gene duplication Phylogenies are not just useful for
... Phylogenies are not just useful for studying morphological traits and geography but they also are essential tools for making sense of the evolutionary history of genomes. As already discussed, trees can be used to infer ancestral gene or protein sequences. While beyond the scope of this primer, stat ...
... Phylogenies are not just useful for studying morphological traits and geography but they also are essential tools for making sense of the evolutionary history of genomes. As already discussed, trees can be used to infer ancestral gene or protein sequences. While beyond the scope of this primer, stat ...
Chapter 8 - Human Genetics and Biotechnology
... Mendelian Inheritance in Humans Mendelian inheritance refers to the inheritance of traits controlled by a single gene with two alleles, one of which may be dominant to the other. Not many human traits are controlled by a single gene with two alleles, but they are a good starting point for understand ...
... Mendelian Inheritance in Humans Mendelian inheritance refers to the inheritance of traits controlled by a single gene with two alleles, one of which may be dominant to the other. Not many human traits are controlled by a single gene with two alleles, but they are a good starting point for understand ...
here - Oxford Academic - Oxford University Press
... therefore, other genes that may be linked to the gene of interest (for instance because that gene name is mentioned in their functional description) may be included in the search results. By clicking on the gene name, the user has the possibility to browse also between different tables and look for ...
... therefore, other genes that may be linked to the gene of interest (for instance because that gene name is mentioned in their functional description) may be included in the search results. By clicking on the gene name, the user has the possibility to browse also between different tables and look for ...
Stop-Gain Mutations in PKP2 Are Associated with a Later
... for PKP2, DSG2, DSC2, DSP, JUP and TMEM43 genes. A total of 70 relatives of four families were also studied. The 30 patients fulfilled definite disease diagnostic criteria. Genetic analysis revealed a pathogenic mutation in 19 patients (13 in PKP2, 3 in DSG2, 2 in DSP, and 1 in DSC2). Nine of these ...
... for PKP2, DSG2, DSC2, DSP, JUP and TMEM43 genes. A total of 70 relatives of four families were also studied. The 30 patients fulfilled definite disease diagnostic criteria. Genetic analysis revealed a pathogenic mutation in 19 patients (13 in PKP2, 3 in DSG2, 2 in DSP, and 1 in DSC2). Nine of these ...
Biotechnology Laboratory
... DNA amplification by polymerase chain reaction (PCR), gene cloning, gene modification, and expression techniques, cell culture, protein production and purification, DNA and protein gel electrophoresis, protein identification by MALDI-TOF (matrix assisted laser desorption ionization, time of flight) ...
... DNA amplification by polymerase chain reaction (PCR), gene cloning, gene modification, and expression techniques, cell culture, protein production and purification, DNA and protein gel electrophoresis, protein identification by MALDI-TOF (matrix assisted laser desorption ionization, time of flight) ...
Functional Genomics I: Transcriptomics and
... OPTIONAL: You can also run a fold change search using this experiment to compare results on a genome scale. Add a step to your strategy and intersect the results of a fold change search using the “Erythrocytic expression time series (3D7, Dd2, HB3) (Bozdech et al. and Linas et al. ...
... OPTIONAL: You can also run a fold change search using this experiment to compare results on a genome scale. Add a step to your strategy and intersect the results of a fold change search using the “Erythrocytic expression time series (3D7, Dd2, HB3) (Bozdech et al. and Linas et al. ...
View
... H2AX organization around the tss in the replicating genome is noteworthy. The canonical nucleosome and the H2AZ variant typically display the arrangement of −1 nucleosome and nucleosome-free region (NFR) upstream of the tss, and +1 nucleosome stably residing just downstream of the tss (17,25) (Suppl ...
... H2AX organization around the tss in the replicating genome is noteworthy. The canonical nucleosome and the H2AZ variant typically display the arrangement of −1 nucleosome and nucleosome-free region (NFR) upstream of the tss, and +1 nucleosome stably residing just downstream of the tss (17,25) (Suppl ...
Hypergeometric Tests for Gene Lists
... independence of categories, but… • Test results often include directly related terms. Is there really evidence for both terms? • Many tests are performed; pvalues must be interpreted with care. ...
... independence of categories, but… • Test results often include directly related terms. Is there really evidence for both terms? • Many tests are performed; pvalues must be interpreted with care. ...
Out of breath: GM-CSFR mutations disrupt surfactant
... role for alveolar macrophages in GMCSF–dependent surfactant homeostasis in mice. In this issue, Suzuki et al. (p. 䊏䊏䊏) and Martinez-Moczygemba et al. (p. 䊏䊏䊏) describe CSF2RA mutations in three patients with primary PAP (4, 5). These studies, along with the previous observations that the majority of ...
... role for alveolar macrophages in GMCSF–dependent surfactant homeostasis in mice. In this issue, Suzuki et al. (p. 䊏䊏䊏) and Martinez-Moczygemba et al. (p. 䊏䊏䊏) describe CSF2RA mutations in three patients with primary PAP (4, 5). These studies, along with the previous observations that the majority of ...
1 An Introduction - ResearchOnline@JCU
... Reichert, 1998; Papaioannou, 2001). Paired-class genes, in particular those related to the Drosophila aristaless gene, are frequently involved in the development of the embryonic brain and specification of the CNS. Originally it was thought that the cnidarian ‘head’, with its mouth-like opening and ...
... Reichert, 1998; Papaioannou, 2001). Paired-class genes, in particular those related to the Drosophila aristaless gene, are frequently involved in the development of the embryonic brain and specification of the CNS. Originally it was thought that the cnidarian ‘head’, with its mouth-like opening and ...
July 2012 Volume 22 In This Issue Dazzling Diamond of Hope
... the intron and the 3' exon is an AG (Figure 2) . These two-base sequences can be found at many locations in an RNA, many of which do not define exon/intron boundaries, so obviously other sequences must contribute to spliceosome recognition. These other sequences however are far less conserved from o ...
... the intron and the 3' exon is an AG (Figure 2) . These two-base sequences can be found at many locations in an RNA, many of which do not define exon/intron boundaries, so obviously other sequences must contribute to spliceosome recognition. These other sequences however are far less conserved from o ...
Chloramphenicol PDF
... Chloramphenicol inhibits host protein synthesis and thus prevents replication of the host chromosome. Plasmid replication, however, is independent of newly synthesized proteins and continues for several hours until up to 2000–3000 copies per cell are accumulated. Alternatively, the cell culture can ...
... Chloramphenicol inhibits host protein synthesis and thus prevents replication of the host chromosome. Plasmid replication, however, is independent of newly synthesized proteins and continues for several hours until up to 2000–3000 copies per cell are accumulated. Alternatively, the cell culture can ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.