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domperidone domperidone
domperidone domperidone

... In some cases of long-term domperidone treatment, leakage of milk and colostrum has occurred. If leakage should occur and foaling does not take place within 24 hours, half the recommended dose should be administered twice daily at approximately 12-hour intervals and continued until foaling. If leaka ...
ASD v3.0 - Nucleic Acids Research
ASD v3.0 - Nucleic Acids Research

... comparing the structure of the allosteric sites before binding (apo structure) with that after binding (holo structure) (23,51,52), which could not only account for the underlying mechanism of specific allosteric triggering action but may also be used to improve the triggering efficacy in allosteric ...
Effect of serotonin depletion on cortical spreading depression
Effect of serotonin depletion on cortical spreading depression

... conditions including migraine. It can induce alterations in both neural and vascular compartments. Serotonin (5-HT) depletion is known as a condition involved in migraine pathophysiology. The hyper-excitability of the cortical neurons to the CSD activation in the low 5-HT state has been previously r ...
Symposium Highlights
Symposium Highlights

... One alternative to the BSC is the total containment cabinet, or isolator. This type of system was developed to contain pathogens, such as the human immunodeficiency virus, and has a nonexchangeable air supply in the work area. Isolators, commonly called glove boxes, are closed cabinets that have ant ...
WHO Drug Dictionary User Guide - User Group Portal
WHO Drug Dictionary User Guide - User Group Portal

... This may confound the outcome of the study – and many organizations choose to exclude subject that take certain drugs in their studies or exclude them from certain types of analysis. The information about the concomitant medication can be of high value – since this information can be an important cl ...
3.2_Kleinschmidt_SupplementsHerbs (KCK from own)4.23.12
3.2_Kleinschmidt_SupplementsHerbs (KCK from own)4.23.12

... notify the FDA 75 days before marketing –  FDA must review - expected to be safe? –  Most supplement ingredients were in use prior to 1994 ...
An Update on Analgesics for the Management of Acute
An Update on Analgesics for the Management of Acute

... other allergy signs and symptoms can occur in susceptible patients as a result of redirecting the arachidonic acid breakdown into the leukotriene pathway, as shown in Fig. 1. Therefore, history of an allergy-like reaction to ASA, particularly an asthmatic reaction, rules out not only ASA, but also a ...
Quantification of Pharmacodynamic Interactions between
Quantification of Pharmacodynamic Interactions between

... Many variables influence the complex relationship between dosage, plasma concentration, and drug effect. To optimize the delivery of anesthetic drugs to individual patients, it is important to distinguish between pharmacokinetic (PK) and pharmacodynamic (PD) interactions. For example, Pavlin et al. ...
YFCC New Pyschoactive Substances
YFCC New Pyschoactive Substances

... as a neuromodulator or a neurotransmitter. Piperazines - are a variety of chemical compounds which simulate the psychostimulant effect of Ecstasy/MDMA. Piperazines are often used as a cutting agent or as the main active ingredient in some ecstasy pills. ...
Aalborg Universitet The medication process in a psychiatric hospital Mainz, Jan
Aalborg Universitet The medication process in a psychiatric hospital Mainz, Jan

... focused on administration errors, one study was based on self-reporting by nurses and did not report any rate of error. The other study was an observational study of administration errors in elderly psychiatric inpatients where administration errors were detected in 25.9% of all opportunities for er ...
Nervous System Cells
Nervous System Cells

... • Researchers have found that neurons constantly grow and lose branches to dendrites and axons. • This growth is related to new experiences and learning. ...
tamoxifen - Cancer Care Ontario
tamoxifen - Cancer Care Ontario

... information (for health professionals) contained in the Drug Formulary (the "Formulary") is intended for healthcare providers and is to be used for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects o ...
Multidrug Resistance-Associated Proteins: Expression and Function
Multidrug Resistance-Associated Proteins: Expression and Function

... functionally unrelated pharmacological agents. The development of MDR is associated with poor clinical outcome in several neurological disorders (Loscher and Potschka, 2005b). At present the cystic fibrosis transmembrane conductance regulator/MRP family (ABC subfamily C) contains 13 members, includi ...
Synergistic interactions between Fenfluramine and
Synergistic interactions between Fenfluramine and

... regurgitation in a series of 24 fen-phen users. Subsequent histopathological analyses revealed a thickening of the affected valves resulting in reduced valve mobility. Subsequent studies have sought to establish the incidence of valve disease as a function of anorexigen exposure. Although phentermin ...
What single drug is the most efficacious for oral conscious minimal
What single drug is the most efficacious for oral conscious minimal

... inexpensive, painless, effective, and easy to administer (Donaldson, 2007). One group of oral medications that are particularly amenable to oral sedation are the benzodiazepines. The major inhibitory neurotransmitter in the central nervous system is gamma-aminobutyric acid (GABA). Benzodiazepines pr ...
Sedative-Hypnotic Drugs
Sedative-Hypnotic Drugs

... 1- 1,3 disubstituted barbiturate is inactive 2-1,3 disubstituted thio barbiturate is inactive 3- 5-mono substituted BA is inactive 4- 5-mono substituted thio BA is inactive 5- 1,3,5 trisustituted BA is inactive 6-1,3,5 trisubstituted thio BA is inactive. 5,5,disubstituted BA is active 5,5 disubstitu ...
Safety in Using Promethazine (Phenergan)
Safety in Using Promethazine (Phenergan)

... irst approved by the U.S. Food and Drug Administration (FDA) in 1951, promethazine (Phenergan) is a medication in common use today. However, despite its familiarity, its use is not without risks. In particular, reports submitted to PA-PSRS illustrate that patients in Pennsylvania are being harmed wh ...
AMERICAN ACADEMY OF PEDIATRICS Neonatal Drug Withdrawal
AMERICAN ACADEMY OF PEDIATRICS Neonatal Drug Withdrawal

... hypertensive episodes, severe mood swings, cerebrovascular accidents, myocardial infarction, and repeated spontaneous abortions.45,46,49 –53 Infant characteristics that may be associated with maternal drug use include prematurity;11,52 unexplained intrauterine growth retardation;50,52 neurobehaviora ...
Challenges and new discoveries in the treatment of
Challenges and new discoveries in the treatment of

... Amphotericin B (deoxycholate) has been given to large numbers of patients with kala-azar that is clinically resistant to Pentostam and pentamidine. In Bihar, 99% of patients were cured with the standard regimen of 20 injections (1 mg/ kg/AD) of amphotericin B. Further studies showed that the duratio ...
Articaine: Efficacy and Paresthesia in Dental Local Anesthesia
Articaine: Efficacy and Paresthesia in Dental Local Anesthesia

... Articaine is distinguished from other amides.The thiophene portion of the molecule gives articaine a high lipid solubility.1,4,5 This fact is critical, as the higher the lipid solubility, the higher the potency and the better the diffusion through the medium into which it is injected, and, therefore ...
2. The contemporary drug problem: characteristics, patterns and
2. The contemporary drug problem: characteristics, patterns and

... increased over time, including through a regulatory approach that entails the implementation of an elaborate system of authorizations and quality controls. The control of psychoactive substances developed in that framework. While the use of psychoactive substances has existed for several thousand ye ...
EA_QA312.3_levothyroxineseakelp
EA_QA312.3_levothyroxineseakelp

... as 1 mg of iodine (5). In addition the iodine content of kelp products can vary considerably, even within products of the same brand (1, 4). When progressively larger doses of iodine are ingested there is an initial rise in thyroid hormone production, but as doses continue to rise production is redu ...
Campus Location: Wilmington Effective Date: 2018
Campus Location: Wilmington Effective Date: 2018

... Differentiate between an agonist and antagonist. List three sources of drug information. List four components of pharmacokinetics. Demonstrate common abbreviations used in writing prescriptions. List ten dosage forms. List five routes of drug administration. List five rights of drug administration. ...
Cucurbit[n]urils as excipients in pharmaceutical dosage forms
Cucurbit[n]urils as excipients in pharmaceutical dosage forms

... DSC in a number of studies (33, 34). An interaction is generally determined by a change in the melting point of one or both of the excipients. To date, CB[6] has been shown to interact with a range of common pharmaceutical excipients (Table 3). Unfortunately, the tests used to determine solid-state ...
PDF - Journal of Applied Pharmaceutical Science
PDF - Journal of Applied Pharmaceutical Science

... nasal mucus and less dilution by gastrointestinal contents(Krishnamoorthy and Mitra, 1998). In recent years many drugs have been shown to achieve better systemic bioavailability through nasal route than by oral administration. Nasal therapy, has been recognized form of treatment in the Ayurvedic sys ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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