thalidomide - Universidade Nova de Lisboa
... studies began being made regarding thalidomide treatments for diseases like cancer or leprosy. Was found useful in treating diseases such as lupus, ...
... studies began being made regarding thalidomide treatments for diseases like cancer or leprosy. Was found useful in treating diseases such as lupus, ...
Dockets Management Branch (HFA-305)
... For reasons stated below, the Office of Advocacy respectfully requests that the cornrnent deadline for the above-referenced FDA Concept Paper be extended by at least 90 days from the time all documents contained in the bibliography and referenced in the Concept Paper have been placed in the docket. ...
... For reasons stated below, the Office of Advocacy respectfully requests that the cornrnent deadline for the above-referenced FDA Concept Paper be extended by at least 90 days from the time all documents contained in the bibliography and referenced in the Concept Paper have been placed in the docket. ...
The Chemistry of Life Reading Questions
... 1. Use the structure of a water molecule to explain why it is polar. Be sure to describe the electrical charge of the atoms. ...
... 1. Use the structure of a water molecule to explain why it is polar. Be sure to describe the electrical charge of the atoms. ...
A review of drug isomerism and its significance
... mixtures as ‑ adverse drug reactions occurring due to one enentiomers are avoided, patients are exposed to less amount of drug so body is exposed to the lesser metabolic, renal and hepatic load of drug, there is easier therapeutic drug monitoring of the active pure active enantiomers. A number of ...
... mixtures as ‑ adverse drug reactions occurring due to one enentiomers are avoided, patients are exposed to less amount of drug so body is exposed to the lesser metabolic, renal and hepatic load of drug, there is easier therapeutic drug monitoring of the active pure active enantiomers. A number of ...
MLAB 2401: Clinical Chemistry Keri Brophy
... Wood/plastic fires Improperly ventilated furnaces ...
... Wood/plastic fires Improperly ventilated furnaces ...
Powerpoint
... (VLDL or LDL) and exchanges them for cholesteryl esters from high density lipoproteins (and vice versa) • A long tunnel with two major binding sites. Docking studies suggest that it possible that torcetrapib binds to both of them. • The torcetrapib binding site is unknown. Docking studies show that ...
... (VLDL or LDL) and exchanges them for cholesteryl esters from high density lipoproteins (and vice versa) • A long tunnel with two major binding sites. Docking studies suggest that it possible that torcetrapib binds to both of them. • The torcetrapib binding site is unknown. Docking studies show that ...
Receptor-based virtual screening solution. SELENE is a
... Receptor-based virtual screening solution. SELENE’s Applications SELENE is a computational tool which identifies active molecules with the ability to bind a receptor. Working with SELENE We need a target and a data base containing molecules of interest. The data base can either be your proper one, p ...
... Receptor-based virtual screening solution. SELENE’s Applications SELENE is a computational tool which identifies active molecules with the ability to bind a receptor. Working with SELENE We need a target and a data base containing molecules of interest. The data base can either be your proper one, p ...
Chemical Reaction Basics
... Advanced Chemistry – Chapter 8 A ____________ ____________ is a process by which one or more substances are changed into one or more ____________ substances. Chemical reactions are represented by some type of ____________. The general form is as follows: ...
... Advanced Chemistry – Chapter 8 A ____________ ____________ is a process by which one or more substances are changed into one or more ____________ substances. Chemical reactions are represented by some type of ____________. The general form is as follows: ...
7th Grade Science Unit 2: Matter and Energy in Chemical Changes
... that substances react chemically with other substances in predictable ways to form new substances (compounds) which have different properties that in physical changes and chemical reactions, atoms do not appear, disappear or change their identities atoms may bond by giving, taking or sharing ele ...
... that substances react chemically with other substances in predictable ways to form new substances (compounds) which have different properties that in physical changes and chemical reactions, atoms do not appear, disappear or change their identities atoms may bond by giving, taking or sharing ele ...
•
... Drug sensitivity/allergy - occurs in an individual who has been previously exposed to the drug and has developed antibodies. Drug allergies can be manifested in a variety of symptoms ranging from minor to serious. ...
... Drug sensitivity/allergy - occurs in an individual who has been previously exposed to the drug and has developed antibodies. Drug allergies can be manifested in a variety of symptoms ranging from minor to serious. ...
pharmacokinetic
... Drugs will accumulate within the body if the drug has not been fully eliminated before the next dose. Steady state concentration is thus arrived at after four half lives. This is all very well if you are willing to wait 4 half lives for the drug to be fully effective, but what if you are not? What ...
... Drugs will accumulate within the body if the drug has not been fully eliminated before the next dose. Steady state concentration is thus arrived at after four half lives. This is all very well if you are willing to wait 4 half lives for the drug to be fully effective, but what if you are not? What ...
Physicochemical properties of drug action
... • Natural compounds: materials obtained from both plant and animal, e.g. vitamins, hormones, amino acids, antibiotics, alkaloids, glycosides…. etc.). • Synthesis compounds: either pure synthesis or synthesis naturally occurring compounds (e.g. morphine, atropine, steroids and cocaine) to reduce thei ...
... • Natural compounds: materials obtained from both plant and animal, e.g. vitamins, hormones, amino acids, antibiotics, alkaloids, glycosides…. etc.). • Synthesis compounds: either pure synthesis or synthesis naturally occurring compounds (e.g. morphine, atropine, steroids and cocaine) to reduce thei ...
DRUGS AFFECTING CLOT FORMATION
... time (PT) 1.5 to 2.5 times the control value or ratio of PT to International Normalized Ratio (INR) of 2 to 3— to evaluate the effectiveness of the drug dose. ■ Evaluate for therapeutic effects of heparin—whole blood clotting time (WBCT) 2.5 to 3 times control or activated partial thromboplastin tim ...
... time (PT) 1.5 to 2.5 times the control value or ratio of PT to International Normalized Ratio (INR) of 2 to 3— to evaluate the effectiveness of the drug dose. ■ Evaluate for therapeutic effects of heparin—whole blood clotting time (WBCT) 2.5 to 3 times control or activated partial thromboplastin tim ...
Chapter 17
... Steady-state: determines how often the drug will be administered – Steady state is reached when the amount taken in is equal to the amount being excreted o Effects of Physical Activity on Pharmacokinetics Exercise in general decreases the absorption after oral administration of a drug Exercise i ...
... Steady-state: determines how often the drug will be administered – Steady state is reached when the amount taken in is equal to the amount being excreted o Effects of Physical Activity on Pharmacokinetics Exercise in general decreases the absorption after oral administration of a drug Exercise i ...
Absorption, distribution, metabolism and excretion
... Learning objectives • Know the processes involved in ADME of drugs • Know how these processes may affect the action of xenobiotics • Appreciate how these processes can affect the outcome of the treatment of patients with drugs • Appreciate how differences in these processes between patients can aff ...
... Learning objectives • Know the processes involved in ADME of drugs • Know how these processes may affect the action of xenobiotics • Appreciate how these processes can affect the outcome of the treatment of patients with drugs • Appreciate how differences in these processes between patients can aff ...
Paclitaxel
... Medical personnel should be readily available at the time of drug administration. Emergency equipment, including Ambu bag, EKG machine, IV fluids, pressors, and other drugs for resuscitation, must ...
... Medical personnel should be readily available at the time of drug administration. Emergency equipment, including Ambu bag, EKG machine, IV fluids, pressors, and other drugs for resuscitation, must ...
Route of drugs administration
... -large molecules(proteins)across through carries called facilitated diffusion and not need energy.(glucose). -e.g:-asprin and phenobarbitone.(lipid soluble). 2)active transport:-substance (drugs) moves form low concentration to an area of high concentration. -need energy for hydrolysis of ATPand spe ...
... -large molecules(proteins)across through carries called facilitated diffusion and not need energy.(glucose). -e.g:-asprin and phenobarbitone.(lipid soluble). 2)active transport:-substance (drugs) moves form low concentration to an area of high concentration. -need energy for hydrolysis of ATPand spe ...
Mastering Medicinal Chemistry Brochure
... Peter J. Tonge, Ph.D., Professor, Chemistry, Institute for Chemical Biology & Drug Discovery, Stony Brook University Participants will be introduced to the fundamentals of time-dependent inhibition and how these factors can impact drug discovery and development. The course will cover a range of topi ...
... Peter J. Tonge, Ph.D., Professor, Chemistry, Institute for Chemical Biology & Drug Discovery, Stony Brook University Participants will be introduced to the fundamentals of time-dependent inhibition and how these factors can impact drug discovery and development. The course will cover a range of topi ...
Diagnostic approach in patients with hypersensitivity
... NSAIDs, paracetamol and local anesthetics. Since only two patients developed anaphylaxis as the only severe reaction observed during 243 challenges, they concluded that drug provocation tests are safe. It has to be mentioned that in this study most patients were challenged with alternative drugs mor ...
... NSAIDs, paracetamol and local anesthetics. Since only two patients developed anaphylaxis as the only severe reaction observed during 243 challenges, they concluded that drug provocation tests are safe. It has to be mentioned that in this study most patients were challenged with alternative drugs mor ...
Chemical and Molecular Formulas PPT
... representative unit of the substance • chemists have identified more than 10 million chemical compounds • some are molecular, such as proteins and hormones in your body, and others are ionic, such as the salts in body fluids ...
... representative unit of the substance • chemists have identified more than 10 million chemical compounds • some are molecular, such as proteins and hormones in your body, and others are ionic, such as the salts in body fluids ...
Inhalation Drug Delivery ‐
... Combinations of HFA‐134a and HFA‐227 can be used to provide better solubility, appropriate aerosol velocity and density of the suspension (i.e. suspension settling). A cosolvent, which is typically ethanol, is used to help dissolve the API in the propellant, lower the vapor pressure of the pro ...
... Combinations of HFA‐134a and HFA‐227 can be used to provide better solubility, appropriate aerosol velocity and density of the suspension (i.e. suspension settling). A cosolvent, which is typically ethanol, is used to help dissolve the API in the propellant, lower the vapor pressure of the pro ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.