PLGA-Alendronate Conjugate as a New Biomaterial
... A number of drugs are effective for the treatment of bone tumours, but their systemic delivery is inevitably associated with significant side effects and lack of targeting. Thereby, targeting specific biochemical patterns inside bone cancer areas may theoretically provide a mean to improve the effic ...
... A number of drugs are effective for the treatment of bone tumours, but their systemic delivery is inevitably associated with significant side effects and lack of targeting. Thereby, targeting specific biochemical patterns inside bone cancer areas may theoretically provide a mean to improve the effic ...
... after surgery (fig. 1). These eight patients were later given mebendazole. Twenty eight patients were given only mebendazole treatment. One patient had a history of expectoration of cyst contents and chest X-ray revealed a perforated cyst. After two years, in which he could not be followed, he was s ...
Morphine Sulphate MOR Drugs
... injured patients is a clinical one. It is essential however, that any such patient who receives analgesia is closely monitored as opiates may cause disproportionate respiratory depression and hence increase intracranial pressure. Acute alcohol intoxication. All opioid drugs potentiate the central ne ...
... injured patients is a clinical one. It is essential however, that any such patient who receives analgesia is closely monitored as opiates may cause disproportionate respiratory depression and hence increase intracranial pressure. Acute alcohol intoxication. All opioid drugs potentiate the central ne ...
coleus amboinicus lour. - Journal of Ayurveda and Holistic Medicine
... microscopical evaluation along with estimation of its physico-chemical parameters such as ash value, extractive values and preliminary phytochemical screening. Results: Preliminary phytochemical screening showed the presence of carbohydrate, alkaloids, protein, glycosides & phenolic compounds. Concl ...
... microscopical evaluation along with estimation of its physico-chemical parameters such as ash value, extractive values and preliminary phytochemical screening. Results: Preliminary phytochemical screening showed the presence of carbohydrate, alkaloids, protein, glycosides & phenolic compounds. Concl ...
GHB: An Important Pharmacologic and Clinical Update
... GABA. Studies suggest that GHB does not consistently affect GABA A or GABA B induced responses.18 However, the data is conflicting.2, 15-19 GHB does not appear to be a GABA prodrug or a GABA agonist. Yet the GHB precursor, Gamma-butyrolactone (GBL), may have limited GABA agonist activity.18 One theo ...
... GABA. Studies suggest that GHB does not consistently affect GABA A or GABA B induced responses.18 However, the data is conflicting.2, 15-19 GHB does not appear to be a GABA prodrug or a GABA agonist. Yet the GHB precursor, Gamma-butyrolactone (GBL), may have limited GABA agonist activity.18 One theo ...
Dose-Response Study of N,N-Dimethyltryptamine in Humans
... Visual imagery predominated in all subjects. At this dose, there was little difference between what was "seen" with eyes opened or closed. Examples of this phenomena included the following comments. "I tried closing my eyes but I saw the same things with my eyes closed as I did with them open." "(Th ...
... Visual imagery predominated in all subjects. At this dose, there was little difference between what was "seen" with eyes opened or closed. Examples of this phenomena included the following comments. "I tried closing my eyes but I saw the same things with my eyes closed as I did with them open." "(Th ...
Tegretol Tegretol -XR WARNINGS
... taking these drugs for any indication. Patients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior. Pooled analyses of 199 placebo-controlled clinical trials (mono- an ...
... taking these drugs for any indication. Patients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior. Pooled analyses of 199 placebo-controlled clinical trials (mono- an ...
full Prescribing Information
... Case reports suggest that patients can experience intense urges to gamble, increased sexual urges, intense urges to spend money, binge eating, and/or other intense urges, and the inability to control these urges while taking one or more of the medications, including RYTARY, that increase central dop ...
... Case reports suggest that patients can experience intense urges to gamble, increased sexual urges, intense urges to spend money, binge eating, and/or other intense urges, and the inability to control these urges while taking one or more of the medications, including RYTARY, that increase central dop ...
Identifying Pseudobulbar Affect in Alzheimer`s
... exploration. However, this apparently sensible and pragmatic thinking is flawed, since it risks overlooking a major cause of such symptoms —pseudobulbar affect (PBA). Affecting as many as two in five people with AD 5,6—but widely under-recognized by clinicians—this important condition must be consid ...
... exploration. However, this apparently sensible and pragmatic thinking is flawed, since it risks overlooking a major cause of such symptoms —pseudobulbar affect (PBA). Affecting as many as two in five people with AD 5,6—but widely under-recognized by clinicians—this important condition must be consid ...
Vioxx Report.indd - The Physicians Committee
... Juni and colleagues identified a 2.24–2.30 relative risk for heart attack among rofecoxib patients (9). Relative risk was consistent whether rofecoxib was compared to a placebo, naproxen, or another nonsteroidal anti-inflammatory drug (NSAID). Juni’s analysis also demonstrated that there was little if ...
... Juni and colleagues identified a 2.24–2.30 relative risk for heart attack among rofecoxib patients (9). Relative risk was consistent whether rofecoxib was compared to a placebo, naproxen, or another nonsteroidal anti-inflammatory drug (NSAID). Juni’s analysis also demonstrated that there was little if ...
Neurolin DS
... Neurolin® is a structural derivative of the inhibitory neurotransmitter gamma-amino butyric acid (GABA). It does not bind directly to GABAA, GABAB, or benzodiazepine receptor. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake. Neur ...
... Neurolin® is a structural derivative of the inhibitory neurotransmitter gamma-amino butyric acid (GABA). It does not bind directly to GABAA, GABAB, or benzodiazepine receptor. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake. Neur ...
Pharmacological Characterization of Noroxymorphone as a New
... barrier due to its low calculated logD value (log octanol/water partition coefficient). Thus, noroxymorphone should have a negligible role in analgesia after systemic administration of oxycodone. Because of its spinal efficacy and long duration of effect, noroxymorphone is an interesting opioid for ...
... barrier due to its low calculated logD value (log octanol/water partition coefficient). Thus, noroxymorphone should have a negligible role in analgesia after systemic administration of oxycodone. Because of its spinal efficacy and long duration of effect, noroxymorphone is an interesting opioid for ...
Experimental Designs for Drug Combination Studies
... experimental design that minimizes the maximum of (6) over the design region is called G-optimum. The volume of the confidence region for the estimates of the model parameters is proportional to the inverse of the determinant of the Fisher’s information matrix (3). The criterion requiring minimizati ...
... experimental design that minimizes the maximum of (6) over the design region is called G-optimum. The volume of the confidence region for the estimates of the model parameters is proportional to the inverse of the determinant of the Fisher’s information matrix (3). The criterion requiring minimizati ...
The Fat Drug - About Dr. Keyser
... daughter had just suffered through several bouts of ear infections. “It’s a no-brainer. You have to ...
... daughter had just suffered through several bouts of ear infections. “It’s a no-brainer. You have to ...
ROBERT E. GOLDSTEIN and STEPHEN E. EPSTEIN 1973;48:917-920 doi: 10.1161/01.CIR.48.5.917
... are, in general, intimately related to the particular drug dose administered. Thus, a larger dose of a given drug may appear relatively "long-acting" simply because more drug and more drug effect were present at the outset. When comparing a single dose of each of two drugs with similar modes of acti ...
... are, in general, intimately related to the particular drug dose administered. Thus, a larger dose of a given drug may appear relatively "long-acting" simply because more drug and more drug effect were present at the outset. When comparing a single dose of each of two drugs with similar modes of acti ...
Treating Anxiety with either Beta Blockers or Antiemetic
... is higher when absorbed by this route rather than orally [13,14]. Propranolol has been delivered sublingually at 10 and 40 mg per dose [12,13], although this can produce mouth paresthesia, an undesirable effect. Also, propranolol has been delivered by rectal administration in mammals [15]. It does n ...
... is higher when absorbed by this route rather than orally [13,14]. Propranolol has been delivered sublingually at 10 and 40 mg per dose [12,13], although this can produce mouth paresthesia, an undesirable effect. Also, propranolol has been delivered by rectal administration in mammals [15]. It does n ...
effects of aripiprazole and haloperidol on neural
... and psychomotor activity, are well documented in schizophrenia and other psychotic disorders, even in antipsychotic-naïve individuals (Liddle, 1987; Dazzan et al., 2004; Dickinson et al., 2007; Morrens et al., 2007; Dazzan et al., 2008). Motor function is modulated by dopaminergic signalling, partic ...
... and psychomotor activity, are well documented in schizophrenia and other psychotic disorders, even in antipsychotic-naïve individuals (Liddle, 1987; Dazzan et al., 2004; Dickinson et al., 2007; Morrens et al., 2007; Dazzan et al., 2008). Motor function is modulated by dopaminergic signalling, partic ...
Synchronisation and control of proliferation in cycling cell
... levels of cytokines [79], which are emitted by tumour cells, or by immune cells that surround tumours; at least one of these cytokines, T GFα , has been experimentally shown, when directly infused in the cerebrospinal fluid of mice (into the third ventricle), to severely disrupt their circadian rhyt ...
... levels of cytokines [79], which are emitted by tumour cells, or by immune cells that surround tumours; at least one of these cytokines, T GFα , has been experimentally shown, when directly infused in the cerebrospinal fluid of mice (into the third ventricle), to severely disrupt their circadian rhyt ...
The effect of food and gastrointestinal residence on drug
... of food intake after dose administration The preceding study encouraged us to examine if enteric coated tablets are susceptible to similar food effects when a standard breakfast meal is ingested 30 min after drug administration. To test this, a mared erythromycin (250 mg) tablet was chosen, and admi ...
... of food intake after dose administration The preceding study encouraged us to examine if enteric coated tablets are susceptible to similar food effects when a standard breakfast meal is ingested 30 min after drug administration. To test this, a mared erythromycin (250 mg) tablet was chosen, and admi ...
Drug-Induced Aplastic Anaemia and Agranulocytosis Incidence and
... exposure to a variety of drugs, due usually to peripheral platelet destruction but occasionally to inhibition of megakaryocytopoiesis. However, this article deals only with drug-induced agranulocytosis and drug-induced aplastic anaemia. Between them, these are infrequent but justifiably feared compl ...
... exposure to a variety of drugs, due usually to peripheral platelet destruction but occasionally to inhibition of megakaryocytopoiesis. However, this article deals only with drug-induced agranulocytosis and drug-induced aplastic anaemia. Between them, these are infrequent but justifiably feared compl ...
of 2011 Edition A DEA REsouRcE GuiDE
... The Assistant Secretary, by authority of the Secretary, compiles the information and transmits back to the DEA: a medical and scientific evaluation regarding the drug or other substance, a recommendation as to whether the drug should be controlled, and in what schedule it should be placed. The medic ...
... The Assistant Secretary, by authority of the Secretary, compiles the information and transmits back to the DEA: a medical and scientific evaluation regarding the drug or other substance, a recommendation as to whether the drug should be controlled, and in what schedule it should be placed. The medic ...
Treatment issues for psychiatric comorbidities of epilepsy
... antidepressant drugs in the same way as primary psychiatric patients. The general impression is that depression in epilepsy is usually mild-tomoderate in severity [14,15] , with good response rates to adequate treatments [16] . If the importance of depression in epilepsy has been increasingly recogn ...
... antidepressant drugs in the same way as primary psychiatric patients. The general impression is that depression in epilepsy is usually mild-tomoderate in severity [14,15] , with good response rates to adequate treatments [16] . If the importance of depression in epilepsy has been increasingly recogn ...
File - Developing Anaesthesia
... Rivaroxaban is an orally active direct Factor Xa inhibitor and not a clotting factor depleting agent, as is the case with warfarin. As such the administration of blood clotting products will not be wholly effective in reversing its effects. ...
... Rivaroxaban is an orally active direct Factor Xa inhibitor and not a clotting factor depleting agent, as is the case with warfarin. As such the administration of blood clotting products will not be wholly effective in reversing its effects. ...
natural and synthetic substances related to human health
... Antibiotics and other anti-infectives Antibiotics are, by definition, natural products or derivatives of natural products. Since the discovery of penicillin, a large number of antibiotics have been isolated from scores of microorganisms [2], and several new antibiotics make it to the clinic each yea ...
... Antibiotics and other anti-infectives Antibiotics are, by definition, natural products or derivatives of natural products. Since the discovery of penicillin, a large number of antibiotics have been isolated from scores of microorganisms [2], and several new antibiotics make it to the clinic each yea ...