Mannich Reaction - SUST Repository
... (X= N,P,S,O,etc) affording X-amino methylationm , such as aliphatic and aromatic NH substrates5. 1.3.2- Phenols and NH-Activated Aryl substrates When aromatic ring is suitably activated by electron – donor substituents (NR2 ,OH or alkoxy groups) for electrophilic attack, it can easily be subjected t ...
... (X= N,P,S,O,etc) affording X-amino methylationm , such as aliphatic and aromatic NH substrates5. 1.3.2- Phenols and NH-Activated Aryl substrates When aromatic ring is suitably activated by electron – donor substituents (NR2 ,OH or alkoxy groups) for electrophilic attack, it can easily be subjected t ...
IB2 SL CHEMISTRY Name: …………………………… Topic 10
... Ethanol and ethanoic acid can be distinguished by their melting points. State and explain which of the two compounds will have a higher melting point. ...
... Ethanol and ethanoic acid can be distinguished by their melting points. State and explain which of the two compounds will have a higher melting point. ...
New Phenylglycine-Derived Primary Amine Organocatalysts for the
... anticipated by us that introducing sterically more demanding side chains through cyclohexylglycine or tert-leucine (amino alcohols 16–17) would enhance the enantioselectivity even further, a hypothesis obviously invalidated by experiment. Clearly, the presence of an aromatic moiety is crucial. Among ...
... anticipated by us that introducing sterically more demanding side chains through cyclohexylglycine or tert-leucine (amino alcohols 16–17) would enhance the enantioselectivity even further, a hypothesis obviously invalidated by experiment. Clearly, the presence of an aromatic moiety is crucial. Among ...
Terrahedron Letters. Vo1.32, No.43, pi 6089
... group over freshly prepared palladium oxide produced the 3-tosyl mannose-4,6-acetonide Several attempts (e.g., bromine in water, etc.) to oxidize 9 to give the corresponding ...
... group over freshly prepared palladium oxide produced the 3-tosyl mannose-4,6-acetonide Several attempts (e.g., bromine in water, etc.) to oxidize 9 to give the corresponding ...
O–H hydrogen bonding promotes H-atom transfer from a C–H bonds
... metal catalyzed C(sp3)–H activation—including, among others, Hartwig’s rhodium-catalyzed borylation of terminal methyl groups (4) and White’s iron-catalyzed oxidation of both secondary (2°) and tertiary (3°) aliphatic C–H bonds (5)—highlight the importance of catalyst structure on site selectivity. ...
... metal catalyzed C(sp3)–H activation—including, among others, Hartwig’s rhodium-catalyzed borylation of terminal methyl groups (4) and White’s iron-catalyzed oxidation of both secondary (2°) and tertiary (3°) aliphatic C–H bonds (5)—highlight the importance of catalyst structure on site selectivity. ...
4888 Journal of the American Chemical Society 1OO:lS 1 July 19
... state of l . 8 3 9 Earlier we emphasized the necessity of further IR studies on both 1 and its perdeuterio derivative 4.1a,5aThe spectral evidence presented herein now disproves the previous conclusion that the ring is square and is only consistent with a geometry less symmetrical than D.$h, very li ...
... state of l . 8 3 9 Earlier we emphasized the necessity of further IR studies on both 1 and its perdeuterio derivative 4.1a,5aThe spectral evidence presented herein now disproves the previous conclusion that the ring is square and is only consistent with a geometry less symmetrical than D.$h, very li ...
O R` R
... • Outline two ways in which 4-methyl-2-octanone can be prepared by conjugate additon of an organocuprate to an ...
... • Outline two ways in which 4-methyl-2-octanone can be prepared by conjugate additon of an organocuprate to an ...
Organic Chemistry II
... These alkyl chloroformates can react with ammonia or amines to form carbamates (urethanes) ...
... These alkyl chloroformates can react with ammonia or amines to form carbamates (urethanes) ...
Reactions involving HCl and their Evaporation
... has to be removed post reaction. The paper further discusses evaporation solutions to the problems which routine use of concentrated HCl can create. Deprotection using Hydrochloric Acid Di-tert-butyl dicarbonate is a widely used reagent in organic synthesis. The carbonate ester group in this reagent ...
... has to be removed post reaction. The paper further discusses evaporation solutions to the problems which routine use of concentrated HCl can create. Deprotection using Hydrochloric Acid Di-tert-butyl dicarbonate is a widely used reagent in organic synthesis. The carbonate ester group in this reagent ...
Drawing Organic Structures Functional Groups Constitutional Isomers
... • What happens to a stereocenter (chirality center) during the course of this reaction? Structure of the Alkyl Halide: • List alkyl halide type (1, 2, 3) in order of decreasing ability to undergo this type of substitution reaction. Are there any types of alkyl halides that do not undergo this typ ...
... • What happens to a stereocenter (chirality center) during the course of this reaction? Structure of the Alkyl Halide: • List alkyl halide type (1, 2, 3) in order of decreasing ability to undergo this type of substitution reaction. Are there any types of alkyl halides that do not undergo this typ ...
temperature and diffusion
... The fact that the reaction rate depends strongly on the temperature, suggests that the conversion rate is controlled by the reaction steps, rather than the mass transport phenomena of the diffusion of the substrates in the interior of the catalyst. On the other hand, when the MBGs are based on AOT, ...
... The fact that the reaction rate depends strongly on the temperature, suggests that the conversion rate is controlled by the reaction steps, rather than the mass transport phenomena of the diffusion of the substrates in the interior of the catalyst. On the other hand, when the MBGs are based on AOT, ...
Organic Chemistry Introduction
... species is higher in energy, therefore, it is easier to get to the less stable product • Reaction is reversable • At high temperatures, sufficient E for both reactions to occur •A B (fast) and A C (slower) • or B A C • We see more stable product dominate. Fall, 2009 ...
... species is higher in energy, therefore, it is easier to get to the less stable product • Reaction is reversable • At high temperatures, sufficient E for both reactions to occur •A B (fast) and A C (slower) • or B A C • We see more stable product dominate. Fall, 2009 ...
Alkyl halide
... Other halo-substituted compounds are providing important leads to new medicines ...
... Other halo-substituted compounds are providing important leads to new medicines ...
HPLC and LC–MS Studies of the Transesterification Reaction of
... positional isomers at the collection stage, the vials were kept on a bed of ice between collections. When the fraction collection was done, the mobile phase in the collected samples was evaporated overnight to dryness with a SpeedVac Plus Concentrator (Model SC210A) (Holbrook, NY). The dry samples w ...
... positional isomers at the collection stage, the vials were kept on a bed of ice between collections. When the fraction collection was done, the mobile phase in the collected samples was evaporated overnight to dryness with a SpeedVac Plus Concentrator (Model SC210A) (Holbrook, NY). The dry samples w ...
Carboxylic Acid Derivatives
... Since esters are, in general, less reactive than more activated carboxylic acid derivatives (like acid chlorides or anhydrides), the reaction of esters with amines, for example, requires higher temperatures and longer reaction times. ...
... Since esters are, in general, less reactive than more activated carboxylic acid derivatives (like acid chlorides or anhydrides), the reaction of esters with amines, for example, requires higher temperatures and longer reaction times. ...
Ch 10 Haloalkanes n haloarenes
... Tert-butyl chloride reacts via SN¹ mechanism because the heterolytic cleavage of C — Cl bond in tert-butyl chloride gives 3 carbocation which is highly stable and favourable for SN¹ mechanism. Moreover, tert-butyl chloride (3°) bring a bulky molecule has steric hindrance which will not allow SN² mec ...
... Tert-butyl chloride reacts via SN¹ mechanism because the heterolytic cleavage of C — Cl bond in tert-butyl chloride gives 3 carbocation which is highly stable and favourable for SN¹ mechanism. Moreover, tert-butyl chloride (3°) bring a bulky molecule has steric hindrance which will not allow SN² mec ...
Organic Chemistry Lecture Outline Chapter 21: Carboxylic Acid
... 1. Acyl halides are usually prepared from carboxylic acids with SOCl2. B. Preparation of Anhydrides 1. Anhydrides are usually prepared by reacting acyl chlorides with carboxylic acids in the presence of pyridine. C. Preparation of Esters: Esters can be prepared in three ways. 1. Fisher Esterificatio ...
... 1. Acyl halides are usually prepared from carboxylic acids with SOCl2. B. Preparation of Anhydrides 1. Anhydrides are usually prepared by reacting acyl chlorides with carboxylic acids in the presence of pyridine. C. Preparation of Esters: Esters can be prepared in three ways. 1. Fisher Esterificatio ...
Question paper - Unit F322 - Chains, energy and resources
... Write your name clearly in capital letters, your Centre Number and Candidate Number in the boxes above. Use black ink. Pencil may be used for graphs and diagrams only. Read each question carefully and make sure that you know what you have to do before starting your answer. Answer all the questions. ...
... Write your name clearly in capital letters, your Centre Number and Candidate Number in the boxes above. Use black ink. Pencil may be used for graphs and diagrams only. Read each question carefully and make sure that you know what you have to do before starting your answer. Answer all the questions. ...
Mechanism of Autoxidative Degradation of Cellulose
... oxygen may be reduced to water by one-electron transfer in four successive stages giving rise to intermediate products, namely, superoxide (HOO/O2ˉ), hydrogen peroxide (H2O2) and hydroxyl radicals (HO). The reaction thermodynamics for these processes are strongly influenced by the solution matrix an ...
... oxygen may be reduced to water by one-electron transfer in four successive stages giving rise to intermediate products, namely, superoxide (HOO/O2ˉ), hydrogen peroxide (H2O2) and hydroxyl radicals (HO). The reaction thermodynamics for these processes are strongly influenced by the solution matrix an ...
I. ALDEHYDES AND KETONES Carbonyl compounds are
... 6. When the -COR group becomes a substituent on another chain, it is referred to as an acyl group and the name is formed using the suffix -yl. ...
... 6. When the -COR group becomes a substituent on another chain, it is referred to as an acyl group and the name is formed using the suffix -yl. ...
Chapter 8
... • Aliphatic amines have about the same base strength, and are slightly stronger bases than NH3. • Aromatic and heterocyclic aromatic. • amines are considerably weaker bases than aliphatic amines. • Note that while aliphatic amines are weak bases by comparison with inorganic bases such as NaOH, they ...
... • Aliphatic amines have about the same base strength, and are slightly stronger bases than NH3. • Aromatic and heterocyclic aromatic. • amines are considerably weaker bases than aliphatic amines. • Note that while aliphatic amines are weak bases by comparison with inorganic bases such as NaOH, they ...
conversion of the OH group into a better leaving group, and
... • When an OH group is bonded to a ring, the ring is numbered beginning with the OH group. • Because the functional group is at C1, the 1 is usually omitted from the name. • The ring is then numbered in a clockwise or counterclockwise fashion to give the next substituent the lowest number. ...
... • When an OH group is bonded to a ring, the ring is numbered beginning with the OH group. • Because the functional group is at C1, the 1 is usually omitted from the name. • The ring is then numbered in a clockwise or counterclockwise fashion to give the next substituent the lowest number. ...
Alkane
... The addition of hydrogen to the C=C double bond always involves catalysis by such metals as Ni, Pt at room temperature and pressure. ...
... The addition of hydrogen to the C=C double bond always involves catalysis by such metals as Ni, Pt at room temperature and pressure. ...
esterification of palmitic acid with methanol in the
... The esterification of palmitic acid with methanol was carried out in a batch reactor system. The data were obtained to study the kinetics of the reaction and to evaluate the kinetic parameters of the esterification process. A pre-mixed method was opted in order to study the behavior of the heterogen ...
... The esterification of palmitic acid with methanol was carried out in a batch reactor system. The data were obtained to study the kinetics of the reaction and to evaluate the kinetic parameters of the esterification process. A pre-mixed method was opted in order to study the behavior of the heterogen ...
Chapter 11: Alcohols and Ethers
... • Alkylation (Ether Formation) Protects OH’s During Synthesis • Can Remove the Protecting Group w/ Dilute Aqueous Acid • Generally Dissolve Alcohol in Acid, THEN add Isobutylene • Addition in this Manner Minimizes Isobutylene Dimerization • Let’s See Why We Might Want to Use a Protecting Group ...
... • Alkylation (Ether Formation) Protects OH’s During Synthesis • Can Remove the Protecting Group w/ Dilute Aqueous Acid • Generally Dissolve Alcohol in Acid, THEN add Isobutylene • Addition in this Manner Minimizes Isobutylene Dimerization • Let’s See Why We Might Want to Use a Protecting Group ...
Hofmann–Löffler reaction
The Hofmann–Löffler reaction (also referred to as Hofmann–Löffler–Freytag reaction, Löffler–Freytag reaction, Löffler–Hofmann reaction, as well as Löffler's method) is an organic reaction in which a cyclic amine 2 (pyrrolidine or, in some cases, piperidine) is generated by thermal or photochemical decomposition of N-halogenated amine 1 in the presence of a strong acid (concentrated sulfuric acid or concentrated CF3CO2H). The Hofmann–Löffler–Freytag reaction proceeds via an intramolecular hydrogen atom transfer to a nitrogen-centered radical and is an example of a remote intramolecular free radical C–H functionalization.