Name__________________________________ Block______
... Physical and Chemical Changes in Matter Put a “P” next to descriptions or indications of physical change or property. Put a “C” next to descriptions or indications of a chemical change or property. 1._____ the physical properties of a substance may change, but the kind of substance does not change 2 ...
... Physical and Chemical Changes in Matter Put a “P” next to descriptions or indications of physical change or property. Put a “C” next to descriptions or indications of a chemical change or property. 1._____ the physical properties of a substance may change, but the kind of substance does not change 2 ...
Molecular modeling in catalysis and chemical technology
... Education effects (P6S_UW, P7S_WG): - knowledge: student knows the most important methods in molecular modeling; knows the methods of building crystal structure of materials used in catalysis and chemical technology; is familiar with possible geometrical models used in molecular modeling - skills: s ...
... Education effects (P6S_UW, P7S_WG): - knowledge: student knows the most important methods in molecular modeling; knows the methods of building crystal structure of materials used in catalysis and chemical technology; is familiar with possible geometrical models used in molecular modeling - skills: s ...
ap chemistry – 2013-2014
... The labs in AP Chemistry require following or developing processes and procedures, taking observations and data manipulation. Students are to communicate and collaborate in lab groups (ideally working in pairs); however, each student writes a laboratory report in a lab notebook for every lab they pe ...
... The labs in AP Chemistry require following or developing processes and procedures, taking observations and data manipulation. Students are to communicate and collaborate in lab groups (ideally working in pairs); however, each student writes a laboratory report in a lab notebook for every lab they pe ...
WHY STUDY ADDICTION IN AP PSYCHOLOGY?
... Babies exposed to legal and illegal drugs in the womb may be born premature and underweight. This drug exposure can slow the child’s intellectual development and affect behavior later in life. Adolescents who abuse drugs often act out, do poorly academically, and drop out of school. They are at risk ...
... Babies exposed to legal and illegal drugs in the womb may be born premature and underweight. This drug exposure can slow the child’s intellectual development and affect behavior later in life. Adolescents who abuse drugs often act out, do poorly academically, and drop out of school. They are at risk ...
Fochon Pharma
... Make the human talents and excellent research & development facilities in Greece and Europe available to Fochon Similarly, Fochon will open up China & Asia’s resources to SELLAS By maximizing the synergy between the two companies, we will build a strong pipeline & a powerhouse that competes in ...
... Make the human talents and excellent research & development facilities in Greece and Europe available to Fochon Similarly, Fochon will open up China & Asia’s resources to SELLAS By maximizing the synergy between the two companies, we will build a strong pipeline & a powerhouse that competes in ...
Powerpoint
... PrEP same drug classes used for therapy Potential for drug resistance in the context of PrEP use in a real life setting 13 RT inhibitors used in the clinic they only belong to two classes: NRTIs and NNRTIs ...
... PrEP same drug classes used for therapy Potential for drug resistance in the context of PrEP use in a real life setting 13 RT inhibitors used in the clinic they only belong to two classes: NRTIs and NNRTIs ...
Internal Medicine Morning Report
... • Elderly have unique pharmacokinetics predisposing them to drug toxicity • High risk medications include ...
... • Elderly have unique pharmacokinetics predisposing them to drug toxicity • High risk medications include ...
Pharmaceutical Dosage Forms
... 7. To provide optimal drug action from topical administration sites (ointments, creams, transdermal patches, and ophthalmic, ear, and nasal preparations) 8. To provide for insertion of a drug into one of the body's orifices (rectal or vaginal suppositories). 9. To provide for placement of drugs dire ...
... 7. To provide optimal drug action from topical administration sites (ointments, creams, transdermal patches, and ophthalmic, ear, and nasal preparations) 8. To provide for insertion of a drug into one of the body's orifices (rectal or vaginal suppositories). 9. To provide for placement of drugs dire ...
From molecule to bedside
... IPS has expertise in the development of a broad range of biological assays and analytical techniques for the evaluation of novel drugs and mechanisms of action. When coupled with in-house in-vivo models and access to key patient groups through our health service partners, this provides a firm founda ...
... IPS has expertise in the development of a broad range of biological assays and analytical techniques for the evaluation of novel drugs and mechanisms of action. When coupled with in-house in-vivo models and access to key patient groups through our health service partners, this provides a firm founda ...
K
... IPS has expertise in the development of a broad range of biological assays and analytical techniques for the evaluation of novel drugs and mechanisms of action. When coupled with in-house in-vivo models and access to key patient groups through our health service partners, this provides a firm founda ...
... IPS has expertise in the development of a broad range of biological assays and analytical techniques for the evaluation of novel drugs and mechanisms of action. When coupled with in-house in-vivo models and access to key patient groups through our health service partners, this provides a firm founda ...
Illegal Drugs - cloudfront.net
... Other Drugs: 1. Anabolic Steroids: Synthetic male testosterone 2. Marijuana: “Weed”- a natural drug with the active ingredient THC. • Used for pain relief, as an appetite stimulant, and euphoria (both legally and illegally) • Hashish: resin from the plant which is solid an smoked in a pipe or boile ...
... Other Drugs: 1. Anabolic Steroids: Synthetic male testosterone 2. Marijuana: “Weed”- a natural drug with the active ingredient THC. • Used for pain relief, as an appetite stimulant, and euphoria (both legally and illegally) • Hashish: resin from the plant which is solid an smoked in a pipe or boile ...
The Biochemistry of Drug Metabolism. Volume 2: Conjugations,
... The next part examines the consequences of drug and xenobiotic metabolism in a pharmacological and toxicological perspective, with due attention paid to full activation, as is found with prodrugs, and to the worrying case of xenobiotic toxification. Parts 6 and 7 cover the inter–individual and intra ...
... The next part examines the consequences of drug and xenobiotic metabolism in a pharmacological and toxicological perspective, with due attention paid to full activation, as is found with prodrugs, and to the worrying case of xenobiotic toxification. Parts 6 and 7 cover the inter–individual and intra ...
Notification of drug dependent person
... the drug is used to the extent and for the purpose for which it was prescribed. The following precautions can be used to reduce potential harm: If you believe there may be sound clinical reasons to prescribe a drug of dependence, prescribe small quantities until you are able to validate the medica ...
... the drug is used to the extent and for the purpose for which it was prescribed. The following precautions can be used to reduce potential harm: If you believe there may be sound clinical reasons to prescribe a drug of dependence, prescribe small quantities until you are able to validate the medica ...
P21 The role of ethanol containing lotions on ethylglucuronide in
... M. Yegles, S. Schneider, R. Wennig Laboratoire National de Sante - Toxicologie, Luxembourg Ethyl glucuronide (EtG) in hair, a non-volatile, direct metabolite of ethanol proved to be an interesting marker for the evaluation of social and chronic excessive alcohol consumption. Regarding the influence ...
... M. Yegles, S. Schneider, R. Wennig Laboratoire National de Sante - Toxicologie, Luxembourg Ethyl glucuronide (EtG) in hair, a non-volatile, direct metabolite of ethanol proved to be an interesting marker for the evaluation of social and chronic excessive alcohol consumption. Regarding the influence ...
BIOASSAY SCREENINGS- IMPORTANCE IN DRUG RESEARCH
... Drug DiscoveryPast and Present In the past, most drugs were either discovered by trial and error (traditional remedies) or by serendipitous discoveries. ...
... Drug DiscoveryPast and Present In the past, most drugs were either discovered by trial and error (traditional remedies) or by serendipitous discoveries. ...
oxycodone
... Believe it or not, prescription drugs are the winners At the head of these cabinet drugs is Oxycodone (Oxycontin) or “Ox cotton,” an opioid derived drug Known for its similarities to the effects of heroin and morphine Believed by users to be stronger than heroin, proved to have 1.5-2xs the p ...
... Believe it or not, prescription drugs are the winners At the head of these cabinet drugs is Oxycodone (Oxycontin) or “Ox cotton,” an opioid derived drug Known for its similarities to the effects of heroin and morphine Believed by users to be stronger than heroin, proved to have 1.5-2xs the p ...
Designer Drugs - Redemption Psychiatry
... Designer Drugs What are designer drugs? Designer drugs are man-made versions of drugs based on another drug. They are also known as "club drugs" because they are often used in dance clubs or raves. Amateur chemists take an existing drug and change its chemical structure. There are many types of desi ...
... Designer Drugs What are designer drugs? Designer drugs are man-made versions of drugs based on another drug. They are also known as "club drugs" because they are often used in dance clubs or raves. Amateur chemists take an existing drug and change its chemical structure. There are many types of desi ...
Multi-target therapeutics - Corporate-ir
... cancer. Traditional chemotherapeutic agents have been routinely applied as co-therapies. For example, adjunctive agents can sensitize cancer cells to DNA-damaging drugs, and newer co-therapy protocols including 5-FU, leucovorin and oxaliplatin (i.e. FOLFOX) are now applied in colorectal cancer. Curr ...
... cancer. Traditional chemotherapeutic agents have been routinely applied as co-therapies. For example, adjunctive agents can sensitize cancer cells to DNA-damaging drugs, and newer co-therapy protocols including 5-FU, leucovorin and oxaliplatin (i.e. FOLFOX) are now applied in colorectal cancer. Curr ...
Lesson Plan I: March 17, March 19
... Scientists develop drugs so that they react in specific ways with specific enzymes; metabolism is the most important part of ADME. 3. How do you know how much of a drug to take? The amount of a drug you take depends on how long your body takes to absorb it. For example, if you have a splitting hea ...
... Scientists develop drugs so that they react in specific ways with specific enzymes; metabolism is the most important part of ADME. 3. How do you know how much of a drug to take? The amount of a drug you take depends on how long your body takes to absorb it. For example, if you have a splitting hea ...
Brain changes and drug addiction
... Cocaine and methamphetamine are strong reinforcers and highly addictive (tolerance and dependence) Following oral use, the effects of usually start within 30 minutes and last for many hours. Later, users may feel irritable, restless, anxious, depressed and lethargic. Upon chronic use: deficits in me ...
... Cocaine and methamphetamine are strong reinforcers and highly addictive (tolerance and dependence) Following oral use, the effects of usually start within 30 minutes and last for many hours. Later, users may feel irritable, restless, anxious, depressed and lethargic. Upon chronic use: deficits in me ...
The Bioanalytical Evaluation of Novel Therapeutic Modalities in
... Analytical data obtained on multiple analytes adds greater depth and validity to calculated measurements and provide details on the integrity of the modality on the molecular level Multiple biomarkers/proteins can be simultaneously measure by detecting unique peptides from each and unique forms ...
... Analytical data obtained on multiple analytes adds greater depth and validity to calculated measurements and provide details on the integrity of the modality on the molecular level Multiple biomarkers/proteins can be simultaneously measure by detecting unique peptides from each and unique forms ...
Toxicology
... Mainly liver (some in GI tract, kidneys, lungs) Phase I – introduce or expose a functional group on the parent compound – losing pharmacological effect Phase II – produces polar conjugates – generally inactive and easily excreted in urine and/or faeces ...
... Mainly liver (some in GI tract, kidneys, lungs) Phase I – introduce or expose a functional group on the parent compound – losing pharmacological effect Phase II – produces polar conjugates – generally inactive and easily excreted in urine and/or faeces ...
Metabolism Phase-I
... 2. Do all drugs need to pass through phase-I metabolism? Which drugs can directly pass to phase-II? 3. Some drugs can be partially eliminated from the body without any metabolism. Why? 4. Drug interacts with metabolizing enzyme in a manner similar to drug-target interaction. However, the later inter ...
... 2. Do all drugs need to pass through phase-I metabolism? Which drugs can directly pass to phase-II? 3. Some drugs can be partially eliminated from the body without any metabolism. Why? 4. Drug interacts with metabolizing enzyme in a manner similar to drug-target interaction. However, the later inter ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.