View CV - The Neurology Center of Southern California
... Multiple Sclerosis Continued MPB8298-SP-03 “A Double-Blind, Placebo Controlled Multi-Center Study to Evaluate the Efficacy and Safety of MBP8298 in Subjects with Secondary Progressive Multiple Sclerosis.” 2007 ACT 10573 “A Double Blind, Placebo-Controlled, Randomized Crossover, Activity Study of Sin ...
... Multiple Sclerosis Continued MPB8298-SP-03 “A Double-Blind, Placebo Controlled Multi-Center Study to Evaluate the Efficacy and Safety of MBP8298 in Subjects with Secondary Progressive Multiple Sclerosis.” 2007 ACT 10573 “A Double Blind, Placebo-Controlled, Randomized Crossover, Activity Study of Sin ...
formulation and evaluation of effervescent granules of an anti
... exposure of effervescence in such a manner has been shown to release water of hydration from dextrose monohydrate, thus giving a convenient means of adding water and then ‘activating’ it to perform rapid moisture stability studies. After thermal stressing, tablets were given a rating from 0–7 (least ...
... exposure of effervescence in such a manner has been shown to release water of hydration from dextrose monohydrate, thus giving a convenient means of adding water and then ‘activating’ it to perform rapid moisture stability studies. After thermal stressing, tablets were given a rating from 0–7 (least ...
Extraction Methods, Basic Structures and Mode of Action as
... entire world and currently is being integrated into mainstream medicine. Different catalogues including De Materia Medica, Historia Plantarum, Species Plantarum have been variously published in attempt to provide scientific information on the medicinal uses of plants. The types of plants and methods ...
... entire world and currently is being integrated into mainstream medicine. Different catalogues including De Materia Medica, Historia Plantarum, Species Plantarum have been variously published in attempt to provide scientific information on the medicinal uses of plants. The types of plants and methods ...
... Drug responses are often mediated by interactions with varied target structures such as receptor proteins, enzymes, and transporters, which are frequently located far from the bloodstream. Consequently, the dose-effect relationship depends upon distribution of the active drug fraction to the binding ...
stability indicating rp hplc method for the determination of
... A mixture of buffer and acetonitrile in the ratio of 30:70v/v was found to be the most suitable mobile phase for ideal separation of candesartan .The solvent mixture was filtered through a 0.45μ membrane filter and sonicated before use. It was pumped through the column at a flow rate of 1.2ml/min. T ...
... A mixture of buffer and acetonitrile in the ratio of 30:70v/v was found to be the most suitable mobile phase for ideal separation of candesartan .The solvent mixture was filtered through a 0.45μ membrane filter and sonicated before use. It was pumped through the column at a flow rate of 1.2ml/min. T ...
ICA-D-12-00158R1 Title: Cisplatin
... and subsequently binds directly to DNA, disrupting replication and transcription, which triggers an ...
... and subsequently binds directly to DNA, disrupting replication and transcription, which triggers an ...
Drug Development Pipeline
... Biologics- What are they? Biological products include a wide range of products such as vaccines, blood and blood components, allergenics, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins. Biologics can be composed of sugars, proteins, or nucleic acids or complex combinatio ...
... Biologics- What are they? Biological products include a wide range of products such as vaccines, blood and blood components, allergenics, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins. Biologics can be composed of sugars, proteins, or nucleic acids or complex combinatio ...
(Antiviral) Drugs
... and even then the availability of doses will be staggered and limited. Furthermore, each individual may need to receive two doses of vaccine to be protected. At this time antivirals (anti-influenza drugs) are the only specific medical intervention that targets influenza and that potentially will be ...
... and even then the availability of doses will be staggered and limited. Furthermore, each individual may need to receive two doses of vaccine to be protected. At this time antivirals (anti-influenza drugs) are the only specific medical intervention that targets influenza and that potentially will be ...
Dialectical behavior therapy versus comprehensive validation
... subjects. Further, those assigned to DBT had significantly better treatment retention (64% retention in DBT; 27% retention in TAU). In social and global adjustment, there were no significant between-group differences during treatment or at 12-month follow-up, but DBT subjects did show significantly ...
... subjects. Further, those assigned to DBT had significantly better treatment retention (64% retention in DBT; 27% retention in TAU). In social and global adjustment, there were no significant between-group differences during treatment or at 12-month follow-up, but DBT subjects did show significantly ...
1-28-17 PPT
... Which of the following is not true of the adverse effects of chloroquine? a. Visual impairment is related the affinity of chloroquine for melanin areas in the eye b. Low blood levels due to distribution to tissues increases the toxicity of chloroquine c. Ototoxicity, myopathy, and peripheral neurop ...
... Which of the following is not true of the adverse effects of chloroquine? a. Visual impairment is related the affinity of chloroquine for melanin areas in the eye b. Low blood levels due to distribution to tissues increases the toxicity of chloroquine c. Ototoxicity, myopathy, and peripheral neurop ...
Infusion therapy in severe heart failure. A reappraisal
... stimulatory effects; beta2 stimulation generally produces a mild reduction in the peripheral vascular resistance and a significant increase in cardiac output. On the basis of these findings dobutamine can be considered as an inotropic-vasodilating compound. The heart rate is generally not influenced ...
... stimulatory effects; beta2 stimulation generally produces a mild reduction in the peripheral vascular resistance and a significant increase in cardiac output. On the basis of these findings dobutamine can be considered as an inotropic-vasodilating compound. The heart rate is generally not influenced ...
DAVID E. McCLURE, Ph. D. 10654 Canyon
... Designed and executed single and multiple-dose Phase 1 studies through CRO. Prepared and packaged SIB-1508Y clinical trial formulation through appropriate CROs. Planned initial Phase 2 patient trial with the Parkinson’s Study Group (PSG) to evaluate safety, tolerability, and efficacy of SIB-1508Y, m ...
... Designed and executed single and multiple-dose Phase 1 studies through CRO. Prepared and packaged SIB-1508Y clinical trial formulation through appropriate CROs. Planned initial Phase 2 patient trial with the Parkinson’s Study Group (PSG) to evaluate safety, tolerability, and efficacy of SIB-1508Y, m ...
Future Development Plan - sun pharma advanced research company
... Except for the historical information contained herein, statements in this presentation and the subsequent discussions, which include words or phrases such as “will”, “aim”, “will likely result”, “would”, “believe”, “may”, “expect”, “will continue”, “anticipate”, “estimate”, “intend”, “plan”, “conte ...
... Except for the historical information contained herein, statements in this presentation and the subsequent discussions, which include words or phrases such as “will”, “aim”, “will likely result”, “would”, “believe”, “may”, “expect”, “will continue”, “anticipate”, “estimate”, “intend”, “plan”, “conte ...
What is Spinal Muscular Atrophy Type 4?
... need to inherit two altered SMN1 genes - one from their mother and one from their father). This is what is called an 'autosomal recessive’ inheritance pattern. The parents of an individual with SMA each carry one copy of the altered SMN1 gene, and are known as ‘carriers’, but they typically do not s ...
... need to inherit two altered SMN1 genes - one from their mother and one from their father). This is what is called an 'autosomal recessive’ inheritance pattern. The parents of an individual with SMA each carry one copy of the altered SMN1 gene, and are known as ‘carriers’, but they typically do not s ...
SPECTROPHOTOMETRIC ESTIMATION OF RUPATADINE FUMARATE AND MONTELUKAST SODIUM IN BULK AND TABLET DOSAGE FORM
... Tablets were finely powdered and mixed thoroughly. Quantity of tablet powder equivalent to 10 mg of RUPA and 10 mg of MONT was weighed accurately, dissolved in 50 ml methanol and sonicated for 20 min. The solution was filtered through Whatman filter paper (No. 41) ...
... Tablets were finely powdered and mixed thoroughly. Quantity of tablet powder equivalent to 10 mg of RUPA and 10 mg of MONT was weighed accurately, dissolved in 50 ml methanol and sonicated for 20 min. The solution was filtered through Whatman filter paper (No. 41) ...
Determining the subjective and physiological effects
... the nucleus accumbens (3 and 10 mg), whereas 5-HT release was only affected with high doses (Baumann et al. 2005). These pharmacological effects are very similar to amphetamine-induced DA stimulation. In addition to the effects of BZP on DA and 5-HT release, BZP has also been shown to cause peripher ...
... the nucleus accumbens (3 and 10 mg), whereas 5-HT release was only affected with high doses (Baumann et al. 2005). These pharmacological effects are very similar to amphetamine-induced DA stimulation. In addition to the effects of BZP on DA and 5-HT release, BZP has also been shown to cause peripher ...
Herbal Supplement - American Dental Hygienists Association
... Second, the amount and quality of scientific evidence is more prevalent on these botanicals as compared to other herbs. Health care professionals have an increasing responsibility to understand the rationale for use of these herbal medications and their reported effects on the body, given the large ...
... Second, the amount and quality of scientific evidence is more prevalent on these botanicals as compared to other herbs. Health care professionals have an increasing responsibility to understand the rationale for use of these herbal medications and their reported effects on the body, given the large ...
Pain Managment in the Optometric Practice
... • About 6 x more potent than codeine • May cause less sedation and constipation than codeine • Available with APAP and Ibuprofen • DEA Class III – Potentially causes mild or low physical dependence, but possibility of high psychological dependence if ...
... • About 6 x more potent than codeine • May cause less sedation and constipation than codeine • Available with APAP and Ibuprofen • DEA Class III – Potentially causes mild or low physical dependence, but possibility of high psychological dependence if ...
Cannabis and driving impairment
... Psychomotor performance compared to control group of occasional drug users Performance on critical tracking and divided attention tasks improved over 3 weeks, but was still significantly poorer than control group Psychomotor function in chronic daily cannabis smokers during sustained abstinence. Bos ...
... Psychomotor performance compared to control group of occasional drug users Performance on critical tracking and divided attention tasks improved over 3 weeks, but was still significantly poorer than control group Psychomotor function in chronic daily cannabis smokers during sustained abstinence. Bos ...
The Effect of Overencapsulation on Disintegration and
... Although encapsulation resulted in a lag time of 2-3 min in disintegration compared with the unencapsulated tablets, the disintegration and dissolution of propranolol and rofecoxib were the same whether tablets were encapsulated in DBcaps capsules or standard gelatin capsules. It can thus be expecte ...
... Although encapsulation resulted in a lag time of 2-3 min in disintegration compared with the unencapsulated tablets, the disintegration and dissolution of propranolol and rofecoxib were the same whether tablets were encapsulated in DBcaps capsules or standard gelatin capsules. It can thus be expecte ...
Benefits of Listing a Patent
... Generic Drugs (cont’d) Bioequivalence • Generally demonstrated by in vivo blood plasma levels (90% confidence interval, log transformed to 80-125% parameters compared to innovator’s product). • In vitro dissolution is often a quality measure but may also be required for more complex dosage forms ( ...
... Generic Drugs (cont’d) Bioequivalence • Generally demonstrated by in vivo blood plasma levels (90% confidence interval, log transformed to 80-125% parameters compared to innovator’s product). • In vitro dissolution is often a quality measure but may also be required for more complex dosage forms ( ...