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Topic 8 Assessed Homework Task - A
Topic 8 Assessed Homework Task - A

... Ethanol is an important fuel. A dilute aqueous solution of ethanol can be produced by the fermentation of an aqueous solution of glucose. It is claimed that the ethanol obtained from this solution is a carbon-neutral biofuel. Write an equation for this fermentation reaction. Give two other essential ...
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... Such changes can complicate the mechanism: for example does the Os(VI) ester get hydrolysed before it is re-oxidised, or does it get oxidised first? The details are still being sorted out. The key observation was: some amines accelerate the reaction (by complexing to Os), though some amines slow it ...
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Wolff–Kishner reduction



The Wolff–Kishner reduction is a reaction used in organic chemistry to convert carbonyl functionalities into methylene groups. In the context of complex molecule synthesis, it is most frequently employed to remove a carbonyl group after it has served its synthetic purpose of activating an intermediate in a preceding step. As such, there is no obvious retron for this reaction. Originally reported by Nikolai Kischner in 1911 and Ludwig Wolff in 1912, it has been applied to the total synthesis of scopadulcic acid B, aspidospermidine and dysidiolide.In general, the reaction mechanism first involves the in situ generation of a hydrazone by condensation of hydrazine with the ketone or aldehyde substrate. Sometimes it is however advantageous to use a pre-formed hydrazone as substrate (see modifications). The hydrazone is deprotonated by alkoxide base followed by a concerted, rate-determining step in which a diimide anion is formed. Collapse of this alkyldiimde with loss of N2 leads to formation of an alkylanion which can be protonated by solvent to give the desired product.Because the Wolff–Kishner reduction requires highly basic conditions, it is unsuitable for base-sensitive substrates. However, this method can be superior over the related Clemmensen reduction for acid-sensitive compounds such as pyrroles and for high-molecular weight compounds.
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