A unique amino acid substitution, T126I, in human
... antigenicity of the virus and the clinical outcome of the infected patient. However, no convincing evidence has been presented for this hypothesis, partly because the 3D structure of the S protein has not been determined. Comparative analysis of viral genes offers an approach to testing this hypothe ...
... antigenicity of the virus and the clinical outcome of the infected patient. However, no convincing evidence has been presented for this hypothesis, partly because the 3D structure of the S protein has not been determined. Comparative analysis of viral genes offers an approach to testing this hypothe ...
Lecture 8: RNA-sequence analysis: Expression, isoforms
... Hypergeometric test for overlap significance N – total # of genes n1 - # of genes in set A n2 - # of genes in set B k - # of genes in both A and B ...
... Hypergeometric test for overlap significance N – total # of genes n1 - # of genes in set A n2 - # of genes in set B k - # of genes in both A and B ...
Resistance to the Pseudomonas syringae Effector
... expressing single corresponding avirulence genes have been particularly fruitful in dissecting specific and common resistance signaling components. However, the major TNL class is represented by a single known P. syringae resistance gene, RPS4. We previously identified hopA1 from P. syringae pv syri ...
... expressing single corresponding avirulence genes have been particularly fruitful in dissecting specific and common resistance signaling components. However, the major TNL class is represented by a single known P. syringae resistance gene, RPS4. We previously identified hopA1 from P. syringae pv syri ...
RIBOSWITCHES - Creighton Chemistry Webserver
... Many aptamers have been generated in the laboratory for a wide range of target molecules (e.g. theophylline aptamer) ...
... Many aptamers have been generated in the laboratory for a wide range of target molecules (e.g. theophylline aptamer) ...
The road to knowledge: from biology to databases and back again
... challenge faced by a growing number of researchers. Analysis of five major metabolic pathway databases reveals that each database has made widely different choices to address this challenge, including how to deal with knowledge that is uncertain or missing. In concise overviews we show how concepts ...
... challenge faced by a growing number of researchers. Analysis of five major metabolic pathway databases reveals that each database has made widely different choices to address this challenge, including how to deal with knowledge that is uncertain or missing. In concise overviews we show how concepts ...
Insight into Metabolic Reprogramming in Tumor Cells
... the TCA cycle enzymes fumarate hydratase and succinate dehydrogenase. Undoubtedly, many connections between tumor genomic alterations and metabolic consequences have yet to be uncovered. ...
... the TCA cycle enzymes fumarate hydratase and succinate dehydrogenase. Undoubtedly, many connections between tumor genomic alterations and metabolic consequences have yet to be uncovered. ...
Mining Large Heterogeneous Cancer Data Sets Using
... Aberrant changes in DNA methylation are known to play a major role in the evolution of multiple cancers, but the molecular events responsible for perturbing methylated genomic landscapes have not been completely characterized. In order to identify somatic mutations in cancer that are directly linked ...
... Aberrant changes in DNA methylation are known to play a major role in the evolution of multiple cancers, but the molecular events responsible for perturbing methylated genomic landscapes have not been completely characterized. In order to identify somatic mutations in cancer that are directly linked ...
Translation - SBI4u Biology Resources
... can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. The genes in DNA encode protein molecules, which are the "workhorses" of the cell, carrying out all the functions necessary for life. For example, enzymes, including those that metaboliz ...
... can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. The genes in DNA encode protein molecules, which are the "workhorses" of the cell, carrying out all the functions necessary for life. For example, enzymes, including those that metaboliz ...
Expressway Plus - Thermo Fisher Scientific
... you’ll save hours of time and labor and produce the protein yields you need for downstream functional analysis. ...
... you’ll save hours of time and labor and produce the protein yields you need for downstream functional analysis. ...
Identification and Characterization of cvHsp
... (6, 7). More recently, Hspb-2, also called MKBP, was shown to bind and activate myotonic dystrophy protein kinase in the yeast two-hybrid system (8). All of these smHsps have been shown to be highly expressed in muscular tissues, including the heart (e.g. see Ref. 8 and references therein). Gene dis ...
... (6, 7). More recently, Hspb-2, also called MKBP, was shown to bind and activate myotonic dystrophy protein kinase in the yeast two-hybrid system (8). All of these smHsps have been shown to be highly expressed in muscular tissues, including the heart (e.g. see Ref. 8 and references therein). Gene dis ...
2.7 DNA Transcription_translation
... Proteins are each specifically designed to build or operate a component of a living cell. ...
... Proteins are each specifically designed to build or operate a component of a living cell. ...
A macrokinetic and regulator model for myeloma cell culture based
... the regulator model which consists of basically two control loops, one is the negative feedback loop, and the other is the positive one. rglc,min stands for the minimum constitutive activity of the regulated pathway. rglc,R represents the actual activity of regulated pathway in analogy to enzyme lev ...
... the regulator model which consists of basically two control loops, one is the negative feedback loop, and the other is the positive one. rglc,min stands for the minimum constitutive activity of the regulated pathway. rglc,R represents the actual activity of regulated pathway in analogy to enzyme lev ...
How will Hemoglobin Affect the Winner of this Year`s Super Bowl
... acid has a certain chemical character in relation to water molecules. Some amino acids love being around water (Hydrophilic), some hate water and hide from it (Hydrophobic), and for some, it doesn’t matter as much. Proteins do not exist as a string of amino acids, but must fold into a 3 dimensional ...
... acid has a certain chemical character in relation to water molecules. Some amino acids love being around water (Hydrophilic), some hate water and hide from it (Hydrophobic), and for some, it doesn’t matter as much. Proteins do not exist as a string of amino acids, but must fold into a 3 dimensional ...
Identification and characterization of the ergochrome gene cluster in
... The yellow ergochromes are dimers of tetrahydroxanthone units [7]. Four different xanthone derivatives were described as ergochrome units in C. purpurea and all possible combinations of two of these units occur in nature [8]. Their concentration in the sclerotia is considerably higher (5 g/kg) than ...
... The yellow ergochromes are dimers of tetrahydroxanthone units [7]. Four different xanthone derivatives were described as ergochrome units in C. purpurea and all possible combinations of two of these units occur in nature [8]. Their concentration in the sclerotia is considerably higher (5 g/kg) than ...
Cell injury
... outer orbit such as super oxide O2, H2O2 , OH , No , these substance are unstable so it react with any organic or inorganic substances to be stable . Free radicals generated within the cell by: 1-Reduction oxidation reaction occur during respiration . 2-Nitric oxide can form in different cells. 3-Ra ...
... outer orbit such as super oxide O2, H2O2 , OH , No , these substance are unstable so it react with any organic or inorganic substances to be stable . Free radicals generated within the cell by: 1-Reduction oxidation reaction occur during respiration . 2-Nitric oxide can form in different cells. 3-Ra ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008.
... based on their sequence and structural similarities they are classified into family 18 and family 19 glycosidases. Family 18 chitinases are structurally different from family 19 chitinases and consist of a highly conserved catalytic motif (DxxDxDWEYP) and are inhibited by allosamidin, a pseudotrisac ...
... based on their sequence and structural similarities they are classified into family 18 and family 19 glycosidases. Family 18 chitinases are structurally different from family 19 chitinases and consist of a highly conserved catalytic motif (DxxDxDWEYP) and are inhibited by allosamidin, a pseudotrisac ...
Structure, expression and phylogenetic analysis of the glycoprotein
... region spanning residue 124 – 137 has recently been identified as a fusogenic domain of G protein of VSV (IND) (Li et al., 1993; Zhang and Ghosh, 1994; Durrer et al., 1995; Frederickson and Whitt, 1995). This region may thus represent the fusion peptide of vesiculovirus G proteins. A conserved regio ...
... region spanning residue 124 – 137 has recently been identified as a fusogenic domain of G protein of VSV (IND) (Li et al., 1993; Zhang and Ghosh, 1994; Durrer et al., 1995; Frederickson and Whitt, 1995). This region may thus represent the fusion peptide of vesiculovirus G proteins. A conserved regio ...
Supplementary figure legend
... expression in the TCGA data set are enriched for cellular functions that include DNA repair, cell cycle regulation, and cell survival as well as canonical pathways that include BRCA1 in DNA damage response and G2/M DNA damage checkpoint repair- analysis done using Ingenuity pathway analysis (A). The ...
... expression in the TCGA data set are enriched for cellular functions that include DNA repair, cell cycle regulation, and cell survival as well as canonical pathways that include BRCA1 in DNA damage response and G2/M DNA damage checkpoint repair- analysis done using Ingenuity pathway analysis (A). The ...
Representing and solving complex DNA identification cases
... However, when b is heterozygous but shares an allele with pf, the paternity ratio is reduced by this additional knowledge: intuitively this is because it becomes more likely that pf is a true homozygote, and hence excluded from paternity. This effect is seen in columns 5 and 6 of Table 1 for the cas ...
... However, when b is heterozygous but shares an allele with pf, the paternity ratio is reduced by this additional knowledge: intuitively this is because it becomes more likely that pf is a true homozygote, and hence excluded from paternity. This effect is seen in columns 5 and 6 of Table 1 for the cas ...
Inquiry into Life Twelfth Edition
... • These are position- and orientationindependent DNA elements that stimulate or depress, respectively, transcription of associated genes • Are often tissue-specific in that they rely on tissue-specific DNA-binding proteins for their activities • Some DNA elements can act either as enhancer or silenc ...
... • These are position- and orientationindependent DNA elements that stimulate or depress, respectively, transcription of associated genes • Are often tissue-specific in that they rely on tissue-specific DNA-binding proteins for their activities • Some DNA elements can act either as enhancer or silenc ...
blast
... • E-value – expectation value; the number of different alignments which would yield a similar or better score if searched though the database by chance alone. • Low E-value – sequences may be homologous ...
... • E-value – expectation value; the number of different alignments which would yield a similar or better score if searched though the database by chance alone. • Low E-value – sequences may be homologous ...
Document
... The need for computation in Biology: An introduction to Bioinformatics, Historical overview, the principles involved, development of tools, internet based access. Introduction to Biological Databases, Database Browsing and Data Retrieval - Sequence databases, Structural databases, Literature and oth ...
... The need for computation in Biology: An introduction to Bioinformatics, Historical overview, the principles involved, development of tools, internet based access. Introduction to Biological Databases, Database Browsing and Data Retrieval - Sequence databases, Structural databases, Literature and oth ...
File
... acid has a certain chemical character in relation to water molecules. Some amino acids love being around water (Hydrophilic), some hate water and hide from it (Hydrophobic), and for some, it doesn’t matter as much. Proteins do not exist as a string of amino acids, but must fold into a 3 dimensional ...
... acid has a certain chemical character in relation to water molecules. Some amino acids love being around water (Hydrophilic), some hate water and hide from it (Hydrophobic), and for some, it doesn’t matter as much. Proteins do not exist as a string of amino acids, but must fold into a 3 dimensional ...
Gene regulatory network
A gene regulatory network or genetic regulatory network (GRN) is a collection of regulators thatinteract with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins.The regulator can be DNA, RNA, protein and their complex. The interaction can be direct or indirect (through their transcribed RNA or translated protein).In general, each mRNA molecule goes on to make a specific protein (or set of proteins). In some cases this protein will be structural, and will accumulate at the cell membrane or within the cell to give it particular structural properties. In other cases the protein will be an enzyme, i.e., a micro-machine that catalyses a certain reaction, such as the breakdown of a food source or toxin. Some proteins though serve only to activate other genes, and these are the transcription factors that are the main players in regulatory networks or cascades. By binding to the promoter region at the start of other genes they turn them on, initiating the production of another protein, and so on. Some transcription factors are inhibitory.In single-celled organisms, regulatory networks respond to the external environment, optimising the cell at a given time for survival in this environment. Thus a yeast cell, finding itself in a sugar solution, will turn on genes to make enzymes that process the sugar to alcohol. This process, which we associate with wine-making, is how the yeast cell makes its living, gaining energy to multiply, which under normal circumstances would enhance its survival prospects.In multicellular animals the same principle has been put in the service of gene cascades that control body-shape. Each time a cell divides, two cells result which, although they contain the same genome in full, can differ in which genes are turned on and making proteins. Sometimes a 'self-sustaining feedback loop' ensures that a cell maintains its identity and passes it on. Less understood is the mechanism of epigenetics by which chromatin modification may provide cellular memory by blocking or allowing transcription. A major feature of multicellular animals is the use of morphogen gradients, which in effect provide a positioning system that tells a cell where in the body it is, and hence what sort of cell to become. A gene that is turned on in one cell may make a product that leaves the cell and diffuses through adjacent cells, entering them and turning on genes only when it is present above a certain threshold level. These cells are thus induced into a new fate, and may even generate other morphogens that signal back to the original cell. Over longer distances morphogens may use the active process of signal transduction. Such signalling controls embryogenesis, the building of a body plan from scratch through a series of sequential steps. They also control and maintain adult bodies through feedback processes, and the loss of such feedback because of a mutation can be responsible for the cell proliferation that is seen in cancer. In parallel with this process of building structure, the gene cascade turns on genes that make structural proteins that give each cell the physical properties it needs.It has been suggested that, because biological molecular interactions are intrinsically stochastic, gene networks are the result of cellular processes and not their cause (i.e. cellular Darwinism). However, recent experimental evidence has favored the attractor view of cell fates.