Neural and psychological mechanisms underlying compulsive drug
... greatly decreased. The second is an S-R mechanism by which reinforcers strengthen an association between the response and the contextual and discrete stimuli present at the time of reinforcement. Habitual behaviour controlled by this process is elicited automatically by CSs, rather than the represen ...
... greatly decreased. The second is an S-R mechanism by which reinforcers strengthen an association between the response and the contextual and discrete stimuli present at the time of reinforcement. Habitual behaviour controlled by this process is elicited automatically by CSs, rather than the represen ...
11-1 Investigational Drug Research
... pharmacologic actions of the drug in humans, the side effects associated with increasing doses, and if possible, to gain early evidence on effectiveness. During Phase 1, sufficient information about the drug’s pharmacokinetics and pharmacological effects should be obtained to permit the design of we ...
... pharmacologic actions of the drug in humans, the side effects associated with increasing doses, and if possible, to gain early evidence on effectiveness. During Phase 1, sufficient information about the drug’s pharmacokinetics and pharmacological effects should be obtained to permit the design of we ...
DiphenhydrAMINE Hydrochloride Injection, USP
... Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid an ...
... Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid an ...
Pharmacokinetics, Pharmacodynamics, and
... The aforementioned data are representative of the degree of variability in enteric absorption that could be expected on the parts of critically patients. Taken together, the data further confirm that enteral absorption of drugs in critically ill patients is highly erratic. If possible, enteral route ...
... The aforementioned data are representative of the degree of variability in enteric absorption that could be expected on the parts of critically patients. Taken together, the data further confirm that enteral absorption of drugs in critically ill patients is highly erratic. If possible, enteral route ...
Oral Fluid Drug Screen Device
... The drug class opiates refers to any drug that is derived from the opium poppy, including naturally occurring compounds such as morphine and codeine and semi-synthetic drugs such as heroin. Opiates act to control pain by depressing the central nervous system. The drugs demonstrate addictive properti ...
... The drug class opiates refers to any drug that is derived from the opium poppy, including naturally occurring compounds such as morphine and codeine and semi-synthetic drugs such as heroin. Opiates act to control pain by depressing the central nervous system. The drugs demonstrate addictive properti ...
Innovative approaches to anti-arrhythmic drug
... Figure 1 | Electrical functioning of the heart. a | Normal heart. The heart has its own pacemaker: the sino-atrial node (SAN), which produces regular electrical impulses at an appropriate rate (normally 60–100 per min, but faster in situations of stress). The impulse spreads across the right atrium ...
... Figure 1 | Electrical functioning of the heart. a | Normal heart. The heart has its own pacemaker: the sino-atrial node (SAN), which produces regular electrical impulses at an appropriate rate (normally 60–100 per min, but faster in situations of stress). The impulse spreads across the right atrium ...
Cilansetron - Open Access Journals
... of ischemic colitis. To date, the few suspected ischemic colitis events associated with cilansetron have resolved within 30 days of drug discontinuation, without any complications. Epidemiologic studies indicate that patients with IBS have a greater risk of ischemic colitis, irrespective of treatmen ...
... of ischemic colitis. To date, the few suspected ischemic colitis events associated with cilansetron have resolved within 30 days of drug discontinuation, without any complications. Epidemiologic studies indicate that patients with IBS have a greater risk of ischemic colitis, irrespective of treatmen ...
Biomarkers and surrogate endpoints: How and when might they
... To increase the efficiency and quality of clinical development, pharmaceutical companies seek to improve their screening processes for NMEs by making critical go/no go decisions early in drug development. If the NME does not demonstrate the proof-of-concept in an appropriatedly designed early clinic ...
... To increase the efficiency and quality of clinical development, pharmaceutical companies seek to improve their screening processes for NMEs by making critical go/no go decisions early in drug development. If the NME does not demonstrate the proof-of-concept in an appropriatedly designed early clinic ...
Grace Davis
... This is due to the “switch” between a depressed episode and a manic episode Antidepressants can induce the “switch” to occur SSRIs and bupropion are less likely to induce Mood Stabilizers such as Lamictal (lamotrigine) ...
... This is due to the “switch” between a depressed episode and a manic episode Antidepressants can induce the “switch” to occur SSRIs and bupropion are less likely to induce Mood Stabilizers such as Lamictal (lamotrigine) ...
Information for Residential Care Staff Handling Cytotoxic Drugs
... Ensure all staff at the Residential Care Facility (nurses, kitchen, cleaning staff, etc.) are aware the patient is receiving chemotherapy, (have a coloured cytotoxic label in the patient’s room). Store chemotherapy as per the directions of your pharmacist. Wear Personal Protective Equipment (PPE) i. ...
... Ensure all staff at the Residential Care Facility (nurses, kitchen, cleaning staff, etc.) are aware the patient is receiving chemotherapy, (have a coloured cytotoxic label in the patient’s room). Store chemotherapy as per the directions of your pharmacist. Wear Personal Protective Equipment (PPE) i. ...
MAXALT® MAXALT-MLT™
... Current theories on the etiology of migraine headache suggest that symptoms are due to local cranial vasodilatation and/or to the release of vasoactive and pro-inflammatory peptides from sensory nerve endings in an activated trigeminal system. The therapeutic activity of rizatriptan in migraine can ...
... Current theories on the etiology of migraine headache suggest that symptoms are due to local cranial vasodilatation and/or to the release of vasoactive and pro-inflammatory peptides from sensory nerve endings in an activated trigeminal system. The therapeutic activity of rizatriptan in migraine can ...
Parrish Waters
... by drug seeking behavior) in rats. Humans report an increase in relapse when confronted with stressful situations. In animal studies stress induced relapse has limitations. It is context dependent. • Footshock must be applied in the lever box The stress must be negative • Sexual stimulation (stress ...
... by drug seeking behavior) in rats. Humans report an increase in relapse when confronted with stressful situations. In animal studies stress induced relapse has limitations. It is context dependent. • Footshock must be applied in the lever box The stress must be negative • Sexual stimulation (stress ...
CorkMaternityNovembe
... Poor adherence and persistence in chronic disease Poor persistence in prevention of osteoporosis Medical model does not sit with the theory of concordance Taking medicines according to the instructions Unintentional drug misadventure e.g., nebulisers and inhalers Completing the course of drug therap ...
... Poor adherence and persistence in chronic disease Poor persistence in prevention of osteoporosis Medical model does not sit with the theory of concordance Taking medicines according to the instructions Unintentional drug misadventure e.g., nebulisers and inhalers Completing the course of drug therap ...
Exercise, Ethanol, and Disease
... “freed the body from fatigue, lifted the spirits, and caused a sense of well-being”. The Pope even gave Mariani a medal for his contributions to society and the use of cocaine was endorsed by many physicians and national leaders before the turn of the century (Czar/Czarina of Russia, Prince of Wales ...
... “freed the body from fatigue, lifted the spirits, and caused a sense of well-being”. The Pope even gave Mariani a medal for his contributions to society and the use of cocaine was endorsed by many physicians and national leaders before the turn of the century (Czar/Czarina of Russia, Prince of Wales ...
Chapter 16 Cholinesterase Inhibitors
... Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. ...
... Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. ...
Conducting Stability Studies
... lots of approved products are retained for stability testing in case of product failures or production process changes. Retained samples can be tested alongside returned samples to determine whether the root cause of the problem was manufacturing or storage related. ...
... lots of approved products are retained for stability testing in case of product failures or production process changes. Retained samples can be tested alongside returned samples to determine whether the root cause of the problem was manufacturing or storage related. ...
Milk Thistle Drug Interactions
... fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp Glucuronidation Milk thistle has been shown in vitro to be (ABCB1), although there is other evidence a potent inhibitor for enzymes responsible of inhibition. Inhibition of glucuronidafor glucuronidation, alth ...
... fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp Glucuronidation Milk thistle has been shown in vitro to be (ABCB1), although there is other evidence a potent inhibitor for enzymes responsible of inhibition. Inhibition of glucuronidafor glucuronidation, alth ...
Meditation - an Effective Treatment Mode for Substance Use
... referred to as “drug addiction” is characterized by physiological dependence accompanied by the withdrawal syndrome on discontinuance of the drug use, psychological dependence with craving, the pathological motivational state that leads to the active drug-seeking behavior, and tolerance, expressed i ...
... referred to as “drug addiction” is characterized by physiological dependence accompanied by the withdrawal syndrome on discontinuance of the drug use, psychological dependence with craving, the pathological motivational state that leads to the active drug-seeking behavior, and tolerance, expressed i ...
IN SITU OF PILOCARPINE Research Article
... solidified into a white semi-transparent hydrogel at body temperature. Gelation properties determine the ability of polymeric system to undergo transition from sol to gel state in response to environmental variables like temperature, pH, pressure, ions etc. The particular temperature when the system ...
... solidified into a white semi-transparent hydrogel at body temperature. Gelation properties determine the ability of polymeric system to undergo transition from sol to gel state in response to environmental variables like temperature, pH, pressure, ions etc. The particular temperature when the system ...
Telenzepine is at least 25 times more potent than pirenzepine
... and of 50 mg pirenzepine (p_0-01). On a molar basis telenzepine proved to be about 25 times more potent than pirenzepine to inhibit acid output. Mean peptone volumes which had to be added during the secretory studies did not show significant differences within the test with pirenzepine or telenzepin ...
... and of 50 mg pirenzepine (p_0-01). On a molar basis telenzepine proved to be about 25 times more potent than pirenzepine to inhibit acid output. Mean peptone volumes which had to be added during the secretory studies did not show significant differences within the test with pirenzepine or telenzepin ...
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) AND
... resources on behalf of their patients. These resources include not only interventions provided by themselves but also those offered by other health-related disciplines. Most patients presenting for physiotherapy treatment have received, or are are currently receiving, some form of pharmacotherapy of ...
... resources on behalf of their patients. These resources include not only interventions provided by themselves but also those offered by other health-related disciplines. Most patients presenting for physiotherapy treatment have received, or are are currently receiving, some form of pharmacotherapy of ...
Fluoroquinolone resistance in mycobacterium tuberculosis strains
... pneumonia, have TB and the use of fluoroquinolones in these patients may not only delay the diagnosis of TB but also stimulate the development of fluoroqunilones resistance in MTB. This study was done to check whether there is fluoroquinolone resistance in MTB strains isolated in Kenya. Materials an ...
... pneumonia, have TB and the use of fluoroquinolones in these patients may not only delay the diagnosis of TB but also stimulate the development of fluoroqunilones resistance in MTB. This study was done to check whether there is fluoroquinolone resistance in MTB strains isolated in Kenya. Materials an ...
Hospital brochure - LMA™ Better by design
... Accurate dosing The syringe enables the accurate measurement of drugs to be delivered. ...
... Accurate dosing The syringe enables the accurate measurement of drugs to be delivered. ...
Principles of Clinical Trials Introduction and Learning Objectives
... ClinicalTrials.gov. FDAAA 801 Requirements. US National Institutes of Health; 2012. Dagher R et al. In: Gad SC. Clinical Trials Handbook. John Wiley & Sons, Inc.; 2009:1153–1171. Gray B et al. Health Aff. 2012;31:140–149. Holford N et al. Clin Pharmacol Ther. 2010;88:166–182. Husereau D et al. Clin ...
... ClinicalTrials.gov. FDAAA 801 Requirements. US National Institutes of Health; 2012. Dagher R et al. In: Gad SC. Clinical Trials Handbook. John Wiley & Sons, Inc.; 2009:1153–1171. Gray B et al. Health Aff. 2012;31:140–149. Holford N et al. Clin Pharmacol Ther. 2010;88:166–182. Husereau D et al. Clin ...