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SENIOR: Solifenacin (VESICARE) vs Oxybutynin
SENIOR: Solifenacin (VESICARE) vs Oxybutynin

... At first glance this trial appears to support the use of solifenacin over oxybutynin because of their differing effects on cognition in  elderly people with MCI. However, this is somewhat misleading as there was no difference in the primary end‐point studied. There is  some potential for differences ...
drug-free school and workplace - New Professions Technical Institute
drug-free school and workplace - New Professions Technical Institute

... e) a clear statement that the institution will impose sanctions on students and employees (consistent with local, State and Federal Law), and a description of those sanctions, up to and including expulsion or termination of employment and referral for prosecution, for violations of the standards of ...
Drugged Driving Expert Panel Report
Drugged Driving Expert Panel Report

... efforts as “laudable attempts to synthesize the results of very many and methodologically different studies into a few paragraphs that are simple to understand” (p. 55). Unfortunately, this necessitates some generalizations that are often not very accurate, and often describe the effects of differen ...
Alepam - Medicines.org.au
Alepam - Medicines.org.au

... Oxazepam is an anti-anxiety agent which belongs to the benzodiazepine class of drugs. The exact mechanism of action of benzodiazepines has not yet been elucidated; however, benzodiazepines appear to work through several mechanisms. Benzodiazepines presumably exert their effects by binding to specifi ...
Non-Clinical Investigation of the Dependence Potential of Medicinal
Non-Clinical Investigation of the Dependence Potential of Medicinal

... The choice of the model used should be justified based on the biochemical, pharmacological and clinical information already available. Pharmaceutical, pharmacokinetic and physico-chemical characteristics of the product may also influence the choice of the model. Specific aspects of dependence potent ...
FORMULATION AND OPTIMIZATION OF OCULAR POLY-D, L-LACTIC ACID NANO DRUG
FORMULATION AND OPTIMIZATION OF OCULAR POLY-D, L-LACTIC ACID NANO DRUG

... prepare colloidal nanosuspension of desired characteristics, which could improve therapeutic effect of ocular AmB. In vitro release, antimicrobial activity and in vivo ocular tolerability were also examined. ...
R D ESEARCH AND EVELOPMENT
R D ESEARCH AND EVELOPMENT

... raise ethical problems. For the time being, the descriptors obtained at a very early stage are mainly those predicting the pharmacokinetics of drugs (via their metabolism genetically determined by cytochromes P450 and their transport). The intermediate situation in which the descriptor is identified ...
FORMULATION AND EVALUATION OF OLMESARTAN MEDOXOMIL FLOATING TABLETS
FORMULATION AND EVALUATION OF OLMESARTAN MEDOXOMIL FLOATING TABLETS

... &F5).HPMC tablet when in contact with the dissolution medium swell due to the breakage of hydrogen bond between the polymer chain and form a thick gel layer and eroded simultaneously. This result indicated that the swelling index of the all formulation changed after 12hrs. The formulation containing ...
What is the risk of developing Serotonin Syndrome following
What is the risk of developing Serotonin Syndrome following

... Answer: Tramadol is a centrally acting analgesic structurally related to codeine and morphine. It is an agonist of the µ opioid receptor. In addition, tramadol inhibits serotonin reuptake and norepinephrine reuptake, enhancing inhibitory effects on pain transmission in the spinal cord (4). Tramadol ...
"פורמט עלון זה נקבע ע"י משרד הבריאות ותוכנו נבדק ואושר"
"פורמט עלון זה נקבע ע"י משרד הבריאות ותוכנו נבדק ואושר"

... The symptoms of toxicity from papaverine hydrochloride often result from vasomotor instability and include nausea, vomiting, weakness, central nervous system depression, nystagmus, diplopia, diaphoresis, flushing, dizziness, and sinus tachycardia. In large overdoses papaverine is a potent inhibitor ...
FORMULATION AND EVALUATION OF ATENOLOL ORODISPERSIBLE TABLETS BY PHASE TRANSITION TECHNOLOGY
FORMULATION AND EVALUATION OF ATENOLOL ORODISPERSIBLE TABLETS BY PHASE TRANSITION TECHNOLOGY

... median pore size of the tablets was increased and tablet hardness was also increased. Heating process enhances the bonding among particles leading to sufficient hardness of tablets which was otherwise lacking owing to low/little compactibility. Atenolol, a β1-blocker, is prescribed widely in diverse ...
Full Text Article - European Journal of Pharmaceutical and Medical
Full Text Article - European Journal of Pharmaceutical and Medical

... skin coloured or erythematous and occurs at areas where the skin is lax. It is generally self limiting but may sometimes result in respiratory tract obstruction, which can prove fatal.[1] Drug induced angioedema without urticaria has a prevalence of 2.3% among patients with adverse drug reactions. V ...
HYPNODORM ®
HYPNODORM ®

... Due to the slight accumulation of flunitrazepam in the plasma,a 2 mg dose of flunitrazepam should not be administered on a daily basis to patients involved in activities requiring concentration during the early part of the day. Severe allergic reactions Rare cases of angioedema involving the tongue, ...
PBG Report – PBI Feldetrex
PBG Report – PBI Feldetrex

... Stakeholder  Assessment  –  Current  Treatment  Overview  for  FM   •  PaBent  response  to  currently  approved  drugs  is  “fairly  well”.  Individual  efficacy   is  just  “fair”.   •  Major  drawback  of  current  medicaBon  is  that  they ...
4427 Naltrexone/Carers.NSW
4427 Naltrexone/Carers.NSW

use
use

... also contains lignans are phenylpropanoid dimers with antioxidant and free radical scavanging properties  present in many plants but especially soy beans and flaxseed and red clover  Some evidence that ingestion of lignans may decrease risk of some cancers (breast)  act like phytoestrogens ...
Sedative-Hypnotics/Alcohol Withdrawal
Sedative-Hypnotics/Alcohol Withdrawal

... PHARMACOLOGY Benzodiazepines ...
Alcohol-related Drug Interactions
Alcohol-related Drug Interactions

... liver by several enzymes. The most important enzymes are aldehyde dehydrogenase and CYP2E1. In people consuming alcohol only occasionally, CYP2E1 metabolizes only a small fraction of the ingested alcohol. In contrast, chronic heavy drinking can increase CYP2E1 activity up to ten-fold, resulting in h ...
Brain death
Brain death

... Look closely for respiratory movement (abdominal or chest excursions that produce adequate tidal volumes) Measure arterial P o2, Pco2 and pH after approximately 8 min and reconnect the ventilar. If respiratory movement are absent and arterial Pco2 is >60mmHg; the apnea test is (+)  support brainste ...
Rx Deplete+Interactions
Rx Deplete+Interactions

... This booklet provides information to help you learn which vitamins and/or minerals are depleted by your medications. It also provides a general list of supplements that might be expected to interact with the drug, and thus need to be avoided while taking these drugs. You can use the “find” function ...
Benzodiazepines (not including sedative/hypnotics*)
Benzodiazepines (not including sedative/hypnotics*)

... the potential for dependence. Unlike anxiety disorder patients, patients with panic disorder are less successful at discontinuing benzodiazepine therapy. Additionally, there is a high prevalence of comorbid depression and/or bipolar disorder in patients with panic disorder. Benzodiazepines are less ...
Absorica - Blue Cross Blue Shield of Arizona
Absorica - Blue Cross Blue Shield of Arizona

... A single course of therapy for 15 to 20 weeks has been shown to result in complete and prolonged remission of disease in many patients. If a second course of therapy is needed, it should not be initiated until at least 8 weeks after completion of the first course, because experience has shown that p ...
Study of the Pepsin Enzymatic Activity in in
Study of the Pepsin Enzymatic Activity in in

... oral drugs in the solid form depends on the solubility and dissolution in physiologic liquids and its permeability through the gastrointestinal tract (Ferraz et al. 2007; FDA, 1997; Manadas, et al. 2002; Pita et al., 2004), factors that influence directly its bioavailability and subsequent pharmacol ...


... distribution experiment, irinotecan dosed at 60mg/kg retained 30nM at 24h and no quantifiable drug was found at 72h in ...
fast dissolving tablets: preparation, characterization and evaluation
fast dissolving tablets: preparation, characterization and evaluation

... forms existing today because of ease of self administration ,compact in nature, easy to manufacture and it can be deliver in accurate dose. One important drawback of solid dosage forms is the difficulty in swallowing (dysphagia) or chewing in some patients particularly pediatric and geriatric patien ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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