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literature review ii
literature review ii

... following literature have been extensively reviewed and complied as follows. 2.1. Review of literature on sustained release dosage form: Mohsen A. et al, 2012; formulated sustained release matrix tablets of aceclofenac with Eudragit® RSPO and Eudragit® RLPO were prepared using three techniques; dire ...
Isha Humagain Gaustabbo Ibrra March 31, 2014 Research paper
Isha Humagain Gaustabbo Ibrra March 31, 2014 Research paper

... Nicotine is absorbed into the body when an individual smokes or chews tobacco. Nicotine causes elevation of mood. This is the principal reason for nicotine causing addiction. The nicotine absorbed by a smoker reaches the brain via blood. This leads to numerous chemical reactions in the brain and cau ...
Drugs - DBDD
Drugs - DBDD

... The currently most important results to come out of the two national representative surveys on the prevalence of consumption of individual drugs are presented together in Table 2. Cannabis remains the dominant illicit drug in Germany. Stimulants (cocaine, amphetamine, crack, ecstasy) are the most co ...
PREPARATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF FINASTERIDE USING CO-PROCESSED EXCIPIENTS
PREPARATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF FINASTERIDE USING CO-PROCESSED EXCIPIENTS

... poor flowability of colloidal silicon dioxide itself [22]. The co processing of excipients other than superdisintegrant is another approach to improve the properties of ODTs as in F10, mannitol with MCC PH 102 and aerosile were co-processed. It was found that the prepared co-processed granules had b ...
Mood stabilizers
Mood stabilizers

... leading them to say or do things that are dangerous or that they might later regret. Untreated bipolar disorder is associated with a high risk of suicide. When people are in a manic state, they sleep little, talk a lot and are active and energetic. They may be happy and feel great or they may be cra ...
Intravitreal Amphotericin B
Intravitreal Amphotericin B

...  Intravitreal Voriconazole has been shown to be less toxic to the retina than intravitreal Amphotericin B.  Based on animal models, intravitreal Voriconazole (VCZ) appears to be nontoxic up to doses of 100 μg. ...
The effect of topical benzamil and amiloride on nasal potential
The effect of topical benzamil and amiloride on nasal potential

... than amiloride for the treatment of CF lung disease. The magnitude of the basal PDs in the CF subjects were similar to those of a previous study [7]. The maximum effect (52% increase from baseline) and short duration of action of amiloride in this study is similar to that previously reported [6, 7, ...
TASTE MASKING TECHNOLOGIES: A REVIEW  Review Article SHALINI SHARMA AND SHAILA LEWIS* 
TASTE MASKING TECHNOLOGIES: A REVIEW  Review Article SHALINI SHARMA AND SHAILA LEWIS* 

... Oral  administration  of  pharmaceuticals  is  one  of  the  most  popular  method  of  drug  dilevery.  Many  orally  administered  drugs  elicit  bitter  taste.  Palatability is an extremly important factor in ensuring the likelihood that the recepient will intake the pharmaceuticals. A  constant  ...
Japanese Guideline on the Investigation of Drug Interactions, 2014
Japanese Guideline on the Investigation of Drug Interactions, 2014

... 4.1.1. Identification of enzymes involved in the major elimination pathway by in vitro metabolism studies 4.1.2. Identification and quantitative evaluation of the major elimination pathway by mass balance studies ...
Annex 1 - Emcdda
Annex 1 - Emcdda

... Information from user self-reports and clinical data on individuals presenting to hospital with acute methoxetamine toxicity (non-fatal intoxications) suggest that the desired effects of methoxetamine are similar to those seen with ketamine, but also include stimulant effects and cerebellar features ...
  STUDY OF EFFECTS OF POST­COMPRESSION CURING ON KOLLIDON  SR BASED FLOATING  TABLETS
  STUDY OF EFFECTS OF POST­COMPRESSION CURING ON KOLLIDON  SR BASED FLOATING  TABLETS

... antagonist  is  used  in  the  treatment  of  hypertension.  It  is  appreciably  soluble  in  lower  and  higher  pH  solutions,  with  minimum solubility between pH 6 to 10. The drug shows variable  bioavailability  ranging  from  10‐80  %  which  may  be  attributed  to  its  instability  in  alk ...
Summary of Product Characteristics
Summary of Product Characteristics

... psychiatric or physical disorder and the patient should be carefully re-evaluated at regular intervals. 4.4.1 Specific patient groups Elderly: See dose recommendations. Due to the myorelaxant effect, there is a risk of falls and consequent injury, particularly for elderly patients when they get up a ...
Effect of grapefruit juice on bioavailability of montelukast
Effect of grapefruit juice on bioavailability of montelukast

... montelukast for up to 4 hours. Study Design: A prospective, crossover study with 23 healthy volunteers was performed in two sessions. Methods: In the first session, volunteers were treated with oral montelukast 10 mg once daily with 250 ml water. After a 10-day washout period, the same volunteers we ...
FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING TABLETS OF SILDENAFIL  CITRARTE  Research  Article   
FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING TABLETS OF SILDENAFIL  CITRARTE  Research  Article   

... An  ideal  dosage  regimen  in  the  drug  therapy  of  any  disease  is  the  one,  which  immediately  attains  the  desired  therapeutic  concentration  of  drug  in  plasma  (or  at  the  site  of  action)  and  maintains  it  constant  for  the  entire  duration  of  treatment.  This  is  possi ...
Epilepsy
Epilepsy

... … It is also used off-label in the treatment of generalized epilepsy. … The mechanisms of antiseizure actions of VNS are unknown in the human. … 23% to 50%of patients achieve > 50% reduction in their seizure frequency ...
Pobierz plik
Pobierz plik

... In recent years, the most important is an individual medication profile for each individual patient to intensify a medicinal care. Especially, it is not possible to schematically dosage of antidepressants from younger to older populations. Individual differences of patients in responses on exposure ...
DEVELOPMENT AND VALIDATION OF LIQUID
DEVELOPMENT AND VALIDATION OF LIQUID

... control, balance, and walking. It does not affect freezing, dementia, or problems with involuntary (autonomic) functions, such as constipation, urinary problems, impotence,or pain. ...
4) Removal of poison/toxic agent from the body Antidotes
4) Removal of poison/toxic agent from the body Antidotes

... * Cocaine alkaloid with nitrogen & Amphetamines · Acidify urine by using ascorbic acid or NH4Cl, IV infusion • To acidify the urine pH < 5, which will Ionize basic drugs ...
The PRIME Theory of motivation and its application to
The PRIME Theory of motivation and its application to

... centres is variable and not necessarily high. The main barriers to providing smoking cessation support appear to be staff smoking, lack of knowledge and skills, concern about effect on ...
Treatment and Prevention of Respiratory Syncytial Virus Disease  Janet A. Englund, M.D.
Treatment and Prevention of Respiratory Syncytial Virus Disease Janet A. Englund, M.D.

... Surfactant POPG ...
Protective  effect  and  duration  of ... aerosol  on  exercise-induced  asthma A rombetta,
Protective effect and duration of ... aerosol on exercise-induced asthma A rombetta,

... The doses used may not be considered equipotent (defining equipotency as reaching the same maximum bronchodilating effect), since equipotency was shown between 6 j.l.g of formoterol and 100 j.l.g of salbutamol: however, the maximum bronchodilation was achieved 60 min after salbutamol and 120 min aft ...
Sequential Parallel Comparison Design for Trials with High Placebo
Sequential Parallel Comparison Design for Trials with High Placebo

... to FDA during 1986 to 2008 (Khin et al., 2011) ...
Hydrocodone Bitartrate
Hydrocodone Bitartrate

... pharmacologic/ adverse effects concomitant administration may result in partial blockade of hydrocodone pharmacologic effects and may precipitate a withdrawal syndrome in some patients requiring chronic hydrocodone therapy; antagonist effects are more likely to occur when OAAs used concurrently with ...
The signal attenuation rat model of obsessive–compulsive disorder
The signal attenuation rat model of obsessive–compulsive disorder

... important to note that the above models were not created on the basis of a known mutation in humans that was found to be related to OCD. Rather, these models are based on behavioral similarity, i.e., the behavior of genetically modified mice was found to be similar in specific respects to that of OC ...
This Item - Mid Essex Hospital Services NHS Trust
This Item - Mid Essex Hospital Services NHS Trust

... Management of CDs” document above: the term “must” relates to statements governed by legal requirements; whereas “should” relates to best practice guidance, some agreed nationally and others agreed locally. However, Trust employees working to these procedures are expected to comply with all statemen ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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