Drugs for primary generalized epilepsy
... Because they are new, the clinical indications for these agents are not yet completely defined, and none are currently used as the first treatment for epilepsy. Felbamate was approved by the FDA in early 1994 and was the first new drug for epilepsy to be approved in 15 years. Although there was grea ...
... Because they are new, the clinical indications for these agents are not yet completely defined, and none are currently used as the first treatment for epilepsy. Felbamate was approved by the FDA in early 1994 and was the first new drug for epilepsy to be approved in 15 years. Although there was grea ...
1 Scope and Impact of Financial Conflicts of
... businesses that sponsor research performed at the same institutions. 11 studies concluded that drug industry-sponsored research tends to yield pro-industry conclusions. Authors who had financial relationships with drug companies were significantly more likely to reach supportive conclusions than aut ...
... businesses that sponsor research performed at the same institutions. 11 studies concluded that drug industry-sponsored research tends to yield pro-industry conclusions. Authors who had financial relationships with drug companies were significantly more likely to reach supportive conclusions than aut ...
Prescribing Information
... Stimulants, including DYANAVEL XR, used to treat ADHD are associated with peripheral vasculopathy, including Raynaud's phenomenon. Signs and symptoms are usually intermittent and mild; however, very rare sequelae include digital ulceration and/or soft tissue breakdown. Effects of peripheral vasculop ...
... Stimulants, including DYANAVEL XR, used to treat ADHD are associated with peripheral vasculopathy, including Raynaud's phenomenon. Signs and symptoms are usually intermittent and mild; however, very rare sequelae include digital ulceration and/or soft tissue breakdown. Effects of peripheral vasculop ...
LIQUID MEMBRANE PHENOMENON IN THE BIOLOGICAL ACTION OF VENLAFAXINE Research Article
... Investigations on a wide variety of surface active drugs belonging to different pharmacological categories have revealed that liquid membranes likely to be generated by the drugs either by themselves or in association with membrane lipids at their respective sites of action may modify access of rele ...
... Investigations on a wide variety of surface active drugs belonging to different pharmacological categories have revealed that liquid membranes likely to be generated by the drugs either by themselves or in association with membrane lipids at their respective sites of action may modify access of rele ...
Citicoline Monograph - Alternative Medicine Review
... group. As reported, “This baseline imbalance may have impacted the overall efficacy results in this trial.” Another double-blind, multicenter trial of citicoline included 899 patients with acute ischemic stroke of the middle cerebral artery. The subjects received either 1,000 mg citicoline twice dai ...
... group. As reported, “This baseline imbalance may have impacted the overall efficacy results in this trial.” Another double-blind, multicenter trial of citicoline included 899 patients with acute ischemic stroke of the middle cerebral artery. The subjects received either 1,000 mg citicoline twice dai ...
Anti-tuberculous drugs
... Anti-TB therapy • Multiple drugs are used to reduce the emergence of resistance • Given as combination tablets • Taken 30 min before the breakfast as absorption of rifampicin is influenced by food ...
... Anti-TB therapy • Multiple drugs are used to reduce the emergence of resistance • Given as combination tablets • Taken 30 min before the breakfast as absorption of rifampicin is influenced by food ...
Medication-Assisted Treatment
... If a person is addicted, medication allows him or her to regain a normal state of mind, free of drug-induced highs and lows. It frees the person from thinking all the time about the drug. It can reduce problems of withdrawal and craving. These changes can give the person the chance to focus on the l ...
... If a person is addicted, medication allows him or her to regain a normal state of mind, free of drug-induced highs and lows. It frees the person from thinking all the time about the drug. It can reduce problems of withdrawal and craving. These changes can give the person the chance to focus on the l ...
Presentation
... Slide 8: How Does Ecstasy Work: Serotonin Pathways in the Brain The nerve pathway that is affected by Ecstasy is called the serotonin pathway. Serotonin is a neurotransmitter that is synthesized, stored, and released by specific neurons in this pathway. It is involved in the regulation of several ...
... Slide 8: How Does Ecstasy Work: Serotonin Pathways in the Brain The nerve pathway that is affected by Ecstasy is called the serotonin pathway. Serotonin is a neurotransmitter that is synthesized, stored, and released by specific neurons in this pathway. It is involved in the regulation of several ...
Neurovance Announces Top-Line Study Results Suggest Lower
... Centanafadine (CTN) sustained-release (SR) is a novel triple reuptake inhibitor being developed for the treatment of adults with ADHD and has shown favorable efficacy with good tolerability in a phase 2a patient study. Centanafadine works by modulating the activity of norepinephrine, dopamine and se ...
... Centanafadine (CTN) sustained-release (SR) is a novel triple reuptake inhibitor being developed for the treatment of adults with ADHD and has shown favorable efficacy with good tolerability in a phase 2a patient study. Centanafadine works by modulating the activity of norepinephrine, dopamine and se ...
UKMi Benzodiazepine Dose Equivalents
... been advised that they switch to an equivalent dose of a benzodiazepine with a long half life such as diazepam (5). Diazepam is available as 2mg tablets which can be halved to give 1mg doses. This means the dose can be reduced in stages of 1mg every 1-4 weeks or more. It is difficult to obtain such ...
... been advised that they switch to an equivalent dose of a benzodiazepine with a long half life such as diazepam (5). Diazepam is available as 2mg tablets which can be halved to give 1mg doses. This means the dose can be reduced in stages of 1mg every 1-4 weeks or more. It is difficult to obtain such ...
OPIOIDS
... prescribing opiates for pain became more common during the last decade of the 20th Century • Opioid therapy became accepted (although often inadequately) for treating acute pain, pain due to cancer, & pain caused by a terminal disease • Still disputed is the use of opioids for chronic pain not assoc ...
... prescribing opiates for pain became more common during the last decade of the 20th Century • Opioid therapy became accepted (although often inadequately) for treating acute pain, pain due to cancer, & pain caused by a terminal disease • Still disputed is the use of opioids for chronic pain not assoc ...
DRUG PRESCRIBING PATTERN FOR MAJOR DEPRESSIVE PSYCHOSIS PATIENTS IN
... unlike some other reports [12,13]. Appropriate therapy reduces depressive symptoms and improves overall well-being. Since mild cognitive impairment, with poor concentration and psychomotor retardation, may result from either depression or dementia, a trial of antidepressant therapy should be initiat ...
... unlike some other reports [12,13]. Appropriate therapy reduces depressive symptoms and improves overall well-being. Since mild cognitive impairment, with poor concentration and psychomotor retardation, may result from either depression or dementia, a trial of antidepressant therapy should be initiat ...
Muscarinic antagonist
... dopaminergic activity. One method of balancing the neurotransmitters is through blocking central cholinergic activity using muscarinic receptor antagonists. Atropine acts on the M2 receptors of the heart and antagonizes the activity of acetylcholine. It causes tachycardia by blocking vagal effects o ...
... dopaminergic activity. One method of balancing the neurotransmitters is through blocking central cholinergic activity using muscarinic receptor antagonists. Atropine acts on the M2 receptors of the heart and antagonizes the activity of acetylcholine. It causes tachycardia by blocking vagal effects o ...
Modelling and simulation to help define MABEL and Starting
... • Extrapolate model to humans using all relevant data (literature, in vitro human etc) • Perform simulations considering both uncertainty in model parameters and in scale-up • This approach should help select a more rational starting dose for FIH within the minimum anticipated biological effect leve ...
... • Extrapolate model to humans using all relevant data (literature, in vitro human etc) • Perform simulations considering both uncertainty in model parameters and in scale-up • This approach should help select a more rational starting dose for FIH within the minimum anticipated biological effect leve ...
Atropine
... dopaminergic activity. One method of balancing the neurotransmitters is through blocking central cholinergic activity using muscarinic receptor antagonists. Atropine acts on the M2 receptors of the heart and antagonizes the activity of acetylcholine. It causes tachycardia by blocking vagal effects o ...
... dopaminergic activity. One method of balancing the neurotransmitters is through blocking central cholinergic activity using muscarinic receptor antagonists. Atropine acts on the M2 receptors of the heart and antagonizes the activity of acetylcholine. It causes tachycardia by blocking vagal effects o ...
A Look at Tylenol And its Effects on Us
... How does it work? -Surprisingly, very little is known as to how acetaminophen works in the body. What is known, though, is that acetaminophen inhibits an enzyme called cyclooxygenase (say that five times fast) – which is a key player in pain, inflammation, and fever. Acetaminophen works in the body ...
... How does it work? -Surprisingly, very little is known as to how acetaminophen works in the body. What is known, though, is that acetaminophen inhibits an enzyme called cyclooxygenase (say that five times fast) – which is a key player in pain, inflammation, and fever. Acetaminophen works in the body ...
rajiv gandhi university of health sciences, karnataka, bangalore
... In case of postoperative pain the cause is tissue injury. Untreated postoperative pain can lead to some of the acute effects like sympathetic nervous system activation and neuroendocrine stress response resulting in increased morbidity and mortality. It is also an important predictive factor in the ...
... In case of postoperative pain the cause is tissue injury. Untreated postoperative pain can lead to some of the acute effects like sympathetic nervous system activation and neuroendocrine stress response resulting in increased morbidity and mortality. It is also an important predictive factor in the ...
Polypharmacy Risk Reduction in the Context of Complexity, Frail
... expectancy and goals of care, as well as from the perspective of the potential aggregation of adverse effects from multiple meds that may affect mobility/function and quality of life. Is the benefit greater than the potential harm? ...
... expectancy and goals of care, as well as from the perspective of the potential aggregation of adverse effects from multiple meds that may affect mobility/function and quality of life. Is the benefit greater than the potential harm? ...
PRINCIPLES OF PHARMACOKINETICS Learning Objectives
... emptying rate, intraluminal and mucosal biotransformation by host or bacterial enzymes, dietary contents, and presence of other drugs. c. First-pass effect: absorbed drug passes via portal circulation through liver which may clear substantial fraction and thus decrease bioavailability (percent of do ...
... emptying rate, intraluminal and mucosal biotransformation by host or bacterial enzymes, dietary contents, and presence of other drugs. c. First-pass effect: absorbed drug passes via portal circulation through liver which may clear substantial fraction and thus decrease bioavailability (percent of do ...
Design and Evaluation of Niosomal Gel Delivery Systems for Topical
... liposomes and niosomes and justify their potential in strengthening the efficacy and safety of the drug. 4. N.K Jain et al11 have prepared a transdermal delivery system of an analgesic agent using elastic liposomes. Common anti inflammatory non-steroidal drug Diclofenac was choosen to provide sustai ...
... liposomes and niosomes and justify their potential in strengthening the efficacy and safety of the drug. 4. N.K Jain et al11 have prepared a transdermal delivery system of an analgesic agent using elastic liposomes. Common anti inflammatory non-steroidal drug Diclofenac was choosen to provide sustai ...
Pharmaceutical Slides - Public Health and Social Justice
... • Schedule V: Low abuse potential - Buprenorphine, Propylhexedrine ...
... • Schedule V: Low abuse potential - Buprenorphine, Propylhexedrine ...
ANTIDIABETIC ACTIVITY OF SOME HERBAL DRUG
... accuracy and certainty since not enough research has been done to ascertain the efficiency, dosage, safety, side effects posed by these drugs or other parameters that are used to determine whether a given drug meets the standard pharmacological standards (Kareru, 2008). Qualifications of the medicin ...
... accuracy and certainty since not enough research has been done to ascertain the efficiency, dosage, safety, side effects posed by these drugs or other parameters that are used to determine whether a given drug meets the standard pharmacological standards (Kareru, 2008). Qualifications of the medicin ...
Types of dementia - Occidental College
... consequence of advancing age.” (1) – “For many people, aging is associated with relatively little cognitive decline ( “healthy” or “successful” aging).” (1) – “Many medical scientists and physicians believe that all changes in senescence are but the cumulative effects of injury and disease.” (2) – “ ...
... consequence of advancing age.” (1) – “For many people, aging is associated with relatively little cognitive decline ( “healthy” or “successful” aging).” (1) – “Many medical scientists and physicians believe that all changes in senescence are but the cumulative effects of injury and disease.” (2) – “ ...
Chemical Genetics: Where Genetics and Pharmacology
... (B) Inhibition of a drug-sensitized yeast cyclin-dependent kinase Cdc28 with a low dose of 1NM-PP1 (0.5 µM) induces cell-cycle arrest at G2/M, whereas a higher dose of 1NM-PP1 (5 µM) induces cell-cycle arrest in G1. Mutant yeast with temperature-sensitive Cdc28 alleles also arrest in G1. (C) An incr ...
... (B) Inhibition of a drug-sensitized yeast cyclin-dependent kinase Cdc28 with a low dose of 1NM-PP1 (0.5 µM) induces cell-cycle arrest at G2/M, whereas a higher dose of 1NM-PP1 (5 µM) induces cell-cycle arrest in G1. Mutant yeast with temperature-sensitive Cdc28 alleles also arrest in G1. (C) An incr ...
Neuroleptics (Anti-psychotic Drugs)
... ☛ Describe the antipsychotic action of neuroleptics. ☛ List the main pharmacokinetic features of neuroleptics ☛ Outline the use of depot preparations of fluphenazine and haloperidol ☛ Describe the main adverse effects of neuroleptics ☛ List the main contraindications of neuroleptics ☛ Outline the ma ...
... ☛ Describe the antipsychotic action of neuroleptics. ☛ List the main pharmacokinetic features of neuroleptics ☛ Outline the use of depot preparations of fluphenazine and haloperidol ☛ Describe the main adverse effects of neuroleptics ☛ List the main contraindications of neuroleptics ☛ Outline the ma ...