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... NOTICE: This product may be subject to certain use restrictions. Before using this product, please refer to the Online Technical Support page (http://technical-support.roche.com) and search under the product number or the product name, whether this product is subject to a license disclaimer containi ...
Degradation of DNA damage-independently stalled RNA
Degradation of DNA damage-independently stalled RNA

... (3). Adverse growth conditions such as lack of nutrients leading to low NTP levels most likely further impair transcription elongation as mimicked by treatment with the drug 6-azauracil (6AU). RNAPII complexes stalled during transcription elongation for a prolonged time might stall irreversibly. Thu ...
QC of RNA - Prostate Cancer Biorepository Network
QC of RNA - Prostate Cancer Biorepository Network

... To describe the procedure for the QC of RNA extracted from frozen tissue by real-time PCR. NOTE: This SOP does not cover detailed procedures for handling Human Biological Materials or hazardous chemicals and it is recommended that personnel following this SOP refer to institutional safety guidelines ...
Characterization of a Negative Thyroid Hormone Response Element
Characterization of a Negative Thyroid Hormone Response Element

... reporter gene expression in transient transfection assays (11). In contrast, we found that the region between nucleotides 2116 to 26 of the a3 gene promoter suppressed chimeric gene expression about 50% in primary cultures of cardiac myocytes incubated in the presence of T3 and cotransfected T3 rece ...
High-resolution dynamics of the transcriptional response to nutrition
High-resolution dynamics of the transcriptional response to nutrition

... accumulated until 7 h postrefeeding, after which time relatively few changes were detected (Fig. 1B). The decrease in observed change points occurs while individuals remained physiologically synchronous since the coefficient of variation among expression ratios did not increase in late relative to e ...
Poster. - Stanford University
Poster. - Stanford University

... nonlinear ICA finds components that are specific to certain biological processes. Genes that exhibit significant up-regulation or downregulation within each component are grouped into clusters. We test the statistical significance of enrichment of gene annotations within each cluster. ICA-based clus ...
Protein synthesis
Protein synthesis

... The ultimate cellular location of proteins is often determined by specific, relatively short amino acid sequence within the proteins themselves. These sequences can be responsible for proteins being secreted, imported into the nucleus or targeted to other organelles. ...
Genes, Genomics, and Chromosomes
Genes, Genomics, and Chromosomes

... The first component has the characteristic of ovalbumin mRNA The second component has the total complexity of 15 Kb (7-8 different mRNA of 2000 bases The last component has the complexity of 26 Mb (~13,000 ...
34. Measuring Selection in RNA molecules.
34. Measuring Selection in RNA molecules.

... Measuring selection on protein molecules exploits the periodicity of the 3 bases forming the amino acid and the genetic code to calculate Ka/Ks. Ka is the number of non­synonymous substitutions per non­ synonymous site, and Ks is the number of synonymous substitutions per synonymous site. The ratio  ...
The stability of mRNA influences the temporal order of the induction
The stability of mRNA influences the temporal order of the induction

...  If the α -fragment of the lacZ gene on the plasmid is intact (that is, you have a non-recombinant plasmid), these two fragments of the lacZ gene (one on the plasmid and the other on the chromosome) complement each other and will produce a functional β galactosidase enzyme. ...
Inquiry into Life Twelfth Edition
Inquiry into Life Twelfth Edition

... • Transposons themselves have contributed dozens of genes to the genome • Bacteria also have donated dozens of genes • Finished draft is much more accurate than working draft, but there are still gaps • Information also about gene birth and death ...
Step 2
Step 2

... Example* - Pipeline for Analysis of Protein Variation Due to Alternative Splicing and SNPs The alternative splicing pipeline will provide a complete characterization of variations in proteins due to splice variation or SNPs evident in repositiories of contiguous genome sequence data and expressed s ...
A New Plant Breeding Technique: Gene Editing
A New Plant Breeding Technique: Gene Editing

... • Gene editing technologies continue the history of improving  crop development through modern targeted mutational  applications • Gene editing allows, for the first time, mutations to be targeted  to a specific, desired location in the plant genome ...
pDsRed-Monomer-Mem Hyg Vector Information
pDsRed-Monomer-Mem Hyg Vector Information

... DsRed-Monomer (DsRed.M1) is a monomeric mutant derived from the tetrameric Discosoma sp. red fluorescent protein DsRed (1). DsRed-Monomer contains a total of forty-five amino acid substitutions. When DsRed-Monomer is expressed in mammalian cell cultures, red fluorescent cells can be detected by eith ...
The Hierarchy of the 3D Genome
The Hierarchy of the 3D Genome

... There are indeed similarities between LADs and NADs. First, through the use of photoactivation and time-lapse fluorescence microscopy, it was shown that NADs either relocalize at the nucleoli or colocalize with the nuclear lamina after cell division (van Koningsbruggen et al., 2010). Furthermore, th ...
Diapositive 1 - ORBi - Université de Liège
Diapositive 1 - ORBi - Université de Liège

... for KLF4) is located between these two sites. To study the interplay between SIP1 and KLF4, we co-transfected reporter vectors mutated for theses binding sites and a SIP1expression vector. ...
MODULE 2
MODULE 2

... 9. Random coils and triple helices are examples to what protein structure? ...
Complete nucleotide sequence and genome organization of a
Complete nucleotide sequence and genome organization of a

... a stable hairpin structure (Fig. 2A) located just upstream of the UAA termination codon of the 29K gene. Fig. 2B shows an alternative RNA folding with pseudoknot formation in this region (stems I and II have free energy -5,5 and -4,0 kcallmol, respectively). Both tentative folding have similar calcu ...
GENETICS and the DNA code NOTES BACKGROUND DNA is the
GENETICS and the DNA code NOTES BACKGROUND DNA is the

... stop codon, signaling the end of the polypeptide. This polypeptide is then folding to make a protein. Some proteins are made of a single polypeptide, while others are made up of multiple polypeptides bonded together. Mutations are changes in a gene in the DNA, which may cause the protein to not form ...
Association of polymorphisms in IL-12/IFN-gamma
Association of polymorphisms in IL-12/IFN-gamma

... activation of cell-mediated immunity required for the elimination of pathogens. Mutations in genes of the IL-12/IFN-gamma axis are known to cause extreme susceptibility to infection with environmental mycobacteria, and subtle variations in these genes may influence susceptibility to more virulent my ...
Decoding the Flu - National Center for Case Study Teaching in
Decoding the Flu - National Center for Case Study Teaching in

... want you to compare the HA gene for the viruses the team was examining with a typical flu virus. Because we don’t have power right now, you will have to do this the old-fashioned way with pencil and paper. I will get you the nucleotide sequence for a typical HA gene. You can start by finding the cod ...
Neuroepigenetica
Neuroepigenetica

... There is clearly good reason for the excitement associated with studies of epigenetics and mental health. While the inaccessibility of the human brain is indeed a major limitation, it is worth noting that earlier studies of peripheral samples contributed to our understanding of the biochemical basi ...
Decoding the Flu - Castle High School
Decoding the Flu - Castle High School

... want you to compare the HA gene for the viruses the team was examining with a typical flu virus. Because we don’t have power right now, you will have to do this the old-fashioned way with pencil and paper. I will get you the nucleotide sequence for a typical HA gene. You can start by finding the cod ...
Ex2 answers
Ex2 answers

... (a, 5 pts) Towards which pole of the gel will the Hrt1 RNA run? Your choices are: positive, negative, neither, both, or inconclusive. Explain your answer. The positive pole. RNA is negatively charged so it will be attracted to the positive pole. RNA is negative because it is made of nucleotides, and ...
Decoding the Flu
Decoding the Flu

... want you to compare the HA gene for the viruses the team was examining with a typical flu virus. Because we don’t have power right now, you will have to do this the old-fashioned way with pencil and paper. I will get you the nucleotide sequence for a typical HA gene. You can start by finding the cod ...
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Transcriptional regulation

In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. A single gene can be regulated in a range of ways, from altering the number of copies of RNA that are transcribed, to the temporal control of when the gene is transcribed. This control allows the cell or organism to respond to a variety of intra- and extracellular signals and thus mount a response. Some examples of this include producing the mRNA that encode enzymes to adapt to a change in a food source, producing the gene products involved in cell cycle specific activities, and producing the gene products responsible for cellular differentiation in higher eukaryotes.The regulation of transcription is a vital process in all living organisms. It is orchestrated by transcription factors and other proteins working in concert to finely tune the amount of RNA being produced through a variety of mechanisms. Prokaryotic organisms and eukaryotic organisms have very different strategies of accomplishing control over transcription, but some important features remain conserved between the two. Most importantly is the idea of combinatorial control, which is that any given gene is likely controlled by a specific combination of factors to control transcription. In a hypothetical example, the factors A and B might regulate a distinct set of genes from the combination of factors A and C. This combinatorial nature extends to complexes of far more than two proteins, and allows a very small subset (less than 10%) of the genome to control the transcriptional program of the entire cell.
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