Life: The Science of Biology, 8e
... Works best with genes that are polymorphic—have multiple alleles. ...
... Works best with genes that are polymorphic—have multiple alleles. ...
Pharmacogenomics Presenter Guide
... Breast Cancer Treatment Timeline: If the three women in this case study had been diagnosed with breast cancer in 1990 they would have had chemotherapy and radiation, but not Tumoricide treatment. Now with the discovery of Tumoricide and the ability to test for the receptor doctors can do a better jo ...
... Breast Cancer Treatment Timeline: If the three women in this case study had been diagnosed with breast cancer in 1990 they would have had chemotherapy and radiation, but not Tumoricide treatment. Now with the discovery of Tumoricide and the ability to test for the receptor doctors can do a better jo ...
General enquiries on this form should be made to
... needed to be amplified. This was successfully done using a technique called GenomiPhi amplification; yielding high concentrations of DNA. This amplified DNA will be the main resource for future screening of the TILLING population for mutations in genes of interest. The strategy for doing this is to ...
... needed to be amplified. This was successfully done using a technique called GenomiPhi amplification; yielding high concentrations of DNA. This amplified DNA will be the main resource for future screening of the TILLING population for mutations in genes of interest. The strategy for doing this is to ...
Japanese Journal of Ophthalmology Vol.47 No.3
... Background: Mutation of the human transforming growth factor beta-induced (TGFBI) gene causes granular corneal dystrophy (GCD) in various ethnic groups. In this report, we identify the genetic defect on the TGFBI gene in a Vietnamese family with atypical GCD. Cases: The patient and her relatives wer ...
... Background: Mutation of the human transforming growth factor beta-induced (TGFBI) gene causes granular corneal dystrophy (GCD) in various ethnic groups. In this report, we identify the genetic defect on the TGFBI gene in a Vietnamese family with atypical GCD. Cases: The patient and her relatives wer ...
mammary gland tumors—dogs
... of cancer (metastasis) Surgery for tumors that have not spread may be curative Median survival after surgical removal of the breast or mammary tissue (mastectomy) with tubular adenocarcinoma—24.6 months Median survival after surgical removal of the breast or mammary tissue (mastectomy) with so ...
... of cancer (metastasis) Surgery for tumors that have not spread may be curative Median survival after surgical removal of the breast or mammary tissue (mastectomy) with tubular adenocarcinoma—24.6 months Median survival after surgical removal of the breast or mammary tissue (mastectomy) with so ...
Gene methylation in gastric cancer
... largely resistant to radio/chemo-therapy, and the main treatment consists of performing a gastrectomy. Although the recent diagnostic and therapeutic advances have provided excellent survival for patients with early gastric cancer, gastric cancer is usually diagnosed at an advanced stage and the pro ...
... largely resistant to radio/chemo-therapy, and the main treatment consists of performing a gastrectomy. Although the recent diagnostic and therapeutic advances have provided excellent survival for patients with early gastric cancer, gastric cancer is usually diagnosed at an advanced stage and the pro ...
Raes - Joossens
... • Creation of a reference gut gene and genome pool • Determining metagenomic variation within the European population, investigation of ...
... • Creation of a reference gut gene and genome pool • Determining metagenomic variation within the European population, investigation of ...
Epigenetic Regulation of Ig and Variability and Exclusion in Host and
... tone deacetylation probably occurs. Reduction in IL7-R signaling at the pre-B stage most likely underlies histone deacetylation and centromeric recruitment as treatment of B cells with IL-7 interferes with centromeric recruitment of the IgH allele, while simultaneously inducing histone acetylation o ...
... tone deacetylation probably occurs. Reduction in IL7-R signaling at the pre-B stage most likely underlies histone deacetylation and centromeric recruitment as treatment of B cells with IL-7 interferes with centromeric recruitment of the IgH allele, while simultaneously inducing histone acetylation o ...
Molecular genetics of vascular malformations
... TIE2, via Angpt1 Žangiopoietin 1., plays an important role in endothelial cell survival and migration ŽWitzenbichler et al., 1998; Jones et al., 1999; Kim et al., 2000; Papapetropoulos et al., 2000.. TIE2 may also be associated with secretion of matrix metalloproteinases ŽKim et al., 2000.. In addit ...
... TIE2, via Angpt1 Žangiopoietin 1., plays an important role in endothelial cell survival and migration ŽWitzenbichler et al., 1998; Jones et al., 1999; Kim et al., 2000; Papapetropoulos et al., 2000.. TIE2 may also be associated with secretion of matrix metalloproteinases ŽKim et al., 2000.. In addit ...
Prioritizing curation of mouse genes by paucity of annotations and
... diseases including some types of retinitis pigmentosa and polycystic kidney disease. Once thought to be restricted to a few cell types, it is now clear that primary cilia are found on almost all vertebrate cells and are critical to Sonic hedgehog (Shh) signaling. Mouse models play a key role in deve ...
... diseases including some types of retinitis pigmentosa and polycystic kidney disease. Once thought to be restricted to a few cell types, it is now clear that primary cilia are found on almost all vertebrate cells and are critical to Sonic hedgehog (Shh) signaling. Mouse models play a key role in deve ...
Ecophysiology of Thioploca ingrica as revealed by the
... 4100 000 000 paired-end metagenomic sequences using the Illumina MiSeq platform. Because lowredundancy sequences derived from minor contaminating bacteria disturbed sequence assembly, 3 000 000 reads were used as input sequences, in accordance with the results of an optimization procedure (see Mater ...
... 4100 000 000 paired-end metagenomic sequences using the Illumina MiSeq platform. Because lowredundancy sequences derived from minor contaminating bacteria disturbed sequence assembly, 3 000 000 reads were used as input sequences, in accordance with the results of an optimization procedure (see Mater ...
Concept Check Questions
... offspring, 15 chicks are gray, 6 are black, and 8 are white. What is the simplest explanation for the inheritance of these colors in chickens? What phenotypes would you expect in the offspring resulting from a cross between a gray rooster and a ...
... offspring, 15 chicks are gray, 6 are black, and 8 are white. What is the simplest explanation for the inheritance of these colors in chickens? What phenotypes would you expect in the offspring resulting from a cross between a gray rooster and a ...
- Wiley Online Library
... mine the testis, regress the Müllerian ducts and differentiate the internal and external genitalia as male. There is a panoply of genes involved in testis determination, many yet to be identified. Syndromes of sex reversal and studies on mouse embryos have been critical in identifying key genes (see ...
... mine the testis, regress the Müllerian ducts and differentiate the internal and external genitalia as male. There is a panoply of genes involved in testis determination, many yet to be identified. Syndromes of sex reversal and studies on mouse embryos have been critical in identifying key genes (see ...
Genesis and the Genome: Genomics Evidence for Human
... that the spatial organization of those genes is also similar. In short, organisms thought to be close evolutionary relatives have their genes in essentially the same order, with small differences arising from known mechanisms such as sequence inversions, translocations, and chromosome fusion events. ...
... that the spatial organization of those genes is also similar. In short, organisms thought to be close evolutionary relatives have their genes in essentially the same order, with small differences arising from known mechanisms such as sequence inversions, translocations, and chromosome fusion events. ...
Nucleic Acids and Chromatin
... complementary to the DNA sequence of the allele to be detected. a. ASOs are usually used in pairs, one ASO being complementary to the normal allele, and the other being complementary to the variant allele that one wishes to detect. ASOs of any sequence can be synthesized and labeled with radioactivi ...
... complementary to the DNA sequence of the allele to be detected. a. ASOs are usually used in pairs, one ASO being complementary to the normal allele, and the other being complementary to the variant allele that one wishes to detect. ASOs of any sequence can be synthesized and labeled with radioactivi ...
The genetics of mental retardation
... gene that acts by regulating other genes. ATR-X is a rare disorder that was first noticed because of an association between a blood disorder (athalassaemia) and MR55. Molecular techniques were used to define a new XLMR syndrome56 and to clone the responsible gene, termed XH257. Since ATR-X patients ...
... gene that acts by regulating other genes. ATR-X is a rare disorder that was first noticed because of an association between a blood disorder (athalassaemia) and MR55. Molecular techniques were used to define a new XLMR syndrome56 and to clone the responsible gene, termed XH257. Since ATR-X patients ...
Leukaemia Section t(1;3)(p36;q21) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... myeloproliferative disorders. The majority of MDS patients transform into AML with a short preleukemic phase. Blood data: frequent thrombocytosis or normal platelet count. ...
... myeloproliferative disorders. The majority of MDS patients transform into AML with a short preleukemic phase. Blood data: frequent thrombocytosis or normal platelet count. ...
Analysis of a piwi-related Gene Implicates Small RNAs in
... 1. The next slide illustrates (without data) an interesting property of the protein (Twi1p) encoded by the TWI1 gene. A tagged Twi1p that can rescue the conjugation lethal phenotype of a TWI1 deletion localizes first in the cytoplasm of conjugating cells. It then localizes exclusively in the old ma ...
... 1. The next slide illustrates (without data) an interesting property of the protein (Twi1p) encoded by the TWI1 gene. A tagged Twi1p that can rescue the conjugation lethal phenotype of a TWI1 deletion localizes first in the cytoplasm of conjugating cells. It then localizes exclusively in the old ma ...
Linkage II
... between two genes – yellow and white are 0.5 cM apart – yellow and miniature are 35.4 cM apart – white and miniature are (35.4-0.5) = 34.9 cM apart • In Drosophila, crossing over occurs only in females, never in males. ...
... between two genes – yellow and white are 0.5 cM apart – yellow and miniature are 35.4 cM apart – white and miniature are (35.4-0.5) = 34.9 cM apart • In Drosophila, crossing over occurs only in females, never in males. ...
PDF
... the distributions observed in gene expression data. They note that the rate of false negatives is high. Thus, the fact that we do not detect high confidence for a feature, does not mean it does not exist, but rather that the data does not strongly support this feature. ...
... the distributions observed in gene expression data. They note that the rate of false negatives is high. Thus, the fact that we do not detect high confidence for a feature, does not mean it does not exist, but rather that the data does not strongly support this feature. ...
Genes Code for Proteins
... The first systematic attempt to associate genes with enzymes, carried out by Beadle and Tatum in the 1940s, showed that each stage in a metabolic pathway is catalyzed by a single enzyme and can be blocked by mutation in a different gene. This led to the one gene : one enzyme hypothesis. Each metabol ...
... The first systematic attempt to associate genes with enzymes, carried out by Beadle and Tatum in the 1940s, showed that each stage in a metabolic pathway is catalyzed by a single enzyme and can be blocked by mutation in a different gene. This led to the one gene : one enzyme hypothesis. Each metabol ...
Molecular-3
... Selection against mutant alleles is more dramatic for X-linked disorders such as DMD. DMD is currently a genetic lethal because affected males usually fail to reproduce. It may, of course, be transmitted by carrier females, who themselves rarely show any clinical manifestation of the disease. Ne ...
... Selection against mutant alleles is more dramatic for X-linked disorders such as DMD. DMD is currently a genetic lethal because affected males usually fail to reproduce. It may, of course, be transmitted by carrier females, who themselves rarely show any clinical manifestation of the disease. Ne ...
Linkage and Recombination
... Peas have N = 7 chromosomes. Somewhat unlikely that each trait is on a different chromosome. In fact we now know they are not. R (round vs. wrinkled) and Gp (green vs. yellow pod) are both on chromosome V ( = syntenic) but still segregate independently. This we know is because they are so far apart ...
... Peas have N = 7 chromosomes. Somewhat unlikely that each trait is on a different chromosome. In fact we now know they are not. R (round vs. wrinkled) and Gp (green vs. yellow pod) are both on chromosome V ( = syntenic) but still segregate independently. This we know is because they are so far apart ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.