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IOSR Journal of Applied Chemistry (IOSR-JAC)
IOSR Journal of Applied Chemistry (IOSR-JAC)

... Limits of Linearity of calibration curves are mentioned in the Table 1 under the title Beer’s law limit. To test the selectivity, known excipients of each drug are added to the pure drug sample and recovery experiments were performed. Ruggedness is resistance of method for a small change in variable ...
Document
Document

... Shelf. As in “just put that on the shelf We may feel we have other problems (cigarettes, debt, sexual compulsion, job problems, family issues) in addition to our addiction, but we postpone dealing with those other problems directly for a while, until we’ve begun to lead a life free from drugs and al ...
this PDF file
this PDF file

... Dexchlorpheniramine, Clemastine and Tripelennamine, [15]. Category C: Animal reproductive studies have shown adverse effects on the fetus and there are no well controlled studies in humans e.g. Promethazine and Hydroxyzine [15]. Seto et al. [16] and Gilbert et al. [17], reported no increased fetal r ...
Bossong et al 2005 proefprint AB-2
Bossong et al 2005 proefprint AB-2

... of 5-HT (Ulrichsen et al., 1992; Baumann et al., 2001). Possibly, this difference between MDMA and mCPP can be explained by the fact that mCPP releases only the cytoplasmatic 5-HT, while MDMA induces the release of both cytoplasmatic and vesicular 5-HT (Gobbi et al., 2002). The doses of mCPP found i ...
Tapered Withdrawal of a Proton Pump Inhibitor to
Tapered Withdrawal of a Proton Pump Inhibitor to

Hazelden`s response to opioid addiction
Hazelden`s response to opioid addiction

... evidence-based recovery programming. The aim is to engage patients for a long enough period of time to allow them to complete treatment, acquire new information, establish new relationships and become solidly involved in recovery. The goal will always be abstinence. Q: How will Hazelden define absti ...
(PK) study with BEKINDA ™ 12 mg (RHB-102)
(PK) study with BEKINDA ™ 12 mg (RHB-102)

... 5-HT3 antagonists such as ondansetron, the active pharmaceutical ingredient in BEKINDA™, have been shown to slow intestinal transit time in humans4. Alosetron (Lotronex®), a 5-HT3 antagonist, has been approved for the treatment of IBS in women with severe chronic IBS-D but is under a restricted pres ...
VI. Antifungal Agents
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... Arrangement of the biomolecular components of the cell wall accounts for the individual identity of the organism. Although, each organism has a different biochemical composition, their gross cell wall structure is similar. There are three general mechanisms of action for the antifungal agents: cell ...
Hallucinogen Notes
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... memories. Mood disorders also have been reported. ...
Reinforcing Effects of Benzodiazepines
Reinforcing Effects of Benzodiazepines

... include the benzodiazepines (alprazolam, diazepam) that increase affinity of GABA for its receptor, and augment GABA-mediated inhibition. ‹ Antagonists (flumazenil) have no intrinsic activity, but block the effects of both agonists and inverse agonists by competitive receptor binding ‹ Inverse agoni ...
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Vivitrol® (naltrexone) (Intramuscular)

... Naltrexone is an oral opiate receptor antagonist. It is derived from thebaine and is very similar in structure to oxymorphone. Like parenteral naloxone, naltrexone is a pure antagonist (i.e., agonist actions are not apparent), but naltrexone has better oral bioavailability and a much longer duration ...
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... have a history of poor blood circulation in the brain. ...
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Users Guide - AHFS Drug Information

... an IRS 501(c)(6) tax-exempt entity. Drugs designated as orphan drugs by FDA and those otherwise considered as orphans are described. An orphan drug is one that is used for the treatment of a rare disease or condition that either occurs in fewer than 200,000 individuals in the US or is more prevalent ...
ASEC 2014 Understanding the Unwanted Side Effects of the
ASEC 2014 Understanding the Unwanted Side Effects of the

... Xylazine's effects upon the cardiovascular system include an initial increase in total peripheral resistance with increased blood pressure followed by a longer period of hypotension. Bradycardia may be seen and some patients develop second degree heart block. Cardiac output may be decreased up to 30 ...
Analgesia - Online CPD Courses for Veterinary Nurses
Analgesia - Online CPD Courses for Veterinary Nurses

... causing serious side effects may preclude their use in some ‘sick’ patients under anesthesia. NSAIDs reduce prostaglandin production by inhibiting cyclo-oxygenase enzymes (COX) which are responsible for prostaglandin synthesis. There are currently thought to be three COX types: COX 1, COX 2 and (the ...
Drug-Induced Hyperandrogenism
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... the duration of administration, individual differences in susceptibility, and the properties of the molecule (the anabolic:androgenic activity ratio varies between 30:1 and 100:1). Athletes often take more than one steroid at the same time and use dosages that sometimes exceed physiological replacem ...
Switching from Kivexa to generic Abacavir/Lamivudine tablets
Switching from Kivexa to generic Abacavir/Lamivudine tablets

... When a drug company makes a new medicine, it is controlled under a patent. It has an approved, or generic name, as well as its own brand name, chosen by the company. For example ibuprofen is a generic name and Nurofen® is the brand name. Once the patent runs out, other drug companies can make the dr ...
Use of angiotensin receptor antagonists in patients with ACE
Use of angiotensin receptor antagonists in patients with ACE

... patients who have experienced adverse effects during the use of an ACE inhibitor. By providing additional information on the safety aspects of using ARAs in patients with previous intolerance to ACE inhibitors, we would like to express our concern, especially in the case of those who have suffered f ...
Impact of drug importation on community pharmacy and patient care
Impact of drug importation on community pharmacy and patient care

... between the United States and other countries. Some attention has been given to the impact of drug importation on the pharmaceutical research industry, its ...
A short introduction to pharmacokinetics
A short introduction to pharmacokinetics

... absorption, the distribution, the biotrasformations and the elimination of drugs in man and animals1. Absorption and distribution indicate the passage of the drug molecules from the administration site to the blood and the passage of drug molecules from blood to tissues respectively. Drug eliminatio ...
A Year in Review: Top New Drugs for 2010
A Year in Review: Top New Drugs for 2010

... Indications: acute bacterial skin infections and CAP in adults >18 yrs. ...
Positive Inotropic Drugs
Positive Inotropic Drugs

... inhibiting the Na, K-adenosine triphosphatase, an enzyme in cardiac cell membrane that decreases the movement of sodium out of myocardial cell after contraction. Calcium enters the cell in exchange for sodium. The calcium activates the contractile proteins and increased myocardial contractility. ...
Chemotherapy
Chemotherapy

... c. Cefazolin is the drug of choice for surgical prophylaxis. It can also be used as an alternative to antistaphylococcal penicillin in allergic patients. ...
Quality assessment of samples of generic and similar aspirin tablets
Quality assessment of samples of generic and similar aspirin tablets

... handling. If a tablet is very friable, it means that it tends to show mechanical erosion. Thus, an important property of a tablet is its ability to resist friction, ensuring that the correct drug amount is administered, and the tablet appearance will not change due to handling (Aulton, 2006). Tablet ...
In understanding the affects of the psychoactive drugs to be
In understanding the affects of the psychoactive drugs to be

... Marijuana has been shown to increase the heart rate by as much as 50%, as well as increasing the blood pressure in some people. However, research suggests that these changes do not create permanent harmful effects on normal hearts and blood vessels and are virtually insignificant among healthy peopl ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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