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GHB
GHB

... Cartridge Cleaner, Plant Food, Fingernail Polish Remover, Paint Stripper. There are more than 80 known names for GHB and its equally deadly analogs. ...
Hypersensitivity to nonsteroidal antiinflammatory drugs (NSAIDs
Hypersensitivity to nonsteroidal antiinflammatory drugs (NSAIDs

... hypersensitivity may reach 25.6% (9). Cutaneous manifestations to NSAIDs may affect 0.3% of general population (5), and the prevalence of aspirin hypersensitivity may be as high as 27–35% in patients with chronic urticaria (10). NSAIDs have been reported to be the major (11) or the second group of d ...


... rolithiasis otherwise urinary calculi a pathogenic continues to be more or less of an ambigue and the predicament found to an ancient and worldwide distributed. The different calculi are painful urinary disorders that start as salt/chemical crystals which precipitate out from urine. Under normal cir ...
AGNP Consensus Guidelines for Therapeutic Drug Monitoring in
AGNP Consensus Guidelines for Therapeutic Drug Monitoring in

... pregnant women, elderly patients, individuals with intelligence disabilities, forensic patients, patients with known or suspected genetically determined pharmacokinetic abnormalities or individuals with pharmacokinetically relevant comorbidities. However, the potential benefits of TDM for optimizati ...
A study was conducted to determine the prevalence, motives
A study was conducted to determine the prevalence, motives

... are damaging physically and psychologically. Steroids may seem to be the best and easiest way to enhance your body, but they only work for so long. Once the side effects start surfacing, the user will have trouble exercising or may not even be able to exercise. Therefore, everything that they have w ...
Methadone—metabolism, pharmacokinetics and interactions
Methadone—metabolism, pharmacokinetics and interactions

... drug to bind to the enzyme. Inhibition of activity of the enzyme decreases the metabolism of the drug, and therefore, increases its pharmacological activity [36]. Pharmacokinetic interaction can also occur when two or more drugs that are metabolic substrates of the same CYP are administered concurre ...
MIKANIA SCANDENS (L.) WILLD. ALCOHOL INDUCED HEPATOTOXICITY IN RATS  Research Article
MIKANIA SCANDENS (L.) WILLD. ALCOHOL INDUCED HEPATOTOXICITY IN RATS Research Article

... liver disease in Western countries. About 12% of American adults had an alcohol dependence problem at some time in their life. Steatosis (fatty liver) will develop in any individual who consumes a large quantity of alcoholic beverages over a long period of time. Chronic alcohol consumption leads to ...
The adjuvant use of lansoprazole, clonazepam and dimenhydrinate
The adjuvant use of lansoprazole, clonazepam and dimenhydrinate

Herbs
Herbs

... Double-blind, placebo-controlled crossover design ...
Local Anesthetics
Local Anesthetics

... sensation. Local anesthetics produce anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by anesthetics reversibly binding to and inactivating sodium channels. Sodium influx through these channels is necessary for the depolarization o ...
4: Central nervous system - Gateshead Health NHS Foundation Trust
4: Central nervous system - Gateshead Health NHS Foundation Trust

... pharmacodynamic interactions (serotonin syndrome, hypotension, drowsiness) and pharmacokinetic interactions (e.g. elevation of tricyclic plasma levels by some SSRIs). The serotonin syndrome may include restlessness, diaphoresis, tremor, shivering, myoclonus, confusion, convulsions and death. ...
selective activation of thalamic pulvinar in humans
selective activation of thalamic pulvinar in humans

... intensive care unit (ICU) (Venn et al., 1999), was chosen in favour of the more traditional a2 agonist clonidine due to its high selectivity for the a2 receptor (Scheinin et al., 1987; Virtanen et al., 1988). This new drug provides reversible sedation and mild cognitive impairment without compromisi ...
LA`s - Notes For ANZCA Primary Exam
LA`s - Notes For ANZCA Primary Exam

... A. Is predominantly by albumin B. Is predominantly by alpha-1 acid glycoprotein C. Is greater for tetracaine than for bupivacaine D. Neonates have a greater number of binding sites E. Plasma binding is directly proportional to local anaesthetic concentration. (Comment: wording in option E was 'plasm ...
This PDF is a selection from an out-of-print volume from... of Economic Research
This PDF is a selection from an out-of-print volume from... of Economic Research

... manipulations are orderly and have generality across different species (Johanson and Fischman 1989; Johanson and Schuster 1995). These commonalities across species support a theoretical position that cocaine produces use and abuse via basic, normal processes of conditioning. Understanding that reinf ...
Diastolic Dysfunction in the Population
Diastolic Dysfunction in the Population

... Duality of interests S.Yusuf has received fees for lecturing and research grants from Cadilla Pharma, as well as from 6 other pharma companies that produce CVD drugs ...
Media Kit - Perosphere
Media Kit - Perosphere

... The new oral anticoagulants (NOACs) offer significant advantages over the heparins and warfarin therapies with regards to route of administration, drug interactions and predictability of bioactivity. However, the NOACs currently lack a specific reversal agent. As such concern over serious bleeding, ...
Diastolic Dysfunction in the Population
Diastolic Dysfunction in the Population

... Duality of interests S.Yusuf has received fees for lecturing and research grants from Cadilla Pharma, as well as from 6 other pharma companies that produce CVD drugs ...
evidence based pharmaco- clinical studies on ashwagandha
evidence based pharmaco- clinical studies on ashwagandha

... important hormone precursors that can convert into human physiologic hormones as needed. Ashwagandha is thought to be amphoteric i.e., it can help to regulate important physiologic processes. The theory is that when there is an excess of a certain hormone, the plant-based hormone precursor occupies ...
The Transfer of Drugs and Therapeutics Into Human Breast Milk: An
The Transfer of Drugs and Therapeutics Into Human Breast Milk: An

... or avoid taking essential medications because of fears of adverse effects on their infants. This cautious approach may be unnecessary in many cases, because only a small proportion of medications are contraindicated in breastfeeding mothers or associated with adverse effects on their infants. Inform ...
Safety of allopurinol compared with other urate
Safety of allopurinol compared with other urate

... majority of adverse events were mild. Four patients in the febuxostat groups died (0.8 %) and none in the allopurinol group, although the investigators did not find any relation with the study drugs. There was, however, a higher number of withdraws with higher doses of febuxostat (120 mg) compared t ...
Noradrenaline (Norepinephrine) 2016
Noradrenaline (Norepinephrine) 2016

... Newborns with septic shock: Noradrenaline 0.2−0.5 microgram/kg/minute increased blood pressure, urine output and reduced lactate in newborns with septic shock refractory to volume expansion and dopamine/dobutamine. [4] (LOE IV, GOR C) Newborns with PPHN and circulatory failure refractory to fluid re ...
Product Information - Therapeutic Goods Administration
Product Information - Therapeutic Goods Administration

... term memory, to a major syndrome which may include convulsions, tremor, abdominal and muscle cramps, confusional state, delirium, hallucinations, hyperthermia, psychosis, vomiting and sweating. Such manifestations of withdrawal, especially the more serious ones are more common in patients who have r ...
Cannabis Dependence
Cannabis Dependence

... 3. Thomas, H. 1993. Psychiatric symptoms in cannabis users. British Journal of Psychiatry 163: 141-149. 4. Jaffe, J.H. 1985. Drug addiction and drug abuse. In A.G. Gilman, L.S. Goodman & F. Murad (Eds), The pharmacological basis of therapeutics. 7th edition. Macmillan: USA. 5. Baumrind, D. & Moselle ...
Appetite Suppressor Induced Psychosis
Appetite Suppressor Induced Psychosis

... Anti-obesity drugs work by acting on one of two major mechanisms, central and peripheral. The drugs with a central mechanism control appetite by affecting brain neurotransmitters such as norepinephrine and serotonin. On the other hand, the drugs that act on peripheral pathways influence digestion or ...
Nonsteroidal anti-inflammatory drugs in veterinary - GEAC-UFV
Nonsteroidal anti-inflammatory drugs in veterinary - GEAC-UFV

... [40,41]. Clinical signs associated with salicylate toxicity in cats include hyperthermia, metabolic acidosis with compensatory respiratory alkalosis, methemoglobinemia, hemorrhagic gastritis, and renal and hepatic injury [10]. Accidental feline poisonings as a result of oral acetaminophen ingestion ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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