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Formulation Development of Chlorpheniramine Maleate Tablet by
Formulation Development of Chlorpheniramine Maleate Tablet by

... and other common defects of direct compression. These comparative results showed that chlorpheniramine (DC) had better or nearly equal dissolution and assay. This seems that the direct compression method can be used for manufacturing of low dose drugs like chlorpheniramine maleate tablets. In contra ...
How To Protect Yourself Against Malaria
How To Protect Yourself Against Malaria

... of microscopic crystals, made surfaces lethal to mosquitoes for months. But, although this residual insecticide reversed the odds in the struggle, within a few years the Anopheles had developed a resistance to these chemicals. Other pesticides followed, always with the same inglorious result. Today, ...
Liposomes in drug delivery
Liposomes in drug delivery

... drug to be encapsulated is included either in the aqueous hydration buffer (for hydrophilic drugs) or in the lipid film (tbr lipophilic drugs). Thin-film hydration method produces a heterogeneous population of MLV (1 5/~m diameter) which can be sonicated or extruded through polycarbonate filters to ...
Prescribing Information
Prescribing Information

... Immune reconstitution syndrome has been reported in patients treated with combination antiretroviral therapy, including TIVICAY. During the initial phase of combination antiretroviral treatment, patients whose immune systems respond may develop an inflammatory response to indolent or residual opport ...
2. tablets
2. tablets

... • Coated tablets are tablets covered with one or more layers of mixtures of substances such as natural or synthetic resins, polymers, gums, fillers, sugars, plasticizers, polyols, waxes, colouring matters, flavouring substances, and sometimes also API. A broken section, when examined under a lens, s ...
Methyldopa Methyldopa Description
Methyldopa Methyldopa Description

... especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet. Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important ...
Title: Embryotoxicity of Orally Administered Misoprostol to Pregnant
Title: Embryotoxicity of Orally Administered Misoprostol to Pregnant

... vehicle treated control fetuses (Figs. 2-5). Histological studies of fetuses recovered from vehicle control group showed well developed brain, eye and heart. Within the brain, diencephalon, lateral, third and fourth ventricles pinna were found well develop (Fig. 6A). Moreover, well developed medulla ...
American Society of Clinical Oncology Guideline for Antiemetics in
American Society of Clinical Oncology Guideline for Antiemetics in

... treatment guidelines coming from this meeting have been published on the Internet (mascc.org) and in print.12-19 An overall summary of the meeting has been published as well.20 It was agreed that each of the nine oncology organizations participating in the meeting would also publish the meeting resu ...
Rep. Waxman`s Statement: Merck Documents Show Aggressive
Rep. Waxman`s Statement: Merck Documents Show Aggressive

... another major study, over 100 million Vioxx prescriptions in the United States had been filled. We now laow that many of these prescriptions were dangerous and unnecessary. ...
Effects of different doses of venlafaxine on serotonin and
Effects of different doses of venlafaxine on serotonin and

... which 5-HT is eluted with an acetate buffer (pH 5.1). We used an internal standard (2 nmol/ml N-methyl5-hydroxytryptamine oxalate salt) and its per cent recovery was used to correct for methodological losses during the extraction and chromatographic procedures and ensure correction for losses during ...
Interactions between the cytochrome P450 system and
Interactions between the cytochrome P450 system and

... the phase I reactions. They are mediated by the family of enzymes that constitute the CYP system. At least 17 mammalian CYP gene families have been defined, and more than 30 human gene products have been identified.11,12 CYPs with 40% or greater DNA sequence homology are classified in the same famil ...
Placebo
Placebo

... Compared the cholecystokinin antagonist (proglumide) to placebo. ...
narcotic analgesics - Kamala Nehru Polytechnic (Pharmacy)
narcotic analgesics - Kamala Nehru Polytechnic (Pharmacy)

... respiratory depression , cold skin , pin point pupil , hypotension , shock , coma , death.Death is due to respiratory depression. Treatment: Two major lines of treatment are the administration of specific antagonist ; Naloxone and Gastric lavage. Naloxone 0.4 mg IV repeated every 2-3 minutes till na ...
Paclitaxel-coated Angioplasty Catheters for Local Drug Delivery
Paclitaxel-coated Angioplasty Catheters for Local Drug Delivery

... Area stenosis is percentage reduction of the cross-sectional area of the free vessel lumen compared with the total vessel area inside the stent struts, determined by histomorphometry four weeks after the intervention. Control = no drug; CM Pac = paclitaxel in contrast medium; Paccocath = paclitaxel- ...
Calcium Calmodulin-Stimulated Adenylyl Cyclases Contribute to
Calcium Calmodulin-Stimulated Adenylyl Cyclases Contribute to

... 1994; Zhuo, 2004). More interestingly, inhibitors of new protein synthesis applied locally to the spinal cord attenuated behavioral nociceptive responses to formalin injection (Kim et al., 1998). Therefore, it is hypothesized that activation of NMDA or other receptors leads to gene transcription and ...
(Cannabis genus) for use as animal feed
(Cannabis genus) for use as animal feed

... psychotropic effects of 0.2-0.3 mg/kg bw. In a study with patients suffering from spasticity due to spinal cord injury by Hagenbach et al. (2007) patients tolerated daily doses of 15-60 mg oral THC. EFSA cited a study by Chesher et al. (1990) of a healthy population dosed orally with 5 mg of THC fol ...
In vitro - In vivo Correlation: From Theory to
In vitro - In vivo Correlation: From Theory to

... J Pharm Pharmaceut Sci (www. cspsCanada.org) 9 (2): 169-189, 2006 ...
Data Sheet
Data Sheet

... produced no teratogenicity or embryotoxicity when given from days 6 through 15 of pregnancy. When paracetamol was given from day 16 of pregnancy through a 3-week lactation period, no deleterious effect was noted on pregnancy rate or on percent of live births, but a decrease in body weight gain and s ...
prefilled syringes
prefilled syringes

... wild or staggering. They are not going lead to a transformation of medicine as we know it in the same way that, for instance, intelligent biomechanical implants and other micro- and nanotechnologies might. Instead, with prefilled syringes, we encounter measured, solid improvements over previous, con ...
Assessment report on Vitex agnus-castus L., fructus
Assessment report on Vitex agnus-castus L., fructus

... MEDLINE), the database of the division for Complementary and Alternative Medicines of the Federal Institute for Drugs and Medical Devices (BfArM) and information received from other countries. Vitex agnus-castus, which grows in the region of the Mediterranean Sea, is a shrub which belongs to the Ver ...
FORMULATION, CHARACTERIZATION AND COMPARATIVE IN VITRO IN VIVO EVALUATION
FORMULATION, CHARACTERIZATION AND COMPARATIVE IN VITRO IN VIVO EVALUATION

... The following study involves formulation and evaluation of simple highly drug loaded matrix tablets of theophylline anhydrous (THF) containing ethylcellulose (EC) polymer as a release retardant at low concentrations (1- 9 %w/w) using wet granulation technique. An optimum formula was chosen on the ba ...
Smoking Cessation chapter from CPhA`s Therapeutic Choices
Smoking Cessation chapter from CPhA`s Therapeutic Choices

... trimester; low level of tobacco dependence; sharing a household with nonsmokers; higher education; not suffering from depression. The relapse rate postpartum is about 60% at 6 months, and reflects the chronic relapsing nature of tobacco addiction. Pregnancy is seen as a “teachable moment” in terms o ...
5-HT1A Receptor Null Mutant Mice Responding Under a Differential
5-HT1A Receptor Null Mutant Mice Responding Under a Differential

... previously described by Heisler et al. [1]. To minimize genetic variation, 5HT1AR KO mice were backcrossed 12 generations onto the C57BL/6J background. After backcrossing, mice for this study were produced by crossing heterozygous mice for the null mutation to obtain Wt and 5-HT1AR KO mice and were ...
Non-IOP-Lowering and Unconventional IOP
Non-IOP-Lowering and Unconventional IOP

... systemic hypotension. In one long-term study, all subjects undergoing a trial of marijuana to lower IOP eventually abandoned its use. Attempts to deliver the drug through other routes and thus to bypass effects on the central nervous system have so far been mostly unsuccessful. While a topical deliv ...
Drug Metabolism Test Results
Drug Metabolism Test Results

... the tested individual.  Absence of a detectable mutation does not exclude the possibility that the patient has a different drug metabolism phenotype due to harboring untested phenotypically important polymorphisms, drug-drug interactions, co-morbidities, lifestyle habits or other non-genetic factors ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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