Drug-related morbidity and mortality: Pharmacoepidemiological aspects Anna K. Jönsson
... the patient as well as for society. Suspected ADRs have been reported to occur in about 214% of hospitalised patients. In about 5% of deceased hospitalised patients suspected ADRs may have caused or contributed to the fatal outcome. When a pharmaceutical drug is approved for marketing, the drug has ...
... the patient as well as for society. Suspected ADRs have been reported to occur in about 214% of hospitalised patients. In about 5% of deceased hospitalised patients suspected ADRs may have caused or contributed to the fatal outcome. When a pharmaceutical drug is approved for marketing, the drug has ...
Antidepressants - Dr BL Lim Centre for Psychological Wellness
... • SSRIs can cause Persistent Pulmonary Hypertension of the Newborn (PPNH), older antidepressants like TCAs safer in ...
... • SSRIs can cause Persistent Pulmonary Hypertension of the Newborn (PPNH), older antidepressants like TCAs safer in ...
Drug-like properties and the causes of poor solubility
... evolutionary pressures. Biological receptors evolved with a high degree of selectivity towards a ligand so as to minimize receptor cross-talk between agonists, thereby enhancing signal to noise ratio. This evolutionary trend translates into a high dimensional occupancy of biological receptors in che ...
... evolutionary pressures. Biological receptors evolved with a high degree of selectivity towards a ligand so as to minimize receptor cross-talk between agonists, thereby enhancing signal to noise ratio. This evolutionary trend translates into a high dimensional occupancy of biological receptors in che ...
Leptin Receptor Immunoreactivity in Chemically Defined Target
... LR-IR neurons were distributed widely in the rat brain. Incubation of sections from rat brain, including interalia choroid plexus, cerebral cortex, thalamus, and hypothalamus, with LR antiserum preabsorbed with control peptide, corresponding to amino acids 877– 894 mapping at the C terminus of LR of ...
... LR-IR neurons were distributed widely in the rat brain. Incubation of sections from rat brain, including interalia choroid plexus, cerebral cortex, thalamus, and hypothalamus, with LR antiserum preabsorbed with control peptide, corresponding to amino acids 877– 894 mapping at the C terminus of LR of ...
Neuronal basis of age-related working memory decline
... prefrontal cortex (PFC) dysfunction1–4. The PFC guides behaviour and thought using working memory5, which are essential functions in the information age. Many PFC neurons hold information in working memory through excitatory networks that can maintain persistent neuronal firing in the absence of ext ...
... prefrontal cortex (PFC) dysfunction1–4. The PFC guides behaviour and thought using working memory5, which are essential functions in the information age. Many PFC neurons hold information in working memory through excitatory networks that can maintain persistent neuronal firing in the absence of ext ...
6.4 METABOLIC REACTIONS OF ALCOHOLS 6.41
... appears to be due to the presence of alcohol dehydrogenase in the stomachs of males, but not females, resulting in significant conversion of ethanol into acetate before the ethanol is absorbed into the blood stream. There are also substantial variations in the level of aldehyde dehydrogenase. In gen ...
... appears to be due to the presence of alcohol dehydrogenase in the stomachs of males, but not females, resulting in significant conversion of ethanol into acetate before the ethanol is absorbed into the blood stream. There are also substantial variations in the level of aldehyde dehydrogenase. In gen ...
Modern Methods in Drug Discovery
... From within the plasma the drug has to reach other compartments, depending on its target. Substances that act on the central nervous system (CNS) have to cross the blood-brain barrier. Conversely, other drugs should not pass this barrier. ...
... From within the plasma the drug has to reach other compartments, depending on its target. Substances that act on the central nervous system (CNS) have to cross the blood-brain barrier. Conversely, other drugs should not pass this barrier. ...
Modern Methods in Drug Discovery - uni
... From within the plasma the drug has to reach other compartments, depending on its target. Substances that act on the central nervous system (CNS) have to cross the blood-brain barrier. Conversely, other drugs should not pass this barrier. ...
... From within the plasma the drug has to reach other compartments, depending on its target. Substances that act on the central nervous system (CNS) have to cross the blood-brain barrier. Conversely, other drugs should not pass this barrier. ...
Cardiac Arrhythmia - Thieme Medical Publishers
... leaves that taper off toward the base; they are trinervate and undivided. The color of the petals can range from purple to white. The purple color is darkest in Echinacea purpurea, which is why it bears that name. The expressed juice of the aerial parts of the blooming purple coneflower has been mos ...
... leaves that taper off toward the base; they are trinervate and undivided. The color of the petals can range from purple to white. The purple color is darkest in Echinacea purpurea, which is why it bears that name. The expressed juice of the aerial parts of the blooming purple coneflower has been mos ...
f''ou&-YE&& for ?ngqlotions DEGREE
... bromate, Pot' permanganate, Titanous chloride and Sodium 2,^6- di;hl;rophenol indophenol. ...
... bromate, Pot' permanganate, Titanous chloride and Sodium 2,^6- di;hl;rophenol indophenol. ...
Pre-Proposal Template
... please indicate the novelty/differentiation of this target or approach relevant to disease mechanism (if there are other treatments available, please describe why this is different – greater efficacy/safety etc.) ...
... please indicate the novelty/differentiation of this target or approach relevant to disease mechanism (if there are other treatments available, please describe why this is different – greater efficacy/safety etc.) ...
clozaril - GuildLink
... is complicated by the possibility of an increase background risk of diabetes mellitus in patients with schizophrenia and the increasing incidence of diabetes mellitus in the general population. Given these confounders, the relationship between atypical antipsychotic use and hyperglycaemia-related ad ...
... is complicated by the possibility of an increase background risk of diabetes mellitus in patients with schizophrenia and the increasing incidence of diabetes mellitus in the general population. Given these confounders, the relationship between atypical antipsychotic use and hyperglycaemia-related ad ...
File
... being surveyed. About 6,000 people a day in 2004 used marijuana for the first time—2.1 million Americans. Of these, 63.8% were under age 18. In the last half of 2003, marijuana was the third most commonly abused drug mentioned in drug-related hospital emergency department (ED) visits in the continen ...
... being surveyed. About 6,000 people a day in 2004 used marijuana for the first time—2.1 million Americans. Of these, 63.8% were under age 18. In the last half of 2003, marijuana was the third most commonly abused drug mentioned in drug-related hospital emergency department (ED) visits in the continen ...
Drug treatment of hypertensive emergencies
... rapid onset of action (5 minutes or less) makes it the only ß-blocker that is useful in the treatment of hypertensive emergencies. Labetalol is safe in patients with active coronary disease, since it does not increase the heart rate. On the other hand, labetalol should generally be avoided in patien ...
... rapid onset of action (5 minutes or less) makes it the only ß-blocker that is useful in the treatment of hypertensive emergencies. Labetalol is safe in patients with active coronary disease, since it does not increase the heart rate. On the other hand, labetalol should generally be avoided in patien ...
Biomedical Product Development
... as well as development activities carried on or supported in the pharmaceutical, biological, chemical, medical, and related sciences, including psychology and psychiatry, if the purpose of such activities is concerned ultimately with the utilization of scientific principles in understanding diseases ...
... as well as development activities carried on or supported in the pharmaceutical, biological, chemical, medical, and related sciences, including psychology and psychiatry, if the purpose of such activities is concerned ultimately with the utilization of scientific principles in understanding diseases ...
orodispersible_dosage_forms
... metabolism and can be an advantage in drugs that undergo a great deal of hepatic metabolism. However, if the amount of swallowed drug varies, there is the potential for inconsistent bioavailability. While the claimed increase in bioavailability is debatable, it is clear that the major advantage of t ...
... metabolism and can be an advantage in drugs that undergo a great deal of hepatic metabolism. However, if the amount of swallowed drug varies, there is the potential for inconsistent bioavailability. While the claimed increase in bioavailability is debatable, it is clear that the major advantage of t ...
PowerPoint - GRECC Audio
... for Stage 1, Simple Hypertension Begin with nonpharmacological approach – weight loss, exercise, salt restriction. Consider low dose diuretic as initial drug selection; an ACE inhibitor is an alternative. Base alternative drug selection or combination therapies on individual patient characteri ...
... for Stage 1, Simple Hypertension Begin with nonpharmacological approach – weight loss, exercise, salt restriction. Consider low dose diuretic as initial drug selection; an ACE inhibitor is an alternative. Base alternative drug selection or combination therapies on individual patient characteri ...
Epilepsy in elderly: Neelima Thakur, M.D.
... albumin and decreased of protein binding body fat Metabolism and excretion. hepatic metabolism renal clearance ...
... albumin and decreased of protein binding body fat Metabolism and excretion. hepatic metabolism renal clearance ...
Opiate Abuse 2011
... constituting only 4.6% of the world's population, have been consuming 80% of the global opioid supply, and 99% of the global hydrocodone supply, as well as two-thirds of the world's illegal drugs. With the increasing therapeutic use of opioids, the supply and retail sales of opioids are mirrored by ...
... constituting only 4.6% of the world's population, have been consuming 80% of the global opioid supply, and 99% of the global hydrocodone supply, as well as two-thirds of the world's illegal drugs. With the increasing therapeutic use of opioids, the supply and retail sales of opioids are mirrored by ...
Slides - Paradigm Outcomes
... Effectiveness of opioids in chronic pain Despite the marketing and extraordinary growth in sales... Lack of reliable long-term proof of effectiveness (>16 weeks)! ■ Neuropathic pain: Official Disability Guidelines: no reliable long-term studies. No studies on long-term use for neuropathic pain inclu ...
... Effectiveness of opioids in chronic pain Despite the marketing and extraordinary growth in sales... Lack of reliable long-term proof of effectiveness (>16 weeks)! ■ Neuropathic pain: Official Disability Guidelines: no reliable long-term studies. No studies on long-term use for neuropathic pain inclu ...
Isoniazid, rifampicin and pyrazinamide plasma concentrations 2 and
... than expected ranges, could therefore aid in avoiding drug resistance as well as unnecessary costs. In the case of PZA, the majority of our patients had concentrations within the target range, which is perhaps due to the wide reference range for PZA (20–50 μg /ml). The prevalence of low drug plasma ...
... than expected ranges, could therefore aid in avoiding drug resistance as well as unnecessary costs. In the case of PZA, the majority of our patients had concentrations within the target range, which is perhaps due to the wide reference range for PZA (20–50 μg /ml). The prevalence of low drug plasma ...
Gastroenterology
... Oesophageal clearance – gravity and peristalsis; peristaltic dysfunction sometimes occurs in GORD Hiatus hernia can impair oesophageal clearance Saliva contains bicarbonate to neutralize acid. Oesophageal mucosa – mucous, bicarbonate and prostaglandins are protective Ability to repair/heal also impo ...
... Oesophageal clearance – gravity and peristalsis; peristaltic dysfunction sometimes occurs in GORD Hiatus hernia can impair oesophageal clearance Saliva contains bicarbonate to neutralize acid. Oesophageal mucosa – mucous, bicarbonate and prostaglandins are protective Ability to repair/heal also impo ...
Antihypertensive Drugs 1
... Angiotensin receptor blockers Angiotensin II receptor blockers (ARBs) interfere with the renin-angiotensin system by impairing the binding of angiotensin II to the AT1 receptor on the cell membrane, thereby inhibiting the action of angiotensin II. Blockade of the action of angiotensin II leads to el ...
... Angiotensin receptor blockers Angiotensin II receptor blockers (ARBs) interfere with the renin-angiotensin system by impairing the binding of angiotensin II to the AT1 receptor on the cell membrane, thereby inhibiting the action of angiotensin II. Blockade of the action of angiotensin II leads to el ...