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REACHING THE `INCURABLE`
REACHING THE `INCURABLE`

... Introducing the Nix-TB trial. In May 2015, TB Alliance and partners announced the launch of the world’s first clinical trial to study an XDR-TB drug regimen with minimal pre-existing resistance. This regimen is known as BPaL. If successful, the injection-free regimen being tested in the so-called N ...
Antiseizure Drugs
Antiseizure Drugs

... - It is the first choice drug for partial seizures and for generalized tonicclonic seizures. - In complex partial seizures carbamazepine prevents the attacks in 6065% of patients. - The antiepileptic effect can undergo tolerance in 10-20% of patients. - Absence, myoclonic and akinetic seizures often ...
PIERIS PHARMACEUTICALS, INC.
PIERIS PHARMACEUTICALS, INC.

... projections risks and relating uncertainties. to our In competitors some cases, and you ourcan industry; identifyour forward-looking ability to establish statements collaborations; by terminology our expectations including regarding “anticipates,” the time “believes,” which we “can,” will“continue,” ...
annexure – ii
annexure – ii

... Highly active anti-retroviral therapy (HAART) strategy involves the use of combination anti-retroviral agents for synergistic therapeutic outcomes. With the adoption of HAART, the average survival of HIV/AIDS patients has increased from less than 1 year to over 10 years. Despite the success of HAART ...
Pharmaceutical Care III Fall 2007
Pharmaceutical Care III Fall 2007

... taken first to open the airways and allow other types of medications to be more effectively inhaled into the lungs. Corticosteroids and cromolyn are inhaled after bronchodilating drugs. Avoid the use of over-the-counter inhalers. Most of these contain epinephrine, which is effective for only a short ...
20809 AlleRx.indd
20809 AlleRx.indd

... Methscopolamine nitrate is a quaternary ammonium derivative of the anticholinergic scopolamine which possesses the peripheral actions of the belladonna alkaloids, but does not exhibit the central actions because of its lack of ability to cross the blood-brain barrier. Its antimuscarinic effect cause ...
Amines, what they are and what they do
Amines, what they are and what they do

... • Cocaine hydrochloride is a ionic solid and consequently has a high melting point. (about 200o celcius). ...
Glossary of Research Terms
Glossary of Research Terms

... effectiveness of new drugs or devices or of behavioral interventions. COGNITIVELY IMPAIRED Having either a psychiatric disorder (e.g., psychosis, neurosis, personality or behavior disorders, or dementia) or a developmental disorder (e.g., mental retardation) that affects cognitive or emotional funct ...
Drugs on Skeletal Muscle
Drugs on Skeletal Muscle

... another nACh autoreceptor has been identified and it is most easily demonstrated at low frequencies of stimulation. When activated, these nACh receptors inhibit subsequent stimulation-induced release of transmitter ACh, but their functional significance is uncertain. ...
Chapter 8
Chapter 8

... 3. It is more likely to be used for nonmedical purposes - such as ‘speed freaks’ going on binges - shooting up every few hours over a 5 or 6 day period before crashing - this is followed by sleep, which can last anywhere from 12 hours to 4 days 4. Between 2002 and 2005, there were over 3,000 deaths ...
Active B-Complex | Information Sheet
Active B-Complex | Information Sheet

... and bioactive form of folic acid. The Preferred Form of Folate Because humans cannot synthesize folates, they must obtain them from dietary sources. (6S)-5-methyl-tetrahydrofolate (known as 5-MTHF or L-methylfolate) is the predominant form of dietary folate and the only species normally found in the ...
Suicide Attempt by Ingestion High Doses of Risperidone, Citalopram
Suicide Attempt by Ingestion High Doses of Risperidone, Citalopram

... the risk that a psychiatric patient may use the prescribed psychotherapeutic medication in an overdose in an attempt to commit suicide (8). Many people, attempting suicide, take more than one drug or substance which may increase the death risk due to lethal interactions. Frequently, high doses of ps ...
EVALUATION OF MORINGA OLEIFERA ROOTS AND FLOWERS
EVALUATION OF MORINGA OLEIFERA ROOTS AND FLOWERS

... In transdermal drug delivery because of their high drug loading capacity they can provide higher concentration gradient, thus increasing driving force across the skin. Emulgels has low interfacial tension and will allow excellent contact with skin surface, with the vehicle filling even wrinkles and ...
G/TBT/N/CAN/160/Rev.1 Page 1 World Trade Organization G/TBT/N
G/TBT/N/CAN/160/Rev.1 Page 1 World Trade Organization G/TBT/N

... the cinchona tree and was used for centuries as the primary treatment for malaria. The use of quinine as a malaria treatment declined over the years as new synthetic derivatives of the drug such as chloroquine and mefloquine were developed and used. However, with increasingly drug-resistant strains ...
Outline
Outline

... Dose: 30–50 mg/kg per day, divided into 3 oral doses on alternate days for 20–30 day ___________________________________________________ D. Schistosomiasis ...
557-1648-1-SP - Journal of Drug Delivery and Therapeutics
557-1648-1-SP - Journal of Drug Delivery and Therapeutics

... To produce a nanosuspension with a higher concentration of solids, it is preferred to start homogenization with very fine drug particles, which can be accomplished by pre-milling. The major advantage of high- pressure homogenization over media milling is that it can be used for both diluted as well ...
The Role of Urine Drug Testing In Chronic Pain
The Role of Urine Drug Testing In Chronic Pain

... The most important limitation to understand is that a UDM result cannot determine exposure time, dose, or frequency of drug use, and certainly cannot be used to diagnose addiction. Test results should not in themselves dictate therapeutic decisions, but must be interpreted in the context of addition ...
Myths - Cholesterol , Heart Attack and Statins
Myths - Cholesterol , Heart Attack and Statins

... in their body. But the elderly people have low CoQ10 levels. As a result they experience fatigue, m uscle pain, and possibly heart failure. Most statin cholesterol lowering drugs arrest the body’s ability to make CoQ10. They thus lower CoQ10 in the body. Let us hear what an expert and researcher in ...
Introduction - Dr Ted Williams
Introduction - Dr Ted Williams

... Non-steroidal anti-inflammatory (NSAID) medications block the activity of cyclooxygenase (COX) enzymes. Isoenzymes COX-1 and COX-2 have differing effects, with COX-2 being the more inducible form and COX-1 more active at a basal level. Therapeutic effects of analgesia, antipyresia, and anti-inflamma ...
Stahl_3rd_ch12_Part1..
Stahl_3rd_ch12_Part1..

Reproductive Health Drugs
Reproductive Health Drugs

... meds only when absolutely necessary  Drugs chosen should be based on stage of pregnancy and known information  Any drugs used should be in the lowest possible dosages  Live viral vaccines should be avoided due to possible harm to fetus ...
Party DRUGS - Australian Doctor
Party DRUGS - Australian Doctor

... and sensation, and its stimulant properties include mood elevation and increased energy levels. It has been called an ‘empathogen’ because it heightens communication, closeness and intimacy between individuals. While MDMA increases levels of both dopamine and noradrenaline in the brain, its primary ...
Drug
Drug

... The drug can have local effects - Epinephrine for asthma. The drug can have systemic effects - general anesthetics Large surface area, limited thickness of pulmonary membrane and high blood flow allow for almost instant absorption by diffusion Avoid first pass effect Disadvantages: Administration is ...
Additivity Versus Synergy: A Theoretical Analysis of - Area-c54
Additivity Versus Synergy: A Theoretical Analysis of - Area-c54

... RESULTS: Drugs that compete for a single receptor, and that similarly affect the receptor, must be additive in their effects. Receptors that bind suppressors in serial circuits, or enhancers in parallel circuits, increase the apparent potency of the drugs and the steepness of the concentration versu ...
D. To increase stability of the drug
D. To increase stability of the drug

... mutations in the retinoblastoma (RB) pathway, can be used as a safe and efficient vector for the delivery of gene products to the tumor,” said Leonard Post, Ph.D., Onyx senior vice president, research and development. “Onyx’ proprietary technology for inserting the therapeutic gene into the vector i ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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