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Slide 1
Slide 1

... reddish-brown colour of iodine solution being formed during the reaction. Note also, that sodium chlorate(I) solution is alkaline and contains a sufficietly high [OH-] to carry out the second half of the reaction. In effect you are making I2 “in situ” so the tests are essentially the same. ...
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Arginine- or Lysine-catalyzed Michael Addition of Nitromethane to α

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... For example, CaO melts at 2572°C, a temperature well beyond the range of an ordinary fire. Calcium compounds such as lime (CaO) were known and used in ancient times. Calcium metal, however, was first prepared in 1808 by Sir Humphry Davy, who also prepared magnesium, strontium, and barium in the same ...
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Strychnine total synthesis



Strychnine total synthesis in chemistry describes the total synthesis of the complex biomolecule strychnine. The first reported method by the group of Robert Burns Woodward in 1954 is considered a classic in this research field. At the time it formed the natural conclusion to an elaborate process of molecular structure elucidation that started with the isolation of strychnine from the beans of Strychnos ignatii by Pierre Joseph Pelletier and Joseph Bienaimé Caventou in 1818. Major contributors to the entire effort were Sir Robert Robinson with over 250 publications and Hermann Leuchs with another 125 papers in a time span of 40 years. Robinson was awarded the Nobel Prize in Chemistry in 1947 for his work on alkaloids, strychnine included. The process of chemical identification was completed with publications in 1946 by Robinson and later confirmed by Woodward in 1947. X-ray structures establishing the absolute configuration became available between 1947 and 1951 with publications from J. M. Bijvoet and J.H. Robertson .Woodward published a very brief account on the strychnine synthesis in 1954 (just 3 pages) and a lengthy one (42 pages) in 1963.Many more methods exist and reported by the research groups of Magnus, Overman, Kuehne, Rawal, Bosch, Vollhardt, Mori, Shibasaki, Li, Fukuyama Vanderwal and MacMillan. Synthetic (+)-strychnine is also known. Racemic synthesises were published by Padwa in 2007 and in 2010 by Andrade and by Reissig.In his 1963 publication Woodward quoted Sir Robert Robinson who said for its molecular size it is the most complex substance known.
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