中国科学技术大学有机合成讲义-2
... G. J. Am. Chem. Soc. 1965, 87, 5661). Dicyclohexylcarbodiimide (DCC) functions as the electrophilic activating agent in conjunction with a Br?nsted acid promoter. Typically, oxidations are carried out with an excess of DCC at or near 23 °C. Separation of the by-product dicyclohexylurea and MTM ether ...
... G. J. Am. Chem. Soc. 1965, 87, 5661). Dicyclohexylcarbodiimide (DCC) functions as the electrophilic activating agent in conjunction with a Br?nsted acid promoter. Typically, oxidations are carried out with an excess of DCC at or near 23 °C. Separation of the by-product dicyclohexylurea and MTM ether ...
Organic Chemistry/Fourth Edition: e-Text
... Chloral is trichloroethanal, CCl3CH . Chloral hydrate is the addition product of chloral and water. ...
... Chloral is trichloroethanal, CCl3CH . Chloral hydrate is the addition product of chloral and water. ...
Chem. Soc. Rev., 2015, 44, 2202--2220 - RSC Publishing
... group) and B(C6F5)3 (Si–H bond) were mainly attributed to the electronic nature of their boron centres. Just recently, Piers, Tuononen, and co-workers finally presented the long-awaited experimental evidence for the missing link of the catalytic cycle, that is the hydrosilane–borane adduct IV.17 The ...
... group) and B(C6F5)3 (Si–H bond) were mainly attributed to the electronic nature of their boron centres. Just recently, Piers, Tuononen, and co-workers finally presented the long-awaited experimental evidence for the missing link of the catalytic cycle, that is the hydrosilane–borane adduct IV.17 The ...
Design of mesoporous silica templates for nanoparticle - IFM
... Figure 2.3: Possible synthesis pathway for the synthesis of hexagonal silica [2]. The reaction mechanism can be viewed at three length scales: the molecular one, the mesoscopic scale and the macro scale. In these scales one can study the interactions between the molecules, the development of micella ...
... Figure 2.3: Possible synthesis pathway for the synthesis of hexagonal silica [2]. The reaction mechanism can be viewed at three length scales: the molecular one, the mesoscopic scale and the macro scale. In these scales one can study the interactions between the molecules, the development of micella ...
Ion Exchange Resins: Catalyst Recovery and Recycle
... with RhCl3 and a methyl iodide/methanol/acetic acid mixture under reaction conditions (190 °C, 5.0 MPa carbon monoxide pressure, low water content) generates in situ both the N-methylpyridinium iodide ion-exchanger derivative and, subsequently, the immobilized catalyst, by substitution of iodide wit ...
... with RhCl3 and a methyl iodide/methanol/acetic acid mixture under reaction conditions (190 °C, 5.0 MPa carbon monoxide pressure, low water content) generates in situ both the N-methylpyridinium iodide ion-exchanger derivative and, subsequently, the immobilized catalyst, by substitution of iodide wit ...
Module I Oxidation Reactions
... The catalytically active species in the reaction most likely is an imidotrioxo osmium(VIII) complexes, which is formed in situ from the osmium reagent and the stoichiometric nitrogen source, i.e. chloroamine (Scheme 14). Experiments under stoichiometric conditions have been shown that imidotrioxo os ...
... The catalytically active species in the reaction most likely is an imidotrioxo osmium(VIII) complexes, which is formed in situ from the osmium reagent and the stoichiometric nitrogen source, i.e. chloroamine (Scheme 14). Experiments under stoichiometric conditions have been shown that imidotrioxo os ...
C−C, C−O, C−N Bond Formation on sp2 Carbon by Pd(II)
... at the University of Insubria in 2004. She is currently carrying out her Ph.D. program on Pd-catalyzed domino reactions under the cosupervision of Dr. Gianluigi Broggini of the University of Insubria and Professor Giovanni Poli of the University Pierre et Marie Curie (Paris). Gianluigi Broggini, bor ...
... at the University of Insubria in 2004. She is currently carrying out her Ph.D. program on Pd-catalyzed domino reactions under the cosupervision of Dr. Gianluigi Broggini of the University of Insubria and Professor Giovanni Poli of the University Pierre et Marie Curie (Paris). Gianluigi Broggini, bor ...
Title Several Reactions of Isocyanide and Related Compounds
... LIST OF PUBLISHED PAPERS . . . . • • . . . . . . . . . . . . . . . • . . ...
... LIST OF PUBLISHED PAPERS . . . . • • . . . . . . . . . . . . . . . • . . ...
Transition Metal Catalyzed Selective Oxidation of Sugars and Polyols
... I thank my supervisor Prof. Marcel Schlaf at the University of Guelph for his guidance through this research project and nurturing my interest in chemistry. I gained invaluable experience in the past years and hope to adopt his style of research in the future. I also thank Prof. Peter Klüfers as my ...
... I thank my supervisor Prof. Marcel Schlaf at the University of Guelph for his guidance through this research project and nurturing my interest in chemistry. I gained invaluable experience in the past years and hope to adopt his style of research in the future. I also thank Prof. Peter Klüfers as my ...
Alcohols
... – they do not react with reducing agents such as H2 in the presence of a transition metal catalyst – they are not affected by most acids or bases at moderate temperatures (but can eliminate) ...
... – they do not react with reducing agents such as H2 in the presence of a transition metal catalyst – they are not affected by most acids or bases at moderate temperatures (but can eliminate) ...
06. Alcohols. Phenols. Ethers
... are called monohydric alcohols. These are further classified as primary (1'), secondary (2'), and tertiary (3') according as the ОН group is attached to primary, secondary and tertiary carbon atoms respectively. For example: ...
... are called monohydric alcohols. These are further classified as primary (1'), secondary (2'), and tertiary (3') according as the ОН group is attached to primary, secondary and tertiary carbon atoms respectively. For example: ...
Synthesis And Antifungal Activity Of Terbinafine Analogues
... The treatment of fungal infection is still challenging due to an increase in mycotic infection and emergence of drug resistance has necessitated development of new antifungal agents1-2. Squalene epoxidase (SE; squalene monooxygenase; EC 1.14.99.7) is a membrane-bound enzyme in fungi that is responsi ...
... The treatment of fungal infection is still challenging due to an increase in mycotic infection and emergence of drug resistance has necessitated development of new antifungal agents1-2. Squalene epoxidase (SE; squalene monooxygenase; EC 1.14.99.7) is a membrane-bound enzyme in fungi that is responsi ...
kinetic and thermodynamic studies of the oxidation of perfumery
... *E-mail: [email protected] ABSTRACT Oxidation is one of the most important industrial reactions as it yields useful products. Literature survey indicates the use of a variety of organic oxidants for the oxidation of alcohols to the corresponding carbonyl compounds but inorganic oxidants have rare ...
... *E-mail: [email protected] ABSTRACT Oxidation is one of the most important industrial reactions as it yields useful products. Literature survey indicates the use of a variety of organic oxidants for the oxidation of alcohols to the corresponding carbonyl compounds but inorganic oxidants have rare ...
CHEM 203 Material
... Example: the C atom in CH4 has formally acquired 4 electrons, thereby assuming the oxidation state of –4. This produces a significant concentration of electronic density around the C atom. One may predict that the C atom in methane will behave as an electron donor in its reactions; that is, it will ...
... Example: the C atom in CH4 has formally acquired 4 electrons, thereby assuming the oxidation state of –4. This produces a significant concentration of electronic density around the C atom. One may predict that the C atom in methane will behave as an electron donor in its reactions; that is, it will ...
Naming Organic Compounds I
... N.B.: A complex substituent is alphabetized under the first letter of its name. Branched alkyl groups On page 40, it was shown that straight-chain alkyl (n-alkyl) groups are formed by removal of a terminal (end) hydrogen atom from straight-chain alkanes. It is also possible to generate a large numbe ...
... N.B.: A complex substituent is alphabetized under the first letter of its name. Branched alkyl groups On page 40, it was shown that straight-chain alkyl (n-alkyl) groups are formed by removal of a terminal (end) hydrogen atom from straight-chain alkanes. It is also possible to generate a large numbe ...
Nucleophilic ring opening of aziridines
... opening of aziridines with carbanions was demonstrated in stereo and regio-controlled synthesis of 3-amino-4-substituted piperidines in our laboratory recently.21 As shown in Scheme 3, piperidinyl aziridine 6 bearing an N-phosphonate activating group was treated with various Grignard reagents/CuI gi ...
... opening of aziridines with carbanions was demonstrated in stereo and regio-controlled synthesis of 3-amino-4-substituted piperidines in our laboratory recently.21 As shown in Scheme 3, piperidinyl aziridine 6 bearing an N-phosphonate activating group was treated with various Grignard reagents/CuI gi ...
(omit), and Epoxides
... – In ethyl vinyl ether, for example, the ether oxygen is bonded to one sp3 hybridized carbon and one sp2 hybridized carbon. ...
... – In ethyl vinyl ether, for example, the ether oxygen is bonded to one sp3 hybridized carbon and one sp2 hybridized carbon. ...
Application of Novel Phosphine Ligands in Palladium
... new catalytic cycle. Often, these not chemical but physical reaction steps are rate-determining for the whole reaction. The third part of catalyzed reactions constitutes the transformations promoted by biomolecules, namely enzymes. Thus, nature can be considered as the world’s leading catalyst desig ...
... new catalytic cycle. Often, these not chemical but physical reaction steps are rate-determining for the whole reaction. The third part of catalyzed reactions constitutes the transformations promoted by biomolecules, namely enzymes. Thus, nature can be considered as the world’s leading catalyst desig ...
19.7 Reversible Addition Reactions of Aldehydes and Ketones
... selective than LiAlH4 • LiAlH4 reacts with alkyl halides, alkyl tosylates, and nitro groups, but NaBH4 does not ...
... selective than LiAlH4 • LiAlH4 reacts with alkyl halides, alkyl tosylates, and nitro groups, but NaBH4 does not ...
CH221 CLASS 13
... Addition of water to alkenes to give alcohols is one of the most important reactions of alkenes. In industry, this is accomplished by the use of strong acid catalysts and high temperatures, but this is not really of much value in the laboratory. However, tertiary alcohols can be produced from highly ...
... Addition of water to alkenes to give alcohols is one of the most important reactions of alkenes. In industry, this is accomplished by the use of strong acid catalysts and high temperatures, but this is not really of much value in the laboratory. However, tertiary alcohols can be produced from highly ...
Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.