Nucleic Acids - Farmasi Unand
... • Unwinding may start at the end or more commonly in a central section of the DNA helix. It is initiated by the binding of the DNA to specific receptor proteins that have been activated by the appropriate first messenger (see section 8.4). prof. aza ...
... • Unwinding may start at the end or more commonly in a central section of the DNA helix. It is initiated by the binding of the DNA to specific receptor proteins that have been activated by the appropriate first messenger (see section 8.4). prof. aza ...
Differential Regulation of a-Lactalbumin and
... gland on various days of pregnancy and lactation. Chart 8 pups during lactation; casein messenger levels are dimin shows total protein synthesized as a function of the pg of ished (Chart 9A). When a-lactalbumin mRNA activity was measured at RNA added to the translation system. It is apparent from th ...
... gland on various days of pregnancy and lactation. Chart 8 pups during lactation; casein messenger levels are dimin shows total protein synthesized as a function of the pg of ished (Chart 9A). When a-lactalbumin mRNA activity was measured at RNA added to the translation system. It is apparent from th ...
dbPSP: a curated database for protein phosphorylation sites in
... its critical roles in various cellular processes such as signal transduction. Thus, an integrative data resource of the prokaryotic phosphorylation will be useful for further analysis. In this study, we presented a curated database of phosphorylation sites in prokaryotes (dbPSP, Database URL: http:/ ...
... its critical roles in various cellular processes such as signal transduction. Thus, an integrative data resource of the prokaryotic phosphorylation will be useful for further analysis. In this study, we presented a curated database of phosphorylation sites in prokaryotes (dbPSP, Database URL: http:/ ...
Write on zinc fingers
... Cys2His2 The Cys2His2-like fold group is by far the best-characterized class of zinc fingers and is extremely common in mammalian transcription factors. These domains adopt a simple ββα fold and have the amino acid Sequence motif: X2-Cys-X2,4-Cys-X12-His-X3,4,5-His This class of zinc fingers can hav ...
... Cys2His2 The Cys2His2-like fold group is by far the best-characterized class of zinc fingers and is extremely common in mammalian transcription factors. These domains adopt a simple ββα fold and have the amino acid Sequence motif: X2-Cys-X2,4-Cys-X12-His-X3,4,5-His This class of zinc fingers can hav ...
Late events of translation initiation in bacteria: a kinetic analysis
... independent and then the initiation codon-dependent binding of fMet-tRNAfMet (Wintermeyer and Gualerzi, 1983; Canonaco et al., 1986; Gualerzi and Wintermeyer, 1986; La Teana et al., 1996); subsequently, IF2 stimulates the association of 30S and 50S subunits (GrunbergManago et al., 1975) and ®nally a ...
... independent and then the initiation codon-dependent binding of fMet-tRNAfMet (Wintermeyer and Gualerzi, 1983; Canonaco et al., 1986; Gualerzi and Wintermeyer, 1986; La Teana et al., 1996); subsequently, IF2 stimulates the association of 30S and 50S subunits (GrunbergManago et al., 1975) and ®nally a ...
REGULATION BY EXERCISE OF SKELETAL MUSCLE CONTENT
... exercise-training. The adaptive response of muscle to training differs dramatically depending on the nature of the adaptive stimulus. Heavy resistance exercise, also referred to as strength training, results in hypertrophy of the muscle cells with an increase in strength, without major changes in bi ...
... exercise-training. The adaptive response of muscle to training differs dramatically depending on the nature of the adaptive stimulus. Heavy resistance exercise, also referred to as strength training, results in hypertrophy of the muscle cells with an increase in strength, without major changes in bi ...
a curated database for protein phosphorylation sites in prokaryotes
... As one of the most important post-translational modifications, phosphorylation is highly involved in almost all of biological processes through temporally and spatially modifying substrate proteins. Recently, phosphorylation in prokaryotes attracted much attention for its critical roles in various c ...
... As one of the most important post-translational modifications, phosphorylation is highly involved in almost all of biological processes through temporally and spatially modifying substrate proteins. Recently, phosphorylation in prokaryotes attracted much attention for its critical roles in various c ...
AMP-activated protein kinase phosphorylates transcription factors of
... doi:10.1152/japplphysiol.00900.2007.—AMP-activated protein kinase (AMPK) has been identified as a regulator of gene transcription, increasing mitochondrial proteins of oxidative metabolism as well as hexokinase expression in skeletal muscle. In mice, musclespecific knockout of LKB1, a component of t ...
... doi:10.1152/japplphysiol.00900.2007.—AMP-activated protein kinase (AMPK) has been identified as a regulator of gene transcription, increasing mitochondrial proteins of oxidative metabolism as well as hexokinase expression in skeletal muscle. In mice, musclespecific knockout of LKB1, a component of t ...
Supplementary Text S1: Detailed PCR Protocols
... Figure S5A) and regression plot (inset in Supplementary Figure S5A) of the real-time heminested PCR for the IFNB1 gene demonstrated that the quantity of IFNB1 can be detected accurately down to 4 copies of template, where the standard error in cycle numbers (Cp) expands only to 1.3 for 12 repeated m ...
... Figure S5A) and regression plot (inset in Supplementary Figure S5A) of the real-time heminested PCR for the IFNB1 gene demonstrated that the quantity of IFNB1 can be detected accurately down to 4 copies of template, where the standard error in cycle numbers (Cp) expands only to 1.3 for 12 repeated m ...
Expanded roles of leucine-responsive regulatory protein in
... et al., 2002). A certain proportion of the regulated genes are involved, as originally proposed, in transport and metabolism of amino acids, but Lrp has also been suggested to regulate genes involved in biosynthesis and degradation of various metabolites other than amino acids (Brinkman et al., 2003 ...
... et al., 2002). A certain proportion of the regulated genes are involved, as originally proposed, in transport and metabolism of amino acids, but Lrp has also been suggested to regulate genes involved in biosynthesis and degradation of various metabolites other than amino acids (Brinkman et al., 2003 ...
Get - Wiley Online Library
... (and sequence) of DNA, but these vary dramatically between species. The genome of each organism or virus is organized into a unique number of DNA–protein complexes, called chromosomes. The smallest genomes are carried by viruses and may be fewer than 104 base pairs. Escherichia coli has one chromoso ...
... (and sequence) of DNA, but these vary dramatically between species. The genome of each organism or virus is organized into a unique number of DNA–protein complexes, called chromosomes. The smallest genomes are carried by viruses and may be fewer than 104 base pairs. Escherichia coli has one chromoso ...
Serine/Threonine Phosphatases
... (A) Structure of free calcineurin (also called PP2B), which consists of calcineurin A (CNA, blue) and calcineurin B (CNB, gold). The CNB-binding helix (BBH) of CNA and the two calmodulin (CaM)-like domains of CNB together form a composite surface. The autoinhibitory loop forms an α helix and binds t ...
... (A) Structure of free calcineurin (also called PP2B), which consists of calcineurin A (CNA, blue) and calcineurin B (CNB, gold). The CNB-binding helix (BBH) of CNA and the two calmodulin (CaM)-like domains of CNB together form a composite surface. The autoinhibitory loop forms an α helix and binds t ...
Discovery of Paralogous Nuclear Gene Sequences Coding for the
... DeSalle (1996) suggested that nucleic acid sequences and their translated amino acid codings could be combined to address this problem. We performed combined, as well as separate, amino acid and DNA sequence analyses. Intron sequences were removed from the alignments prior to analysis, and the prese ...
... DeSalle (1996) suggested that nucleic acid sequences and their translated amino acid codings could be combined to address this problem. We performed combined, as well as separate, amino acid and DNA sequence analyses. Intron sequences were removed from the alignments prior to analysis, and the prese ...
Metabolic rate depression in animals
... becomes intermittent, and kidney filtration rate is reduced. Organisms do not eat so the energetic costs of digestion, nutrient absorption, and peristalsis are eliminated. A substantial part of total energy savings comes from the suppression of these physiological activities. Metabolic rate is also i ...
... becomes intermittent, and kidney filtration rate is reduced. Organisms do not eat so the energetic costs of digestion, nutrient absorption, and peristalsis are eliminated. A substantial part of total energy savings comes from the suppression of these physiological activities. Metabolic rate is also i ...
Inhibitors of HIV-1 Reverse Transcriptase—Associated
... as well as ribonuclease H (RNase H) activity that degrades the RNA component of the RNA/DNA hybrids duplex intermediate formed during reverse transcription. All of these RT activities are essential for transformation of the viral single-strand genomic RNA into double-strand DNA that can then be inte ...
... as well as ribonuclease H (RNase H) activity that degrades the RNA component of the RNA/DNA hybrids duplex intermediate formed during reverse transcription. All of these RT activities are essential for transformation of the viral single-strand genomic RNA into double-strand DNA that can then be inte ...
Inhibitors of HIV-1 Reverse Transcriptase—Associated
... as well as ribonuclease H (RNase H) activity that degrades the RNA component of the RNA/DNA hybrids duplex intermediate formed during reverse transcription. All of these RT activities are essential for transformation of the viral single-strand genomic RNA into double-strand DNA that can then be inte ...
... as well as ribonuclease H (RNase H) activity that degrades the RNA component of the RNA/DNA hybrids duplex intermediate formed during reverse transcription. All of these RT activities are essential for transformation of the viral single-strand genomic RNA into double-strand DNA that can then be inte ...
Mapping Post-Transcriptional Modifications onto Transfer
... While mass spectrometry, in general, and LC‐ESI‐MS/MS, in particular, are powerful analytical platforms for mapping tRNA modifications, direct analysis of intact tRNAs is typically beyond the capabilities of common mass spectrometry instrumentation requiring specialized high‐end capabilit ...
... While mass spectrometry, in general, and LC‐ESI‐MS/MS, in particular, are powerful analytical platforms for mapping tRNA modifications, direct analysis of intact tRNAs is typically beyond the capabilities of common mass spectrometry instrumentation requiring specialized high‐end capabilit ...
structure and mechanism of dna polymerases
... idea, proposed by Watson and Crick (1953a,b) based on the structure of DNA, was that selection could be determined by the A‐T and G‐C hydrogen bond–mediated base pairing. However, replicative polymerases have error rates for nucleotide insertion in the range of 10–3–10–6/base replicated and the diff ...
... idea, proposed by Watson and Crick (1953a,b) based on the structure of DNA, was that selection could be determined by the A‐T and G‐C hydrogen bond–mediated base pairing. However, replicative polymerases have error rates for nucleotide insertion in the range of 10–3–10–6/base replicated and the diff ...
Cloning and analysis of the mobile element gypsy from D. virilis
... Structure of gypsy from D. virilis and its similarity to gypsy from D. melanogaster The D. virilis genomic library was screened with the probes derived from regions corresponding to the first and the third ORFs and LTR of gypsy from D. melanogaster. Two clones containing presumably full-length copie ...
... Structure of gypsy from D. virilis and its similarity to gypsy from D. melanogaster The D. virilis genomic library was screened with the probes derived from regions corresponding to the first and the third ORFs and LTR of gypsy from D. melanogaster. Two clones containing presumably full-length copie ...
Microsoft Word
... for the apo form of human eIF4E by multidimensional NMR [47] and for the murine factor by hydrogendeuterium exchange combined with electrospray mass spectrometry [48]. The secondary elements were preserved in apo eIF4E while the loops exhibited mobility on the ns - ps time scale that became abrogat ...
... for the apo form of human eIF4E by multidimensional NMR [47] and for the murine factor by hydrogendeuterium exchange combined with electrospray mass spectrometry [48]. The secondary elements were preserved in apo eIF4E while the loops exhibited mobility on the ns - ps time scale that became abrogat ...
02 Cholesterol Metabolism2012-03-18 01:50617 KB
... • Sterol Regulatory Element (SRE) is a recognition sequence in the DNA • SREBP (SRE binding protein) binding to SRE is essential for transcription of this gene • SREBP cleavage-activating protein (SCAP) is an intracellular cholesterol sensor ...
... • Sterol Regulatory Element (SRE) is a recognition sequence in the DNA • SREBP (SRE binding protein) binding to SRE is essential for transcription of this gene • SREBP cleavage-activating protein (SCAP) is an intracellular cholesterol sensor ...
Ribozyme catalysis: not different, just worse
... there are only a limited number of mechanisms through which a reaction can be catalyzed. The overall goal is to stabilize the transition state of the reaction relative to the ground state. To do this, the catalyst can pay for the cost of entropy lost in achieving the transition state by positioning ...
... there are only a limited number of mechanisms through which a reaction can be catalyzed. The overall goal is to stabilize the transition state of the reaction relative to the ground state. To do this, the catalyst can pay for the cost of entropy lost in achieving the transition state by positioning ...
Conformational Changes in HIV-1 Reverse Transcriptase Induced
... Keywords: HIV-1 reverse transcriptase; nonnucleoside reverse transcriptase inhibitor; DNA polymerase; ribonuclease H. INTRODUCTION Reverse transcription of the viral single-stranded (+) RNA genome into double-stranded DNA is an essential step in the human immunodeficiency virus (HIV) life-cycle. Alt ...
... Keywords: HIV-1 reverse transcriptase; nonnucleoside reverse transcriptase inhibitor; DNA polymerase; ribonuclease H. INTRODUCTION Reverse transcription of the viral single-stranded (+) RNA genome into double-stranded DNA is an essential step in the human immunodeficiency virus (HIV) life-cycle. Alt ...
Synthesis of Oligonucleotides
... chosen, since they are stable for long periods during mildly basic and acidic conditions used during oligonucleotide synthesis, and are removed with concentrated ammonia at the end of the synthesis (Section 4.1.4). The benzoyl group is used to protect both adenine and cytosine, while isobutyryl is u ...
... chosen, since they are stable for long periods during mildly basic and acidic conditions used during oligonucleotide synthesis, and are removed with concentrated ammonia at the end of the synthesis (Section 4.1.4). The benzoyl group is used to protect both adenine and cytosine, while isobutyryl is u ...
Biochemical Oscillations
... (either its affinity for substrates or its rate of converting bound substrates into products). Such enzymes are called “allosteric” because in addition to substrate-binding sites, they have “other sites” for binding regulatory molecules that either activate or inhibit the enzyme. Allosteric proteins ...
... (either its affinity for substrates or its rate of converting bound substrates into products). Such enzymes are called “allosteric” because in addition to substrate-binding sites, they have “other sites” for binding regulatory molecules that either activate or inhibit the enzyme. Allosteric proteins ...