Methadone - Center for Substance Abuse Research
... “maintenance” is used in describing these programs because the goal is to “maintain” a narcotics abuser for the purpose of helping him or her avoid the negative and sometimes severe withdrawal symptoms.17 This type of treatment views addiction as a disease rather than a psychological disorder or cha ...
... “maintenance” is used in describing these programs because the goal is to “maintain” a narcotics abuser for the purpose of helping him or her avoid the negative and sometimes severe withdrawal symptoms.17 This type of treatment views addiction as a disease rather than a psychological disorder or cha ...
Synapses with short-term plasticity are optimal
... As a first step, we concentrated on the interaction between a pair of cells and on reproducing as close an estimate as possible to the exact presynaptic membrane potential on the postsynaptic side. Of course, vt can be changed by many factors other than synaptic currents, such as voltage signals pro ...
... As a first step, we concentrated on the interaction between a pair of cells and on reproducing as close an estimate as possible to the exact presynaptic membrane potential on the postsynaptic side. Of course, vt can be changed by many factors other than synaptic currents, such as voltage signals pro ...
- MIT Press Journals
... attempt to gain some insights into the mechanisms involved. Psilocybin, the main hallucinogenic compound found in Psilocybe mushrooms, is the primary focus of this study as it is known to transiently alter an individual’s cognitive and perceptual state (Carter, Pettigrew, Hasler, et al., 2005; Carte ...
... attempt to gain some insights into the mechanisms involved. Psilocybin, the main hallucinogenic compound found in Psilocybe mushrooms, is the primary focus of this study as it is known to transiently alter an individual’s cognitive and perceptual state (Carter, Pettigrew, Hasler, et al., 2005; Carte ...
Analgesia and sedation in emergency situations and in the pediatric
... these doses are more effective at obtaining an artificial airway than conventional doses. Temporary hypotension is observed even in hemodynamically stable patients. Propofol was also used for short-term and long-term sedation in pediatric intensive care units. 23 However, the use was suspended due t ...
... these doses are more effective at obtaining an artificial airway than conventional doses. Temporary hypotension is observed even in hemodynamically stable patients. Propofol was also used for short-term and long-term sedation in pediatric intensive care units. 23 However, the use was suspended due t ...
PDF(104KB)
... Thermal analysis techniques such as TGA, DSC and Modulated DSC® should be the fastest and most reliable way to detect drug-excipient incompatibility because they have extremely high sensitivity for detecting changes in composition, thermal stability and structure. However, thermal analysis is seldom ...
... Thermal analysis techniques such as TGA, DSC and Modulated DSC® should be the fastest and most reliable way to detect drug-excipient incompatibility because they have extremely high sensitivity for detecting changes in composition, thermal stability and structure. However, thermal analysis is seldom ...
Potential Herb-Drug Interactions for Commonly
... as much as 40%. All maintained an undetectable viral load. (Patients were also taking a low dose of ritonavir.)42 ...
... as much as 40%. All maintained an undetectable viral load. (Patients were also taking a low dose of ritonavir.)42 ...
drug product distribution requirements for pharmacy
... This document has two lists: Professional Service Area Items (Schedule II) and Professional Products Area Items (Schedule III). Within each list, drugs are categorized according to their common indications for use. These lists are meant to be used as a resource and are not exhaustive. The Drug Sched ...
... This document has two lists: Professional Service Area Items (Schedule II) and Professional Products Area Items (Schedule III). Within each list, drugs are categorized according to their common indications for use. These lists are meant to be used as a resource and are not exhaustive. The Drug Sched ...
PDF full-Text - Journal of Investigational Allergology and Clinical
... antihistamines on real driving Over 25 years ago, in Maastrich (Netherlands), a standardized test was made on driving in normal trafÀc [45] and, since then, numerous double blind studies have been carried out against placebo and active comparatives in healthy volunteers. The studies take place with ...
... antihistamines on real driving Over 25 years ago, in Maastrich (Netherlands), a standardized test was made on driving in normal trafÀc [45] and, since then, numerous double blind studies have been carried out against placebo and active comparatives in healthy volunteers. The studies take place with ...
DEVELOPMENT AND INVITRO EVALUATION OF SALBUTAMOL SULPHATE MUCOADHESIVE BUCCAL PATCHES
... effective plasma levels. Because of the low tissue permeability for compounds such as peptides, buccal administration is then often ranked as less effective when compared to nasal delivery, and better than transdermal delivery. In the case of a sufficiently potent pepti ...
... effective plasma levels. Because of the low tissue permeability for compounds such as peptides, buccal administration is then often ranked as less effective when compared to nasal delivery, and better than transdermal delivery. In the case of a sufficiently potent pepti ...
Pharmacokinetics Warfarin
... • A patient taking Cefdinir may experience a lowering of her INR due to the gut flora being altered. False (INR would be increased) • The interaction of aspirin and warfarin is due to warfarin being displaced from protein binding sites causing an increased INR. False (It doesn’t displace binding sit ...
... • A patient taking Cefdinir may experience a lowering of her INR due to the gut flora being altered. False (INR would be increased) • The interaction of aspirin and warfarin is due to warfarin being displaced from protein binding sites causing an increased INR. False (It doesn’t displace binding sit ...
Medications in Pregnancy and Lactation
... Pregnancy risk factors together with an increased incidence of chronic diseases and the rise in mean maternal age predict an increase in medication use during gestation. However, as highlighted in the first installment of this series, relatively few medications have specifically been tested for safe ...
... Pregnancy risk factors together with an increased incidence of chronic diseases and the rise in mean maternal age predict an increase in medication use during gestation. However, as highlighted in the first installment of this series, relatively few medications have specifically been tested for safe ...
Pharmacological Approaches to Fat Loss: Targeting
... Lets go back and take a closer look at these steps. In Step One, it is important to realize that ephedrine does not interact directly with adrenergic receptors. It is through its effects on the release of NA that ephedrine increases adrenergic activity.1 This was determined by examining the effects ...
... Lets go back and take a closer look at these steps. In Step One, it is important to realize that ephedrine does not interact directly with adrenergic receptors. It is through its effects on the release of NA that ephedrine increases adrenergic activity.1 This was determined by examining the effects ...
Dose translation from animal to human studies revisited
... to adjust an individual patient’s drug dose clouds the use of BSA for allometric conversion of doses and creates confusion in the scientific community as well as in the media. When animal studies such as those involving resveratrol are completed and media reports distort the dose translation between ...
... to adjust an individual patient’s drug dose clouds the use of BSA for allometric conversion of doses and creates confusion in the scientific community as well as in the media. When animal studies such as those involving resveratrol are completed and media reports distort the dose translation between ...
Methylergonovine Maleate Injection, USP (0.2 mg/ml)
... Clinical studies of methylergonovine maleate did not include sufficient number of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in response between the elderly and younger patients. In ...
... Clinical studies of methylergonovine maleate did not include sufficient number of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in response between the elderly and younger patients. In ...
A functional dissociation of the anterior and posterior
... Abstract Excitotoxic lesions of posterior, but not anterior pedunculopontine tegmental nucleus (PPTg) change nicotine self-administration, consistent with the belief that the anterior PPTg (aPPTg) projects to substantia nigra pars compacta (SNC) and posterior PPTg (pPPTg) to the ventral tegmental ar ...
... Abstract Excitotoxic lesions of posterior, but not anterior pedunculopontine tegmental nucleus (PPTg) change nicotine self-administration, consistent with the belief that the anterior PPTg (aPPTg) projects to substantia nigra pars compacta (SNC) and posterior PPTg (pPPTg) to the ventral tegmental ar ...
International Journal of Biomedical and Advance Research
... outermost layer, the epidermis, is approximately 100 to 150 micrometers thick, has no blood flow and includes a layer within it known as the stratum corneum. This is the layer most important to transdermal delivery as its composition allows it to keep water within the body and foreign substances out ...
... outermost layer, the epidermis, is approximately 100 to 150 micrometers thick, has no blood flow and includes a layer within it known as the stratum corneum. This is the layer most important to transdermal delivery as its composition allows it to keep water within the body and foreign substances out ...
Haloperidol and Slot Machine Gambling
... unclear. Dopamine (DA) mediates aspects of instrumental responding, and D2 antagonists reliably alter this process. This study investigated the effects of the preferential D2 antagonist, haloperidol (3 mg) on reward-related betting behavior in 20 subjects with pathological gambling (PG) and 18 healt ...
... unclear. Dopamine (DA) mediates aspects of instrumental responding, and D2 antagonists reliably alter this process. This study investigated the effects of the preferential D2 antagonist, haloperidol (3 mg) on reward-related betting behavior in 20 subjects with pathological gambling (PG) and 18 healt ...
LONGRANGE® (eprinomectin) and IVOMEC® (ivermectin) Brand
... The macrocyclic lactones have a unique mode of action. Compounds of this class bind selectively and with high affinity to glutamate-gated chloride ion channels that are present in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions ...
... The macrocyclic lactones have a unique mode of action. Compounds of this class bind selectively and with high affinity to glutamate-gated chloride ion channels that are present in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions ...
Anesthetics-3
... rapidly crosses blood brain barrier and if given sufficient dosage, produces hypnosis in one circulation time. Similar drugs such as thiamylal and methohexital, causes plasma brain equilibrium occurs rapidly( within 1 min) because of high lipid solubility. ...
... rapidly crosses blood brain barrier and if given sufficient dosage, produces hypnosis in one circulation time. Similar drugs such as thiamylal and methohexital, causes plasma brain equilibrium occurs rapidly( within 1 min) because of high lipid solubility. ...
50 animal models relevant to schizophrenia disorders
... this approach has been termed pharmacologic isomorphism (2). The fact that such models are developed and validated by reference to the effects of known therapeutic drugs frequently limits their ability to identify new drugs with novel mechanisms of action. Similarly, an important limitation inherent ...
... this approach has been termed pharmacologic isomorphism (2). The fact that such models are developed and validated by reference to the effects of known therapeutic drugs frequently limits their ability to identify new drugs with novel mechanisms of action. Similarly, an important limitation inherent ...
A Case Study
... only on-off control of psychiatric symptoms as micronutrients are consumed or withdrawn, but also simultaneous on-off use of cannabis and cigarettes, despite not directly targeting this substance use as part of the treatment protocol. This case adds to a growing body of research supporting the use o ...
... only on-off control of psychiatric symptoms as micronutrients are consumed or withdrawn, but also simultaneous on-off use of cannabis and cigarettes, despite not directly targeting this substance use as part of the treatment protocol. This case adds to a growing body of research supporting the use o ...
Next Generation Therapeutics for Disorders of Complement
... acids and cyclization to increase stability, potency, cell permeability, and bioavailability Rapid lead generation capabilities Utility ...
... acids and cyclization to increase stability, potency, cell permeability, and bioavailability Rapid lead generation capabilities Utility ...