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Gene Technology
Gene Technology

... large amounts of mRNA. mRNA for the insulin gene was isolated and purified. This mRNA has the advantage that the junk DNA sequences (introns) have already been removed.  The mRNA was incubated with DNA nucleotides and a reverse transcriptase to make DNA i.e. the insulin gene  Then the single stran ...
Genetic_diseases_case_study
Genetic_diseases_case_study

... Watch the following video about Hayden, a young boy with Tay Sach’s Disease. http://www.pbs.org/wgbh/nova/genome/program.html Click on the “One Wrong Letter” link. 1. What were some of the early warning signs that Hayden’s parents noticed by the time he was a year old, indicating there was something ...
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1) Lecture notes: effects of bile salts on cholesterol metabolism
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TRANSCRIPTION AND TRANSLATION
TRANSCRIPTION AND TRANSLATION

Glossary Excerpted with modification from the Glossary in Genes V
Glossary Excerpted with modification from the Glossary in Genes V

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A rough guide to molecular biology.
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... gene 0.3 protein, also known as ocr for ‘overcome classical restriction’, expressed immediately by bacteriophage T7 upon infection of Escherichia coli [3]. The ocr protein drastically reduces the effectiveness of all type I DNA restriction systems within the host cell and enables successful infectio ...
Chem 317 Exam II
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... 17. DNA double helix model was proposed by James Watson and Francis Crick. They both obtained Nobel Prize in 1953 by discovering DNA double helix model. The following is a list of specific non-covalent interactions. A. Base stacking through π-π interactions B. Electrostatic interactions between posi ...
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... DNA is a kind of molecule called a nucleic acid. Like the other important nucleic acid in our bodies, RNA, the job of DNA is to carry the information for how to build and work our bodies. The DNA molecule is shaped like a ladder that is twisted into a spiral shape. This shape is called a double heli ...
20DNAtech - Mid
20DNAtech - Mid

... cell and transferred it into an infertile woman's egg. This material allowed the woman's egg to become fertile. The donor egg contained DNA from mitochondria, little organs inside the cell that create the energy to do life's work. The group believes that problems with the mitochondria prevented the ...
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... beta-hemoglobin gene, which alters a single amino acid in the protein produced. 2. change a codon to one that encodes the same amino acid and causes no change in the protein produced. These are called silent mutations. 3. change an amino-acid-coding codon to a single "stop" codon and cause an incomp ...
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Chapter06_Outline

... • DNA fragments on a gel can often be visualized by staining with ethidium bromide, a dye that binds DNA • Particular DNA fragments can be isolated by cutting out the small region of the gel that contains the fragment and removing the DNA from the gel. • Specific DNA fragments are identified by hybr ...
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Nucleic acid double helix



In molecular biology, the term double helix refers to the structure formed by double-stranded molecules of nucleic acids such as DNA. The double helical structure of a nucleic acid complex arises as a consequence of its secondary structure, and is a fundamental component in determining its tertiary structure. The term entered popular culture with the publication in 1968 of The Double Helix: A Personal Account of the Discovery of the Structure of DNA, by James Watson.The DNA double helix polymer of nucleic acids, held together by nucleotides which base pair together. In B-DNA, the most common double helical structure, the double helix is right-handed with about 10–10.5 base pairs per turn. This translates into about 20-21 nucleotides per turn. The double helix structure of DNA contains a major groove and minor groove. In B-DNA the major groove is wider than the minor groove. Given the difference in widths of the major groove and minor groove, many proteins which bind to B-DNA do so through the wider major groove.
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