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Acidity and basicity of drugs
Acidity and basicity of drugs

... membranes that line the gut, then it must be in its lipophilic unionised form to partition out of the aqueous ...
Alkylating Agents
Alkylating Agents

... injection may be administered via a side-arm drip. Post-treatment hydration: Adequate hydration and urinary output must be maintained during the 24 hours following infusion. It has been suggested that IV hydration continue after treatment with the aim to administer 2 litres of sodium chloride IV inf ...
Sex differences in the vulnerability to drug abuse
Sex differences in the vulnerability to drug abuse

... employ progressive ratio (PR) schedules and/or behavioral economic measures to determine the reinforcing effectiveness of the drug [19]. Additionally, modeling the escalation from steady-state maintenance patterns of drug intake to dysregulated and accelerated patterns of drug intake provides inform ...
Block of Delayed-Rectifier Potassium Channels by Reduced
Block of Delayed-Rectifier Potassium Channels by Reduced

Anticonvulsive Effect of Seed Extract of Caesalpinia bonducella
Anticonvulsive Effect of Seed Extract of Caesalpinia bonducella

... unaffordable, but also possess many toxic adverse effects. There is, therefore, a dire need for the development of cheap, effective and safe anticonvulsant agents from plants and other sources. In folk core medicine, C. bonducella seed oil is used in the treatment of convulsions and paralysis [15]. ...
pdf Educational Brief
pdf Educational Brief

... age, underlying pulmonary disease, severe obesity, kyphoscoliosis, paralysis of the phrenic nerve, or hepatic or renal disease); and those patients having their therapy initiated at a high dose (morphine or morphine-equivalent daily dosage >1 mg/day). Exposure to systemic opioids does not necessaril ...
Medication Use in Older Adults
Medication Use in Older Adults

... same schedule –Take the same amount of the medication but take it less often ▪Remind your providers that you have reduced kidney function when they prescribe medications ...
Chemo and endocrine
Chemo and endocrine

... progestins inhibit pglycoprotein, an effect that could enhance sensitivity to drugs such as doxorubicin. The apoptosis inhibitor Bcl-2 is down-regulated by tamoxifen, possibly enhancing sensitivity to drugs using this cell death pathway. ...
Mechanism of action
Mechanism of action

... • Result from the destruction of transplant by preformed antibodies, which are results of previous transplants or blood transfusion which leads to • Tissue damage can be mediated through antibodydependent, cell-mediated cytotoxicity or through activation of the complement cascade. • Decreased blood ...
Protonil Tablet - Renata Limited
Protonil Tablet - Renata Limited

... pantoprazole to pregnant women. However this drug should be used during pregnancy, only if clearly needed. The elderly: No problems with Pantoprzole have been encountered in clinical use in this patient group. Concurrent disease: No dosage adjustment of Pantoprazole is required in patients with mild ...
DIAZEPAM Oral Solution 5 mg per 5 mL DIAZEPAM
DIAZEPAM Oral Solution 5 mg per 5 mL DIAZEPAM

... Diazepam is not of value in the treatment of psychotic patients and should not be employed in lieu of appropriate treatment. As is true of most preparations containing CNS-acting drugs, pa­tients receiving diazepam should be cautioned against engaging in hazardous occupations re­quir­ing com­plete m ...
10 Facts About MDMA - Drug Policy Alliance
10 Facts About MDMA - Drug Policy Alliance

... cause harm than legal drugs like alcohol.16 Some researchers suggest that slight brain changes may result from heavy use, such as impacts on memory,17 but the evidence is far from conclusive.18 In fact, MDMA use alone does not appear to cause cognitive differences between people who use it and those ...
Glossary - CHRISTUS Health
Glossary - CHRISTUS Health

... Clinical Research Coordinator (CRC) - Site administer for the clinical study. Duties are delegated by the investigator. Also called research, study or healthcare coordinator, and data manager, research nurse or protocol nurse. Clinical Research - Study of drug, biologic or device in human subjects ...
DOES NEW MEAN BETTER
DOES NEW MEAN BETTER

... The differences between these agents are minimal. Unlike sildenafil, and for that matter vardenafil, tadalafil may increase the spontaneity of sexual activity due to its rapid onset and longer duration of action. Whether this translates into therapeutic benefit or increased adverse effects remains t ...
Treatment Guidelines HTN, DM, Hyperlipidemia
Treatment Guidelines HTN, DM, Hyperlipidemia

... American Heart Association (AHA) scientific statement as blood pressure that remains above goal in spite of concurrent use of three antihypertensive agents of different classes Thus, patients whose blood pressure is controlled with four or more medications should be considered to have resistant hype ...
THE KOREAN HERBAL PHARMACOPOEIA
THE KOREAN HERBAL PHARMACOPOEIA

... General Requirements for Pharmaceutical Preparations, and the provisions of General Tests and Assays for their conformity to the Korean Pharmacopoeia. However, absorbance, acidity or alkalinity, boiling point, congealing point, congealing point of fatty acid, crystal form, melting point, odor (excep ...
Guidelines for the medical management of patients with
Guidelines for the medical management of patients with

... Amphetamines are central nervous system stimulants with sympathomimetic and adrenergic agonist activity. Amphetamine administration increases mood, arousal and physical activity2-5 and produces an increase in heart rate and blood pressure.2,6-9 Both methamphetamine and its principal metabolite amphe ...
Benzodiazepines Dr A Battersby 16th March 2012
Benzodiazepines Dr A Battersby 16th March 2012

... • Initially thought to only cause dependence in high dose ...
Drugs for constipation and Diarrhoea
Drugs for constipation and Diarrhoea

... stool, accumulates fluids and fatty substance thus softening the stool. • Administered orally or as retention enema. • Should not be given with liquid paraffin, because increase absorption of it. ...
563-2180-2-SP - Iranian Journal of Kidney Diseases
563-2180-2-SP - Iranian Journal of Kidney Diseases

... (Figure 2).It is clear that combination therapy was not more effective than Losartan alone in decreasing of proteinuria in our studied patients. Discussion It is estimated that more than 150 million people suffer from type II diabetes and its complications. Its prevalence will be double fold during ...
New Psychoactive Substances
New Psychoactive Substances

... many parts of the world. The emergence of NPS (referring to a new substance that has not yet been scheduled under one of the international drug conventions) has lead to an extraordinary diversity of substances on the market available to new generations of users and raises some fundamental questions ...
Overdose in the Emergency Department
Overdose in the Emergency Department

...  5 y/o female that “is not acting right” after a phenergan suppository (flushed with dilated pupils)  Antidote for severe cases:  Physostigmine: inhibitor of acetylcholinesterase, the ...
1430_Zimmet_PL55E4
1430_Zimmet_PL55E4

... Polidocanol has been shown to have an embryocidal effect in rabbits when given in doses approximately equal (on the basis of body surface area) to the human dose. This effect may have been secondary to maternal toxicity. There are no adequate and wellcontrolled studies in pregnant women. Asclera sho ...
Primary Hypertension in Adults - Georgia Coastal Health District
Primary Hypertension in Adults - Georgia Coastal Health District

... Gradually titrate dosage until BP goes down, maximum dose is reached or side effects appear. Before increasing dosage(s) or changing drug(s), determine why a client is not responding to treatment. The main cause of resistant hypertension is nonadherence to therapy. If pressure reduction is not at go ...
DESIGNER DRUG AWARENESS PROJECT
DESIGNER DRUG AWARENESS PROJECT

... completely irrational, vomiting, seizures, coma, brain damage, death ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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