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Locally evoked potentials in slices of the rat nucleus - UvA-DARE
Locally evoked potentials in slices of the rat nucleus - UvA-DARE

Study Objectives
Study Objectives

... 10. Describe the symptoms that characterize Korsakoff’s syndrome. 11. Describe and discuss the most common cause and summarize the neuropathology associated with this Korsakoff’s syndrome. 12. Note the similarities between Korsakoff’s syndrome and other medial temporal lobe disorders. 13. Using clin ...
full text - TReAD Lab
full text - TReAD Lab

... The subiculum is a transitional cortical area that lies adjacent to the CA1 subfield of the hippocampus, and along with the entorhinal cortex and hippocampus, is considered to be an integral part of the hippocampal formation. It has been traditionally viewed as an output structure for the hippocampa ...
the premotor cortex of the monkey
the premotor cortex of the monkey

... experiments. Although the motor tasks for the two monkeys were somewhat different, the basic behavioral patterns were comparable. The description of methods and results will focus on one of these animals. However, all of the conclusions and observations agree with the data obtained from both monkeys ...
Brief neonatal maternal separation alters extinction of conditioned
Brief neonatal maternal separation alters extinction of conditioned

... NR1, and staining was quantified. Brief maternal separation did not alter acquisition or initial extinction, but impaired extinction recall. Brief maternal separation did not alter GR or NR1 expression in basolateral amygdala. However, brief maternal separation increased GR and decreased NR1 expressi ...
Frontal Lobes and Memory - University of California, Berkeley
Frontal Lobes and Memory - University of California, Berkeley

... in patients with frontal lesions (Janowsky et al., 1989•). Recently, however, Wheeler et al. (1995) performed a meta-analysis of studies that assessed memory performance in patients with frontal lesions. Across these studies, significant impairment was observed on tests of free recall (80% of studie ...
Evolutionarily conserved prefrontal-amygdalar dysfunction in early
Evolutionarily conserved prefrontal-amygdalar dysfunction in early

... polysynaptically connected brain regions.19 This structural backbone encompasses a number of cortical regions that are especially well developed in primates, including the anterior cingulate cortex (ACC), insula and prefrontal cortex (PFC).21–23 Although it widely believed that the synchronized flow ...
FREE Sample Here
FREE Sample Here

... Learning goals: structures of the brain and their functions 45. Dr. Becker is interested in identifying the pathways of connectivity in the brain and nervous system. Which of the following techniques will Dr. Becker most likely use in his research? A. Brain lesioning B. Staining C. Positron emission ...
Lights, Camembert, Action! - Human Reward and Decision Making lab
Lights, Camembert, Action! - Human Reward and Decision Making lab

... instances.33 However, given that in many cases, animals (including humans) can distinguish a predictive cue from the UCS itself, as indicated by distinct behavioral responses in these two cases, it seems likely from that there are at least two distinct associative mechanisms in the brain, one based ...
MIRROR NEURON FUNCTION: AN EXAMINATION OF
MIRROR NEURON FUNCTION: AN EXAMINATION OF

... food does not move his fingers. Another important aspect is that activation ceases when the food is made available to him. Whereas, if these neurons were related to pre-motor neurons then activation would have increased in response to preparation of movement execution, not decreased. This supports t ...
Emerging role of the brain in the homeostatic regulation of
Emerging role of the brain in the homeostatic regulation of

... adiposity to the brain. In hypothalamic neurons, insulin activates the insulin receptor substrate-2 (IRS2)–phosphatidylinositol 3-kinase (PI3K) signaling pathway. Neuronal deletion of insulin receptor and IRS2 results in increased food intake and susceptibility to diet-induced obesity.61,62 The adip ...
Short Communication - NYU Psychology
Short Communication - NYU Psychology

... Thus, perhaps surprisingly, natural language has ways to fit together meanings that appear to be incompatible. What psychological mechanisms are at play in type-mismatch resolution? Behavioral studies on several constructions have shown that type-mismatch has measurable consequences for real-time com ...
Preview Sample 1
Preview Sample 1

... 41. An ____ is a drug that mimics or increases a neurotransmitter’s effects. An ____ is a drug that blocks a neurotransmitter’s effect. A. agonist / antagonist B. antagonist / agonist C. axon / endorphin D. endorphin / axon Answer: A Bloom’s Taxonomy: knowledge Difficulty Level: easy Feedback: page ...
Beyond the classical receptive field: The effect of contextual stimuli
Beyond the classical receptive field: The effect of contextual stimuli

... take distant global inputs into account. The idea of an extended (called nonclassical or extraclassical today) RF was not new. Kuffler (1953, p. 45) already wrote, ‘‘. . . not only the areas from which responses can actually be set up by retinal illumination may be included in a definition of the rece ...
Cerebral correlates of delta waves during non
Cerebral correlates of delta waves during non

... NREM sleep than during wakefulness in normal human subjects and as this study was aimed at exploring the cerebral correlates of rhythms that characterize NREM sleep, the presence of waking values of delta power is likely to obscure the interpretation of the results. Therefore, in our second analysis ...
Embodied Cognition and Mirror Neurons
Embodied Cognition and Mirror Neurons

... whether the activity during retrieval of color knowledge (e.g., TAXI = yellow) was greater than that during a control task requiring subjects to evaluate whether a particular motor property was associated with an object (e.g., HAIR = combed). The authors found a greater signal for the color knowledg ...
Motor systems Basal ganglia
Motor systems Basal ganglia

... the adjacent figure. The caudate and putamen have similar functions, and we will consider them as one in this discussion. Together the caudate and putamen are called the neostriatum or simply striatum. All input to the basal ganglia circuit comes via the striatum. This input comes mainly from motor ...
Dopaminergic and Glutamatergic Dysfunctions
Dopaminergic and Glutamatergic Dysfunctions

... hypodopaminergia that may cause striatal hyperdopaminergia. Together, these observations led to the hypothesis that a deficit in dopamine transmission at D1 receptors in the prefrontal cortex might be implicated in the cognitive impairments and negative symptoms of schizophrenia [7, 29], whereas the ...
Randy Kobes Poster Contest Workshop
Randy Kobes Poster Contest Workshop

... belong to and where they are in space. In standard clinical practice, doctors use MRI to detect large causes of cognitive decline such as stroke and tumours. These scans cannot detect more subtle changes in the hippocampus. This project aims to develop more complex methods that reveal details which ...
Frailty – Elders At Risk - College of Nursing and Health Innovation
Frailty – Elders At Risk - College of Nursing and Health Innovation

... present in individuals with frailty. It is important to keep in mind however, that frailty, as defined by the various measures in Table 1, can also occur in individuals, most often women, who are obese (BMI >30). Despite their high BMI, obese individuals can still lose weight due to malnutrition, an ...
Distinctive Personality Traits and Neural Correlates Associated with
Distinctive Personality Traits and Neural Correlates Associated with

... using permutation testing of cluster mass (34) with 32 randomizations. The expected number of false-positive clusters was set at less than one. The whole-brain statistical maps for each test were thresholded at cluster level of r1 error clusters per image and had equivalent p values: control volunte ...
Rethinking Mammalian Brain Evolution1
Rethinking Mammalian Brain Evolution1

... and certain fluorescent dyes. These techniques have now made it possible to investigate the organization of axonal circuitry in full microscopic detail. In this regard the most basic functional anatomy of the brain has at last become available for study. We are still far from possessing a complete c ...
multiple reward signals in the brain
multiple reward signals in the brain

... frequently distinguish between different liquid and food rewards56. Expectations change systematically with experience. Behavioural studies suggest that, when learning to discriminate rewarded from unrewarded stimuli, animals initially expect to receive a reward on all trials. Only with experience d ...
100 The Molecular and Structural Basis of Amblyopia
100 The Molecular and Structural Basis of Amblyopia

... Bear, 2003). Although it is now appreciated that there are many mechanisms for LTD in different brain regions, some of these are well conserved (Malenka & Bear, 2004). The study of LTD in hippocampus and visual cortex has led to a detailed understanding of how activity triggers a loss of synaptic st ...
PDE5 Exists in Human Neurons and is a Viable Therapeutic Target
PDE5 Exists in Human Neurons and is a Viable Therapeutic Target

... cerebellum are normalized to cortex. See Supplementary Information for full, uncut blots. C) Values from B are quantified (3 samples in each group – each sample is from a different human subject; error bars are standard error). We evaluated the results using a two-tailed t-test. For both antibodies, ...
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Aging brain

Age is a major risk factor for most common neurodegenerative diseases, including Mild cognitive impairment, Alzheimer's disease, cerebrovascular disease, Parkinson's disease and Lou Gehrig's disease. While much research has focused on diseases of aging, there are few informative studies on the molecular biology of the aging brain (usually spelled ageing brain in British English) in the absence of neurodegenerative disease or the neuropsychological profile of healthy older adults. However, research does suggest that the aging process is associated with several structural, chemical, and functional changes in the brain as well as a host of neurocognitive changes. Recent reports in model organisms suggest that as organisms age, there are distinct changes in the expression of genes at the single neuron level. This page is devoted to reviewing the changes associated with healthy aging.
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