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... antimuscarinic properties and is also a potent serotonin reuptake inhibitor (1). Clomipramine (CMI) is one of the most sedating tricyclic (24). The drug is recommended in obsessive compulsive disorders (OCD), in cataplexy associated with narcolepsy, and in depression when sedation is required (5-7). ...
Gotu kola has been used as a medicinal herb for thousands of years
Gotu kola has been used as a medicinal herb for thousands of years

... has been in use since prehistoric times. Its active constituents include pentacyclic triterpene derivatives. Studies have been conducted in particular to investigate the madecassosides and asiaticosides. In common with most traditional phytotherapeutic agents, Centella asiatica is used in folk medic ...
Pharmacotherapy Treatment Options for Insomnia
Pharmacotherapy Treatment Options for Insomnia

... amnesia, complex sleep-related behaviors, and impaired balance with subsequent falls. As suggested above, the superiority of non-benzodiazepines over benzodiazepines have recently been questioned [31]. Although the 2005 NIH consensus conference [1] and a recent meta-analysis [32] supported a superio ...
Treatment of Bronchial Asthma
Treatment of Bronchial Asthma

...  They are 1000-fold more potent than histamine in stimulating airway smooth muscle constriction.  They also promote microvascular leakage, mucus secretion and eosinophil chemotaxis.  Pathway augmented by COX inhibitors (i.e. NSAIDs) ...
Clinical Medicine: Therapeutics pharmacotherapy of Fibromyalgia
Clinical Medicine: Therapeutics pharmacotherapy of Fibromyalgia

... inhibitors, duloxetine was approved by US Food and Drug Administration to treat FMS. Duloxetine is used for the management of major depressive disorder, neuropathic pain, generalized anxiety disorder, and stress incontinence. In the pharmacotherapy of fibromyalgia, a focus is presented on the drug d ...
William Llewellyn`s ANABOLICS
William Llewellyn`s ANABOLICS

... anabolic/androgenic steroids and other drugs. Legitimate pharmaceuticals are labeled and grouped by their country of manufacture. The following terms are used to identify the origin of individual drug products. Real (or no specification other than country): These legitimate pharmaceutical products a ...
Dantrolene Sodium Caps
Dantrolene Sodium Caps

... SGPT, alkaline phosphatase, total bilirubin) for a baseline or to establish whether there is pre-existing liver disease. If baseline liver abnormalities exist and are confirmed, there is a clear possibility that the potential for dantrolene sodium hepatotoxicity could be enhanced, although such a po ...
Revivogen Scalp Therapy Serum Review
Revivogen Scalp Therapy Serum Review

... nutrients. If the roots of your hair do not have an ample supply of blood, hair follicles sop producing hair. Loss of circulation can occur for many reasons. Old age causes deterioration in vascular tissue, tense muscles in the neck and forehead can constrict capillaries and prevent sufficient blood ...
Androgenic anabolic steroids and arterial structure and function in
Androgenic anabolic steroids and arterial structure and function in

... drug testing of urine samples to ensure drug-free status as a requirement for eligibility. Bodybuilders actively using AAS and non-AAS-using bodybuilding controls were recruited from these two associations. In every case, self-report was verified by urine drug testing (see below). Anabolic steroid u ...
Covariate Analysis of QTc and T
Covariate Analysis of QTc and T

... T-wave morphology, such as those seen in congenital LQT2, can be used as sensitive descriptors of repolarization abnormality in this syndrome.14 These T-wave characteristics have also been shown to be independent of heart rate15 and to be more sensitive than QTcF (Fridericia’s correction) to repolar ...
AusPAR: Retigabine - Therapeutic Goods Administration
AusPAR: Retigabine - Therapeutic Goods Administration

... rapidly that the initial focal phase is not clinically apparent. Antiepileptic drugs (AEDs) can often reduce the frequency and severity of seizures, producing lasting seizure free intervals in some patients, but up to 30% of patients with epilepsy are resistant to drug treatment and continue to have ...
psychiatric aspects of marihuana intoxication
psychiatric aspects of marihuana intoxication

... Marihuana has been known as a passport to euphoria since ancient times. It has fascinated men of imagination, and descriptions of its effects upon the mind and body have been given in popular and scientific literature countless times. The literature has been adequately considered by Walton (1) and b ...
Minireview Low-Turnover Drug Molecules: A Current Challenge for
Minireview Low-Turnover Drug Molecules: A Current Challenge for

... hepatocyte incubations, similar to data using microsomes, generally underpredicts in vivo clearance. Thus, there are additional, and as yet unknown, factors unaccounted for in these predictions that have not been improved despite the presence of a complete metabolic milieu in hepatocyte systems. Whi ...
Influence of Two Commercial Fibers in the Pharmacokinetics of
Influence of Two Commercial Fibers in the Pharmacokinetics of

... (Silk, 1989; Scheppach et al., 1990) with extensive advertising campaigns directed to the consumer. This information shows these products as highly effective in the treatment of obesity and constipation prevention, for decreasing blood cholesterol and glucose levels and even for preventing the devel ...
PATIENT CONTROLLED ANALGESIA (PCA) MODULE Education
PATIENT CONTROLLED ANALGESIA (PCA) MODULE Education

... titration of subsequent doses will be needed. Integral to achieving the analgesic corridor is the monitoring of effect. Regular pain assessments are required so the end point or goal is know to have been reached. This also facilitates opioids being given on a regular basis. The “when necessary”, prn ...
) PCH
) PCH

... DNA synthesis, repair, and cellular replication. Actively proliferating tissues such as malignant cells, bone marrow, fetal cells, buccal and intestinal mucosa and cells of the urinary bladder are in general more sensitive to this effect of methotrexate . When cellular proliferation in malignant tis ...
Low Impulsive Action, but not Impulsive Choice, Predicts
Low Impulsive Action, but not Impulsive Choice, Predicts

... more for a cocaine-paired stimulus following punishmentinduced abstinence (Economidou et al, 2009). Likewise, high impulsive action was related to greater seeking responses directed at a sucrose-paired stimulus (Diergaarde et al, 2009). Notably, these preclinical studies demonstrated that poor impul ...
Myers Samantha Myers Paige French General Medical Conditions 5
Myers Samantha Myers Paige French General Medical Conditions 5

... developing synthetic compounds of marijuana without causing the side effects of cognitive problems or the “high sensation.”6 Because these synthetic compounds are developed with “consistent potency” it would be easier to regulate dosage.6 In addition to MS and epilepsy benefits, THC in marijuana has ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... Pain is a more terrible lord of mankind than death itself. Satisfactory pain relief has always been a difficult problem in clinical practice. It is found that operative pain is more severe after surgery and thereafter gradually diminishes over the next 24 hours. Epidural anesthesia is superior to Sp ...
Clinical Update on Hyperkalemia: Diagnosis, Evaluation and
Clinical Update on Hyperkalemia: Diagnosis, Evaluation and

... Jain N, Kotla S, Little BB, et al. Predictors of hyperkalemia and death in patients with cardiac and renal disease. Am J Cardiol. 2012;109:1510-1513. Moranne O, Froissart M, Rossert J, et al; NephroTest Study Group. Timing of onset of CKD-related metabolic complications. J Am Soc Nephrol. 2009;20:16 ...
Maintenance therapy with zuclopenthixol decanoate: associations
Maintenance therapy with zuclopenthixol decanoate: associations

... Patients were recruited from the population of schizophrenic outpatients already receiving maintenance monotherapy with zuclopenthixol-decanoate (ZD) at Tartu University Psychiatric Clinic and Jämejala Psychiatric Hospital, Estonia. All patients were of Estonian or Russian origin and they were infor ...
NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS)
NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS)

... generation of a protective barrier of mucous and bicarbonate, and promoting adequate blood flow to the gastric muscosal cells. Since NSAIDs block PG biosynthesis in the GI tract, they block these cytoprotective processes. The primary toxicity seen with the NSAIDs is GI irritation which may lead to t ...
PhD thesis
PhD thesis

... ABSTRACT  Over  the  past  decades  there  has  been  increasing  focus  on  the  effects  of  endocrine  disrupting compounds (EDCs) on humans. However, pharmaceuticals have not received  much attention as potential EDCs, even though several classes of drugs e.g. antiepileptic  drugs (AEDs), select ...
[Product Monograph Template
[Product Monograph Template

... If hypotension occurs, the patient should be placed in supine position and, if necessary, receive an intravenous infusion of normal saline. A transient hypotensive response is not a contraindication to further doses which usually can be given without difficulty once the blood pressure has increased ...
Naloxone Hydrochloride Injection MIN-I-JET CONSUMER
Naloxone Hydrochloride Injection MIN-I-JET CONSUMER

... rare occasions the treated person has had a fit but this may not have been due to the naloxone. ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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